44th Annual Meeting scientific program by derma.tda

SCIENTIFIC PROGRAM

Table of Contents Welcome Message .................................................................................... 003 Organizing Committee ............................................................................... 006 General Information ................................................................................... 007 Registration ................................................................................................ 008 Transportation ............................................................................................ 009 Floor Plan ................................................................................................... 010 Program at a Glance .................................................................................. 014 SERDF & Prof. Lu Memorial Lectureship ................................................... 017 International Society of Dermatology (ISD) / Taiwan Dermatological Association (TDA).................................................. 020 ISD/TDA Speakers ................................................................................. 035 ISD/TDA Abstracts .................................................................................... 057 Medical Mycology Training Network (MMTN) ............................................ 098 MMTN Speakers ........................................................................................ 101 MMTN Abstracts .................................................................................. 105 Taiwan Dermatopathology Conference (TDPC). ....................................... 112 TDPC Speakers ......................................................................................... 116 TDPC Abstracts .......................................................................................... 121 Free Papers ............................................................................................... 125 Case Reports ............................................................................................. 132 E-posters .................................................................................................... 138 Sponsors .................................................................................................... 147

Welcome Message Dear colleagues, It is with great pleasure that we assemble in Taipei for this important and prestigious meeting. The International Society of Dermatology (ISD) is proud to participate in the 6th Continent Congress of Dermatology 2018 and to share this honor with our colleagues from the Taiwanese Dermatological Association. This is our first meeting together and it is with great anticipation that we attend. Many of the Society’s executive board will be here and together wish to thank the organizing committee and especially Dr. Ji-Chen Ho, Honorary C o n g r e s s P r e s i d e n t , D r. We n - H u n g C h u n g , H o n o r a r y C o n g r e s s President and Dr. Jason, CH Yang, Congress Chair for their hard work and dedication. The ISD is supporting this Congress through scholarships, travel grants and speakers which contribute to its international exposure. For me, this is also a prized opportunity to see and meet colleagues and make new friends while enjoying the culture, hospitality and history of this extraordinary country. These experiences and contacts are at the heart of a meeting’s success and an opportunity for new and seasoned dermatologists to network and learn. I also wish to welcome our new members to the Society The ISD is already represented by members from Taiwan and is stronger because of their contributions. This meeting will be a lasting bridge between your country and global dermatology. This Congress will communicate some of dermatology’s cutting edge ideas while highlighting Taiwan’s role in international medicine. We are grateful for this opportunity to come to Taipei and learn from our colleagues, each of us leaving richer for the experience. Let us enjoy these next few days of learning and international fellowship. Sincerely,

George Reizner, MD President, International Society of Dermatology

Dear Colleagues and Friends, On behalf of the organizing committee of the Taiwan Dermatological Association (TDA), we are pleased to welcome you to the 6th Continental Congress of Dermatology (CCD), incorporating the 44th Annual Meeting of Taiwanese Dermatological Association (TDA), that will be held at the Taipei International Conference Center (TICC) in Taipei, Taiwan from November 16-18th, 2018. Over the last 10 years, the TDA annual meeting has become synonymous with WKH KLJKHVW FDOLEHU VFLHQWLÂżF PHHWLQJ LQ 'HUPDWRORJ\ DFURVV $VLD ,W LV RXU KRQRU to host the 6th CCD with the International Society of Dermatology (ISD). The highlights of this year are Nail, Dermoscope, Skin Surgery, Drug Immunology and Fungal Infection. With an overriding theme of â&#x20AC;&#x153;Expanding Horizons,â&#x20AC;? this conference will provide an extensive program, including plenary VHVVLRQV LQYLWHG OHFWXUHV LQWHUDFWLYH VHVVLRQV DQG ZRUNVKRSV 7KH VFLHQWLÂżF program will cover the spectrum of dermatology, dermatology surgery, and aesthetic subspecialties. Renowned international and regional experts will be sharing their latest discoveries, practice pearls, and up-to-date lectures. Given that Taipei is a distinctly cosmopolitan city with a truly welcoming people, coupled with superior conference venues, we expect the 6th CCD, held in conjunction with the 44th TDA Annual meeting 2018 to be a resounding success. The congress venue is the Taiwan International Conference Center (TICC), a world-class conference center situated in the heart of Taipei, Taiwanâ&#x20AC;&#x2122;s most vibrant and stylish city, right next to the famous Taipei 101. Last but not least, we would like to thank the International Society of Dermatology (ISD), as well as the organizing committee, scientific committee, speakers, participants, and sponsors for making the meeting a resounding success. We wish you a pleasant and memorable stay here in Taipei, and a fruitful time at the conference. Get ready to inspire and be inspired. Yours sincerely, Honorary Congress President, Ji-Chen Ho Honorary Congress President, Wen-Hung Chung Congress Chair, Jason, CH Yang

Ji-Chen Ho Honorary Congress President

Wen-Hung Chung Honorary Congress President

Jason, CH Yang Congress Chair

Yao-Yu Chang Congress Secretary

⏫ἴ䚕冁䦸⏳Ẩ⎱凮㛪憒⸒Ɲ 嬠Ị塏凡䁊䚕冁䦸憒⭟㛪䰳₀⦻Ⓢ㛪媇㑖㭈徵⏫ἴ⎪⊇凡䁊䚕冁䦸憒⭟㛪䬓 44 Ⱝ⹛㛪Ə⏳㘩凮䬓⅔Ⱝ Continental Congress of Dermatology ᷧ⏳Ḣ徍Ə 㜓㬈⤎㛪⯮㛪凰徍㖣 2018 ⹛ 11 㛯 16 凚 18 㗌✏⏗⋾⛲暂㛪字Ḕ⾪˛✏怵⎢ ⌨ ⹛ 敺Ə 凡䁊䚕冁䦸憒 ⭟ 㛪 ᷧ ⹛ ᷧ ⺍䙫 ⹛ 㛪 ℣ 䄝 ⷙ ㇷ䂡 ✏ 㩒巏㕛 ῲ ẅ 㴙 ✗ ⌧檿㰛㹽䙫䚕冁䦸⭟⤎㛪˛ὃ䂡ẅ㴙✗⌧楽Ⱜᷧ㋮䙫⛲暂❲㛪字ƏㇸῸ䛟䕝㦕⹟僤⤇䈔⎽∗凮 International Society of Dermatology (ISD) ᷧ⏳Ḣ徍䬓⅔Ⱝ CCD˛ 㜓Ⱝ㛪字䙫Ḣ栳㶜咲 Nail˚Dermoscope˚Dermatopathology˚Skin Surgery˚ Drug Immunology ⑳ Fungal InfectionƏ岒䩦Ḣ栳䙫Ḕ⾪〄ペ䂡˥㓛ⰼ好憵Ə ⰼ㜂㜑Ὥ˦˛ㇸῸ奶≪ṭᷧῲ䛟䕝⻊斱䙫字䧲䮫䕮Ə⋬㋓Ḣ栳㻻嬂˚恧媲㻻嬂Ə 恫㛰ṹ⊼『䙫媙䧲⎱ⷌὃ✱ƞ媙䧲ⅎ⮠∮⋬㋓ṭ䚕冁⭟˚䚕冁䛟旃㈲堺⑳憒⭟併 ⮠䛟旃⯯㥔˛䟌⏴䙫⯯⮝Ọ⎱⯯敧柿⟆䙫⭟俬⯮㛪⇭Ẓ㛧㖗䙫䟻䩝䙣䏥˚㛧徸㜆䙫㜆⇱㕮䍢Ọ⎱悊ẂẽῸ䙫⯝岛䵺樾˛ ⏗⋾ⷩ孤㛰㛧⎲╫➵ⷩḲ䨘Əⅴ⊇ᷱ⛲暂ᷧ㴨䙫㛪字Ḕ⾪ƏㇸῸ㜆⽬⛇䂡㛰わ䙫 ⎪凮Ə䬓⅔Ⱝ CCD 凮䬓 44 Ⱝ凡䁊䚕冁憒⭟㛪⹛㛪⯮㛪⛺㻦ㇷ⊆˛怀㬈㛪字凰徍✗滅⺎吤㖣⏗⋾ⷩⷩḔ⾪䙫⏗⋾⛲暂㛪字Ḕ⾪ƋTICCƌƏ凮⏗䁊㛧檿䙫 ✗㨀⏗⋾ 101 䂡愗Əㄆ⎾⏗⋾䙫㴢⊂凮㘩Ⰱ˛ 㛧⽳Əㄆ嬄 ISD 恫㛰㈧㛰䙫䰳₀⦻Ⓢ˚⭟堺⦻Ⓢ˚嬂⸒˚凮㛪俬⎱峱⊐┭⎪凮⤎㛪˛ 㜆㜂Ὥ⏗⋾⎪㛪䙫わ惤僤⤇䕀ᷲヰ⿒᷻曊⾿䙫䵺㭞Ƅ 䬓 44 Ⱝ凡䁊䚕冁䦸憒⭟㛪⹛㛪㦕孤㛪敞 Ἴ⮃㉦㦕孤㛪敞揿㕮⭶ Ḣ⸔ 㤱⾾⋂ 㕓ᷱ

Ji-Chen Ho Ἴ⮃㉦㦕孤㛪敞

Wen-Hung Chung 揿㕮⭶ 㦕孤㛪敞

Jason, CH Yang 㤱⾾⋂ ⤎㛪Ḣ⸔

Yao-Yu Chang ⼜㛃⭮ ⤎㛪䦿㛟敞

Organizing Committee

Organizer: Taiwanese Dermatological Association (TDA) Co-organizer: Dermatology Chang Gung Memorial Hospital, Taiwan Society for Dermatological and Aesthetic Surgery (TSDAS), Taiwanese Society for Investigative Dermatology (TSID), Taiwanese Photomedicine Society, Asia Fungal Working Group (AFWG), Asian Society of Dermatopathology (ASD) Honorary President: Ji-chen Ho ( áźźâŽ&#x192;ă&#x2030;Ś ), Wen-hung Chung ( ć?żă&#x2022;Žâś ) Chairman: Chih-hsun Yang ( ă¤ąâžžâ&#x2039;&#x201A; ) Conference Secretary: Yao-yu Chang ( âź&#x153;ă&#x203A;&#x192;âŽ ) Academic Research Section: Hassan Galadari, Evangeline B. Handog, Yu-huei Huang ( ćşŞăŽşă&#x192;&#x2021; ), Nellie Konnikov, Cheng-che E. Lan ( ĺ&#x2013;´ ă&#x201D;Ś â&#x201C;&#x2122; ) , Pei-hsuan Lu ( â?Š á˝? ä&#x2018;Ž ), Margaret Mann, Pei-lun Sun ( â&#x2019;â&#x; â&#x20AC;&#x2019; ), Shyam Verma, Yen-jen Wang ( ä?˛ä&#x;ťáşĄ ), Yu-hung Wu ( â?&#x161;ĺ&#x201A;&#x2122;âťż ) Finance Section: Ya-Ching Chang ( âź&#x153;ć&#x161;Źĺ&#x17D;¨ ), Hsin-pei Chen ( ć&#x2122;&#x161;ăŹ&#x160;á˝? ), Hua-en Lee ( ă&#x153;ľĺ?&#x2013;ă ? ), Jing-Yi Lin ( ă?žć?&#x192;ă&#x20AC;&#x2C6; ), Documentation Section: Rosaline Chung-yee Hui ( ĺ¨&#x2DC;áť&#x2122;ä&#x2018;&#x2039; ), Chien-yio Lin ( ă?žâ&#x152;Şâ&#x17D;Ż ), I-hsin Shih ( ă&#x2013;¤áˇ§ă&#x2013;&#x2014; ), Ming-Ying Wu ( â?&#x161;ă&#x2014;ľä¨ľ ) Logistic Section: Yung-yi Lee ( ă&#x153;ľâ&#x160;ŽăŽŹ ), Chun-wei Lu ( ä&#x203A;&#x17D;ážąä?˛ ) Activity Section: Pei-han Kao ( ćŞżä?&#x2022;ĺ?&#x2C6; ), Charlene Chau-yee Ng ( ćşŞă&#x2DC;&#x201D;ä&#x2018;&#x192; ), Sze-wen Ting ( áˇ¨ă&#x20AC;&#x201E;ă&#x2022;Ž ), Jennifer Wu( â?&#x161;â?°âŚ&#x2022; ) Information Section: Chun-bing Chen ( ć&#x2122;&#x161;ážąĺ˛ş ), Hsi Yen ( ć śä&#x2019;¤ ) Conference Secretary: Chia-jung Lin (ă?žá˝&#x161;ĺ&#x2019;°), Min-jyun Luo (ä˝Źă&#x201D;śâ?&#x201A;), Yu-han Wu (â?&#x161;ć&#x203A;?ăś&#x153;), Mamie Hao-an Chao (ĺś&#x20AC;ă&#x2122;&#x17D;â°)

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General Information VENUE

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Taipei International Convention Center (TICC) is located in the heart of Taipei, adjacent to the iconic Taipei 101 (which was at one point the tallest building in the world). Not only are there many malls and attractions nearby, it is also easily accessible by metro. Taipei International Convention Center (TICC) 1 Hsin-Yi Road, Section 5 Taipei 11049, Taiwan ROC Email: ticc@taitra.org.tw Tel: +886(2)2725-5200 / Fax: +886(2)2723-2589

1. The Gala Dinner will be held at TICC from 18:00 - 20:00 on Nov 17, 2018. 2. Lunches and coffee breaks are included in the registration fee.

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1. Due to cost considerations, the registration fee is non-refundable if the attendee cannot attend for personal reasons. 2. Should the meetings need to be cancelled or rescheduled for any catastrophic or weather causes, registration fees will be refunded in full by the Taiwanese Dermatological Association (TDA).

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Saturday 17 Nov. 2018 08:00 - 17:30 Sunday 18 Nov. 2018 08:00 - 17:00

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3KRWR LGHQWL¿FDWLRQ ZLOO EH UHTXLUHG IRU UHJLVWUDWLRQ 2. Registration for each conference day: Friday, Nov 16: 08:00-17:30 Saturday, Nov 17: 08:00-17:30 Sunday, Nov 18: 08:00-13:30 3. The onsite registration desk is located on the first ÀRRU RI 7DLSHL ,QWHUQDWLRQDO &RQYHQWLRQ &HQWHU 7,&& (1 Hsin-Yi Road,Section 5,Taipei 11049,Taiwan ROC). For details, please refer to the following linkƝhttp:// www.ticc.com.tw/main_en/index.aspx

The Taipei International Conference Center (TICC) provides complimentary wireless internet access service. WiFi for mobile phones, tablets, and laptops

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$FFHVV &RQWURO 1. Please wear your name badge at all times; attendees will need the name badge to gain admission to VFLHQWL¿F VHVVLRQV DQG WKH H[KLELWLRQ DUHD Please note that our staff members are instructed not to permit entry without a name badge. 2. The Congress does not provide childcare. Children

photograph, or video-record is prohibited during the lectures

will be accessible within the Center by selecting the ĄTICCą signal. No special registration process or fees are required.

&HUWL¿FDWH RI $WWHQGDQFH The certificate of attendance can be obtained online DIWHU FRQJUHVV HYDOXDWLRQ WKURXJK WKH FRQJUHVV RI¿FLDO website.

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and infants are not permitted in any of the congress session rooms or events. Disruptive behavior will result in the revocation of attendance privileges. Attendees must be 18 years of age or older to attend any social activities.

Registration Fee Before Oct. 15th Pre-Registered Fee

Nov. 16th- 18th Onsite Register Fee

Member

NTD 4,500 (approx. 150 USD)

NTD 5,500 (approx. 180 USD)

Associate Member*

NTD 3,000 (approx. 100 USD)

NTD 3,500 (approx. 120 USD)

For TDA members registered as residents

International Society of Dermatology (ISD)

Member

NTD 4,500 (approx. 150 USD)

NTD 5,500 (approx. 180 USD)

An ISD member ID or a membership application form required for discounted rates

International Society for Human and Animal Mycology (ISHAM)

Member

NTD 4,500 (approx. 150 USD)

NTD 5,500 (approx. 180 USD)

League of ASEAN Dermatological Societies (LADS)

Member

NTD 4,500 (approx. 150 USD)

NTD 5,500 (approx. 180 USD)

NTD12,000 (approx. 400 USD)

NTD 15000 (approx. 500 USD)

NTD 1500 (approx. 50 USD)

NTD 2,000 (approx. 65 USD)

NTD 3,000 (approx. 100 USD)

NTD 3,500 (approx. 120 USD)

Sponsored Symposium

Climate Change/ Sponsored Tropical Symposium Dermatology Coffee Break

䬓⅒Ⱝ告Ṳ㛪䔘Ἴ⮃㉦告Ṳ敞㛪⏳⏴孤告Ṳ⭒╆䒆⎱ṳ⌨ἴ告ṲƝ≰〄㥏˚㤱⛲㜷˚僈ᾱ⻿˚␚備⻿˚⅏泛搟˚ὀ⹟⏟˚ ␚勘ᾱ˚㜵⾾⭶˚㝾敞䆀˚㝾䑅⮃˚㤱⾾⋂˚㴑⭶侻˚䳧䦧取˚僈㶸䎙˚⼜⍁⋄˚晚䦧䐛˚晚⛲䅶˚晚柭总˚㛥凯晭˚⺽䚱媇˚ 漱⾪㎏ⰼ㛪⋀Əᾪ怙⏗䁊䚕冁䦸⭟ᷴ㖞⽧∴恨怙˛ ᵒ⟥䈌曃 1Ʊ 䲪サ宠Ʊ䴺⸾摉Ṅ ⌀亾∽㐗㉆䮾⺳姙ⵥ Professor Lu Yau-Chin Memorial Lectureship ( Since 1992 ) 娔䪲㖣 1992 ⹛Ə˥␩俧⍦㕀㍯䳧⿜嬂⺎˦Ḫ䂡䳧⿜⏗䁊䚕冁䦸∴弐柿⯵ạ␩俧⍦㕀㍯˛嬂⺎恧媲䕝Ị䚕冁䦸⭟ 㳗㕾㖣㮶⹛⏗䁊䚕冁䦸憒⭟㛪⹛㛪䙣塏⯯栳㻻嬂˛徫ằⷙ恧媲 25 ἴ嬂⺎⭟俬咅⏗㻻嬂 ( 媲奲昫塏 )˛ ␩俧⍦㕀㍯ (1925-1991) 㘖ṳ㈗⽳⏗䁊䚕冁䦸憴奨柿⯵ạḲᷧ˛䕉㥔凑⛲䪲⏗䁊⤎⭟憒⭟晉Ə✏⏗⤎䚕冁䦸敲╆ṭ 尷䛂䙫䚕冁䦸䔆㶖˛1964 ⹛Ọ 39 㭙勘⹛㗮Ợ㭊㕀㍯Ə㭞Ợ⏗⤎憒晉䚕冁䦸ḢỢ⤁⹛ (1972-1975, 1982-1989)Ə⯴⏗⤎ 䚕冁䦸Ḳ㕀䟻僤憶Ə岉䍢⻊⤎㷘恇˛ᷧ⺍媦䛨䪲⏗⌾憒晉㒻Ợ晉敞ƞḍ㖣 1966 ⹛嵛併⛲㝃Ⅎ⤎⭟⸒⾅ Conant 㕀㍯䟻῕憒䔏䜆厳⭟Ə㋨乳㷘俼Ə㖣 1977 ⹛䍙㗌㜓㝘⋾⤎⭟憒⭟⍁⣒⭟ἴ˛␩㕀㍯㖣⭟堺䟻䩝岉䍢剖⤁ƏˣḔ⛲ạ䚕冁䖬⛽孃ˤ⛂弖Ḫ憴奨吾ὃ˛1963 ⹛䙣塏⤁⬻『䚕䈮Ḳ媽㕮㖣㗌㜓˥䚕冁䦸Ḳ减⹱˦曃婳Ə廪䏥ằ䆆䟌Ḳ Tanner “mesh graft” Ⰱ㗐ᷧ⹛㎷⇡˛ ␩㕀㍯㛪⏳⤁ἴ䚕冁憒⭟ℯ怙Ə㖣 1975 ⹛≜䪲凡䁊䚕冁䦸憒⭟㛪Əḍ㦕Ợ≜㛪䏭Ṳ敞⛂Ⱝ˛␩俧⍦㕀㍯䕉䔆凛⊂⏗䁊䚕冁䦸䙣ⰼƏ䚕冁䦸⏳Ẩㇽ㛰⹟⽾妑䂀ℯ峉Ə倭偤⅝㕀䚱Əㇽ᷽Ị䛟ₚƏ䞢ỗ梏䮫˛ằ㗌Ọ˥␩俧⍦㕀㍯䳧⿜嬂⺎˦䷓㇞ℯ峉Ə乣⽧敲ὭƏ㔃㈲⥕怙Ə㈺怇㛛⣖斱䙫⏗䁊䚕冁䦸˛ ⌀亾∽㐗㉆䮾⺳姙ⵥ㨵⬄⨶仃 (1993-2018) 濣 ⴲⵤ

⊮㼡䕬偘䢏恩⨶㗁 ⴲ㗁⬄㐶

᳹幤⑬ḋ

᳹姙⨶仃

1993

⏗⋾敞⺁

Richard L. Dobson 㕀㍯ ( 併⛲ )

1994

檿暫憒⤎

䟚㨲⺞㭊㕀㍯ ( 㗌㜓 )

1995

ᷰ庴两憒晉

Kowichi Jimbow 㕀㍯ ( ⊇㋦⤎ )

1996

檿暫敞⺁

Hideo Yaoita 㕀㍯ ( 㗌㜓 )

1997

⏗䁊⤎⭟

Eugene Bauer 㕀㍯ ( 併⛲ ) Eugene A. Bauer 㕀㍯ ( 併⛲ )

1998

榓‼憒晉

Georg Stingl 㕀㍯ ( ⥎✗∐ )

1999

ㇷ⊆⤎⭟

奦ⷄ㭍ṳ㕀㍯ ( 㗌㜓 )

2000

⏗⋾敞⺁

嗮㕮⍁㕀㍯ ( 併⛲ )

2001

檿暫憒⤎

Tezuka Tadashi 㕀㍯ ( 㗌㜓 )

2002

⏗䁊⤎⭟

Stephen I. Katz 㕀㍯ ( 併⛲ )

2003

⏗⋾憒⤎

Kunihiko Tamaki 㕀㍯ ( 㗌㜓 )

2004

⏗⋾㦕两

Massko Mizoguchi 㕀㍯ ( 㗌㜓 )

2005

ㄯ㿆⤎⭟

Vincent J. Hearing 㕀㍯ ( 併⛲ )

2006

榓‼憒晉

≰㉝㝘㕀㍯ ( 併⛲ )

2007

ㇷ⊆⤎⭟

Yasuo Kitajima 㕀㍯ ( 㗌㜓 )

2008

⏗⋾敞⺁

Yoshiki Miyachi 㕀㍯ ( 㗌㜓 )

2009

檿暫憒⤎

Masutaka Furue 㕀㍯ ( 㗌㜓 )

ⴲⵤ

⊮㼡䕬偘䢏恩⨶㗁 ⴲ㗁⬄㐶

᳹幤⑬ḋ

᳹姙⨶仃

2010

⏗䁊⤎⭟

Shinji Shimada 㕀㍯ ( 㗌㜓 )

2011

⏗⋾憒⤎

Jean-Hilaire Saurat 㕀㍯ ( 䑅⣒ )

2012

⏗⋾㦕两

捥㭊㗵㕀㍯ ( 併⛲ )

2013

⏗⋾敞⺁

Jean-Claude Roujeau 㕀㍯ ( 㲼⛲ )

2014

ㇷ⊆⤎⭟

Peter M. Elias 㕀㍯ ( 併⛲ )

2015

凡䁊䚕冁䦸憒⭟㛪

Harvey Lui 㕀㍯ ( ⊇㋦⤎ )

2016

凡䁊䚕冁䦸憒⭟㛪

Jean L. Bolognia 㕀㍯ ( 併⛲ ) Yoshiki Tokura 㕀㍯ ( 㗌㜓 )

2017

凡䁊䚕冁䦸憒⭟㛪

Sinichi Sata 㕀㍯ ( 㗌㜓 )

2018

凡䁊䚕冁䦸憒⭟㛪

Sybren de Hoog 㕀㍯ ( 卞嘔 )

