Glycoproteins Research

Fig.1 Initiation and maturation of glycoproteins in membrane pathway.
(Fuertes-Martín, 2020)

One of the major modifications that a protein may undergo after the synthesis of its peptide chains is the attachment of sugar residues. Many proteins of diverse origin and biological function are known to contain such covalently linked carbohydrates and are designated as glycoproteins. These glycoproteins are an abundant class of molecules that are found in cellular membranes. The carbohydrate moiety is responsible for many important physiochemical properties of the protein and plays a role in cell recognition, fertilization, and development. Analysis of the SWISS-PROT database indicated that more than half of all proteins are glycosylated and about 1% of the human genome is devoted to maintaining and manipulating the glycosylation of cells. Therefore, glycoproteins research has occupied an important position in the field of biology. As a leading company in the protein science area, Creative Biolabs has established a mature and comprehensive platform for glycoproteins research with a variety of sophisticated technologies. Based on rich experience and proficient skills in protein engineering, we offer all kinds of commercial or customized services in glycoproteins research to meet your requirement.

Introduction of Glycoproteins

Glycoproteins are proteins that contain glycans covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. Two major types of covalent addition of glycan are found. These involve the modification to amino acid side-chains: N-glycosylation of asparagine amino groups and O-glycosylation of serine or threonine hydroxyl groups.

Importance of Glycoproteins

Glycoproteins are involved in many cellular activities, in embryogenesis and development, and are often structurally and functionally changed in disease. They fulfill their roles as elements of structure, as biologically active molecules, and as adhesive ligands. Many glycoproteins that serve as ligands or receptors can modulate or transduce information concerned with signaling, cell-cell binding, cell growth, differentiation, and cell death.

Synthesis of Glycoproteins

Glycosylation usually occurs in the endoplasmic reticulum and the Golgi and their biosynthesis is controlled at the level of gene expression, mRNA, glycosyltransferases activity and localization, and through substrate and cofactor concentrations at the site of synthesis. Recently, based on our mature glycoprotein research platform, we have developed both chemical synthesis, chemoenzymatic synthesis, and biosynthesis methods to obtain specific glycoproteins.

What can we do?

With the rapid development of protein science, more novel technologies have been applied to glycoprotein research. Therefore, Creative Biolabs launched one-stop glycoprotein-related services and products to accelerate your project. For more detail on glycoprotein research or our services, please click follow key words or directly contact us.

• Glycoprotein Definition
• Glycoprotein Structure
• Glycoprotein Function
• Glycoprotein Synthesis
• Purification Methods of Glycoprotein
• Current Detection Methods of Glycoprotein
• Glycotype Analysis Strategy of Protein Drugs
• Glycoprotein Biomarkers Research
• Research Progress of Glycoprotein Vaccine
• Research Progress of Glycoprotein Antibodies

Reference

1. Fuertes-Martín, R.; et al. Human serum/plasma glycoprotein analysis by 1H-NMR, an emerging method of inflammatory assessment. Journal of clinical medicine. 2020, 9(2), 354.

Related Services:

1. What is Glycobiology?
2. Glycan Research
3. Post-translational Modification Research
4. Therapeutic Glycoprtein