2Ʊ 䕬偘恩⨶僅⥐榒㭆䠔㘮㐗㉆䈌 Professor Tsu-Chieh Shen Award (Since 2014) 2014 ⹛Ə楽≜Ą㱯䤽㝗㕀㍯䌵Ə㭋䌵䙫䛕䙫✏䌵⋜ₚ㒔⩹檻䙫㕮⬾⠘⯵ㇽ⽘柚ⅎ⮠Ə㗵桖僤ᾪ怙䤥㛪⤎䜥憴好凑庒䚕冁⁌⺞Ə㎷⌮䚕冁䦸⭟䙫⯯㥔⽉屈⑳䤥㛪⽘柦⊂ (Image and Impact) ˛㮶⹛㕍媲⯯⮝娼⯐Ə㖣㮶⹛⏗䁊䚕冁䦸憒⭟㛪⹛㛪柹䌵˛㮶ờ⽾䌵ὃ⒨䌵憸㖗⏗⹊ṻ吓KƏḍ凛峯䳧⿜䌵⺎凮嬰㛟Ə㮶⹛柷⮁䌵⋜ᷧ凚ᷰờὃ⒨˛⏫ἴ㛪Ⓢ 勌✏⠘䫇曃婳ㇽ䶙巖䛲∗ℑ䦧䙫⠘⯵ὃ⒨Ə㭈徵⯮姱ざ㎷ᾂ䵍㜓⟡憸㛪˛勌婙ὃ⒨㛧⽳⎾⯯⮝娼⯐朹䝅Ə㦕䍙㱯䤽㝗㕀㍯䌵㭱㦕Ə㎷ᾂ俬ẍ⏖䍙啫慓˛ 㜓⟡憸㛪怊䵈曢婘 : 02-2711-8288 ₚ䜆 : 02-2752-3368 E-mail: serdf220@gmail.com 㭆䠔㘮㐗㉆䈌㨵⬄⹕᳹ 2014

嗲㞃㗌⠘悘ᾱ⏰姿俬

2015

⏗䁊㖗䔆⠘吓⍁嵬˚僈㮺屑姿俬

2016

偖⏯⠘晚曏摒姿俬

2017

Ḕ⤕态姱䤥晚‰⺔姿俬

2018

偖⏯⠘㜵㨠ạ姿俬

㱯䤽㝗㕀㍯㘖⏗䁊䚕冁䦸⭟䙣ⰼ䙫憴奨柿⯵ạƏ⎪凮≜䪲⏗䁊䚕冁䦸憒⭟㛪ḍ㋨乳岉䍢⅝勨⣖˛㜓⟡憸㛪⾜⽾㱯㕀㍯⮝ạ⏳ヶƏỌ⅝⏴嫘䂡㭋䌵柬⑤⏴Ə䳧⿜ẽ⯴⏗䁊䚕冁䦸⭟䙣ⰼ䙫㷘恇⽘柦˛ 㱯䤽㝗㕀㍯ (1923-2001) 婼䔆㖣⏗⌾ⷩ㖗䇆⌧Ə1945 ⹛㗌㜓Ⲑ㈲憒⭟⯯敧⭟㠈憒䦸䕉㥔Ə㛴⋀⏗⤎昫娔憒晉䚕冁䦸 (1955-1958) ⽳Əㆰ㝃偗㗵晉敞Ḳ恧⎪凮檿暫憒⭟⤎⭟ㇷ䪲㗐㜆⻡娔˛ᷧ䔆溪憸㭙㛯暢㈲敲≜檿暫憒⭟⤎⭟䚕冁䦸Ə㎏⊼㛴⋀凮䟻䩝Əὃ備勘㈴Ə⥇⟡檿憒䚕冁䦸ㇷ䂡⏗䁊䚕冁䦸⭟憴掕˛㱯㕀㍯ὃ備勘㈴˚㠪㜵㻦敧凮ᾪ怙⛲暂䟌 ⏴⭟俬咅⏗⭟堺ẋ㴨˛ 3Ʊ ≘㟋㑮䏝ᶡ◉教䱑椕 AAD (American Academy of Dermatology) Mentorship Program (Since 2015) ⤁⹛ὭƏ朙⽾㷬⅓⏟㮶⹛峱⊐⤁⏴䚕冁䦸ἶ晉憒⸒⎪⊇ American Academy of Dermatology (AAD) ⹛㛪˛䂡㎷⌮ ἶ晉憒⸒⎪⊇㭋⛲暂⭟堺㛪字䙫⭟侹ㇷ㔯Ə㜓⟡憸㛪㮶⹛峱⊐ᷧἴ⛲ⅎ岮㷘䚕冁䦸憒⸒⎪凮 AAD ⹛㛪Əḍ㒻Ợἶ晉憒⸒Ḳ mentor˛⸝柿ἶ晉憒⸒⎪凮 AAD ⹛㛪㜆敺㴢⊼˚⭟侹奶䕒˚䵺樾⇭Ẓ⎱䔆㴢䅎㖀˛AAD Mentorship Program ⯮凮朙⽾㷬⅓⏟峱⊐ἶ晉憒⸒姯䕒䛟廻䛟ㇷ˛ Ɣ 䔚媲岮㠣 1. 岮㷘䚕冁䦸⯯䦸憒⸒ ( 敲㥔ㇽ憒晉⟞㥔憒⸒✮⏖ƌ˛ 2. ⤁㬈⎪⊇ AAD ⹛㛪Ə⯴⅝怲ὃ㛰䵺樾ḍ⅞㕀⭟㛴⋀䆘⿘˛ 3. 曧僤愴⏯㜓⟡憸㛪䛟旃ὃ㥔㋮⻼˛ Ɣ 峱⊐憸栴 ⋬␒娢ⅱ岢˚䵺㿆剀Ὥ⛅㩆䥏凮㛪字㜆敺⟡㜓䔆㴢岢˛㮶⹛㎈⮁栴䵍ếƏ暏⃠㠣㳉⊼恐䕝媦㕛˛

Ɣ 䔚媲㖠⻶ (1) 媲₀⦌ῲạ CV Ə䰈㗵ⷌὃ姯䕒ƏE-mail ㇽ惜⮫凚㜓⟡憸㛪㛪✧˛媲娢㗵䔚媲⹛⺍Ə壮恟⤁ῲ⹛⺍ẍ⏖㎌⎾˛ ⍚㗌嵞㎌⎾䔚媲 2020, 2021, 2022 ⹛⺍ AAD Mentorship Program˛ (2) 㮶⹛⅒㛯⹼∴㈑㭉䔚媲㬈⹛⺍ AAD MentorshipƏ⌨㛯⹼⅓ⷪ㬈⹛ AAD Mentorship 䍙恟⏴▕˛ (3) 2019 AAD ⮁㖣ᷰ㛯 1-5 㗌 (Washington, DC) Ə2020 AAD Mentorship Program ⠘⏴㖣 2019 ⹛⅒㛯 31 㗌㈑㭉˛ 2020 AAD 㖣ᷰ㛯 20-24 㗌䦸佬㊰⤁ⷅ Denver ⷩ˛㭈徵⏫ἴ㛪Ⓢ帛年⠘⏴Ə 2021 AAD 㖣ᷰ㛯 19-30 㗌 ( San Francisco, California) Ə 2022 AAD ⮁㖣ᷰ㛯 25-29 㗌 (Boston, Massachusetts) Boston 㘖併⛲㭞⏙⏴➵Ə ‣⽾怇娑˛ 㨵ⴲ AAD Mentorship Program ⹕䈌恩⳩ ⴲⵤ

AAD ◮涜

䈰䈌恩⳩

㗋↗㤝㢉

2015

San Francisco

愔䙥䎱

⤮併憒晉

2016

Washington DC

≰⤵嘔

檿暫敞⺁憒晉

2017

Orlando, Florida

㜵㍞䐍

曀⑳憒晉

2018

San Diego

㖤ᷧ㖗

⏗⋾敞⺁憒晉

2019

Washington DC

⼜㛃⭮

⏗⋾敞⺁憒晉

4Ʊ淑↳ⴲ巓恩⳩傲⅙㑺⨶圑䛒䤴 Stellar Success Award Young Scientist Award in Psoriasis Research Program 滺⋜⛲ⅎ⹛廼䚕冁䦸憒⸒⯴ṥ䙓䙫㴨堳䖬⭟˚䖬り䔆㴢⒨峑˚减⹱㲢䘩˚⟡䣵䖬䏭䔆䏭䬰⏫㖠杉⤁⁁䟻䩝˛㮶⹛ 柷姯柹䙣ᷧ凚⛂⏴ℑ䦧媽㕮⽾䌵俬˛峱⊐憸栴䂡㖗⏗⹊ᷰ凚ᷪ吓K˛峱⊐⹛廼䚕冁䦸憒⸒⤁⾅Ṳ䛟旃䟻䩝凮⭟堺ẋ㴨˛ 2017 ⹛⽾䌵俬䂡僈㥁㝥˚溪朽‒˚㜵⭆䨾˚㝾Ⰱ⭶˚䍲滵刃䬰ṻἴ⹛廼憒⸒˛ Ɣ 䔚媲㖠⻶媲₀⦌ῲạ CVƏỊ塏『吾ὃ⅏㕮ƏE-mail ㇽ惜⮫凚㜓⟡憸㛪㛪✧˛媲娢㗵䔚媲⹛⺍Ə㮶ῲ⹛⺍㈑㭉㔝ờ㗌㜆䂡 ⅒㛯 31 㗌˛㜓⟡憸㛪偖䵈㖠⻶Ɲ 岈⛿㲼ạ䚕冁䦸⭟䙣ⰼ㕮㕀⟡憸㛪怊䵈曢婘 : 02-2711-8288 ₚ䜆 : 02-2752-3368 E-mail: serdf220@gmail.com 㛪✧ : ⏗⋾ⷩ⤎⭰⌧⿇⭄㝘巖⛂㮜 333 噆 3 㧺㨵ⴲ妔㑅䈌䈰䈌恩⳩ ⴲⵤ

䈰䈌恩⳩

2017

僈㥁㝥˚溪朽⮳˚㜵⭆䨾˚㝾Ⰱ⭶˚䍲滵刃

2018

㝾Ⰱ⭶˚悘桖掗˚僈㥁㝥˚唈暬䫠

ᵒƱ⋏宅㲯恩⳩傲㐪凡䁊䚕冁䦸憒⭟㛪僤⏖ằ㗌哓⊪䙣ⰼ凮⯯㥔⽉屈⎱䤥㛪✗ἴƏḪ␩㕀㍯⏳⤁ἴ䚕冁憒⭟ℯ怙䙫徂⋋敲≜⎱ᷴ㖞㛰 ℑ䦧㖗堧⊇⅌㈧⅘⏳⭳ㇷ˛㜓⟡憸㛪晋姯䕒䵍⹛廼䙫憒⸒滺⋜㈺㰊⣽Ə⏳㘩奨⏸⛲ⅎ娘⤁岮㷘䙫˚‣⽾⭟侹˚⯴䤥㛪㛰䨴㥜⤰䍢䙫岮㷘憒⸒塏总媇㑖䙫㕓ヶ˛㜓⟡憸㛪㮶⹛⯮柹䙣ᷧ凚ᷰ⏴ SERDF Lifetime Achievement AwardƏ塏㏁怀 Ẃ岮㷘憒⸒怵⎢⤁⹛⯯㥔ᷱ䙫⊑⊂凮㋨乳䙫䤥㛪⤰䍢Ə㜓⟡憸⯮㛪嬠喰吾怀ῲ㩆㛪Ə塏总ㇸῸ䙫ㄆ嬄˚㕓ヶ凮㉦嫥˛ 㜓⟡憸㛪㛪⊑⊂ₚ㉦Ə忤暏ẽῸ䙫党㭌Ə㋨乳䙫旃㇞˚㛴⋀怀壈䙫ạ㯸Ə孺ㇸῸ䙫⯯㥔㛛⎾∗䤥㛪⯱㕓凮傖⮁˛ 㨵ⴲ䰀嵩⠇䈹䈌䈰䈌恩⳩ ⴲⵤ

䈰䈌恩⳩

2017

惔㉦䵘憒⸒˚⭒╆䒆憒⸒

2018

Ⱐ⛲曽憒⸒˚嶀㦕䙣憒⸒

Friday, 16 NOV. RM 201ABC Level 2 08:30-10:00

Nail Surgery Moderators: Eckart Haneke (Germany), Yung-Yi Lee ( 㘌ↅ㪃 , Taiwan)

澽 08:30-08:40 澽 08:40-08:55 澽 08:55-09:15 澽 09:15-09:35 澽 09:35-10:00

The concept of onychodermis Surgical management of benign nail tumors Surgical management of malignant nail tumors Management of ingrowing nails (including pincer nail) Nail surgery: an expert approach from the Japanese experience

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.XQLDNL 2KDUD -DSDQ

10:30-12:20

Approach and Diagnosis of Nail Disease Moderators: H. Peter Soyer (Australia), Yang-Chin Lin ( 㙕㊘⺕ , Taiwan)

澽 10:30-10:45 澽 10:45-11:15 澽 11:15-11:45 澽 11:45-12:05 澽 12:05-12:20

How to diagnose nail unit melanoma? Histopathology of the nail: Onychopathology Dermoscopy of nails Differential diagnosis: Dystrophic nails and onychomycosis How to approach and treat onycholysis?

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Yang-Chin Lin ( 㙕㊘⺕ , Taiwan

13:20-15:00

Nail Surgery: Video Demonstration Moderators: Kuniaki Ohara (Japan), Yi-Hua Liao ( ⶔ⻟劭 , Taiwan)

澽 13:20-13:35 澽 13:35-14:00 澽 14:00-14:25 澽 14:25-14:35 澽 14:35-15:00

Nail unit biopsy technique Management of ingrowing nails Surgical management of in-situ melanoma of the nail Surgical management of malignant nail tumors.Tips Management of ingrowing nails (including pincer nail)

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15:30-17:30

Miscellaneous Nail Disease Moderators: Robert L. Baran (France), Hsiu-Cheng Hsu ( 壯Ậ奞 , Taiwan)

澽 15:30-15:50 澽 15:50-16:10 澽 16:10-16:30 澽 16:30-16:50 澽 16:50-17:10 澽 17:10-17:30

Phenol Matricectomy of Ingrown Toenails Leukonychia Exogenous and self-induced nail disorder Nail involvement in paraneoplastic syndromes Hello, Onychomycosis Interesting cases seen at the Nail clinic

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Friday, 16 NOV. RM 201D Level 2 08:30-09:10

TDA Young Dermatologist Awards Moderators: Sung-Jan Lin ( ã&#x2122;&#x2022;æ&#x203A;&#x160;ã¿´ , Taiwan), Chih-Chiang Chen ( æ&#x201D;±âº&#x2022;â·µ , Taiwan)

æ¾½ 08:30-08:40 Utility of dermoscope in diagnosing various facial melanoses: A crosssectional descriptive study æ¾½ 08:40-08:50 Correlation between autoantibodies and skin manifestation in SLE patients æ¾½ 08:50-09:00 Changes in skin physiological parameters in breast cancer patients undergoing radiotherapy æ¾½ 09:00-09:10 Cutaneous application of anthranilate derivatives for inhibiting QHXWURSKLOLF LQÃ&#x20AC;DPPDWLRQ LQ SVRULDVLV OLNH PRXVH PRGHO

Depali Rathod (India) Le Huyen My (Vietnam) Chu-Sung Hu ( ä¾&#x;ã &#x2DC;ã&#x2DC;¼ , Taiwan) Zih-Chan Lin ( ã&#x2122;&#x2022;å®&#x2026;â¬&#x201C; , Taiwan)

09:20-09:50

Maria Duran Awards Moderators: *HRUJH 7 5HL]QHU 86$ 1HOOLH .RQQLNRY 86$

æ¾½ 09:20-09:35 Atypical mycobacterial cutaneous infections: A 5 years retrospective study æ¾½ 09:35-09:50 $ UDQGRPL]HG GRXEOH EOLQG FRQWUROOHG VWXG\ RQ WKH VDIHW\ DQG HIÂ¿FDF\ of 25% Tinosporarumphii (Makabuhay) cream versus 2% mupirocin FUHDP RQ VXSHUÂ¿FLDO S\RGHUPDV FDXVHG E\ 6WDSK\ORFRFFXV DXUHXV

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ISD Global Education Awards Moderators: *HRUJH 7 5HL]QHU 86$ 1HOOLH .RQQLNRY 86$

æ¾½ 10:30-10:38 A randomized, double-blind, comparative study on the safety and efficacy of Virgin coconut oil against 1% Hydrocortisone as an antiLQÃ&#x20AC;DPPDWRU\ DQG DQWL SUXULWLF SUHSDUDWLRQ IRU PRVTXLWR ELWHV UHDFWLRQV æ¾½ 10:38-10:46 &OLQLFDO GHUPRVFRSLF DQG WUHDWPHQW SURÂ¿OH RI RQ\FKRP\FRVLV LQ 7XQLVLD æ¾½ 10:46-10:54 A randomized, double-blind clinical trial on the efficacy and safety of turmeric 1% cream in the treatment of plaque-type psoriasis in adults æ¾½ 10:54-11:02 Digital analyses of patients with rosacea-implications for treatment æ¾½ 11:02-11:10 Does platelet rich plasma really work synergistically with microneedling and subcision for grade 4 atrophic acne scars? æ¾½ 11:10-11:18 A Randomised control comparison of treatment of Acne vulgaris using carbon augmented Q switched Nd:YAG versus salicylic acid chemical peeling æ¾½ 11:18-11:26 (IÂ¿FDF\ DQG VDIHW\ RI IUDFWLRQDO FDUERQ GLR[LGH &2 ODVHU FRPELQHG topical therapy for the treatment of onychomycosis æ¾½ 11:26-11:34 Muco-cutaneous manifestations of hiv infected patients in anti-retroviral era: a cross-sectional study from central nepal æ¾½ 11:34-11:42 Gingival enlargement revealing a laryngeal and pulmonary tuberculosis æ¾½ 11:42-11:50 Unusual presentations of Kaposi Sarcoma :Series of clinical cases æ¾½ 11:50-11:58 Patterns of vitamin D deficiency in dermatological diseases: A crosssectional study æ¾½ 11:58-12:06 $QWL LQÃ&#x20AC;DPPDWRU\ WKHUDS\ ZLWK WXPRU QHFURVLV IDFWRU LQKLELWRUV LV DVVRFLDWHG with reduced risk of major adverse cardiovascular events in psoriasis æ¾½ 12:06-12:14 The utility of Tele-Derm in the diagnosis and management of two rare dermatological presentations æ¾½ 12:14-12:22 Frontal Fibrosing Alopecia in a Latinamerican man

Veronica Uy (Philippines)

Asma Toumi (Tunisia) Bryan Guevara (Philippines) Ana Maria Draganita (Romania) Shashank Bhargava (India) Mehak Singh (India) Anil Kumar Bhatta (Nepal) Ayush Jha (Nepal) Fatma Jendoubi (Tunisia) Mihoub Bourakba (Algeria) Awatef Kelati (Morocco) Shivani Reddy (USA) Frank Po-Chao Chiu (Australia) Nathalia H. Malvehy (Colombia)

Friday, 16 NOV. RM 201D Level 2 13:30-15:00

Psoriasis Researches in Taiwan Symposium 澽 13:30-13:40 Opening Ji-Chen Ho ( ḓ⩚ㄽ , Taiwan) 澽 13:40-14:00 7UHDWPHQW ZLWK 71) Į LQKLELWRU UHFWLILHV 0 PDFURSKDJH SRODUL]DWLRQ Shang-Hung Lin ( 㙕⫘⩍ , Taiwan) from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation 澽 14:00-14:20 6DIHW\ 3UR¿OH RI 6HFXNLQXPDE LQ 7UHDWPHQW RI 3DWLHQWV ZLWK 3VRULDVLV Hsiang-Yi Chu ( 彯札扮 , Taiwan) and Concurrent Hepatitis B or C: A Multicentric Prospective Cohort Study 澽 14:20-14:40 Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Stephen Chu-Sung Hu ( 侟㠘㘼 , Taiwan) Vascular Events, Cardiovascular Risk Factors and Implications for Treatment 澽 14:40-15:00 Anti-interleukin and interleukin therapies for psoriasis: current evidence Ya-Chu Tsai ( 叟斃䦷 , Taiwan) and clinical usefulness

Friday, 16 NOV. RM 202A Level 2 08:30-12:30 Sponsor by

Facial Reconstruction Workshop

2YHUYLHZ Reconstruction of facial defects is always the most challenging yet rewarding part of skin cancer surgery. Good knowledge of facial anatomy, appropriate assessment of the defect, and meticulous surgical techniques are key to successful cosmetic outcomes. In this session, speakers will go through reconstruction pearls and tips of individual facial anatomical locations, and participants will practice facial reconstruction on a head model under guidance from the speaking faculty 08:30-10:00 Moderators: Ren-Yeu Tsai ( ĺ?&#x;áľżć&#x2013;Ś , Taiwan), Kee-Yang Chung (Korea) ćž˝ 08:30-09:10 Reconstruction of the foreheads and cheeks ćž˝ 09:10-10:00 Reconstruction of the nose

Yao-Yu Chang ( âˇłă&#x2013;&#x161;âŠ&#x2026; , Taiwan) William Lao ( ć˘Żä&#x152;&#x2030;â&#x201A;Ż , Taiwan)

10:30-12:30 Moderators: Ren-Yeu Tsai ( ĺ?&#x;áľżć&#x2013;Ś , Taiwan), Kee-Yang Chung (Korea)

ćž˝ 10:30-11:10 Reconstruction of the periorbital area ćž˝ 11:10-11:50 Reconstruction of the perioral area ćž˝ 11:50-12:30 Reconstruction of the ears

Ren-Yeu Tsai ( ĺ?&#x;áľżć&#x2013;Ś , Taiwan)

Kee-Yang Chung (Korea)

Yao-Yu Chang ( âˇłă&#x2013;&#x161;âŠ&#x2026; , Taiwan)

William Lao ( ć˘Żä&#x152;&#x2030;â&#x201A;Ż , Taiwan)

Yen-Jen Wang ( ä&#x2030;&#x2030;ä&#x203A;&#x2019;áľ¸ , Taiwan) Kee-Yang Chung (Korea) Gary Chuang (USA)

Yen-Jen Wang ( ä&#x2030;&#x2030;ä&#x203A;&#x2019;áľ¸ , Taiwan)

Gary Chuang (USA)

13:30-17:00

Phlebology Workshop 2YHUYLHZ This workshop will provide an overview introduction to the main principles of phlebology and sclerotherapy RI YDULFRVH YHLQV $IWHU FRPSOHWLQJ WKLV ZRUNVKRS SDUWLFLSDQWV ZLOO EH DEOH WR GHVFULEH WKH DQDWRP\ RI YHQRXV UHĂ&#x20AC;X[ identify the advantages and disadvantages of various sclerosing agents and foaming technique, and identify leg veins, spider veins, and truncal varicosities. The ultimate goal is to enable clinicians to determine the appropriate use of sclerotherapy, laser, phlebectomy, or endovenous ablation for each patient. Instructors will perform live demonstrations of patient evaluation, sclerosing foam production, spider vein injection, and ultrasound-guided injection techniques. Participants will have the opportunity to perform ultrasound exams and practice sclerotherapy on simulation pads. 13:30-15:00 Moderators: Chih-Hsun Yang ( ă &#x2C6;âş&#x2022;â&#x2020;&#x2122; , Taiwan), Margaret Mann (USA) ćž˝ 13:30-13:50 ćž˝ 13:50-14:10 ćž˝ 14:10-14:40 ćž˝ 14:40-15:00

Lower Leg Venous Anatomy and Pathophysiology Duplex Ultrasound Examination Hands-on: Ultrasound examination Sclerotherapy

Yao-Yu Chang ( âˇłă&#x2013;&#x161;âŠ&#x2026; , Taiwan) Yao-Yu Chang ( âˇłă&#x2013;&#x161;âŠ&#x2026; , Taiwan) All faculty Margaret Mann (USA)

15:30-17:00 Moderators: Chih-Hsun Yang ( ă &#x2C6;âş&#x2022;â&#x2020;&#x2122; , Taiwan), Margaret Mann (USA)

ćž˝ 15:30-15:50 ćž˝ 15:50-16:20 ćž˝ 16:20-16:40 ćž˝ 16:40-17:00

Complications of Sclerotherapy Hands-on: Sclerotherapy Endovenous Laser Overview Whatâ&#x20AC;&#x2122;s New in Endovenous Procedures

Margaret Mann (USA)

Margaret Mann (USA) All faculty Chih-Hsun Yang ( ă &#x2C6;âş&#x2022;â&#x2020;&#x2122; , Taiwan) Margaret Mann (USA)

Chih-Hsun Yang ( ă &#x2C6;âş&#x2022;â&#x2020;&#x2122; , Taiwan)

Yao-Yu Chang ( âˇłă&#x2013;&#x161;âŠ&#x2026; , Taiwan) 23

Friday, 16 NOV. RM 202B Level 2 15:00-17:30

Nail Brace Workshop

Sponsor by

2YHUYLHZ Minimally invasive interventions are a trend in medicine, and the use of nail braces as a noninvasive treatment modality for patients with ingrown nails has become a novel solution to a common problem. Not only is it quick and effective, nail braces provide an alternative option for patients who have reservations regarding direct nail surgery, either due to the operation itself or its potential complications. Why do we consider nail brace for ingrown nails? Conventional treatment of ingrown nails with simple nail avulsion is commonly performed by many general surgery physicians. However, it can be associated with a high recurrence rate. Combining nail avulsion with adequate matricectomy can achieve a better outcome compared to nail avulsion alone. However, patients with underlying diseases including diabetes, venous insufficiency, or cardiovascular disease under anti-coagulant medication have the potential for poor wound healing. In addition, some patients, especially young children, can be fearful of conventional nail surgery. For such patients, nail brace can provide an attractive non-invasive alternative with good results. What can I expect from the training course? There will be a full presentation to provide the essential knowledge regarding ingrown nails as well as the underlying concept of nail brace treatment. You can be confident that with this course, you will be able to explain the utility of nail brace to your patients. Afterward the presentation, there will be a hands-on session where experienced clinicians will teach you how to install the nail brace one-on-one. After the workshop, you can receive a certificate of participation. What type of hands-on material will the course provide? We will prepare the necessary instruments and provide you one set of free metal wires. Participants will practice installing nail braces on each other. 15:00-17:30 Moderator: Jonathan Te-Peng Tseng ( 㖼⹵㗉 , Taiwan) 澽 15:00-15:10 澽 15:10-15:20 澽 15:20-15:40 澽 15:40-15:50 澽 15:50-17:30

Causes and development of ingrown nails Concept of different nail brace treatments Practical steps and tips on installing nail braces Combination therapy utilizing nail brace with other treatments Hands-on session: nail brace installation

Jonathan Te-Peng Tseng ( 㖼⹵㗉 , Taiwan)

Yung-Yi Lee ( 㘌ↅ㪃 , Taiwan)

Yi-Chin Chen ( 攱延め , Taiwan)

Yung-Yi Lee ( 㘌ↅ㪃 , Taiwan) Yi-Chin Chen ( 攱延め , Taiwan) Jonathan Te-Peng Tseng ( 㖼⹵㗉 , Taiwan) Ching-Yu Huang ( 涁㔭㓯 , Taiwan) Yung-Yi Lee ( 㘌ↅ㪃 , Taiwan) Yi-Chin Chen ( 攱延め , Taiwan) Jonathan Te-Peng Tseng ( 㖼⹵㗉 , Taiwan) Ching-Yu Huang ( 涁㔭㓯 , Taiwan) Chih-Hao Chang ( ⷳ⺕嬨 , Taiwan)

Ching-Yu Huang ( 涁㔭㓯 , Taiwan)

Chih-Hao Chang ( ⷳ⺕嬨 , Taiwan)

Friday, 16 NOV. North Lounge Level 3 09:00-12:30

Injection Workshop

Sponsor by

This comprehensive half-day workshop will focus on the use of dermal fillers utilizing both a didactic and FDVH GHPRQVWUDWLRQ DSSURDFK 'LGDFWLF SOHQDU\ VHVVLRQV ZLOO LQFRUSRUDWH WKH VFLHQWLÂżF DQG SUDFWLFDO DVSHFWV of dermal fillers including safe and effective techniques for advanced application on facial aesthetics. Live demonstration will also be present. In this course, a simulation of real clinical situation will be set to allow the learners to observe how international experts (Eastern and Western) apply and integrate their knowledge, VNLOOV DQG FULWLFDO WKLQNLQJ WR DQDO\]H HYDOXDWH DQG WUHDW WKH SDWLHQWV WKH\ PHHW IRU WKH ÂżUVW WLPH 09:00-10:00 Hour 1: Upper face Moderators: +HPD 6XQGDUDP 86$ Patrick Po-Han Huang ( ćś ă&#x161;?äşŽ , Taiwan) ćž˝ 09:00-09:15 Physical Properties of Fillers ćž˝ 09:15-09:30 Upper Face Injection technique and anatomy ćž˝ 09:30-10:00 Live Demo Upper Face

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10:00-11:00 Hour 2: Mid face Moderators: -DLVKUHH 6KDUDG ,QGLD Nai-Jen Hsu ( ĺŁŻá´ áľż , Taiwan)

ćž˝ 10:00-10:15 Injectable Rhinoplasty in Asian: Pearls to successful and safe treatment ćž˝ 10:15-10:30 Gender Differences in Filler Injections ćž˝ 10:30-11:00 Live Demo Mid Face

11:00-12:30 Hour 3: Lower Face Moderators: +DVVDQ *DODGDUL 8$( Chao-Chin Wang ( ä&#x2030;&#x2030;ă&#x201C;Ťă§ť , Taiwan) ćž˝ 11:00-11:15 ćž˝ 11:15-11:30 ćž˝ 11:30-12:00 ćž˝ 12:00-12:30

Complications of Filler Injections The Art of Injecting the Lips Live Demo Lower Face Discussion and Closing Remark

Hema Sundaram (USA)

Patrick Ho-Han Huang ( ćś ă&#x161;?äşŽ , Taiwan)

Gary Chuang (USA)

Hassan Galadari (UAE)

Jaishree Sharad (India)

Chao-Chin Wang ( ä&#x2030;&#x2030;ă&#x201C;Ťă§ť , Taiwan) +DVVDQ *DODGDUL 8$(

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Patrick Po-Han Huang ( ćś ă&#x161;?äşŽ , Taiwan) Jaishree Sharad (India) Fang-Wen Tseng ( ă&#x2013;źäłżäź&#x153; , Taiwan) All Speakers

Nai-Jen Hsu ( ĺŁŻá´ áľż , Taiwan)

Chao-Chin Wang ( ä&#x2030;&#x2030;ă&#x201C;Ťă§ť , Taiwan)

Fang-Wen Tseng ( ă&#x2013;źäłżäź&#x153; , Taiwan)

15:30-17:40

Asian SCAR Meeting SCAR Consortium Forum

Moderators: Wen-Hung Chung ( ć&#x2039;&#x2013;ă&#x2018;&#x2026;âŠ? , Taiwan), Fu-Ren Zhang ( âˇłäĄ?áľż , China)

ćž˝ 15:30-16:10 ćž˝ 16:10-16:20 ćž˝ 16:20-16:30 ćž˝ 16:30-16:40 ćž˝ 16:40-16:50 ćž˝ 16:50-17:00 ćž˝ 17:00-17:10 ćž˝ 17:10-17:20 ćž˝ 17:20-17:40

Free paper Management of cular complication f Stevens-Johnson syndrome Progress of SCAR in China Progress of SCAR in Singapore Progress of SCAR in Taiwan Progress of SCAR in Japan Progress of SCAR in Malaysia Progress of SCAR in Hong Kong Discussion of collaborations in Asian SCAR Consortium

David Hui-Kang Ma ( ćĄŞâž&#x17E;âľľ , Taiwan) Fu-Ren Zhang ( âˇłäĄ?áľż , China) Yen-Loo Lim (Singapore) Wen-Hung Chung ( ć&#x2039;&#x2013;ă&#x2018;&#x2026;âŠ? , Taiwan) Riichiro Abe (Japan) Latha Selvarajah (Malaysia) Nai Ming Luk (Hong Kong)

Saturday, 17 NOV. RM 201ABC Level 2 08:30-10:00

CCD Opening Ceremony 澽 08:30-09:00 CCD Opening Ceremony

Li-Fang Wang ( 䉉則共 , Taiwan) Wen-Hung Chung ( 拖㑅⩍ , Taiwan) Chih-Hsun Yang ( 㠈⺕↙ , Taiwan)

Moderators: Nellie Konnikov (USA), Ji-Chen Ho ( ḓ⩚ㄽ , Taiwan) 澽 09:00-09:30 Melanoma, changing treatments, management and survival 7KH FDUH DQG PDQDJHPHQW RI PHODQRPD LV D TXLFNO\ HYROYLQJ ¿HOG with surgery, radiation, immunotherapy and novel new treatments contributing to improved patient outcomes. This lecture reviews melanoma epidemiology, diagnosis and the concepts behind the new advances in multispecialty treatment of this disease. We are entering an era when durable remissions and conceivably even the elusive “cure” may be possible for some patients with advanced disease.

澽 09:30-10:00 Implementation of Photodynamic therapy in Medicine and Esthetics It will be a review on the current knowledge of Photodynamic Therapy (PDT) and the historical basis of the method's evolution since its introduction. Since its approval, PDT protocols has evolved significantly in terms of increasing method efficacy and patient safety. In this era of evidence-based medicine, it is expected that much effort will be put into creating a worldwide accepted consensus on PDT. European and US guidelines recommend PDT for treatment RI SUHFDQFHURXV OHVLRQV DQG VXSHU¿FLDO QRQ PHODQRPD VNLQ FDQFHUV to prevent progression to invasive disease. We are witnessing a broadening of the spectrum of skin diseases that are treated by PDT. Field directed PDT is becoming a standard of care for multiple AKs, because of the malignant potential and the unpredictability of the transformation from AK to SCC. Daylight photodynamic therapy (PDT) is emerging as an efficacious treatment for AK, particularly for patients who require treatment of large areas of chronic actinic damage that can be exposed easily to daylight. In addition, as life expectancy increases, the elderly seek intervention modalities to improve their appearances and reverse signs of aging. Mild to severe textual changes on the sun exposed areas are due to chronic actinic damage, resulting in clinical appearance of multiple AKs. In this presentation we will review utilization of PDT within Boston VA Healthcare, our hands-on protocols, photosensitizing agents, light sources, potential side effects, and outcomes of PDT.

George T. Reizner (USA) President, International Society of Dermatology

Nellie Konnikov (USA) Secretary General, International Society of Dermatology

Saturday, 17 NOV. RM 201ABC Level 2 10:30-12:30

Dermoscopy (I) Moderators: H. Peter Soyer (Australia), Yin-Jui Chang ( ⷳ冯䘽 , Taiwan)

澽 10:30-11:00 澽 11:00-11:30 澽 11:30-12:00 澽 12:00-12:30

General introduction of dermoscopic patterns and structures Dermoscopy of melanocytic lesions Dermoscopy of the scalp and hair: alopecia Anticancer therapy induced alopecia

H. Peter Soyer (Australia) Cheng-Sheng Chiu ( 彯ノ㴤 , Taiwan) Antonella Tosti (USA) Mario E. Lacouture (USA)

12:30-13:30

Bullous Dermatoses Moderators: Hua-En Lee ( 㘌劭⼧ , Taiwan), I-Hsin Shih ( 㑻Ჾ㑮 , Taiwan) 澽 12:30-12:50 Novel Therapies for Epidermolysis Bullosa 澽 12:50-13:10 Biologic agents in blistering diseases 澽 13:10-13:30 Biologics for pemphigus

Dedee F. Murrell (Australia) Razzaque Ahmed (USA) Dedee F. Murrell (Australia)

13:30-15:00

Dermoscopy (II) Moderators: Je-Ho Mun (Korea), Chieh-Shan Wu ( ⋱ᶉ⬯ , Taiwan) 澽 13:30-14:10 Dermoscopy of non-melanocytic lesions 澽 14:10-14:40 Dermoscopoy of the nail-Assessment of longitudinal melanonychia using dermoscopy 澽 14:40-15:00 Smartphone wallpapers for dermatoscopy training of medical students and residents

H. Peter Soyer (Australia) Je-Ho Mun (Korea) Fang-Ying Wang ( 䉉共䤌 , Taiwan)

15:30-17:30

Psoriasis Moderators: Tsen-Fang Tsai ( 叟⌆共 , Taiwan), Yun-Ting Chang ( ⷳ新ᵫ , Taiwan) 澽 15:30-15:55 Psoriasis pathogenesis and the development of novel targeted immune therapies Sponsor by 澽 15:55-16:20 Management of psoriasis with evolving biologics Sponsor by 澽 16:20-16:45 Review and differentiate IL17 inhibitors and IL23 inhibitors in psoriasis treatment 澽 16:45-17:10 Psoriasis: the effect of biologics on cardiovascular disease 澽 17:10-17:30 Panel Discussion

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Saturday, 17 NOV. RM 201D Level 2 08:30-10:10

Vitiligo and Photodermatology (I) Moderators: Cheng-Che E. Lan ( 咋㏽⎰ , Taiwan), Feng-Jie Lai ( 宲嬎὏ , Taiwan)

澽 08:30-08:55 澽 08:55-09:20 澽 09:20-09:45 澽 09:45-10:10

Appraisal of Laser Therapies for Melasma New discoveries in the pathogenesis and treatment of vitiligo Emerging therapies in Vitiligo Autologous minigrafting in vitiligo : evolution and evaluation

Boon-Kee Goh (Singapore) Amit G. Pandya (USA) Vinod K. Sharma (India) Koushik Lahiri (India)

10:30-12:35

Vitiligo and Photodermatology (II) Moderators: Cheng-Che E. Lan ( 咋㏽⎰ , Taiwan), Feng-Jie Lai ( 宲嬎὏ , Taiwan)

澽 10:30-10:55 澽 10:55-11:20 澽 11:20-11:45 澽 11:45-12:10 澽 12:10-12:35

Phototherapy in the practice of dermatology – is it obsolete? Photogenodermatoses Beyond sun damaged skin Solar Lentigines: The Neglected Half-Sister of Photoaging Braf, the past, present and future

Thomas M. Ruenger (USA) John McGrath (UK) Shirley L. Van (USA) Sewon Kang (USA) Julio Cesar Salas-Alanis (Mexico)

13:30-15:00

Teledermatology Moderators: Francisco D. Rivera IV (Philippines), Yu-Chuan Li ( 㘌⊉⫆ , Taiwan)

澽 13:30-13:50 Innovations in Teledermatology: Direct Patient–Specialist Care 澽 13:50-14:10 Teledermatology: Service Delivery Network for Geographically Isolated and Disadvantaged Areas 澽 14:10-14:30 Dealing with e-patients in practice 澽 14:30-14:50 Implementation of TeleDermatology within VA Healthcare system. How to make it work. 澽 14:50-15:00 Panel discussion

April Armstrong (USA) Francisco D. Rivera IV (Philippines) Koushik Lahiri (India) Nellie Konnikov (USA)

15:30-17:00

TDA Dermoscopy Bowl Moderators: H. Peter Soyer (Australia), Cheng-Sheng Chiu ( 彯ノ㴤 , Taiwan)

澽 15:30-15:45 Pattern analysis and algorithms for dermoscopic diagnosis for young dermatologists Ying-Jui Chang ( ⷳ冯䘽 , Taiwan) 澽 15:45-16:45 TDA Dermoscopy Bowl H. Peter Soyer (Australia), Je-Ho Mun (Korea) Cheng-Sheng Chiu ( 彯ノ㴤 , Taiwan), Jennifer Wu ( ⋱⋇⡬ , Taiwan) Fang-Ying Wang ( 䉉共䤌 , Taiwan) 澽 16:45-17:00 Ceremony for winners Chin-Hsun Yang ( 㠈⺕↙ , Taiwan)

28 28

Saturday, 17 NOV. RM 101AD Level 1 Immune Forum 08:30-10:10

General Dermatology Moderators: Nai Ming Luk (Hong Kong), Sheau-Chiou Chao ( 屗㖇䢉 , Taiwan)

澽 08:30-08:35 澽 08:50-09:10 澽 09:10-09:25 澽 09:25-09:40 澽 09:40-09:55 澽 09:55-10:10

Opening Autoimmune Blistering Diseases What's New in Urticaria: Laboratory Examination and Treatment 'LDJQRVLV DQG 0DQDJHPHQW RI ,QÀDPPDWRU\ +DLU 'LVRUGHUV Alopecia Totals: What’s New in Mechanism and Management Host Immunity in Mycobacteria Infection

Wen-Hung Chung ( 拖㑅⩍ , Taiwan) Razzaque Ahmed (USA) Chia-Yu Chu ( 㗯⩴䌚 , Taiwan) Mimi Chang (Hong Kong) Chih-Chiang Chen ( 攱⺕ⷵ , Taiwan) Hong-Sheng Wang ( 䉉㯨䏝 , China)

10:30-12:10

,QÁDPPDWRU\ 6NLQ 'LVRUGHUV Moderators: Liang-Dan Sun ( ⨩儭᳷ , China), Wen-Hung Chung ( 拖㑅⩍ , Taiwan)

澽 10:30-10:50 7\SH ,QÀDPPDWLRQ LV .H\ WR WKH 'HYHORSPHQW RI $WRSLF (F]HPD 澽 10:50-11:10 The Diagnosis of Atypical Atopic Dermatitis and Application of Diagnostic Tools 澽 11:10-11:30 A Practical Wet Wrap Therapy for the Management of Atopic Dermatitis: experience from Hong Kong 澽 11:30-11:50 Current Concepts in the Immunogenomic Mechanism of Psoriasis 澽 11:50-12:10 Why Psoriasis Vulgaris Recur After External Application of Glucocorticoids?

Jean-Francois Nicolas (France) Zhi-Rong Yao ( ⢘⺕刡 , China) Fong Cheng Ip (Hong Kong) Liang-Dan Sun ( ⨩儭᳷ , China) Jie Zheng ( 快㈵ , China)

13:30-15:05

Cutaneous Adverse Drug Reactions (I) Moderators: Jie Zheng ( 快㈵ , China), Chao-Kai Hsu ( 壯悕₯ , Taiwan)

澽 13:30-13:50 Dermatologic adverse events induced by anticancer therapies 澽 13:50-14:05 New Emerging Immune-elated Adverse Events: Updated Pathomechanism 澽 14:05-14:20 The Role of Beta-blocker in EGFR Inhibitors Induced Paronychia with Pyogenic Granuloma Like Lesions 澽 14:20-14:35 The Sadness of Dapsone: Hypersensitivity reactions 澽 14:35-14:50 What is the Functional Role of HLA in Dapsone Hypersensitivity 澽 14:50-15:05 Amino acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity in Addition to HLA-B*13:01

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Chun-Bing Chen ( 攱Ẉ宑 , Taiwan) Chun-Wei Lu ( 䖥Ẉ䌉 , Taiwan) Fu-Ren Zhang ( ⷳ䡍ᵿ , China) Chuang-Wei Wang ( 䉉➭䱫 , Taiwan) Yong-Hu Sun ( ⨩ↅ唌 , China)

15:30-16:50

Cutaneous Adverse Drug Reactions (II) Moderator: Chia-Yu Chu ( 㗯⩴䌚 , Taiwan)

澽 15:30-15:50 Drug-induced anaphylaxis in Taiwan 澽 15:50-16:10 A Practical Guide of Skin Tests in Drug Allergies: experience from 澽 16:10-16:30 Therapeutic Approaches using IVIg Treatment in SCAR: Experience in China and updated review 澽 16:30-16:50 Quiz and Prize

Yi-Ting Lin ( 㙕⻟ⶵ , Taiwan) Yen-Loo Lim (Singapore) Chao Ji ( 䮾屃 , China) Wen-Hung Chung ( 拖㑅⩍ , Taiwan)

Saturday, 17 NOV. RM 103 Level 1 08:30-10:00

Mycology Forum (I) Moderators: Ming-Tsan Wang ( 䉉慖䂤 , Taiwan), Cheng-Lung Ku ( 朥㨡⯗ , Taiwan)

澽 08:30-09:00 Hair fungal Infection-precise diagnosis and therapeutic effect evaluation E\ GHUPRVFRS\ DQG ÀXRUHVFHQW VWDLQLQJ 澽 09:00-09:30 Differential diagnosis of onychomycosis 澽 09:30-10:00 7KH ¿JKWLQJ EHWZHHQ 7DODURP\FHV PDUQHIIHL DQG KXPDQ KRVW

Yu-Ping Ran ( ⁇䉇ⴱ , China) Antonella Tosti (USA) Cun-Wei Cao ( 㖷⨖ⲋ , China)

10:30-12:15

Mycology Forum (II) Moderator: Ming-Long Hsu ( 壯㓌敄 , Taiwan)

澽 10:30-10:45 澽 10:45-11:15 澽 11:15-11:45 澽 11:45-12:15

Primary Candida onychomycosis in immune-competent patients 0DODVVH]LD IROOLFXOLWLV 3UR¿OH RI FDVHV VHHQ LQ 6LQJDSRUH Epidemic of Dermatophytosis in the Indian subcontinent (Part 1) Epidemic of Dermatophytosis in the Indian subcontinent (Part 2)

Steven K.W. Chow (Malaysia) Chew-Swee Seow (Singapore) Shyam Verma (India) Shyam Verma (India)

13:30-15:00

Mycology Forum (III) Moderator: Pei-Lun Sun ( ⨩⚷ứ , Taiwan)

澽 13:30-14:00 Therapy of fungal skin and nail infection: available drugs and when treatment fails 澽 14:00-14:30 Dermatophytes and their resistance 澽 14:30-15:00 Problems and prospects in training professionals to manage dermatomycoses in Japan

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15:30-17:30

Aesthetic Dermatology (I) Moderators: Hassan Galadari (UAE), Sindy Hu ( 侟ủ⤵ , Taiwan)

澽 15:30-15:50 澽 15:50-16:10 澽 16:10-16:30 澽 16:30-16:50 澽 16:50-17:10 澽 17:10-17:30

Treatment of Dark Eye Circles Year ender Thoughts on Melasma: Truth and Fallacies Update on management of melasma Evidence-based treatment of melasma-how exciting is it? How Stem Cells Meets Aesthetic Dermatology Panel discussion

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Evidence Based Dermatology and Dermatoepidemiology Moderator: Ching-Chi Chi ( 䮾㔭䋨 , Taiwan)

澽 08:30-09:30 澽 09:30-10:05 澽 10:05-10:20 澽 10:20-10:30

Dermatoepidemiology: Psoriasis as an Example From Clinical Questions to Evidence-Based Research Evidence-Based Dermatology: Psoraisis an Example Q&A

Tao-Hsin Tung ( 匡弑僆 , Taiwan) Ching-Chi Chi ( 䮾㔭䋨 , Taiwan) Yun Fu ( ὃ䨞 , Taiwan)

Saturday, 17 NOV. North Lounge Level 3 08:30-10:00

Melanoma Forum (I) Moderators: Chung-Hsing Chang ( ⷳᳫ僆 , Taiwan), Benjamin Wood (Australia)

澽 08:30-09:00 Emerging concept of pathways of melanocytic neoplasia Benjamin Wood (Australia) 澽 09:00-09:30 Using p53 reactivation as a therapeutic approach to dysplastic nevi and Chung-Hsing Chang ( ⷳᳫ僆 , Taiwan) melanoma in mouse models 澽 09:30-10:00 Melanoma in Koreans Kee-Yang Chung (Korea)

10:30-12:30

Melanoma Forum (II) Moderators: Kee-Yang Chung (Korea), Shiou-Hwa Jee ( 䮾䡾劭 , Taiwan)

澽 10:30-11:00 澽 11:00-11:30 澽 11:30-12:00 澽 12:00-12:30

Challenges of cinical and pathological diagnosis of melanoma Yen-Jen Wang ( 䉉䛒ᵸ , Taiwan) Compare wide local excision with Mohs micrographic surgery for melanoma Kee-Yang Chung (Korea) Immunotherapy in melanoma John Wen-Cheng Chang ( ⷳ㑅旅 , Taiwan) Cutaneous adverse reaction related to immunotherapy in melanoma Jennifer Wu ( ⋱⋇⡬ , Taiwan)

Sunday, 18 NOV. Plenary Hall Level 3 08:30-10:00

Maria Duran Lecture/Lu Yao Chin Lecture/TDA Plenary Lecture Moderators: Hsin-Su Yu ( ḗⴶ⊶ , Taiwan), George T. Reizner (USA), Ji-Chen Ho ( ḓ⩚ㄽ , Taiwan) 澽 08:30-09:00 Maria Duran Lecture 烉 Oral Skin Lightening Agents: Do they work

Brown skin is beautiful. Normally, for those who want to be fairer or unfortunately have disfiguring patches, topical hypopigmenting agents are prescribed, chemical peels advised and laser procedures recommended in cases of pigmentary disorders resistance. 2UDO VNLQ OLJKWHQLQJ DJHQWV UDLVH H\HEURZV DQG VFHSWLFV ZLOO EH GLI¿FXOW to convince unless we show the mechanism of action and the evidence in clinical trials.

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Six oral skin lightening agents which mostly are photoprotective and antioxidants will be discussed. Namely: Tranexamic acid, procyanidin, melatonin, carotenoids, polypodium leucotemus and glutathione. 澽 09:00-09:30 Lu Yao Chin Lecture 烉 Dermatophytes-evolution and emerging resistance The dermatophytes all belong to a single family of the fungal Kingdom, the Arthrodermataceae. Novel taxonomy, with seven genera, is based on reconstruction of main evolutionary patterns of these fungi; only three genera (Trichophyton, Epidermophyton, Microsporum) are relevant in daily routine. Recent evolution has led to the emergence of anthropophilic species which are unique in having host-to-host transmission and prevalently reproduce clonally. In general, human infections caused by zoophilic species are more inflammatory than infections transmitted between human hosts. However, some species IURP GRPHVWLFDWHG DQLPDOV GR QRW VHHP WR IROORZ WKLV UXOH ,QÀDPPDWRU\ infections are currently emerging due to misuse of widely available creams that contain corticosteroids and low-doses antifungal mixtures. This has led to the recent emergence of multi-resistant dermatophytes e.g. in India. It is expected that this problem will soon acquire global dimensions.

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澽 09:30-10:00 TDA Plenary Lecture 烉 What’s new in nail disease and treatment

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Sunday, 18 NOV. Plenary Hall Level 3 10:30-12:20

BJD Editor & Genetic Forum CCD/TDA/TSID Recent Progresses in Researches and Genomic Studies in Dermatology

Sponsor by

Moderators: Fu-Tong Liu ( ⅇㄴ㘯 , Taiwan), Wen-Hung Chung ( 拖㑅⩍ , Taiwan)

澽 10:30-11:00 澽 11:00-11:20 澽 11:20-11:40 澽 11:40-12:00

Recent research highlights in the BJD: choices by the BJD editor-in-chief Genome-Wide Association Study in Dermatology: Experience From China New Era of Whole Genome Sequencing Studies in Dermatology Identification of novel defective genes related to severe early-onset atopic dermatitis by whole genome sequencing 澽 12:00-12:20 Emerging Landscape of Genomic Study in Taiwan: Bringing Genetics into Clinical Practice

Alex Anstey (UK) Liang-Dan Sun ( ⨩儭᳷ , China) Wen-Hung Chung ( 拖㑅⩍ , Taiwan) Wen-Lang Fan ( 凁㑅後 , Taiwan) Pui-Yan Kwok ( 徫㭙⼧ , Taiwan)

RM 201ABC Level 2 10:30-12:10

Acne and Rosacea (I) Moderators: Sewon Kang (USA), Li-Cheng Yang ( 㠈浕䊋 , Taiwan)

澽 10:30-10:55 澽 10:55-11:20 澽 11:20-11:45 澽 11:45-12:10

Acne treatment and Oral isotretinoin Pin-Chi Chiu ( 彯⍿済 , Taiwan) Confessions from a Dermatologist-how I deal with troubled Acne Patients Maria Juliet E. Macarayo (Philippines) Modern tactics of managing patients with rare and complicated forms of acne Marianna Drozhdina (Russia) Common acneiform eruptions- pitfalls and diagnostic tips Roman Yaremkevych (Ukraine)

13:30-15:10

Acne and Rosacea (II) Moderators: Woan-Ruoh Lee ( 㘌䋪冣 , Taiwan), Pei-Hsuan Lu ( ⌀ḧ䍅 , Taiwan) 澽 13:30-13:55 澽 13:55-14:20 澽 14:20-14:45 澽 14:45-15:10

Genetic vs. environmental factors associated with rosacea The effect of the local skin microbiome on rosacea What does the red face tell us? Recent topical treatments of Rosacea

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15:30-16:50

Aesthetic Dermatology (III) Moderators: Yu-Huei Huang ( 涁㪑⾞ , Taiwan), Hema Sundaram (USA)

澽 15:30-15:50 The current progress of pulsed dye laser in combination with antiangiogenic agents for the treatment of Port-Wine Stain 澽 15:50-16:10 Aesthetic Application of Radiofrequency and their Relevance to Asian Patients 澽 16:10-16:30 Pulse Dye Laser: Emerging Indications in Diverse Patient Populations 澽 16:30-16:50 Panel discussion

Lin Gao ( 榖䋱 , China) Hema Sundaram (USA) Hema Sundaram (USA) All Faculty

RM 201EF level 2 15:30-17:10

Dermatologic Surgery Moderators: Chien-Hsun Chen ( 攱ⶸ↱ , Taiwan), Le Huu Doanh (Vietnam)

澽 15:30-15:50 澽 15:50-16:10 澽 16:10-16:30 澽 16:30-16:50 澽 16:50-17:10

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William Lao ( 梯䌉₯ , Taiwan) Boon-Kee Goh (Singapore) Johannes F. Dayrit (Philippines) Shirley L. Van (USA) All Faculty 33

Sunday, 18 NOV. RM 201D Level 2 13:30-14:50

Medical Dermatology Moderators: Tak-Wah Wong ( ä&#x2030;&#x2030;âšľĺ&#x160; , Taiwan), Su-Ni Wang (Singapore)

ćž˝ 13:30-13:50 Atopic Dermatitis Whatâ&#x20AC;&#x2122;V QHZ 0LFURLQĂ&#x20AC;DPPDWLRQ ćž˝ 13:50-14:10 Understanding Psychocutaneousdisease: Psychosocial and psychoneuroimmunologic perspectives in Psychodermatology ćž˝ 14:10-14:30 Practical psychodermatology. Psychotherapy approaches in Atopic dermatitis and Psoriasis treatment ćž˝ 14:30-14:50 Different Clinical Facets of Cutaneous Tuberculosis

Jean-Francois Nicolas (France) Mohammad Jafferany (USA) Roman Yaremkevych (Ukraine) Francisco D. Rivera IV (Philippines)

RM 102 Level 1 13:30-14:50

Sexually-Transmitted Diseases Moderators: 1RQJ 5HDNVPH\ &DPERGLD Gwo-Shing Chen ( ć&#x201D;ąâ&#x2014;&#x2030;ä ? , Taiwan) ćž˝ 13:30-13:50 HIV in the Philippines: Role of the Dermatologist in Detection and Management ćž˝ 13:50-14:10 Features of the course of syphilitic infection at the present stage. Russian experience ćž˝ 14:10-14:50 Pre-Exposure Prophylaxis for HIV Infection

Ricky H. Hipolito (Philippines) Marianna Drozhdina (Russia) Chien-Ching Hung ( ăŻ¨áźŁăł&#x192; , Taiwan)

RM 103 Level 1 10:30-12:00

Mycology Forum (IV) Moderator: Wei-Ming Wang ( ä&#x2030;&#x2030;áź&#x2021;ć&#x2026;&#x2013; , Taiwan)

ćž˝ 10:30-11:00 Mycobiome and skin diseases ćž˝ 11:00-11:30 Molecular diagnosis and molecular epidemiology of dermatophytes ćž˝ 11:30-12:00 Innate immunity and cutaneous fungal infections

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13:30-14:45

Climate Change/Tropical Dermatology Moderators: Yi-Ju Chen ( ć&#x201D;ąâť&#x;âĄ&#x20AC; , Taiwan), Chan Vicheth (Cambodia)

ćž˝ 13:30-13:45 ćž˝ 13:45-14:00 ćž˝ 14:00-14:15 ćž˝ 14:15-14:30

Climate Chang and the Skin Climate change and its effect on marine dermatological diseases Dermatologic mimickers of Hansenâ&#x20AC;&#x2122;s Disease Dermatology in the Tropics: Interesting cases from a Tertiary Referral and Training Institution ćž˝ 14:30-14:45 Panel Discussion

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North Lounge Level 3 10:30-11:50

Aesthetic Dermatology (II) Moderators: Evangeline B. Handog (Philippine), Pa-Fan Hsiao ( ĺ?Ťä&#x201D;źĺ&#x2026;Ş . Taiwan)

ćž˝ 10:30-10:50 ćž˝ 10:50-11:10 ćž˝ 11:10-11:30 ćž˝ 11:30-11:50

Pearls to avoid complications with neuromodulators Lower face rejuvenation with injectables Pan Facial Harmonization and Rejuvenation Mesotherapy: adverse effect

Jaishree Sharad (India) Jaishree Sharad (India) Ma. Cristina A. Puyat (Philippines) Ramos-e-Silva Marcia (Brazil)

Speakers ISD/TDA

George T. Reizner, Dr. Reiznerâ&#x20AC;&#x2122;s began his education at the University of Michigan graduating Phi Beta Kappa with a bachelorâ&#x20AC;&#x2122;s in science with Highest Honors in 1976. He then attended The George Washington University School of Medicine and Public Health finishing with Distinction in 1980. He completed a categorical Internal Medicine internship at the University of Wisconsin followed by a Dermatology residency and becoming board certified in 1984. This was followed by a research year as a Clinical Instructor at the University of Wisconsin and later a Dermatopathology Fellowship at the Mayo Clinic, Rochester, MN becoming board certified in this subspecialty in 1986. He is currently a Professor of Dermatology, at the University of Wisconsin School of Medicine and Public Health where he has served since 1986. He also has a Veterans Administration Hospital appointment where he manages patients and teaches medical student and dermatology residents.

Evangeline B. Handog, Dr. Evangeline B. Handog obtained her medical degree from the University of Santo Tomas, Faculty of Medicine and Surgery, Bene Meritus. After her residency in the field of Dermatology at the Dermatology Research and Training Center under the Department of Health, she received scholarships to Bangkok, Japan and Sydney for advanced studies. She served as chair of the Department of Dermatology of Asian Hospital and Medical Center (2008-2017) and is a well-loved volunteer consultant at the Research Institute for Tropical Medicine as well, heading its Cosmetic Dermatology Unit. Dr. Handog is currently a member of the Council of Advisers of the Philippine Dermatological Society, member of the Acne Board of the Philippines, member emeritus of the Philippine Medical Association, honorary member of the American Dermatological Association, Italian Society of Dermatology, Sigma XI the Scientific Research Society, Cosmetic Dermatology Society (India), Nagasaki Dermatological Society, Indian Association of Dermatovenereology and Leprology, Philippine Academy of Dermatologic Surgery Foundation, Inc.

Nellie Konnikov, Professor of Dermatology at Boston University School of Medicine, USA.

Graduated and received her MD. degree from Moscow Medical School and after moving to United States completed her Dermatology residency at the Boston University-Tufts University in Boston, in addition to a DermFoundation Fellowship in Immunology. Former Director of Dermatology Residency Program at Tufts, currently, she is a Chief of Dermatology and Director of Tele Dermatology at Boston VA Healthcare System in Boston. Dr. Konnikov has developedthe largest referral center for medical and surgical Dermatology, Photodynamic therapy and Facial Volume restoration in special patient population. She is a newly appointed Lead for Dermatology Services within the VA New England Healthcare System. Dr. Konnikovâ&#x20AC;&#x2122;s unique and engaging teaching skills make her a highly sought lecturer, presenter, and instructor at master classes in USA and worldwide. behalf of American Society of Dermatologic Surgeons. Prof. Konnikov is an active member of many national and international societies and professional organizations and currently is SecretaryGeneral of International Society of Dermatology and Chair of Committee on International Affairs at American Academy of Dermatology. (AAD)

Hassan Galadari, An American board certified graduate of the Boston University/Tufts University dermatology program in the USA, Dr. Galadari completed a dermatologic surgery and laser fellowship in the University of CaliforniaSan Francisco and is currently a fellow of the American Academy of Dermatology. He is a member of numerous committees in many international societies, including the American Academy of Dermatology, the American Society for Dermatologic Surgery and the International Society of Dermatology as well being a board member of the International League of Dermatological Societies. His main area of interest is cosmetic dermatology, particularly the field of soft tissue augmentation. He currently works as an Assistant Professor of Dermatology in the UAE University.

Antonella Tosti, Dr Antonella Tosti is a worldwide recognized expert in hair and nail disorders and contact dermatitis.

She has been invited to lecture at major international conferences, including the annual meetings of the European Academy of Dermatology and Venereology, and the American Academy of Dermatology. She is the author of Dermoscopy of Hair and Scalp Disorders, the first hair and scalp dermoscopy atlas ever published. She is also editor of two textbooks on diagnosis and treatment of hair disorders and four Textbooks on nail disorders. Dr. Tosti is the main author of the chapter on nail disorders in several major textbooks . Dr. Tosti is member of numerous dermatological societies including the American Academy of Dermatology, the American Dermatological Association, the European Academy of Dermatology, the Women Dermatological Society, the American Society for Contact Dermatitis and the International Society of Dermatology. She is secretary and treasurer on the American Hair Research Society and Secretary and Founder of the International Society of Trichoscopy. Professor Antonella Tosti is the author of over 700 scientific publications.

Dedee F. Murrell, Professor Dedee Murrell is Chair of the Department of Dermatology at St George Hospital, University of NSW, in Sydney, Australia. She completed medical training at Cambridge and Oxford Universities, 3 years of internal medicine in the UK and USA, dermatology training at UNC-Chapel Hill, a fellowship in dermatopharmacology at Duke, blistering diseases and cell biology at New York University, and then became a clinical scholar at Rockefeller University, focussing on epidermolysis bullosa. She holds a doctorate on the pathogenesis of blistering disorders, her main subspecialty interest, and her current research focusses on the development and validation of clinical outcome measures for EB and the Autoimmune blistering diseases to enable clinical trials to proceed in these orphan diseases. She has 264 peer reviewed papers and has edited 6 books on blistering diseases, including the new textbook. She lectures at international congresses regularly and is a visiting professor in 5 continents. She was recently elected as the first International Board Member of the EADV, has served as Executive Vice President of the International Society of Dermatology from 2011-13 , as Chair of Communications for the ISD, 2013-17, and will be the Congress President of the ICD 2021, in Melbourne, Australia.

Koushik Lahiri, Dr. Koushik Lahiri is the Vice President of International Society of Dermatology, Editor emeritus of Indian Journal of Dermatology, Past president of Association of Cutaneous Surgeons of India and Past National Secretary General of Indian Association of Dermatologists, Venereologists and Leprologists(IADVL) Dr. Lahiri is a Foundation Fellow of Asian Academy of Dermatology-Venerology, Fellow of IADVL Academy of Dermatology, Fellow of American Academy of Dermatology, Founder council member of Asian Skin Foundation and Asian Society for Pigment Cell Research (ASPCR). His focus of interests is vitiligo minigrafting, lasers, acne and psoriasis. He is a Fellow of all the three the Royal College of Physicians of England, FRCP (London, Edinburgh and Glasgow). He has received various awards both in and out of the country with includes both the highest orations awards for Indian Dermatologists, the Dr. B M Ambady memorial oration and Dr. P N Behl oration. Today his name is inseparable with an extremely familiar entity among the dermatologist community in India, TSDF or Topical Steroid Dependent/Damaged Face. This term was coined by him.

Lali Mekokishvili, Doctor Dermato-Venereologist, Infectologist

2006-2012-Dean of the Faculty of Health care at Telavi State University; 2012-2015-Dean of the Faculty of Medicine at Petre Shotadze Tbilisi Medical Academy; 2016-up today-Dean of the Faculty of Medicine at Caucasus International University Supervisor of postgraduate residency program in Dermato-venereology; Since 2013-An official expert at the Ministry of Labour, Health and Social Affairs of Georgia in Dermatology; Since 2012-President and founder of Georgian Association of Photodermatology and Skin Cancer; Dr. Mekokishvili earned her medical degree at medical faculty of Tbilisi State Medical Institute in 1985; scientific degree of PhD. MD.-at the Gramashevski Scientific Institute of (Kiev, Ukraine) in 1992. Dr. Mekokishvili has a practical working experience in infectology since 1990, and in dermato-venereology since 1996. She enhanced qualification in various dermatological clinics of Germany.

Shyam Verma

Consultant Dermatologist, Vadodara, Gujarat MBBS, DV&D, FRCP (London), FAAD Founding Editor, Indian Dermatology Online Journal (IDOJ) Over 120 scientific publications in indexed journals Over 175 invited international lectures all over the world Currently Chair of ITATSA Immediate Past VP and now Director of International Society of Dermatology Current Interest, Dermatophytosis in India

Miriam Emily P. Soriano, PROF. DR. MIRIAM EMILY PIANSAY-SORIANO is the Founder-President of the Philippine Academy of Dermatologic Surgery Foundation Inc. (PADSFI), the Philippinesâ&#x20AC;&#x2122;premier dermatologic surgery society which has focused on teaching surgical skills (anatomy, lasers, liposuction, nail surgery, skin cancer surgery, phlebology, toxins, fillers, etc.) to dermatologists, through its pocket workshops and annual conventions since the year 2000. She is an International Mentor and Traveling Professor of the American Society for Dermatologic Surgery International Traveling Mentorship Program (ASDS-ITMP) under Professor Lawrence Field, having given lectures and live surgical demonstrations in more than 30 countries. In her hometown, she is an Attending Consultant in Dermatology and Dermatologic Surgery at the Davao Doctors Hospital since 1990; and an Associate Professor and Chairman of the Department of Dermatology at the Davao Medical School Foundation in Davao City, Philippines, where in 2016 she was honored with a Service Award for 20 years of Teaching. She is an International Editor of the Journal of Clincal and Aesthetic Dermatology (Matrix Medical, USA) and member of the Editorial Advisory Board of the Asian Aesthetic guide.

Riichiro Abe, Dr. Riichiro Abe studied medicine at the Hokkaido University, Sapporo, Japan, and received his MD

degree in 1994. Following his clinical training in dermatology at the Hokkaido University, he studied immunology and regenerative medicine supervised by Prof. Richard Bucala at the Picower Institute for Medical Research, New York. He received a Ph.D. degree in 2001 from the Hokkaido University. Under the supervision of Prof. Hiroshi Shimizu he LGHQWLÂżHG DQG FKDUDFWHUL]HG ERQH PDUURZ GHULYHG NHUDWLQRF\WH DQG VKRZHG WKH DYDLODELOLW\ IRU FRQJHQLWDO VNLQ GLVRUGHUV as regenerative therapy. In the year 2015, he accepted the professorship for Dermatology at Niigata University. His UHVHDUFK LV LQ WKH ÂżHOG RI LPPXQRGHUPDWRORJ\ ZLWK VSHFLDO HPSKDVLV RQ VHYHUH DGYHUVH GUXJ UHDFWLRQV +LV LQWHUHVW in severe adverse drug reactions was sparked by clinical experiments and study on cell death. He has revealed the mechanism of cell death in the diseases and developed the rapid diagnostic test. Subsequently, he focused his research activities on the development of therapeutic drugs targeting cell death mechanism.

Razzaque Ahmed, Dr. A. Razzaque Ahmed is the Director of the Center Blistering Diseases and Professor of Dermatology, Tufts University School of Medicine in Boston, MA, USA. He graduated from the All India Institute of Medical Science, New Delhi, India. He trained in Internal Medicine at U of Pittsburgh, Dermatology at the U of Buffalo, NY and Allergy & Immunology at University of California at Los Angeles(UCLA). He earned a Doctor of Science degree in Molecular Immunology from the Harvard Faculty of Medicine. After six years on Faculty at UCLA, he was on +DUYDUG )DFXOW\ IRU \HDUV 'U $KPHG LV SLRQHHU DQG JOREDO OHDGHU LQ WKH ÂżHOG RI $XWRLPPXQH %OLVWHULQJ 'LVHDVH +LV UHVHDUFK VSDQV IURP VWXG\LQJ HWLRSDWKRJHQHVLV WR GHVFULELQJ QHZ WUHDWPHQWV 7KH ÂżUVW WR GLVFRYHU WKH DVVRFLDWLRQ of HLA-DQB1*0402 with Jewish pemphigus patients and HLA-DQB1*0501 with non-Jewish patients, he demonstrated presence of low titers of pemphigus autoantibody in haploidentical relatives. He described IgG4 as the pathogenic and IgG1 as non-pathogenic pemphigus autoantibody. From Northwestern Iran, he sequenced the DQB1*0402 gene in PV patients, and showed it had 100 % homology in Ashkenazi Jewish PV patients in the US and in Israel. This research provided molecular evidence that Ashkenazi Jews may have originated in Kazaristan in Central Asia.

Alex Anstey, Alex Anstey is a dermatologist in Bangor, North Wales, UK. He is Honorary Professor of Dermatology at Cardiff University and Advisory Professor of Dermatology to Jiao Tong University, Shanghai, China. He is the editor of the BJD (2013-2019). Innovations introduced during his term as editor of the BJD include plain language summaries for all BJD original articles in English and Mandarin. AlexÄ&#x2021;s academic career was built on foundations of clinical research studies as part of medical doctorate thesis research. His main research interests are in photodermatology. According to Google Scholar Alex has an h-index of 47 and his papers have been cited nearly 8,000 times. In addition to research DQG VFLHQWLÂżF SXEOLFDWLRQV $OH[ LV DOVR GHYRWHG WR PHGLFDO HGXFDWLRQ DQG WHDFKLQJ Alex is married to Sarah and has two children, Rebecca and Ben. Alex also supports an unsuccessful soccer team, Crystal Palace FC. Every year they fail to win anything; survival is all they seek to achieve. One of the most famous Crystal Palace players of all time is Fan Zhiyi (1998-2001) who played for the club 88 times, becoming club captain DQG VFRUHU RI IRXU JRDOV +H ZDV WKH ÂżUVW &KLQHVH SOD\HU WR SOD\ LQ %ULWLVK IRRWEDOO +RZHYHU QR 7DLZDQHVH SOD\HU KDV yet appeared for Ä&#x201E;The EaglesÄ&#x2026;. Alex hopes this may change before too long. When Alex is not working he enjoys listening to classical music, reading and thinking.

April Armstrong, Dr. April Armstrong is Associate Dean at the Keck School of Medicine at the University of Southern California. She also serves as Director of Clinical Research Support for the Southern California Clinical and Translational Research Institute (SC CTSI). In the Department of Dermatology at USC, she serves as Vice Chair, Director of Clinical Trials and Outcomes Research, and Director of the Psoriasis Program. Dr. Armstrong obtained her medical degree from Harvard Medical School and completed dermatology residency at the Harvard Dermatology Residency Program. She also obtained a Master of Public Health degree from Harvard School of Public Health. Prior to joining faculty at the USC, Dr. Armstrong served as Vice Chair at dermatology departments at the University of California Davis and later at the University of Colorado. Dr. Armstrongâ&#x20AC;&#x2122;s clinical expertise lies in psoriasis and other inflammatory skin diseases. For her research focus, Dr. Armstrong is particularly interested in the appropriate use of systemic agents, comparative effectiveness research, technology-enabled healthcare delivery, and comorbidities associated with inflammatory skin diseases. She has conducted over 120 clinical trials and published over 200 articles in peer-reviewed scientific journals.

Robert L. Baran

Dr. Robert Baran was born in Paris, France and qualified in dermatology at HĂ´pital Saint Louis. He is the pioneer of nail disease and serve as clinical investigators for several pharmaceutical companies, Head of the Nail Disease Center in Cannes, France, and Consultant Dermatologist to the Gustave Roussy Cancer Institute in Villejuif, France. Dr. Baran is the Head of Nail Disease Centre, Former Head of the Dermatology Unit of Cannes General Hospital. He is the Honorary Professor of the University of Franche-ComtĂŠ. Dr. Baran has contributed over 500 papers to the dermatological literature, in addition to serving as an editor or contributor to several books on nails, the hair, and scalp. He is a full member or a corresponding member of several dermatological societies and serves on the editorial board of a number of dermatogical journals.

Cun-Wei Cao

PROFESSIONAL EXPERIENCE 2009-present: Professor, Department of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University MAJOR INTEREST Talaromyces marneffei, gene function, molecular epidemiology, clinial therapy and early diagnosis, PUBLICATIONS 2018, Cunwei Cao, Jazeer A. Khader, Rhinofacial Entomophthoromycosis. N Engl J Med 378;9 2017, Yanyin Ouyang, Shuangqi Cai, Hao Liang, Cunwei Cao *. Administration of Voriconazole in Disseminated Talaromyces (Penicillium) marneffei Infection:A Retrospective Study. Mycopathologia. 182:569â&#x20AC;&#x201C;575. 2016, Kylie J. Boyce, Cunwei Cao, Alex Andrianopoulos. Two-Component Signaling Regulates Osmotic Stress Adaptation via SskA and the High-Osmolarity Glycerol MAPK Pathway in the Human Pathogen Talaromyces marneffei. mSphere. 2,24:1-17.

Mimi Chang, Dr. Mimi Chang graduated from the Chinese University of Hong Kong in 2003 with distinction in

Medicine. She completed her basic and higher physician training in the Prince of Wales Hospital (PWH), obtaining her MRCP in 2006 and fellowships in Dermatology and Venereology and Advanced Internal Medicine in 2012. She was a clinical fellow in the Singapore National Skin Center, and visited Singapore General Hospital, in 2008-09. She pursued subspecialty training in Trichology under Professor R. Trueeb, Switzerland, in 2016 and in skin cancer and nail surgery under Prof E. Haneke and Dr. Loeser, Germany, in 2018. Dr. Chang was the Chief of Division of Dermatology and associate consultant in PWH, where she managed dermatology service, residency training and medical students teaching. She is a managing editor of the HKJDV and has contributed in local registries. Her subspecialty interests include hair and scalp disorders, hospital dermatology, blistering dermatoses and psoriasis. After working 15 years in hospital, she is now in private practice and visits the PWH weekly.

Chung-Hsing Chang, Dr. Chang is a physician in clinical dermatology and a scientist in cutaneous biology. She is

enthusiastic to integrate the advanced knowledge of basic science with the emerging need of patient care. Her research ÂżHOGV LQFOXGH FXWDQHRXV LPPXQRORJ\ VNLQ FDQFHU FDUFLQRJHQHVLV GHYHORSPHQWDO ELRORJ\ DQG UHJHQHUDWLRQ PHGLFLQH Her team is investigating the Wnt and p53 signallings in skin physiology including skin pigmentation and hair follicle cycling regulation, and melanoma growth control. Efforts are being made to read the poetic message from skin in regeneration and carcinogenesis.

John Wen-Cheng Chang, Dr. Chang, John Wen-Cheng is interested in the diagnosis, treatment and experimental

therapy in lung cancer, kidney cancer and skin cancer. With great interests in malignant melanoma, he devoted himself to improvement of the quality of care in Asian melanoma. In the past 20 years he has published many important articles of malignant melanoma in Taiwan to understand the natural course of Asian melanoma and treatment outcome of primary surgery, sentinel node biopsy and lymph node dissection as well as using chemotherapy, immunotherapy and experimental DC vaccine. He is currently the Director of Immune-Oncology Center of Excellence in CGMH. The goal is to improve the safety and integrity of I-O medicine treatment of every cancer group, and establish the distinguishing feature of CGMH.

Chih-Hao Chang, Doctor Chih-Hao Chang is a surgical dermatologist of Chang Gung Memorial Hospital, keelung

branch. He completed his residency and fellowship in the Department of Dermatology in Chang Gung Memorial +RVSLWDO +H LV LQWHUHVWHG LQ WKH ÂżHOG RI VXUJLFDO GHUPDWRORJ\ SDUWLFXODU RQFRORJ\ SKOHERORJ\ DQG RQ\FKRORJ\ +H ZRXOG like to share his experience in the nail brace workshop.

Yao-Yu Chang, Dr. Yao-Yu Chang is a board-certified dermatologist in Taiwan. After finishing his dermatology residency, he went to Johns Hopkins Dermatology for further study of Mohs surgery, cutaneous oncology and cosmetic surgery. His clinical interests are Mohs surgery, cutaneous oncology and varicose vein. He has been invited to lecture in many domestic and international dermatology meetings, and has trained many physicians on their surgical skills.

Yin-Jui Chang, Dr. Ying-Jui Chang is the superintendent of Dr. Deungâ&#x20AC;&#x2122;s Skin Clinic, New Taipei City, Taiwan. Prior

to opening his clinic, Dr. Chang has served as Director of Dermatology and Medical Aesthetic Center at Far Eastern Memorial Hospital and Director of Skin Laser Center at Taipei Medical University Wanfang Medical Center. Dr. Chang got his M.D. degree from Kaohsiung Medical College, master and Ph.D. degree from Taipei Medical University. Dr. Chang completed his residency at Mackay Memorial Hospital, Taipei, and then received Dermatologic Surgery fellowship at Toranomon Hospital and National Cancer Center Central Hospital in Japan. 'U &KDQJ LV LQWHUHVWLQJ LQ 'HUPDWRORJLF 6XUJHU\ LQFOXGLQJ 0RKV VXUJHU\ /DVHU VXUJHU\ ERWXOLQXP WR[LQ ÂżOOHUV LQMHFWLRQV and Dermoscopy.

Yi-Chin Chen

Education: 2003~2010 Medical degree, China Medical University, Taiwan. Experience: 2010~2011 Resident doctor, Department of Pathology, National Taiwan University Hospital, Taiwan. 2011~2015 Resident doctor, Dermatology department, Mackay memorial hospital, Taipei, Taiwan. 2015~2016 Chief resident, Dermatology department, Mackay memorial hospital, Taipei, Taiwan. 2016~ Attending physician, Dermatology department, Mackay memorial hospital, Taipei, Taiwan. 2016 Fellow, Yonsei University, Severance Hospital, Seoul 2017 Visiting scholar, CHU Brugmann UVC (Brugmann University Hospital) %RDUG FHUWLÂżFDWLRQ %RDUG RI GHUPDWRORJ\ 3URIHVVLRQDO $IĂ&#x20AC;LDWLRQ Member, Taiwan Dermatological Association Member, Taiwan Dermatology & Aesthetic surgery Association International member, American Academy of Dermatology Member, European Nail Society

Chun-Bing Chen, Doctor Chun-Bing Chen received his medical degree from the Chang Gung Memorial Hospital. He received one year residency training in the Department of Medicine in Taipei Veterans General Hospital. He subsequently completed his residency and fellowship training in the Department of Dermatology in Chang Gung Memorial Hospital. He went on to obtain his PhD in Graduate Institute of Clinical Medical Sciences in Chang Gung University. Doctor Chen is an active physician of dermatology and consultant of Drug Hypersensitivity Clinical and Research Center, and Immune-Oncology Center of Excellence in Chang Gung Memorial Hospital. His research interest focus on severe cutaneous adverse reactions, immune-related adverse events, cutaneous immunological disorders and pharmacogenomics.

Chih-Chiang Chen, Dr. Chih-Chiang Chen received his MD and PhD degrees from National Yang Ming University. He is currently the Chief of Division of Dermatological Diagnosis and in charge of hair disease clinic at Taipei Veterans General Hospital. He leads the hair research group and his research is focus on the stem cell regulation and hair regeneration, especially the macro-environmental regulation of hair stem cells. His recent work which showed that stem cells could be activated efficiently through the behavior of â&#x20AC;&#x153;quorum sensingâ&#x20AC;? open a new window in treating alopecia as well as other degenerative disorders.

Ching-Chi Chi, Professor Ching-Chi CHI graduated from the School of Medicine, Taipei Medical University. He

further completed a Master of Medical Science at Chung Shan Medical University in Taiwan followed by a DPhil in Clinical Medicine at the prestigious University of Oxford in the United Kingdom. Currently a Professor of Dermatology at Chang Gung Memorial Hospital, Linkou, he is passionate about the application of evidence-based medicine. He is also heavily involved in the development of clinical practice guidelines. Professor Chi has authored 11 Cochrane reviews and coauthored two pan-European Dermatology Guidelines. He is also a member of the Clinical Practice Guidelines Committee of the Taiwanese Dermatological Association.

Pin-Chi Chiu, Pin-Chi, Chiu, MD has served as an executive director of board of trustees and the leader of the

cosmetic group within Taiwanese Dermatological Association(TDA) from 2012 to 2015. He was appointed as the chairman of International Aesthetic Medical Center, China Medical University Hospital from 2014 to 2018. Dr. Chiu is a recognized expert on cosmeceuticals, aesthetic dermatology, cosmetic dermatology and acne/rosacea/melasma/ sensitive skin management. He is appointed to give lectures about cosmeceuticals and medical dermatology at annual meetings of TDA for many years. Also, he has been frequently invited to speak at national and international conferences about many aesthetic and medical related topics.

Cheng-Sheng Chiu, Dr. Cheng-Sheng Chiu is a board-certificated dermatologist and the chief of Chiu skin and beauty clinic, Taipei, Taiwan. Dr. Chiu is an expert in practical dermatology and dermatologic surgery, and active in giving lectures about various topics in dermoscopy, dermatological surgery and micro-cosmetic surgery. Dr. Chiu received his MD degree from National Yang Ming University in Taiwan, and M.P.H. from the Johns Hopkins University. He became a diplomat of Dermatology in Taiwan, an international diploma of Dermatopathology, a research fellow of diagnostic pathology in Tokyo Medical University, and a clinical fellow of dermatologic surgery in Toranomon Hospital in Japan. Dr. Chiu used to be an assistant professor of Dermatology in Chang Gung Memorial Hospital, Taipei.

Steven K.W. Chow, Dr Steven Chow has guided the development of the League of ASEAN Dermatological Societies (LADS) since 1990 and as the founding secretary-general, was instrumental in forming the Asian Academy of Dermatology and Venereology in 2009. He is the Chairman of the Board of the Asian Dermatological Association and Foundation Chairman of the Asian League of Dermatological Societies, and the is President of the Federation of Private Medical Practitionersâ&#x20AC;&#x2122; Association in Malaysia Apart from being a Fellow of the Royal College of Physicians of Ireland and the Academy of Medicine Malaysia, Dr Chow is also Honorary Fellow of numerous international and regional associations, including the American Academy of Dermatology, the Royal College of Physicians of London and of Thailand, Academy of Medicine (Singapore), the College of Physicians of Singapore and of the Philippines and the Royal Australasian College of Physicians. He currently sits on the International Advisory Editorial Board of the British Journal of Dermatology and the Indian Journal of Dermatology and is on the panel of reviewers for the JAAD. Dr Chowâ&#x20AC;&#x2122;s research interests include the pharmaco-economics of biologic and immune-modulators in dermatology, molecular basis of skin and hair health, and the clinical epidemiology and economics of skin diseases in Asian communities.

Chia-Yu Chu, Dr. Chia-Yu CHU is currently Professor of Dermatology at National Taiwan University College of

Medicine. His main research interests include drug eruptions, urticaria, atopic dermatitis, and autoimmune blistering diseases. During 2008-2010, he was a Visiting Professor in the University of Paris XII. In the past 15 years, he has been involved in in many clinical trials including novel treatments for atopic dermatitis, urticaria, pemphigus and pemphigoid. He also collaborated with several international research groups to investigate the basic immunologic mechanisms, natural history, and disease burden of urticaria and atopic dermatitis. As a dermatologist specialized in immunology and allergy, he has published more than 10 book chapters and 170 articles.

Gary Chuang, Dr. Gary Chuang is a board-certified dermatologist and a fellowship-trained Mohs surgeon. He

currently works at Ivy Dermatology Group in Los Angeles, California. Prior to private practice, he was an Assistant Professor at UCLA David Geffen School of Medicine, Director of Dermatologic and Cosmetic Surgery at Tufts Medical Center, Visiting Assistant Professor at Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School.

Kee-Yang Chung, Dr. Kee-Yang Chung is a Professor and Chairperson of Dermatology at Yonsei University College

of Medicine in Seoul, Korea. He specializes in Mohs micrographic surgery and reconstruction for skin cancers, including melanoma, autologous fat transfer and keloid surgery. He is an active member of numerous international academic societies including ASDS (mentor of the ITMP), and DASIL (board member). He also serves as a board member for the Asian Dermatological Association and a fellow of the Asian Academy of Dermatology and Venereology.

Wen-Hung Chung, 'U &KXQJ LV D SK\VLFLDQ RI GHUPDWRORJ\ DQG D VSHFLDOLVW RI WKH ¿HOG LQ VHYHUH FXWDQHRXV DGYHUVH drug reactions and cutaneous immunologic disorders. He currently serves as director of department of dermatology and drug hypersensitivity clinical and research center at Taipei & Linkou Chang Gung Memorial Hospital, Taiwan. Dr. Chung has devoted himself into the investigation of severe adverse drug reactions (SCARs) for over a decade and KLV GHYRWLRQ DQG ¿QGLQJV KDYH JUHDW LPSDFW LQ FOLQLF 'U &KXQJ DQG KLV WHDP KDV LGHQWL¿HG JHQHWLF DQG ELR PDUNHUV IRU SCARs. These important breakthroughs had been published on Nature, Nature Medicine and JAMA. These markers have been used in clinic to prevent patients from the development of SCARs in many countries.

Johannes F. Dayrit, Johannes F. Dayrit, FPDS is currently Clinical Professor and Consultant Dermatologist at the

De La Salle Health Sciences Institute and Medical Center. He is also a Consultant Dermatopathologist at the Research Institute for Tropical Medicine (RITM), Manila. He finished his dermatology residency training at the Department of Dermatology, RITM and underwent further training in Clinical Dermatology at the National Skin Centre in Singapore and Fellowship training in Dermatopathology at the St. John’s Institute of Dermatology, UK and Dermatologikum Hamburg, Germany. He was a recipient of scholarship grants and awards from the International Society of Dermatology, Dubai Derma and EADV. Dr. Dayrit has lectured on lasers, disorders of pigmentation, dermatopathology and dermoscopy in many countries and has written book chapters in internationally recognized textbooks. He has authored and co-authored over 40 scientific papers in reputed medical journals and has served as peer reviewer in the British Journal of Dermatology since 2007. He is presently a member of the Committee on Climate change of the International Society of Dermatology, member of the Skin Study Group of the University of the Philippines-National Institute of Health, International Society of Dermoscopy, and the Asian Society of Pigment Cell Research.

Marianna Drozhdina, Professor Marianna Drozhdina graduated from the State Institution of Higher Professional

Education “Kirov State Medical Academy” in 1997, clinical internship in the specialty "Dermatovenereology"-in 1999. From 1999 to 2005 worked in the Kirov Region Dermatovenerologic Hospital as a doctor of the Department of venereology, and as an assistant at the Department of Dermatovenereology Kirov State Medical Academy. From 2005 to 2013-Deputy Dean of the Faculty of Medicine, Kirov State Medical Academy. PhD graduated in 2009. From 2012 to present-Professor of the Department of Dermatovenereology and Cosmetology Kirov State Medical University. From 2013 to 2016-Head of the department of International Affairs Kirov State Medical University. At the Department of Dermatovenereology Kirov State Medical University conducts practical seminars and lectures at students of medical, pediatric and dental faculties, clinical residents and practicing doctors. Publications: 40 in different sections of Dermatovenerology: syphilis, sexually transmitted deseases, bullous dermatoses, atopic dermatitis, mycoses, scabies et al.

Wen-Lang Fan, I am assistant research fellow at Chang Gung Memorial Hospital.I was educated at National

Central University where I obtained a masterâ&#x20AC;&#x2122;s and Ph.D's degree in Physics. I was employed Academia Sinica as a postdoctoral fellow from 2009 to 2013, then moving to Genomics bioSci & tech. Co., Ltd as Manager from 2013 to 2015. During this period my field of research was, genome/transcriptom assembly and quantification by using NGS data. I was employed at the Chang Gung Memorial Hospital at 2015. Since 2015 my work has focused on the biomedical application of computational genomics via whole genome/exome sequencing, especially on topics related to the understanding of rare/complex disease and the discovery of biomarkers of drug induced adverse reactions.

Yun Fu, Dr. Yun Fu graduated from School of Medicine, Chang Gung University, Taoyuan, Taiwan. She is currently

a resident in the Department of Dermatology at Chang Gung Memorial Hospital Linkou Medical Center. She is enthusiastic about the clinical application and development of evidence-base dermatology. She is presently a member of Taiwan Evidence-Based Medicine Association as well.

Lin Gao, Dr. Gao graduated from The Fourth Military Medical University with a PhD degree in dermatology and

venerology in 2008 and has been working in the Department of Dermatology at Xijing hospital since then as an attending physician and lecturer, Chief resident of Inpatient Division, director of Venerology and Mycology Division, administrative and educational secretary of the department, director of Cosmetic Laser Center, and currently chief cosmetic dermatologist, director of TCM Dermatology Division and associate professor. She worked as a visiting scholar at Beckman Laser Institution, Department of Surgery, University of California, Irvine, USA under the auspices of Dr. John Stuart Nelson during 2012.11-2013.8. Dr. Gaoâ&#x20AC;&#x2122;s expertise is on cosmetic treatments for various skin disorders and lesions, such as Port Wine Stain, KHPDQJLRPD QHYXV RI RDWD DFQH IUHFNOHV VFDUV ZULQNOHV DQG IDFLDO UHMXYHQDWLRQ LQFOXGLQJ DHVWKHWLF ÂżOOHU LQMHFWLRQ IRU removal of wrinkles and restoration of volumes on face. Dr. Gaoâ&#x20AC;&#x2122;s research interest is in the pathogenesis of Port Wine Stain and development of novel therapeutic strategies to LPSURYH WKH HIÂżFDF\ RI FXUUHQW ODVHU WUHDWPHQWV IRU WKLV GLVHDVH $V WKH KROGHU RI QDWLRQDO SDWHQWV VKH KDV SXEOLVKHG ERRNV SDSHUV LQ 6&, MRXUQDOV DQG LQ &KLQHVH FRUH MRXUQDOV LQ WKH ÂżHOG

Mahmoud Afif Ghannoum, Mahmoud Ghannoum, PhD, Director of the Center for Medical Mycology, Case

Western Reserve University (Case) and University Hospitals Case Medical Center, and a tenured Professor in the Department of Dermatology, Cleveland, Ohio, USA. He received his PhD in Microbial Physiology from Loughborough University of Technology in England. He received his MBA from the Weatherhead School of Business, Case. Dr. Ghannoum received the Freedom to Discover Award from Bristol-Myers Squibb for his expertise in the field of fungal biofilms, and the Billy Cooper Award from the Mycological Societies of the Americas for his contribution to the field of clinical mycology. He served as the Chair of the Clinical and Laboratory Standards Instituteâ&#x20AC;&#x2122;s (CLSI) Subcommittee on Antifungal Susceptibility Testing. More recently Dr. Ghannoum research has focussed on the mycobiome in health and disease. Dr Ghannoum published nearly 400 articles in the field of biofilms, microbial pathogenesis and preclinical in vitro and in vivo evaluations of antimicrobials, and 5 books. He served as a member of the editorial board of a number of biomedical journals, and is a fellow of the Infectious Diseases Society of America and the American Academy of Microbiology, the International Society for Human and Animal Mycology, and a Member of the American Academy of Dermatology.

Boon-Kee Goh, Dr Boon-Kee Goh is the Consultant Dermatologist and Medical Director of Skin Physicians Private Limited. Prior to joining Skin Physicians, Dr Goh was the Chief of Pigment Clinic and Deputy Director of Research at the National Skin Centre, Singapore. Dr Goh graduated from the University of Leeds (UK) with First Class Honours in Chemical Pathology and with the John Ingram Prize in Dermatology for his medical degree. He completed his specialist training in Internal Medicine and Dermatology in Singapore, and is a Fellow of the Royal College of Physicians (Edinburgh). Besides general dermatology, Dr Goh has special interests in pigmentary disorders and transplantation surgery for vitiligo. He started the transplant service for vitiligo in Singapore, and has successfully treated more than 1000 cases of vitiligo with non-cultured cellular grafting. He has also instructed and trained specialists at the National Skin Centre on this procedure. Apart from his clinical work, Dr Goh is active in research and has published extensively in the fields of pigmentary disorders, vitiligo and DarierÄ&#x2021;s disease. He has previously served as the President of the Asian Society for Pigment Cell Research, and the Vice-President of the League of ASEAN Dermatological Societies.

Eckart Haneke, Dr Hanekeâ&#x20AC;&#x2122;s main research interests include nail diseases, dermatopathology, dermatological surgery, diseases of the oral mucosa and aesthetic dermatology. Dr Haneke is professor at the Department of Dermatology, Inselspital, University Bern, Switzerland. Dermatologist at the Clinic for Dermatology Dermaticum, Freiburg, Germany; Senior Consultant at the Dermatology Centre Epidermis, Institute CUF, Porto, Portugal; and Senior Consultant at Department Dermatol, Acad Hosp, University Gent, Belgium. Dr Haneke has published over 300 journal articles and 160 book chapters. He is an author of one book, co-editor of five books and has presented over 1200 lectures at national and international meetings. He is also a member of the editorial board of several journals and an ad hoc manuscript reviewer for the following journals: Archives of Dermatology, British Journal of Dermatology, European Journal of Dermatology, Der Hautarzt, Journal of the American Academy of Dermatology, Journal of the European Academy of Dermatology and Venereology and Journal of the German Society of Dermatology.

Ricky H. Hipolito, Dr. Hipolito is a clinician and researcher with locally and internationally published work. He was

awarded the American Contact Dermatitis Mentorship Award in 2016. He was given a rare opportunity by the ACDS to be trained in Patch Testing under the Mentorship of Dr. Andrew J. Scheman in Chicago, Il, USA. Dr Scheman gave him the opportunity to work on a research paper entitled â&#x20AC;&#x153;Contact Allergy Cross-Reactions: Retrospective Clinical Data and Review of the Literatureâ&#x20AC;?. This was published in Dermatitis in 2017. He previously presented in the International Free Paper presentation of the CCD in November 2014. His paper then was â&#x20AC;&#x153;Small Red Bumps, Big Red Flag: AIDS Associated Kaposi Sarcoma, A Clinical Challengeâ&#x20AC;?. He is currently a tenured consultant at the Research Institute for Tropical Medicine as head of the Contact Dermatitis Unit. His research endeavors include contact dermatitis and Leprosy. His advocacy includes the successful treatment and socio-economic reintegration of Leprosy patients to be able to live productive lives after being cured of their disease. He coauthored several researches concerning Leprosy management. He maintains a busy dermatology practice in several hospital and clinical facilities in Metro Manila and nearby cities. Dr Hipolito is now embarking on a research project aiming to provide contact allergen positivity data among healthcare workers in the Philippines.

Sybren de Hoog, Prof Sybren de Hoog has written over 750 refereed papers. He was co-organiser and co-editor of HGLWLQJ RI V\PSRVLD RQ \HDVWV \HDVW OLNH DQG PHGLFDO IXQJL OHDGLQJ WR ERRNV DQG VSHFLDO LVVXHV DQG LV ÂżUVW DXWKRU RI the Atlas of Clinical Fungi (online 2018, about 3000 pages). He was program chairman of the TIFI/ECMM congress (2003) and the ISHAM congress (2018), both in Amsterdam. His teaching activities involve the international CBS Course on Medical Mycology for medical microbiologists, mycologists and laboratory technologists, and courses for biomedical VWXGHQWV RI WKH 8QLYHUVLWLHV RI $PVWHUGDP DQG %HLMLQJ +H HVWDEOLVKHG D SULYDWHO\ ÂżQDQFHG IXQG IRU VXSSRUW RI PHGLFDO mycology in Africa and another for workers from developing countries. His current focus is in area of interest is the taxonomy, ecology and evolution of black yeast-like fungi, with emphasis on possible lines of adaptation to the human host and applications in bioremediation. In general patterns of phylogeny of extremotolerance are analyzed in the light of remarkable physiological abilities of black yeasts, systemic fungi and dermatophytes.

Po-Han Huang, Dr. Huang was appointed as the Chair of Department of Dermatology and awarded as the Outstanding Educator at Chang Gung Memorial Hospital-Kaohsiung before. He is the Executive Director of Taiwanese Dermatological Association and also the founder and executive director of the Taiwanese Society for Dermatologic and Aesthetic Surgery. He is also one of the pioneers in expanding the roles of dermatologists in Asia. He established and organized the Taiwan Dermatology and Aesthetic Conference in 2013. In 2016, he served as the course director of IMCAS Asia 2016. He has published more than 20 peer-reviewed articles in SCI journals and invited to speak at more than 40 international meetings. He has been the international traveling mentors of American Society for Dermatologic Surgery since 2018.

Ching-Yu Huang

Current Appointment

Attending Physician, Dr. Young & Dr. Huang Dermatology & Aesthetics Clinic, Taipei City Attending Physician of Dermatology, ANSN Clinic, Hsin-Chu City Education and Training 1999-2006 Department of Medicine, Chung Shan Medical University 2006-2007 Resident, Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung 2007-2012 Resident, Department of Dermatology, MacKay Memorial Hospital, Taipei Appointments 2012-2013 Attending Physician, Department of Dermatology, MacKay Memorial Hospital, Taipei 2012-2013 Attending Physician, Department of Dermatology, Tzu Chi Hospital, Taipei Society Memberships Taiwanese Dermatological Association Taiwanese Society for Dermatological and Aesthetic Surgery Laser and Photonics Medicine Society of The Republic of China European Academy of Dermatology and Venereology European Nail Society

Chien-Ching Hung, joined the Division of Infectious Diseases at the National Taiwan University Hospital as a staff physician since 1996. He is currently a Clinical Professor of Medicine and Professor of Tropical Medicine and Parasitology at the National Taiwan University College of Medicine, Taipei, Taiwan. Dr. Hung received his medical degree from the National Taiwan University College of Medicine in 1989. After an internship in the Department of Internal Medicine, National Taiwan University Hospital, he completed a residency in the Department of Internal Medicine at the National Taiwan University Hospital. This was followed by a fellowship in Division of Infectious Diseases at the National Taiwan University Hospital. He subsequently obtained master degree of international health at the Swiss Tropical and Public Health Institute, Basel, Switzerland in 2006, followed by PhD degree of Graduate Institute of Medical Sciences, University of Antwerp, Antwerp, Belgium in 2009. His research interests include clinical management of HIV-related opportunistic infections, combination antiretroviral therapy, amoebiasis, sexually transmitted infections, and viral hepatitis coinfections. He has authored more than 320 articles in several peer-reviewed journals and, in the past several years

Fong Cheng Ip, Dr. IP graduated from the Faculty of Medicine of the University of Hong Kong in 1997. He received his training in internal medicine at Queen Mary Hospital, Hong Kong. After completing the basic internal medicine training, he pursued his training in the specialty of Dermatology and Venereology under the Social Hygiene Service of WKH 'HSDUWPHQW RI +HDOWK RI +RQJ .RQJ DQG REWDLQHG WKH VSHFLDOLVW TXDOLÂżFDWLRQ LQ ,Q KH UHFHLYHG overseas training in paediatric dermatology in the Royal Children's Hospital in Melbourne, Australia under the supervision of Professor John Su and Dr. David Orchard. After returning from overseas training, he continued to serve in the public sector and had set up the paediatric eczema clinic and paediatric skin clinic in a regional government dermatological clinic to look after children with severe atopic dermatitis and other dermatological problems. Dr. IP is currently the Honorary Clinical Assistant Professor of the Department of Medicine and Therapeutics of the Chinese University of Hong Kong and the Department of Paediatrics and Adolescent Medicine of the University of Hong Kong. He is also currently the Chairman of the Hong Kong Society for Paediatric Dermatology and the managing editor of the Hong Kong Journal of Dermatology and Venereology. His main clinical and research interests are atopic dermatitis, infantile hemangioma, vascular malformation and genodermatoses. Mohammad Jafferany, Dr. Mohammad Jafferany, is Clinical Associate Professor at Central Michigan University and Director Psychodermatology Clinic. He has combined training in Dermatology and Psychiatry. He completed his residency training at Hennepin County Medical Center in Minneapolis, Minnesota and fellowship training at University of Washington in Seattle, Washington. He is past president and current Executive Secretary of Association for Psychocutaneous Medicine of North America. He has more than 30 scholarly texts and publications to his credit on various psychodermatologic topics. He is the co-editor and author of books on Pediatric Psychodermatology, Geriatric Psychodermatology, Stress and skin disorders, Trichotillomania and has written chapters on psychocutaneous disorders in many text books. He is a researcher, writer, lecturer and invited speaker in various national and international conferences on Psychodermatology around the world. Trichopsychodermatology, Pediatric psychodermatology, Geriatric psychodermatology and skin picking are his areas of interest and expertise. His current focus is on World Psychodermatology Association.

Chao Ji

Education: Nanjing Medical University (MD & PhDĆ?Dermatology) Nanjing University (MPA) University of California, San Francisco (Post-doctorĆ?Dermatology) University of Chicago (Post-doctorĆ?Dermatology) Ackerman Academy of Dermatopathology (FellowshipĆ?Dermatopathology) Science and Technology Award: 2010 Ä&#x201E;Jiangsu Province Medical Science and Technology PrizeÄ&#x2026; First PrizeĆ?Third Author (Jiangsu Medical Association) 2011 Ä&#x201E;Chinese Medical Science and Technology PrizeÄ&#x2026; Third PrizeĆ?Second Author (Chinese Medical Association) 2015 Ä&#x201E;Chinese Outstanding Young DermatologistÄ&#x2026; (Chinese Medical Doctor AssociationĆ?CMDA)

Sewon Kang, Doctor Sewon Kang is the Noxell Professor and Chairman of the Department of Dermatology at the

Johns Hopkins University School of Medicine and the Dermatologist-in-Chief of Johns Hopkins Hospital. He is the founder and co-Director of the Cutaneous Translational Research Program (CTReP) at Hopkins. A recipient of the Dermatology Foundationâ&#x20AC;&#x2122;s Career Development Award, he has received numerous research awards and grants from diverse sources including the National Institutes of Health (Roadmap T32, K24, and R01), Defense Advanced Research Projects Agency (DARPA) of the Department of Defense, the American Dermatological Association, and the National Psoriasis Foundation. His research focus has been in the areas of skin pharmacology and photomedicine. He is the Immediate Past President of the Photomedicine Society, and the American Acne and Rosacea Society. An author on over 200 publications and book chapters, Dr. Kang is also the editor-in-chief of the upcoming 9th edition of the Fitzpatrickâ&#x20AC;&#x2122;s Dermatology textbook. A graduate with honors from Williams College and the University of Michigan, he completed dermatology residency and fellowship at the Harvard Medical School/Massachusetts General Hospital. Prior to joining Johns Hopkins, Dr. Kang was the Arthur C. Curtis Professor of Dermatology and Director of Clinical Pharmacology Unit at the University of Michigan.

John Koo, John Koo, MD is Professor of dermatology at the University of California San Francisco (UCSF) School

of Medicine. Dr. Koo started Psoriasis Treatment Center and Phototherapy Unit, Dermatology Drug Research Unit, and Psychodermatology Clinic at University of California San Francisco Department of Dermatology more than 30 years ago. Dr. Koo received his medical degree from Harvard Medical School in Boston, Massachusetts, where he was a Harvard National Scholar, a title awarded to only one student per graduating class. He completed an internship and residency in psychiatry at the University of California at Los Angeles and subsequently served as chief resident in psychiatry. He DOVR FRPSOHWHG D UHVLGHQF\ LQ GHUPDWRORJ\ DW 8&6) 0HGLFDO &HQWHU %RDUG FHUWLÂżHG LQ ERWK SV\FKLDWU\ DQG GHUPDWRORJ\ he is a member of the American Psychiatric Association and the American Academy of Dermatology. He is the recipient of 2014 American Skin Association (ASA) Annual Research Award which was presented to him at SID Annual Meeting in New Mexico, Best Speaker Award at Fall Clinical Symposium presented at Las Vegas in 2013 and Best Mentor Award at his home institution of UCSF Medical Center which was presented to him in May 2014. Lastly, he is the 3rd recipient of Lifetime Achievement Award by National Psoriasis Foundation. In its 40+ year history, the National Psoriasis Foundation has only awarded this â&#x20AC;&#x153;lifetime achievement awardâ&#x20AC;? to two other individuals

Pui-Yan Kwok, Dr. Pui-Yan Kwok is Professor of Dermatology and Henry Bachrach Distinguished Professor at UCSF. Since October 2017, he is also Distinguished Research Fellow and Director of the Institute of Biomedical Sciences, Academia Sinica, Taiwan. Dr. Kwokâ&#x20AC;&#x2122;s research focuses on developing tools and strategies to study the human genome. In July 2018, he launched the Taiwan Precision Medicine Initiative to bring genetic information into clinical management, with a pilot study to obtain genetic profiles of 1 million people. Dr. Kwok was elected a member of the American Dermatological Association and received the 2017 Distinguished Service Award from the University of Chicago Pritzker School of Medicine. In July 2018, Dr. Kwok was elected Academician of the Academia Sinica.

Mario E. Lacouture, Dr. Lacouture is an Associate Professor and the director of the Oncodermatology Program in

the Dermatology Service at Memorial Sloan Kettering Cancer Center in New York City. He did his postdoctoral work at Brigham and Womenâ&#x20AC;&#x2122;s Hospital in Boston, MA, an internship in General Surgery at Cleveland Clinic and residency in dermatology at The University of Chicago, IL. He received his MD degree from Javeriana University in Bogota, Colombia, where he grew up. His research interests span the disciplines of dermatologic conditions in cancer patients, and those that arise as a consequence of chemotherapy and/or radiotherapy or stem cell transplants. Dr. Lacouture is currently the Principal Investigator for â&#x20AC;&#x153;The CHANCE Trialâ&#x20AC;?, A Prospective, Longitudinal Study of Chemotherapy-Induced Hair Changes and Alopecia, Skin Aging and Nail Changes in Women with Non-Metastatic Breast Cancer. Dr. Lacouture is a well-known lecturer in the US and abroad on dermatologic conditions as a result of cancer therapies. He founded a clinical program that encompasses patient care, education, and research on dermatologic care in cancer patients and survivors. He is currently Co-Chair of the Skin Toxicity Study Group of the Multinational Association of Supportive Care in Cancer and is on the advisory board of Cancer.Net and Bridges, the Newsletter for Cancer Survivors. In 2012, CancerCare named Dr Lacouture as Physician of the Year for his contributions to the education of people living with cancer. Dr Lacouture has published over 180 articles in peer-reviewed journals and is the author of Dr Lacoutureâ&#x20AC;&#x2122;s Skin Care Guide for People Living With Cancer and Editor of the textbook Dermatologic Principles and Practice in Oncology.

William Lao, William Lao, MD earned his bachelorâ&#x20AC;&#x2122;s degree double majored in Biomedical Engineering and Computer Science and later earned his Doctorate of Medicine degree (MD) both from The Johns Hopkins University. Dr. Lao then completed six years of integrated residency training in Plastic and Reconstructive Surgery at the Medical College of Wisconsin. After residency, he completed the most sought out aesthetic surgery fellowship in Manhattan, New York under the guidance of Dr. Sherrell J. Aston. He is licensed in both the United States and in Taiwan and double boarded in Plastic Surgery in both countries. He returned home to Taiwan and currently serves as an Attending Physician in the Department of Plastic Surgery in Chang Gung Memorial Hospital in Taipei and Linkou.

Dong-Youn Lee, Dong-Youn Lee is a professor and chair of the Department of Dermatology at Samsung Medical

Center Sungkyunkwan University, Seoul, Korea. He is a director for education program in Korean Dermatological Association. Dr. Lee graduated from Seoul National University (M.D., Ph.D.) and completed his dermatology residency and fellowship at the Seoul National University Hospital. In 2004, he received International Board of Dermatopathology. As a clinical dermatologist, he has focused on skin cancer, nail, hair and vitiligo. His strong interests are melanoma and nail disorders. Every year he has seen several hundred foreign patients coming from abroad at international health services of Samsung Medical Center. In addition, he has been doing skin research. He has been publishing more than (QJOLVK ZULWWHQ DUWLFOHV ,Q WKH SDVW KH GHÂżQHG VSHFLDOL]HG QDLO PHVHQFK\PH DQG PHVHQFK\PDO FHOOV LQ WKH QDLO unit and proposed to call them onychofibroblasts and onychodermis respectively. He has presented many times at international dermatology meetings including WCD, AAD and ASDP meetings.

Joyce Siong-See Lee, Dr. Joyce Lee is a Senior Consultant Dermatologist at the National Skin Centre (NSC), Singapore. She completed her Dermatopathology Fellowship at the Skin and Cancer Foundation, Australia, and obtained the ICDP-UEMS International Board Certification in Dermatopathology in 2006. Dr. Lee currently heads the Dermatopathology and Laboratories Division at NSC, and is also the Consultant-in-charge of the Hair and Nail clinic. Her subspecialty interests lie in hair disorders and hair pathology. She is actively involved in research at NSC, with most of her research interests in the areas of hair disorders and dermatopathology, and is a recipient of various national research grants. As an active member of the academia, Dr. Lee is Clinical Tutor to medical students from both Yong Loo Lin School of Medicine, and Lee Kong Chian School of Medicine, Singapore. She is the course organizer for the Dermatopathology National Training Program, and serves as core clinical faculty member for the Dermatology Senior Residency Program at NSC. Dr. Lee also oversees the Dermatopathology Fellowship program at NSC since it became an ICDP-UEMS accredited specialty training centre in 2015. Dr. Lee had served in the executive committee of the International Society of Dermatopathology, and in the International Committee for Dermatopathology. Yung-Yi Lee, Yung-Yi Lee is a lecturer attending physician of department of dermatology at Chang Gung Memorial Hospital, Taipei branch. He graduated from Chung Shan Medical University in 2008. After that, he received 1-year resident training of department of urology at National Taiwan University Hospital. In 2009, he joined the training system of residency at Chang Gung Memorial Hospital. In 2013, he became an attending physician of department of dermatology at Chang Gung Memorial Hospital. In 2014, he was upgraded as a lecturer in the same hospital. His LQWHUHVW ÂżHOG IRFXVHV RQ GHUPDWRORJLF VXUJHU\ HVSHFLDOO\ WKH QDLO VXUJHU\ +H LV DOVR SDVVLRQDWH LQ HGXFDWLQJ WKH \RXQJ dermatologist.

Yen-Loo Lim, A/Prof Lim is a senior consultant dermatologist at the National Skin Centre (NSC), Singapore. She is the Chief of Immunodermatology Unit and Head of Drug Eruption Clinic at NSC. She is also an adjunct associate professor at both the Yong Loo Lin School of Medicine, National University of Singapore and Lee Kong Chian School of Medicine. She is the president of the Dermatological Society of Singapore since 2014.

Yi-Ting Lin, Yi-Ting Lin is a Taiwanese dermatologist with scientific interest in immune-mediated diseases in

dermatology. She focus on studies in immediate type hypersensitivity reactions (including anaphylaxis, angioedema, urticaria) and atopic dermatitis. She is one of the specialists in Drug Hypersensitivity Center in Chang Gung Memorial Hospital, with expertise in skin tests in diagnosing drug hypersensitivity reactions. She hopes to improve the diagnosis, management, and prevention of the life threatening anaphylaxis events.

Chun-Wei Lu, Dr. Lu Chun-Wei, Chang Gung Memorial Hospital Dermatology Lecturer Attending Physician; Deputy

Secretary General of Taiwan Evidence Base Medicine Association; Ph.D candidate, Institute of Clinical Medicine, Chang Gung University. My study focus on adverse drug reaction, cutaneous adverse effect of anti-cancer medication and woudn healing.

Nai Ming Luk, Dr. Luk graduated at the Chinese University of Hong Kong in 1987 and obtained the Membership of Royal College of Physicians, UK in 1992. He then worked under the Social Hygiene Service, Department of Health, Hong Kong Special Administrative Region and further his training in dermatology at the St. John’s Institute of Dermatology, London. In 1998, Dr. Luk was elected the fellow of Hong Kong Academy of Medicine and Hong Kong College of Physicians. He has also been appointed honorary associated professor of the medical faculty of the Chinese University of Hong Kong and honorary consultant of the Hospital Authority. Currently, Dr. Luk is the chairman of Hong Kong Dermatology Foundation which is a charitable organization providing free clinical skin service for the underprivileged populations in Hong Kong. Dr. Luk has been council member of Hong Kong Society of Dermatology & Venereology and the secretary of the subspecialty board in Dermatology & Venereology of the Hong Kong College of Physicians. His interests include Severe Adverse Drug Reaction, skin cancers, contact dermatitis, acne, onychomycosis and geriatric dermatology.

David Hui-Kang Ma, Professor David Hui-Kang Ma is currently professor and director of Limbal Stem Cell (LSC) Laboratory in the Department of Ophthalmology, Chang Gung Memorial Hospital (CGMH), Taipei. He is also the editorin-chief of Taiwan Journal of Ophthalmology. Since 2003, he became the director of Limbal Stem Cell Laboratory, a laboratory dedicated to cell therapy clinical trial. From 2008-2011, he served as the director of Section of Cornea. From 2011-2015, he served as the chairman of the department. He was also a member of standing committee of Taiwan Ophthalmology Society. Professor Maćs research focused on regulation of LSC proliferation and cultivated epithelial stem cell transplantation. He has published more than 100 SCI papers on LSC biology, tissue engineering, and corneal surgeries.

Maria Juliet E. Macarayo, MARIA JULIET ENRIQUEZ-MACARAYO, MD, FPDS. Born, raised and educated in Manila, Philippines. Premedical and medical years garnered from the University of Santo Tomas, Manila. Dermatology Residency obtained at Jose R Reyes Medical Center, Manila. Practicing Clinical Dermatology at Pampanga (Central Luzon province of the Philippines) for 26 years now with consultancy affiliation at Angeles University Foundation Medical Center (AUFMC). Active with the Philippine Dermatological Society (PDS), American Academy of Dermatology and the International Society of Dermatology (ISD), being the Editor-in-Chief of PDS Skincontact and Asst. Editor-in-Chief of ISD Connection and the Scientific Committee Chair of the recently concluded 2017 PDS 40th Annual Convention and the upcoming 2018 PDS 41st Annual Convention in collaboration with the International Society of Dermatology. Presently working with several interest groups and serving as advisory board member for the pharmaceutical industry. Foci of interests are acne, melasma, psoriasis, atopic dermatitis and other eczemas and bacterial infections. Writing and editing are fractions of her world, being the co-editor of the 2017 Melasma and Vitiligo in Brown Skin Springer book and contributor to several book chapters and on-line dermatology infosource.

Margaret Mann, Dr. Margaret Mann is the Director of Aesthetic Dermatology at University Hospitals Case Medical

Center. She is also the Associate Director of Dermatologic Surgery and an Associate Professor of Dermatology at Case Western Reserve School of Medicine. Dr. Mann is a board-certified dermatologist with fellowship training in Mohs surgery, dermatologic surgery, cosmetic surgery and vein surgery. She is also certified with the American Board of Venous and Lymphatic Medicine. Currently she serves on the Board of Directors of the American College of Phlebology. Dr. Mann completed her medical education and dermatology specialty training at Washington University School of Medicine in St. Louis, Missouri. She then completed a fellowship in Mohs Surgery and Cosmetic Dermatologic Surgery at the Center of Dermatologic and Cosmetic Surgery at Washington University. Prior to joining University Hospitals in the Northeast Ohio area, Dr. Mann was the Chief of Clinical Services in the Department of Dermatology at the University of California, Irvine. She was also the Co-Director of Dermatologic and Cosmetic Surgery and the Mohs Surgery Fellowship Program at UC Irvine.

Ramos-e-Silva Marcia, Dr. Marcia Ramos-e-Silva is Full Professor and Chair of the Sector of Dermatology of the Federal University of Rio de Janeiro; Executive Vice-President of the International Society of Dermatology; and VicePresident for South America of the International Academy of Cosmetic Dermatology. She received very important honors: Maria Duran Medal, International Society of Dermatology for Leadership in Dermatology in 2005; Women’s Dermatologic Society International Pioneer Award for Distinguished Women in Dermatology in 2007; 51st Jabuti Prize 2009, 1st place for the book Fundamentos de Dermatologia-category Health and Natural Sciences (most important literature prize in Brazil); and the Clinical Care International Award of the EADV in 2018. Prof. Ramos-e-Silva has almost 400 scientific publications (7 books, 49 book chapters, and more that 300 articles in medical journals). She presented aroud 800 conferences, case reports, etc., in specialty meetings, courses, and symposia in Brazil and all over the world.

John McGrath, John McGrath is the academic head of St John’s Institute of Dermatology in London. He holds the Mary Dunhill Chair in Cutaneous Medicine at King’s College London and is Honorary Consultant Dermatologist to the Guyćs and St Thomasć National Health Service Foundation Trust. He is the current President of the European Dermatology Forum and leads on several national phenotyping and genotyping of rare disease initiatives in the UK. His research focuses on the molecular characterization of inherited skin diseases and the development of novel treatments for rare skin diseases.

Ma. Angela Medina-Lavadia, Dr. Maria Angela M. Lavadia is in the active practice of Clinical Dermatology with special interest in Contact Dermatitis and Environmental Dermatology. She chairs the Department of Dermatology and Skin Center at the East Avenue Medical Center, a tertiary level medical center of the Department of Health, Philippines where she is involved in teaching, training and research at the Dermatology Residency Training Program. She is a Diplomate and Fellow of the Philippine Dermatological Society, an International Fellow of the American Academy of Dermatology, a fellow of the Asian Academy of Dermatology and Venereology, a member of the Asian Dermatological Association and the International Society of Dermatology. Dr. Lavadia is currently serving as the President of the Philippine Dermatological Society. She espouses the society’s aspirations of Skin Health for All by promoting innovative skin health information campaigns for the general public, continuing medical education for health care workers in all levels, social responsibility and networking.

Giuseppe Mical, Giuseppe Micali MD is Professor of Dermatology at University of Catania where he earned his MD

GHJUHH DQG FRPSOHWHG KLV UHVLGHQF\ LQ 'HUPDWRORJ\ +H KDV KHOG IUHTXHQW DQG ORQJVWDQGLQJ VFLHQWL¿F FROODERUDWLRQ ZLWK several US universities (University of Illinois, Northwestern University, New Jersey University, Miami University) leading to publication of several papers and international textbooks along with students exchange also involved in research projects. He is member of several international societies, such as American Academy of Dermatology (AAD), European Academy of Dermatology and Venereology (EADV), International Society of Dermatology (ISD), European Dermatology Forum (EDF) and member of the board of directors of Italian Society of Dermatology (SIDeMaST). Honorary member of the American Dermatological Association (ADA), and Vietnamese Society of Dermatology. In the Editorial Board of Journal of the American Academy of Dermatology, International Journal of Dermatology, Journal of Dermatology Treatment, Skin Appendage Disorders. Prof. Micali main areas of interest include: acne, rosacea, seborrheic dermatitis, non-invasive techniques and their applications in dermatology, male genital disorders. Some of them have been the topic for Symposia, Focus session and Forum chaired by Prof. Micali in the past AAD Meetings since 1996. The scientific activity consists of N°562 publications including 264 original articles in international journals (peer reviewed). Editor of respectively 10 and 10 international and national books.

Takashi Mochizuki, Takashi Mochizuki MD, PhD has been investigating the diagnosis and treatment of dermatomycoses and the mycology of these pathogens for many years. He is known as a specialist of fungal infection in the field of dermatology. His many publications include the ultrastructure of pathogenic fungi, and the molecular identification and epidemiology of dermatophytes. He serves as a member of the Education Committee in the Japanese Society for Medical Mycology (JSMM), and is a board member of the Asia Pacific Society for Medical Mycology (APSMM). He also serves as Section Editor of infection articles of The Journal of Dermatology (JD). He is currently deeply committed to the undergraduate/postgraduate education at Kanazawa Medical University, and also to the postgraduate education of medical mycology in JSMM.

Je-Ho Mun, Dr. Je-Ho Mun is an assistant professor in the Department of Dermatology at Seoul National University

College of Medicine and Seoul National University Hospital. He is also a chief of skin cancer/chemotherapy skin care center at Seoul National University Cancer Hospital. He graduated and received PhD from Pusan National University. He joined the Seoul National University faculty in September 2015. He is a passionate and active member of the Korean Dermatologic Association, the Korean Society for Skin Cancer, and the Korean society for nail research. His clinical practice and research focus mainly on diagnosis and treatment of malignant and benign skin tumors (dermatosurgery, dermatopathology, dermoscopy), nail disorders, and wound healing. He published about 100 articles in international and domestic journals to date.

Jean Francois Nicolas, Professor Jean-François Nicolas, Dermatology, Allergology & Clinical Immunology

Past & Present Jean-François Nicolas is head of the Allergology and Clinical Immunology Department of Lyon University Hospital. He is dermatologist, professor of Immunology and PI of a research team in INSERM Unit 1111-CIRI (co-PI Marc Vocanson) . The main research themes concern immunodermatology and more precisely the pathophysiology of skin inflammation. JF Nicolas received his MD from Lyon University Medical School in 1983. His dermatology speciality degree was obtained through specific training in immunodermatology (Professor Jean Thivolet). He obtained a PhD in 1990, having trained at Scripps Clinic and the University of California, San-Diego (Dr. Jacques Chiller) and having been a recipient of an INSERM young investigator award. He then entered INSERM as Research Director and worked successively in Dermatology (U 209 and U 346, 1990-1992) and Immunology (U80, U999 and U503, 1992-1998) Inserm Research Units.

Kuniaki Ohara,

1973˙Graduated from Tokyo University Staff of Dermatology Department, Tokyo University Hospital 1980˙Associate Professor, Tokyo University 1984˙Dermatologist in Chief, Toranomon Hospital, Tokyo 2007˙Vice President, Toranomon Hospital 2012˙Retirement Consultant Dermatologist, Toranomon Hospital, Komagome Hospital, Hiroo Hospital 2017˙Akasaka Toranomon Clinic

Amit G. Pandya, Amit G. Pandya MD. Dr. Amit G. Pandya is a Professor in the Department of Dermatology at the University of Texas Southwestern Medical Center in Dallas, Texas, U.S.A. He earned his Doctor of Medicine degree from UT Southwestern Medical School and completed residencies in Internal Medicine at Presbyterian Hospital of Dallas and in Dermatology at UT Southwestern Medical Center. Dr. Pandya served as chief resident during his last year of dermatology residency. He has written multiple articles and book chapters in the field of dermatology and has given lectures and served as a visiting professor nationally and internationally. He has a special interest in vitiligo, melasma and other pigmentary disorders. His ongoing clinical and translational research is focused on the etiology, epidemiology, measurement, quality of life, diagnosis and treatment of these cutaneous disorders. He is also interested in mentorship, diversity and pipeline programs. In his free time, he enjoys spending time with his sons, traveling, dancing salsa and bachata, scuba diving and playing tennis.

Kim A. Papp, Dr. Kim Papp is a Member of the College of Physicians and Surgeons of Ontario, a Fellow of the Royal

College of Physicians and Surgeons of Canada, and a Fellow of the American Academy of Dermatology. Dr. Papp has over 25 yearsć experience as a Principal Investigator, and has conducted over 170 psoriasis studies in which he closely supervised and assessed over 2750 subjects. Dr. Papp is an internationally renowned Key Opinion Leader in clinical research who conducts clinical trials on a wide range of dermatological disorders. Dr. Papp, with the support of Probity Medical Research, an organization for which he serves as Founder and President, has earned the distinction of top enrolling investigator in over 70 international dermatology studies. Dr. Papp has conducted early through late phase psoriasis studies, and has been instrumental in the investigation and development of many compounds: Dr. Papp has acted as consultant and/or advisor to over 40 pharmaceutical companies on the development of dermatological compounds. He is instrumental in improving and refining study designs, and serves on a number of Steering Committees and Advisory Boards tasked with developing effective and efficient strategies for the timely development of new treatments. An author on over 275 publications, and a highly sought-after speaker known for delivering engaging, thought-provoking and accessible presentations, Dr. Papp is held in the highest esteem by the academic and medical communities.

Eugenio Reyes Pipo III, Dr. Pipo received his medical degree from the University of Santo Tomas, Manila, Philippines. He finished his residency training program in Dermatology at the Research Institute for Tropical Medicine, Manila, and took up his fellowship training in Cutaneous and Laser Surgery at the Institute of Dermatology in Bangkok, Thailand. Dr. Pipo is a diplomate of the Philippine Dermatological Society, and a member of the International Society of Dermatology. He is one of the recipients of the 2016 Global Education Award of the International Society of Dermatology. He has several publications and international presentations on tropical diseases.

Daniel Popkin, Dr. Daniel Popkin is a physician-scientist who sees and treats patients with dermatologic conditions

as well as heads his own laboratory research efforts in Immunology. Daniel Popkin received his MD in Dermatology and PhD in Immunology from Washington University in St. Louis, MO, USA. He has received numerous awards from the NIH, Veterans Health Administration, Doris Duke Charitable Foundation, and American Skin Association. Dr. Popkin has published numerous articles in the field of dermatology, HIV, rosacea, and viral immunology. He co-wrote the Handbook of Dermatology. He is on the editorial board of Pathogens and Immunity and serves as a reviewer for numerous journals. His lab pursues research in non-melanoma skin cancer visualization, the microbiome of rosacea, HIV cure and fundamental host pathogen interactions using humanized mouse models. Daniel Popkin, MD, PhD, joined Case Western Reserve University and University Hospitals Cleveland Medical Center in 2012. Dr. Popkin earned his medical degree from Washington University School of Medicine, where he also received his PhD. in immunology.

Ma. Cristina A. Puyat, Dr. Puyat is the founder and medical director of Asian Stem Cell Institute,Inc. She completed her Master’s degree in Preventive and Regenerative Medicine from the Dresden International University (Germany), and a Stem Cell fellowship from the American Academy of Anti-Aging Medicine. Dr. Puyat is also a Founding member, board, and pro of World Council of Preventive Medicine (WOCPM), Board member and Vice President of Philippine Academy of Dermatologic Surgery Foundation Inc. (PADSFI), Board member of International Society of Dermatologic Surgery (ISDS), Board of Governor’s Aesthetic Stem Cell Society, Procedural Dermatology Consultant and Subsection Head of Cosmetic Surgery Department in Rizal Medical Center. Dr. Puyat is an invited faculty and panel expert in topics ranging from dermatology to regenerative cellular therapies. She has been an invited faculty at the International Darmstadt Live Symposium in Germany numerous times, and has served in the capacity as a facilitator, faculty, chair and co-chair for the ISDS in Istanbul, Las Vegas, Philippines, Vienna, Thailand, Bucharest, Luzern, and New Delhi; DASIL, APACS, A4M, WOSIAM, Euromedicom Aesthetic Asia, IMCAS, and World Consensus for WOCPM, and ITCAM Anatomy Master Courses.

Yu-Ping Ran, Professor, Dept. of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Completed the Course Medical Mycology, The Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelorćs and Masterćs degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the annual course authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Member of the editor board of Mycolopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board member of the Standing Committee of the Society of Dermatology, Chinese Medical Association, Head of Medical Mycology Group, Chief Scientist of Fungi Research Center.

Francisco D. Rivera IV, Dr. Francisco D. Rivera IV finished his Medical School at University of the East Ramon Magsaysay Memorial Medical Center and his Dermatology residency training program at East Avenue Medical Center. After which he is heavily involved in environmental and occupational medicine in practice. Later on he took his Master’s Degree on Health Systems Administration at the Ateneo Graduate School of Business. With this background he helps in creating a systems of healthcare service delivery on 2 of the biggest ambulatory healthcare network in the Philippines. Recently, Dr. Rivera establishes one of the residency training program in dermatology under the Philippine Dermatological Society and one of the Philippines Regional Referral Center in Dermatology-“The Department of HealthRizal Medical Center”. His passion in establishing network of different healthcare service delivery systems never stopped here. This same passion drives him to start a teledermatology to assist in training local general medicine practitioners and other healthcare workers serving in the geographically isolated and disadvantage areas of the Philippines.

Thomas M. Runger, Thomas M. Rünger, MD PhD has been a Professor of Dermatology at Boston University School of Medicine (BUSM) in Boston, MA, USA since 1999. From 2014–2016, he also served as Chair of the Department of Dermatology at Roger Williams Medical Center (RWMC) in Providence, RI, an academic hospital that is affiliated with BUSM. Dr. Rünger grew up in Germany and received his medical training at the Medical Schools of the Universities of Ulm and Kiel in Germany, followed by research training as a postdoctoral fellow with Dr. Kenneth H. Kraemer at the NIH, in Bethesda, MD, USA and his clinical specialty training in dermatology and in allergology at the University of Würzburg, Germany. Soon afterwards, he was recruited to the University of Göttingen, Germany, to serve as Vice Chair of the Dermatology Department and Professor of Dermatology. A broad experience in general dermatology is extended with special expertise in photodermatology, phototherapy, dermato-oncology, occupational dermatology, and rheumatologic dermatology.

Julio Cesar Salas-Alanis, Affiliation. President of Dystrophic Epidermolysis Bullous Research Association MEXICO AC. Dermatologist from Mexico, researcher since 1995, member of the Local and National Dermatology Societies. Member of the American Academy of Dermatology, and International Dermatology Society. Founder of Dystrophic Epidermolysis Bullosa Research Association Mexico (1995) DEBRA MEXICO AC. More than 200 hundred papers, 80 on pubmed: Science Translational Medicine, Oncotarget, Nature Communications, American Journal of Dermatology, Journal of Investigative in Dermatology, American Human Genetics, PLOS, PNAS, and some others. Local and National awards on the Research field as the National Prize for his volunteer job as Founder and President of DEBRA MEXICO. Community leadership skinpact Galderma award 2016 for the Association DEBRA MEXICO. International Collaborations with different Universities in USA: Columbia, Angela Christiano (Genotrichosis, Epidermolysis Bullosa, Trichotiodystrophy), Thomas Jefferson, Jouni Uitto, Andy South, (Epidermolysis Bullosa, microbiota, squamous cell carcinoma, Desmoglein 2), Stanford, Peter Marinkovici (Epidermolysis Bullosa), Yale, Keith Choate (Hypohidrotic Ectodermal Dysplasias) and London, John McGrath (Genodermatosis).

Seow Chew Swee, Dr Seow graduated from the University Of Malaya in Malaysia and proceeded with post graduate training in Singapore and the United Kingdom where he underwent training in Dermatology, specialising in Medical Mycology at the Institute of Dermatology, University of London. He currently holds the position of Senior Consultant Dermatologist at the National Skin Centre in Singapore and was head of Dermatology department of National University Hospital between 2003 and 2013. His teaching appointments include Senior Lecturer of Yong Loo Lin School of Medicine, and Lee Kong Chian School of Medicine in Singapore. He is also Lecturer and Examiner of the Graduate School of Medicinećs Graduate Diploma in Family Medicine (Dermatology) Course, and lecturer in Medical Mycology of the Department of Microbiology. He is also external examiner for the MD degree of university of Health Sciences, Lahore, Pakistan. His research topics include Malassezia yeast, Scytalidium, leprosy and Asian Skin diseases and had contributed 35 publications .He is member of Editorial Board of the Indian Journal of Dermatology. His professional affiliations are, Treasurer of Asian Academy of Dermatology and Venereology, Board Member of Asian Dermatological Association, President, Singapore Leprosy Relief Association Singapore and many others.

Latha Selvarajah

Academic Qualifications: 2003:MBBS (University of Malaya, Kuala Lumpur) 2010:MRCP (Ireland) 2016:Advanced Master of Dermatology (National University of Malaysia) Current Employment: Head of Department & Consultant Dermatologist, Sultan Ismail Hospital Johor Bahru Current Duties 1.Performing dermatology consultations and procedures. 2.Supervisor for Student Selected Component, Newcastle University Malaysia. 3.Chairperson for Hospital Basic Dermatology Workshop, Johor Dermatology Update and Annual World Psoriasis Day (State Level) 4.Committee member for Clinical Credentialing and Privileging Board, Hospital Sultan Ismail. 5.Reviewer for the National Antibiotic Guideline for Dermatology, 3rd Edition.

Jaishree Sharad, Dr Jaishree Sharad is a renowned cosmetic dermatologist from Mumbai, India. She has completed

her post graduate training in dermatology in 1999. She is the Director of Skinfiniti Aesthetic Skin & Laser Center, Mumbai. She is an International Mentor of the American Society of Dermatologic Surgery. She is one of the Board of Directors of the International Society of Dermatologic Surgery. She is a part of the editorial board of Journal of Cutaneous and Aesthetic Surgery, Dermatologic Therapy and Journal of Cosmetic Dermatology. She has been the Vice President of the Cosmetic Dermatology Society of India from April 2010-March 2018. She has also been scientific chairperson of the National conference of the Cosmetic Dermatology Society of India in 2015,2016,2017, 2018. She received ‘The rising star’ title in two sessions at the World Congress of Dermatology held in Vancouver from 8th to 13th June 2015. She has been awarded with India’s Most Admired Beauty Expert (Medical Profession) Award” at 4th Annual India Leadership Conclave. She was also awarded one of the 50 Outstanding Women in Health Care at The World Health Congress Annual Awards, Mumbai 2017. She has also won the Best Skin Expert at both Vogue and Elle Beauty Awards.

Vinod K. Sharma, Dr Vinod Kumar Sharma is Professor and Chair of Department of Dermatology and Venereology

at All India Institute of Medical Sciences, New Delhi, India since 2001. He is currently Assistant Secretary General of International Society of Dermatology. He has special interest in field of Vitiligo, Psoriasis, Allergic Contact Dermatitis and Drug reactions. He had successfully organised XI International Congress of Dermatology at New Delhi as Congress President in year 2013. He has served as President of Indian Association of Dermatologists, Venereologists & Leprologists, and Vice President of International Society of Dermatology. He has also served on Board of Directors of American Academy of Dermatology. He has published five books on Dermatology and STD & AIDS. He has published large numbers of research papers (more than 340) and contributed to several textbooks of Dermatology. He is on Editorial Board of International Journal of Dermatology and Dermatitis (Official Journal of American Contact Dermatitis Society), and has served as Associate Editor of British Journal of Dermatology. He has won several national awards for research in Dermatology and has also been felicitated by International League of Dermatologic Societies with Certificate of Appreciation.

H. Peter Soyer, Professor H. Peter Soyer has a dual academic/clinical role as the inaugural Chair and Director of the Dermatology Research Centre, The University of Queensland (UQ) Diamantina Institute, at the Translational Research Institute, and as Director of the Dermatology Department at the Princess Alexandra Hospital. Professor Soyer, an academic dermatologist from Austria, is a world leader in the field of dermatology with particular expertise in dermatooncology and dermatologic imaging. His research groupćs main focus is skin cancer (both melanoma and keratinocyte skin cancer) and he is co-inventor in patents for novel skin delivery platforms and microbiospy sampling devices. He initiated establishment (2016) and is Co-leader of the Australian Skin and Skin Cancer (ASSC) Research Centre, He is lead investigator of the Centre of Research Excellence for the Study of Naevi and a Partnership Grant on the early detection of melanoma, both funded by the Australian Government National Health and Medical Research Council (NHMRC), a Queensland Genomics Health Alliance Demonstration Project ‘A Genomics Approach for Screening of Patients at High Risk of Melanoma’, and a UQ Faculty of Medicine Health Outcome Program ‘3D QMelanoma – Targeted Early Detection of Melanoma Utilising a 3D Teledermatology Network’. He was recently awarded a Medical Research Future Fund (MRFF) Next Generation Clinical Researchers Program Practitioner Fellowship (2018-2022).

Liang-Dan Sun, Liangdan Sun, MD, PhD, Professor. Director of scientific research department of the First Affiliated

Hospital of Anhui Medical University (AHMU), China, deputy director of Key Laboratory of Dermatology, Ministry of Education, China and enjoy the special allowance of the state council and Anhui province, China. I am elected as the committee member of Human and Medical Genetic Specialty Committee, Genetics Society of China, Committee Member of Clinical Precision Medicine Special Committee, Chinese Medical Doctor Association, Committee Member of Dermatology Special Committee, Chinese Research Hospital Association, Youth Committee Member of Genetics Society of China, Youth Committee Member of Chinese Society of Dermatology and Chinese Society of Educational Technology in Chinese Medical Association. I was recognized as the Excellent Young Scholars of National Science Foundation, the youth scholar of "the Changjiang Scholars Program", the National New Century Talents Project national candidates, the Outstanding Young Talents of "the National High-Level Talents Special Support Plan" and the outstanding young and middle-aged expert of National Health and Family Planning Commission, New Century Outstanding Talents Project of the Ministry of Education, China.

Yong-Hu Sun, Dr. Sun is Associate Professor of Dermatology in Shandong Provincial Institute of Dermatology and Venereology. He received his PhD. from Anhui Medical University. He was trained for bioinformatics in Genome Institute of Singapore (2012-2014) about the population genetics. His current research mainly focuses the genomic and molecular mechanisms of complex skin diseases, such as ADR. autoimmune bullous disease and leprosy. Recent publications included <Nat Communs>, <J Invest Dermatol>, <JEADV> et al.

Hema Sundaram, Dr. Hema Sundaram is a fellowship-trained dermatologist, and the founding director of her cosmetic dermatology, laser and surgery clinics in suburban Washington, D.C. She has a special interest in elucidating the scientific basis of emerging aesthetic technologies; in research and development of new technologies; and in creating high quality, globally accessible medical education programs. Dr. Hhema’s training includes masters and medical degrees from Cambridge University in England, dermatology residency at the University of Chicago, and a Medical Staff fellowship at the National Institutes of ealth (NIH). She is a Visiting Professor for the American Society of Dermatologic Surgery (ASDS), and has served as a Mentor for the ASDS Future Leaders’ Network. She is a Principal Investigator for US FDA studies; and a Course Director for physician education initiatives and conferences in the US, Asia-Pacific, Europe and the UK. Dr. Sundaram serves on the Editorial Advisory Boards of journals including the Journal of Drugs in Dermatology and Prime; and as a peer reviewer for other plastic surgery and dermatology journals. She is the author of a book, “Face Value” (Rodale), which was honored by the National Press Club.

Jonathan Te-Peng Tseng, Dr. Tseng is a registered dermatologist specialist, now serving as the Chief of Department of Dermatology at Taiwan Adventist Hospital. His key interests include urticaria, atopic dermatitis, psoriasis, rosacea, nail surgery and hair restoration. He has acquired further training of dermatologic surgery (Hair restoration, skin tumor, nail surgery) in U.S.A and Japan. Dr Tseng is a firm believer of educating younger clinicians in dermatology. He is a certified lecturer with the Education Bureau at the College of Medicine, Taipei Medical University. He frequently participates in many national/international meetings as the speaker.

Fang-Wen Tseng, Fang-Wen Tseng, MD is a dermatologist based in Taipei, who specializes in filler injection, laser treatments, and fat sculpting. After graduating with honors from the National Yang-Ming University School of Medicine, he completed his dermatologic training at the Chang-Gung Memorial Hospital in Taipei, and served as an attending physician at the same institution. Currently he is the medical director of Taoyuan Milano Aesthetic Clinic in northern Taiwan. As a speaker/trainer for leading companies of fillers, lasers, and skin tightening technologies, Dr. Tseng is generous in sharing his experiences, to fulfill aesthetic dermatologistsć restless appetite for pursuing perfection.

Tao-Hsin Tung, Tao-Hsin Tung received the PhD degree in Public Health, National Yang-Ming University, Taipei, Taiwan, in 1996 and 2005, and SJD degree in Department of Crime Prevention and Correction, Central Police University, Taoyuan, Taiwan, in 2011 and 2018. In 2004, he joined the Department of Medical Research and Education, Cheng-Hsin General Hospital, as an Associated Researcher, and in 2008 became a Researcher. His current research interests include clinical epidemiology, biostatistics, evidence-based medicine, disease screening, medical law, and criminology.

Rataporn Ungpakorn, Dr. Rataporn Ungpakorn has been a consultant at the Institute of Dermatology, Bangkok,

since 1993 after his dermatology training from King Mongkutklao Medical College Hospital. He received scholarship to attend Fellowship in Medical Mycology at Guy’s, King’s and St. Thomas’ Hospitals in London and became actively involved in many international societies. Renowned for his insights, Dr. Rataporn is a familiar face among Asian and International Medical Congresses. He is also a key international congress organizer for the Dermatological Society of Thailand since 2001. At present, Dr. Rataporn is the Vice-President for International Affairs and Professional Liaison for the Dermatological Society of Thailand, council members for Asian Dermatological Association (ADA), Asia-Pacific Society of Medical Mycology (APSMM) and the League of ASEAN Dermatological Societies (LADS) founding member.

Shirley L. Van, Dr. Shirley Van, MD,FAAD, FAACS, Dr. Van joins a prestigious group of dermatologists as “doublefellows”. She is a Fellow of the American Academy of Dermatology(AAD) as well as the American Academy of Cosmetic Surgery (AACS) . Dr. Van obtained her medical degree from the University of Miami, Florida and completed her dermatology residency training at the University of California, San Francisco. After serving as Chief Resident at UCSF, she joined Loma Linda University to serve as Assistant Professor where she taught Dermatology. In 1989, she began her private practice in Modesto, California, in the Central Valley, where her passion in dermatology was in treating sun-damaged skin and its sequelae. Her experiences in evaluating and treating sun-damaged skin and skin cancers have been widely recognized by her peers as she has been a popular speaker giving lectures and grand rounds at major university medical centers. In recent years, the incidences of skin cancers have risen dramatically. In collaboration with UCSF, Dr. Van has tirelessly studied detection of melanoma at its earliest onset, and specifically at an earlier evolving stage.

Yen-Jen Wang, Dermatologic surgeon in MacKay Memorial Hospital , Taipei, Taiwan. Field of interest: Skin cancers, Mohs micrographic surgery, Vitiligo, Optical Coherence Tomography and Confocal Microscopy

Chao-Chin Wang, Dr. Chao-Chin Wang is a board-certified dermatologist from Taiwan. He is a recognized expert in minimally invasive facial rejuvenation, including energy based devices, injectables and thread lifts. Dr.Wang also also contributes in other different academic area. He held faculty positions in universities, giving lectures on dermatology and aesthetic medicine. Furthermore, he is the secretary general and board of scientific committee of Aesthetic and Antiaging Medicine World Congress (AMWC) Asia and the invited reviewer for the Dermatologic Surgery, Journal European Academy of Dermatology and Venereology (JEADV) and Journal of Cosmetic Dermatology.

Chuang-Wei Wang, My main research interests are "Drug hypersensitivity", "Pharmacogenomics" and

ĄImmunogeneticsą.I have previously develop a nucleic acid–based agent consisting of an anti-CD8 aptamer with granulysin-specific siRNA and can significantly inhibit CTL-mediated drug hypersensitivity, such as that seen in patients ZLWK 6-6 7(1 - $OOHUJ\ &OLQ ,PPXQRO ,) ILUVW DXWKRU , DQG RXU UHVHDUFK WHDP DOVR IRXQG WKDW DQWL 71) Į biologics (etanercept) can improve clinical outcomes in patients with SJS-TEN. (J Clin Invest. 2018; IF=13.25; first author). I further published several papers in J Invest Dermatol. 2016, 2018.

Fang-Ying Wang, Education and Position: 2007-2014 MD, Department of medicine, College of Medicine, Chang Gung University, Taiwan 2014-2015 Post-graduate year resident, Linkou Chang Gung Memorial Hospital, Taiwan 2015-2018 Resident of Dermatology, Linkou Chang Gung Memorial Hospital, Taiwan 2018-Present Chief Resident of Dermatology, Linkou Chang Gung Memorial Hospital, Taiwan

Jennifer Wu, Dr. Jennifer Wu is a board-certified dermatologist, an attending physician and a lecturer at Chang Gung Memorial Hospital in Taipei, Taiwan. She received her MD degree from Chang Gung University, Taoyuan, Taiwan in 2010. She completed the dermatology residency in Department of Dermatology at Chung Gung Memorial Hospital, Linkou, Taiwan and has focused her research interest on severe cutaneous adverse drug reactions (SCARs) and skin toxicities to cancer therapies. As a Visiting Investigator in Dermatology Service at Memorial Sloan Kettering Cancer Center, New York, USA during 2017-2018, she has extended her research interest to include onco-dermatology, immune-related adverse events (irAEs) associated with immunotherapies, and their impacts on quality of life. She is actively involving in the clinical patient care, patient education and research on SCARs and dermatologic adverse events associated with cancer treatments at Drug Hypersensitivity Clinical and Research Center and Immune-Oncology Center of Excellence at Chang Gung Memorial Hospital.

Jashin J. Wu, Through the 7 year Honors Program in Medical Education, Jashin J. Wu, MD, earned a BA in biological sciences from Northwestern University in Evanston, Illinois and an MD from Northwestern University Medical School in Chicago. Dr. Wu completed dermatology residency at the University of California, Irvine, California, where he was chief resident. Dr. Wu is Director of Dermatology Research at the Department of Dermatology at Kaiser Permanente Los Angeles Medical Center. Dr. Wu is a Medical Board member of the National Psoriasis Foundation (NPH) and a Councilor for the International Psoriasis Council. He serves on the American Academy of Dermatology/NPF psoriasis guidelines committee. He is co-editor for 5 books which include Therapy for Severe Psoriasis, 1st edition, 2016; Clinical Cases in Psoriasis, 1st edition; Mild-To-Moderate Psoriasis, 3rd edition, 2014; Moderate-To-Severe Psoriasis, 4th edition, 2014. He is associate editor for the upcoming 4th edition of Comprehensive Dermatologic Drug Therapy projected to publish in 2019. He has written over 220 Pubmed articles, of which over 120 are about psoriasis. He is Past President of the Los Angeles Metropolitan Dermatological Society, Board Member of the California Society of Dermatology & Dermatologic Surgery (CalDerm), and Board Member of the Pacific Dermatology Association.

Chih-Hsun Yang, Professor Jason, Chih-Hsun Yang accomplished his dermatology training at the Chang Gung Memorial Hospital in 1999. He received surgical fellowship training in John Hopkins University and Toranomon Hospital back in year 2001. He has authored more than a hundred publications that are mainly focusing on the treatment of varicose vein and dermatologic surgery. Dr Yang was the director of the Dermatology Department and Cosmetic center, Chang Gung Memorial Hospital since 2007. He is actively involved in many professional activities and international collaborations. Due to his contributions, he was elected as the President of Taiwan Dermatological Association in 2012~2105. Dr Yang directed numerous teaching workshops in dermatology surgery, nail surgery, laser techniques and dermoscopy etc.

Zhi-Rong Yao

Professor of Dermatology Councilor, International Eczema Council (2016-) Deputy President, Chinese Dermatological Association (2017-) Former President , Pediatric Dermatology, Chinese Society of Dermatology (2009-2015) Professional Experience: 2005-present Professor & Chairman, Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine Special Awards & Recognition: Wu Jie-ping Prize for Medicine Shanghai Leading Talent awarded by Shanghai Municipal Government

Roman Yaremkevych, Doctor dermatologist, Head doctor at Uzhhorod National University clinic “Asclepius”. Doctor Yaremkevych is an author of a number of scientific publications in field of psychodermatology and dermatooncology; Co-organizer of courses and national congresses for dermatologists in Ukraine; member of European Academy of Dermatology and Venerology, International Society of Dermatovenereology, European Association of Dermato Oncology, International Dermoscopy Society, Ukrainian Association of Dermatology and Venereology; cofounder of patients community “Ukrainian Atopic Dermatitis Society”. He is attending a lot of profecional meetings, congresses, symposiums as a participant and speaker.

Fu-Ren Zhang, Consultant Dermatologist, Professor and PhD tutor, currently is the director of Shandong Provincial

Institute of Dermatology and Venereology, vice-president of Shandong Academy of Medical Sciences, is the professor of “Taishan Scholar Climbing Project”. He received his MD and PhD certificate in dermatology and venereology from Peking Union Medical College in 1991, used to study in UK and US for two years 2001-2002, and 2004-2005. His interest is mainly on the control of infectious skin disease, including leprosy and sexual-transmitted diseases; and sever skin disease, including adverse drug reaction, psoriasis and autoimmune bullous disorders. He is currently the candidate chairman of China Association of Prevention and Control of leprosy , the chief editor of China Journal of Leprosy and Skin Diseases, the vice president of Shandong Medical Doctor Association, and the vice president of Chinese Society of Dermatology.

Jie Zheng

1977-1982 Student, Shanghai Second Medical College 1982-present Dermatologist, Department of Dermatology, Shanghai Ruijin Hospital

Abstract ISD/TDA

George T. Reizner Melanoma, changing treatments, management and survival Session: CCD Opening Ceremony

Saturday, Nov. 17, 2018-from 09:00 to 09:30 RM 201ABC-LEVEL 2

The care and management of melanoma is a quickly evolving field with surgery, radiation, immunotherapy and novel new treatments contributing to improved patient outcomes. This lecture reviews melanoma epidemiology, diagnosis and the concepts behind the new advances in multispecialty treatment of this disease. We are entering an era when durable remissions and conceivably even the elusive Ä&#x201E;cureÄ&#x2026; may be possible for some patients with advanced disease.

Evangeline B. Handog Oral Skin Lightening Agents: Do they work Session: Lu Yao Chin Lecture

Sunday, Nov. 18, 2018-from 08:30 to 09:00 Plenary Hall-LEVEL 3

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Nellie Konnikov Implemintation of Photodynamic therapy in Medicine and Esthetics Session: CCD Opening Ceremony

Saturday, Nov. 17, 2018-from 09:30 to 10:00 RM 201ABC-LEVEL 2

It will be a review on the current knowledge of Photodynamic Therapy (PDT) and the historical basis of the method's evolution since its introduction. Since its approval, PDT protocols has evolved significantly in terms of increasing method efficacy and patient safety. In this era of evidence-based medicine, it is expected that much effort will be put into creating a worldwide accepted consensus on PDT. European and US guidelines recommend PDT for treatment of precancerous lesions and superficial non-melanoma skin cancers to prevent progression to invasive disease. We are witnessing a broadening of the spectrum of skin diseases that are treated by PDT. Field directed PDT is becoming a standard of care for multiple AKs, because of the malignant potential and the unpredictability of the transformation from AK to SCC. Daylight photodynamic therapy (PDT) is emerging as an efficacious treatment for AK, particularly for patients who require treatment of large areas of chronic actinic damage that can be exposed easily to daylight. In addition, as life expectancy increases, the elderly seek intervention modalities to improve their appearances and reverse signs of aging. Mild to severe textual changes on the sun exposed areas are due to chronic actinic damage, resulting in clinical appearance of multiple AKs. In this presentation we will review utilization of PDT within Boston VA Healthcare, our hands-on protocols, photosensitizing agents, light sources, potential side effects, and outcomes of PDT.

Nellie Konnikov Implementation of Tele Dermatology within VA Healthcare system. How to make it work Session: Teledermatology

Saturday, Nov. 17, 2018-from 14:30 to 14:50 RM 201D-LEVEL 2

Teledermatology is one of the most active applications of telemedicine. The program allows dermatologists to provide care to underserved populations and to provide an expert opinion to remote areas around the world. The implementation of TeleDermatology allows dermatologists to widen their reach to patients in a cost-effective manner, in addition to assisting primary care physicians in adherence to specialist recommendations. One of the largest HealthCare systems, VA is using TeleDermatology to improve access to skin care for veteran patients who live in remote and other areas to save having to travel to a dermatology clinic. Teledermatology offers a potential means to extend specialty care, especially where access to office visits is limited. However, little data exist on frequency of completion of recommended treatment following teledermatology consultation and the ultimate resolution of the clinical problem under consideration.

Antonella Tosti Dermoscopy of nails Session: Approach and Diagnosis of Nail Disease

Friday, Nov. 16, 2018-from 11:15 to 11:45 RM 201ABC-LEVEL 2

Nail dermoscopy (onychoscopy) is a versatile tool that is relatively new to the practice of dermatology. The goal of onychoscopy is improve diagnostic skill in nail disorders .. This review covers technique, normal nail features, and current knowledge of features present in various nail disorders of LQĂ&#x20AC;DPPDWRU\ WUDXPDWLF LQIHFWLRXV DQG QHRSODVWLF RULJLQ 2Q\FKRVFRS\ LV DOVR XVHIXO WR VHOHFW RSWLPDO ELRSV\ VLWH DV ZHOO H[FLVLRQDO PDUJLQV

Antonella Tosti Exogenous and self-induced nail disorder Session: Miscellaneous Nail Disease

Friday, Nov. 16, 2018-from 16:10 to 16:30 RM 201ABC-LEVEL 2

Onychotillomania is an uncommon and likely underreported condition in which patients repetitively manipulate the different constituents of the QDLO XQLW 2Q\FKRWLOORPDQLD LV FKDUDFWHUL]HG E\ D UDQJH RI QRQVSHFLÂżF ÂżQGLQJV LQFOXGLQJ EL]DUUH PRUSKRORJ\ RI WKH QDLO SODWH DQG GDPDJH WR WKH QDLO EHG DQG SHULXQJXDO VNLQ +LVWRSDWKRORJLFDO FKDQJHV DUH DOVR QRQVSHFLÂżF EXW PD\ EH YLHZHG DV DQDORJRXV WR OLFKHQ VLPSOH[ FKURQLFXV DQG prurigo nodularis of the skin. Clinical history is essential to making this diagnosis, as effective treatment modalities may focus on behavioral therapies and psychiatric medications.

Antonella Tosti Dermoscopy of the scalp and hair: alopecia Session: Dermoscopy

Saturday, Nov. 17, 2018-from 11:30 to 12:00 RM 201ABC-LEVEL 2

Onychomycosis is the diagnosis for onychodystrophic nails about 50% of the time . However, there are a variety of other etiologies that may be causing the onychodystrophic nails. These other conditions may mimic onychomycosis in their presentations and must be excluded before initiating antifungal treatment. Mimickers for onychomycosis include inflammatory, infective, and neoplastic nail disorders, as well as nail manifestations of systemic diseases. This presentation will discuss differential diagnosis according to the clinical type of onychomycosis.

Antonella Tosti Differential diagnosis of onychomycosis Session: Mycology Forum (I)

Saturday, Nov. 17, 2018-from 09:00 to 09:30 RM 103-LEVEL 1

Dermoscopy, widely used in dermatology for the evaluation of pigmented skin lesions, represents a valuable, noninvasive and rapid technique DOVR IRU WKH HYDOXDWLRQ RI SDWLHQWV ZLWK KDLU ORVV DOORZLQJ D PDJQLÂżHG YLVXDOL]DWLRQ RI KDLU DQG VFDOS VNLQ ,Q WKLV FDVH GHUPRVFRS\ PD\ EH GHÂżQHG DV â&#x20AC;&#x153;trichoscopyâ&#x20AC;? DQG PD\ EH SHUIRUPHG ZLWK D PDQXDO GHUPRVFRSH [ PDJQLÂżFDWLRQ RU D YLGHRGHUPRVFRSH DOORZLQJ XS WR [ PDJQLÂżFDWLRQ %RWK SRODUL]HG DQG QRQSRODUL]HG OLJKW PD\ EH XVHG ZLWK RU ZLWKRXW WKH XVH RI LPPHUVLRQ RLO â&#x20AC;&#x153;dry dermoscopyâ&#x20AC;?). In particular, WULFKRVFRS\ PD\ EH XVHIXO IRU WKH GLDJQRVLV SURJQRVLV DQG IROORZ XS RI DQGURJHQHWLF DORSHFLD $*$ DORSHFLD DUHDWD $$ WHORJHQ HIĂ&#x20AC;XYLXP trichotillomania, congenital triangular alopecia, scalp infections and infestations, scarring alopecias and hair shaft disorders.

Dedee F. Murrell Novel Therapies for Epidermolysis Bullosa Session: Bullous Dermatoses

Saturday, Nov. 17, 2018-from 12:30 to 12:50 RM 201ABC-LEVEL 2

Background: Targeted therapies are being developed for generalized EB simplex (silencing the keratin 14 gene), Junctional EB (to replace the defective LAMB3 gene), and recessive dystrophic EB (to upregulate or replace the collagen VII gene). This talk will review the current status of treatments. Methods: A literature search was conducted from 1st Jan 2005 to 1st June 2018 and congress abstracts were searched from 1st Jan 2015 to 1st June 2018. Results: Gene repaired skin grafts have succeeded long term in two patients with JEB. Trials are ongoing of COL7A! gene repaired grafts in RDEB patients. Cell therapies have had transient effects and bone marrow transplantation has had a high mortality without cure. PTC readthrough drug gentamicin repaired wounds wtih topical application. Topical allantoin was not successful in most forms of EB. Current trials of oleogel and diacerein are ongoing. Conclusion: There are many exciting developments for specific treatments of EB, at last.

Dedee F. Murrell Biologics for pemphigus Session: Bullous Dermatoses

Saturday, Nov. 17, 2018-from 13:10 to 13:30 RM 201ABC-LEVEL 2

An independent French RCT of rituximab and short course of low dose corticosteroids vs standard high dose corticosteroids conclusively showed that the former was much more effective and safe for treating pemphigus. This lead to FDA registration in 2018 of rituximab for pemphigus. Brutonâ&#x20AC;&#x2122;s Tyrosine Kinase (BTKis an intracellular kinase that is active in B cells and in antibody (IgG, IgE) mediated activation of various non T-cell immune cells via Fc receptor signaling. Case reports of paraneoplastic pemphigus in lymphoma patients responding to ibrutinib suggested that BTK inhibition could be a new therapy for pemphigus. Several BTK inhibitors have been developed for B cell lymphoma which are non-selective and have broad side effects. PRN-1008 is a selective, covalent but reversible-binding small molecule which only acts on the BTK for a short period, thereby minimizing side effects. This has been tested 59

in normal volunteers for safety and in dogs with pemphigus to good effect. A phase II study in pemphigus has recruited 21 patients so far in an open label study. Interim data reported in March 2018 suggested that PRN1008 has the ability to induce control of disease activity and/or achieve clinical remission in a high proportion of patients without the need for high dose corticosteroids. Another approach is the development of a humanized IgG4 monoclonal antibody optimized to inhibit FcRn binding to IgG at both neutral and acidic pH, SYNToo1. SYNT001 rapidly facilitates clearance of IgG and IgG circulating immune complexes (CICs), with the potential to block innate immune responses induced by IgG and CIC, as well as inhibit T cell and B cell activation in response to CIC. A Phase 1B trial reported that 7 pemphigus patients received 5 weekly infusions of 10mg/kg and then were followed up for 12 weeks for safety. Primary endpoint analysis revealed SYNT001 to be well tolerated, with all study drug-related adverse events (AEs) characterized as mild or moderate. No severe or serious study drug-related AEs were reported. The secondary endpoint measures showed a reduction in mean PDAI score from severe to moderate, with clinical effect persisting beyond the treatment period. Rapid and clinically meaningful reductions in pharmacodynamic biomarkers were observed in all patients. At nadir, mean total IgG levels were reduced by 59% (day 30), mean CIC levels were reduced by 50% (day 33), mean anti-DSG1 levels were reduced by 22% (day 14) and mean anti-DSG3 levels were reduced by 24% (day 33). These studies suggest that more specific therapies with better safety profiles than existing treatments for pemphigus will soon be possible.

Koushik Lahiri Autologous minigrafting in vitiligo: evolution and evaluation Session: Vitiligo and Photodermatology

Saturday, Nov. 17, 2018-from 09:45 to 10:10 RM 201D-LEVEL 2

Vitiligo is a result of disrupted epidermal melanization with an undecided etiology and incompletely understood pathogenesis. Various treatment options have resulted in various degrees of success. Various surgical modalities and transplantation techniques have evolved during the last few decades. Of them, miniature punch grafting (PG) has established its place as the easiest, fastest, and least expensive method. Various aspects of this particular procedure are elaborated. The historical perspective, the instruments, evolution of mini grafting down the ages, and the methodology, advantages, and disadvantages will be discussed. A detailed discussion on the topic along with a review of relevant literature has been provided in this article. Surgical correction of vitiligo and other cutaneous achromia has come a long way in the last almost five decades. However, among all other methods, autologous miniature punch grafting has established its place as the easiest, fastest, safest, and least aggressive means of vitiligo surgery.

Koushik Lahiri Dealing with e-patients in practice Session: Teledermatology

Saturday, Nov. 17, 2018-from 14:10 to 14:30 RM 201D-LEVEL 2

An e-patient is a health consumer who participates fully in his/her medical care, primarily by gathering information about medical conditions that impact them and their families, using the Internet and other digital tools. The term encompasses those who seek guidance for their own ailments and the friends and family members who go online on their behalf. E-patients report two effects of their health research: "better health information and services, and different, but not always better, relationships with their doctors." E-patients are active in their care and demonstrate the power of the Participatory Medicine The "e" can stand for "electronic" but has also been used to refer to other terms, such as "equipped", "enabled", "empowered" and "expert". A growing number of people say the internet played a crucial or important role as they helped another person cope with a major illness. 0DQ\ FOLQLFLDQV XQGHUHVWLPDWHG WKH EHQHÂżWV DQG RYHUHVWLPDWHG WKH ULVNV RI RQOLQH KHDOWK UHVRXUFHV IRU SDWLHQWV 0HGLFDO HGXFDWLRQ PXVW adapt to take the e-patient into account, and to prepare students for medical practice that includes the e-patient. Medical online support groups are an important healthcare resource. The information super highway (the World Wide Web including but not limited to the various social networking platforms) has opened up a new arena for CCs. This area could be christened the â&#x20AC;&#x153;e-corridor consultationâ&#x20AC;? (ECC). This includes the consults done on WhatsApp , Facebook , SMS , or even email (with or without images) to substantiate the conversation. 7KH HOHFWURQLF FRQVXOWV DUH RIWHQ WKH ÂżUVW SUHVHQWDWLRQ WR WKH FRQVXOWLQJ GHUPDWRORJLVW We are supposed to read the posts, look at the images and without any relevant history are supposed to give a diagnosis and prescribe something! Social networking platforms such as WhatsApp have an inbuilt feature, where a number once saved in the phone's contact list becomes automatically visible in the network contacts. This leads people to believe that it is acceptable behavior to get into conversation with anyone through social network apps without even bothering to check if the other person is comfortable with the exercise. Physicians tend to share personal cell phone numbers with the patients out of compassion; however, this is not taken in the right spirit by some people. 0DQ\ SDWLHQWV EHOLHYH LW WR EH QRUPDO DQG DFFHSWDEOH WR FDOO WKHLU GRFWRU DERXW GLHWDU\ DGYLFH VNLQ SLJPHQWDWLRQ K\SR RU K\SHU FODULÂżFDWLRQV regarding the medicine prescribed ages ago, etc. It is often the rich, powerful, or famous people (who are supposedly busy enough to have time to visit their doctor) who tend to be the worst offenders when compared to the illiterate, poor, or the genuinely deserving.

Lali Mekokishvili What does the red face tell us? Session: Acne and Rosacea (II)

Sunday, Nov. 18, 2018-from 14:20 to 14:45 RM 201ABC-LEVEL 2

Rosacea is common chronic inflammatory facial diseases, especially among persons with the skin type I. The disease can significantly affect the patient's quality of life; in addition, red face appearance can serve as potential signal for a number of serious diseases. The pathophysiology of rosacea is rather complex and remains uncertain. According to the current knowledge the dysregulation of two types of receptors, thermo receptors and receptors recognizing pathogen make the rosacea skin abnormally sensitive and cause inflammation. This receptors are activated by rosacea triggers selectively, which may determine certain pathological processes and clinical symptoms. Diagnosis of rosacea is made clinically, several studies revealed that dermoscopy is a good diagnostic tool especially if concomitant facial diseases are presented. The retrospective analysis of all rosacea cases in a single clinic during 8 years from 2010 (n=3840) revealed that 25% of rosacea patients have concomitant acne, among them 92% are women with adult acne, and the rest 8%-young women with acne vulgaris and men with or without adult acne. This is the reason why in any case, especially in adult women with redness and papulopustular rash on the face, dermatologist has to distinguish rosacea with late acne, or exclude coexistence of these two diseases. Redness, couperose, itchy and irritant skin in line with signs of late acne, as well dermoscopy clues of rosacea (polygonal vessels, follicular plugs, superficial scales) can serve as diagnostic criteria. The modern treatment of rosacea is based on new â&#x20AC;&#x153;phenotype classificationâ&#x20AC;&#x153;, which was proposed by the International Rosacea Consensus (ROSCO) panel instead of classic subtype classification. The new therapy approach considers presence and severity of particular symptoms of disease. To date, there is no method of treatment that allows to get rid of rosacea forever. Modern methods of treatment suggest eliminating unwanted symptoms and preventing complications. Innovative technologies make it possible to improve the cosmetic acceptability, which significantly improves the quality of life of patients. Analysis and evaluation of current data on the pathogenesis and methods of treatment of Rosacea, as well some original management approach based on long-term individual experience of successful treatment of patients with rosacea will be presented in this report.

Miriam Emily P. Soriano Phenol Matricectomy of Ingrown Toenails Session: Miscellaneous Nail Disease

Friday, Nov. 16, 2018-from 15:30 to 15:50 RM 201ABC-LEVEL 2

Ingrown Nails (a.k.a. onychocryptosis or unguis incarnatus) is a disease usually affecting the big toes of the feet, where the lateral or medial aspect of the nailplate embeds into the soft tissue of the lateral or medial nailfold, creating a foreign body reaction characterized by inflammation, followed by suppuration, and eventual granuloma formation. The incidence is highest is adolescents and young adults, mostly males from ages 20 to 30 years. Predisposing factors include excessive curvature of the nailplate, improper trimming of nails, regular use of constricting footwear, and excessive plantar hyperhidrosis. Pain and limitation of motion associated with ingrown nails can lead to economic losses and poor quality of life, necessitating medical intervention. Mild disease can be treated conservatively by putting gauze or plastic tubing between the embedding nailplate and the soft tissue of the nailfold. Moderate to severe ingrown nails is best treated with partial avulsion of the nailplate (removing that part of the nailplate that is embedding in the nailfold) followed by permanent destruction of the lateral matrix horn (matricectomy) to prevent recurrence. Matricectomy can done by physical modalities such as cryotherapy, electrosurgery, radiofrequency, or carbon dioxide laser which require special equipment that can be expensive; Alternatively, matricectomy can be achieved with the use of caustic chemicals such as phenol, sodium hydroxide, or trichloroacetic acid, which are easy to apply and inexpensive. For chemical matricectomy, Phenol is the most widely used and has the longest history of efficacy and safety in nail surgery. Aside from being a caustic agent, Phenol is also a potent local anesthetic, reducing the incidence of post-op pain. The technique of phenol matricectomy for ingrown nails will be shown in this video lecture.

Miriam Emily P. Soriano Treatment of Dark Eye Circles Session: Aesthetic Dermatology (I)

Saturday, Nov. 17, 2018-from 15:30 to 15:50 RM 103-LEVEL 1

The eyes are considered to be the windows to the soul and are the focal point when one looks at a human face. Having dark eye circles can convey a message of tiredness, insomnia, and even premature ageing . Hence, some patients come and ask what the dermatologist can do to to make their dark eye circles go away. Dark eye circles can be due to true hyperpigmentation of the periorbital skin, which is genetic and prominent in certain races i.e. people from southern India; or this may be due to Pseudohyperpigmentation wherein the dark color of the orbicularis oculi muscle shows through thin lower eyelid skin due to lack of subcutaneous tissue between the skin and the orbicularis oculi muscle. True hyperpigmentation can be treated conservatively with cosmeceutical containing various bleaching agents or by iontophoresis with Vitamin C. While pseudohyperpigmentation can be treated with soft tissue fillers, preferably autologous fat. Autologous fat offers a natural-looking and long-lasting correction of dark eye circles.

Riichiro Abe Progress of SCAR in Japan Session: Asian SCAR Meeting - SCAR Consortium Forum

Friday, Nov. 16, 2018-from 16:50 to 17:00 North Lounge-LEVEL 3

In 2004, Japanese Research Committee on Severe Cutaneous Adverse Reaction (J-SCAR) was established in support with the Ministry of Health, Labour an Walfare of Japan. The achievement of J-SCAR include Establishment of the drug-induced hypersensitivity syndrome (DIHS) 61

GLDJQRVWLF FULWHULD DQG (IÂżFDF\ RI DGGLWLRQDO L Y LPPXQRJOREXOLQ WR VWHURLG WKHUDS\ LQ 6-6 7(1 5HFHQWO\ - 6&$5 KDV OHG WKH FOLQLFDO WULDO WR reveal the effectiveness of steroid therapy in SJS/TEN. J-SCAR will proceed to collaboration with Asia countries.

Razzaque Ahmed Autoimmune Blistering Diseases Session: Immune Forum-General Dermatology

Saturday, Nov. 17, 2018-from 08:50 to 09:10 RM 101AD-LEVEL 1

Autoimmune Blistering Diseases (AIBD) have a unique place in dermatology because they are potentially fatal, can affect multiple mucous membranes, occur globally and are considered orphan diseases. They form a good model to study autoimmunity because of the easy access RI WKH VNLQ DQG RUDO PXFRVD 'LUHFW LPPXQH Ă&#x20AC;XRUHVFHQFH KHOSHG FKDUDFWHUL]H WKH DQWLJHQV DQG DXWR DQWLERGLHV PDNLQJ LW HDVLHU WR VWXG\ WKHLU pathobiology. Bullous Pemphigoid (BP) is the most common and presents with large tense bullae or urticarial plaques, on flexor surfaces. Mortality rate increases with increasing age . The blisters are subepidermal on histology in all patients with pemphigoid. On DIF, IgG, and C3 bind to the BMZ. Autoantibody targets a hemidesmosome protein (BPAg2, BP180) and a cytoplasmic protein (BPAg 1, BP230) in the basement membrane zone (BMZ).Pemphigus foliaceus involves only the skin, while pemphigus vulgaris affects the skin and mucous membranes. The autoantibody targets cell adhesion molecules in the epidermis, desmoglein 1 & 3. On histology, the blisters are intra-epidermal. The DIF shows deposition of IgG on keratinocyte cell surface. Mucosa of the nose, conjunctiva, pharynx, larynx, esophagus, genitalia and anal canal, scalp and nails can be involved. Mucous membrane pemphigoid MMP) predominantly affects mucousal tissues similar in distribution to PV. When the anti-BMZ autoantibody target only alpha 6 integrin oral pemphigoid is observed. When it targets beta 4 integrin other mucosae and skin are involved. The critical issue in MMP is that as blisters heal, there is scar formation, which has serious consequences and sequelae. Scarring of conjunctiva can lead to blindness, in the larynx sudden asphyxiation and death, in the anal canal constant fecal leakage. Scarring of other mucosal sites compromises quantity of life. Pemphigoid manifesting in a pregnant female is known as pemphigoid gestations. It can have effects on the fetus and may cause stillbirths. Epidermolysis Bullosa Acquisita (EBA) causes skin fragility and blisters on sites of trauma which heal with scars and milia formation. It can involve mucous membrane. The autoantibody targets type 7 collegen and binds to the dermal side of salt split skin. It can be associated with systemic disease which should be evaluated and excluded. Linear IgA Bullous Diseases (LABD) involves the skin in most patients but can involve the mucosal sites also. There is a band like deposition of an IgA autoantibody on the BMZ. When it occurs in children it is referred to as chronic bullous dermatosis of childhood (CBDC). It is frequently self-limiting. Dermatitis Herpetiformis (DH) affects knees, elbows and external surfaces, with presence of autoantibody to epidermal transglutaminases. Clinical celiac disease is not observed, but patients have skip area of gluten sensitive enteropathy in the intestine. On DIF granular deposits of IgA are observed in the papillary dermis. Unlike some of other patients in dermatology clinics or practices, patients with autoimmune blistering diseases require detailed thorough comprehensive initial work up to make accurate diagnosis, developing a treatment plan and meticulous follow-up.

Razzaque Ahmed Biologic agents in blistering diseases Session: Bullous Dermatoses

Saturday, Nov. 17, 2018-from 12:50 to 13:10 RM 201ABC-LEVEL 2

Conventional therapy of blistering diseases consist of systemic corticosteroids and immunosuppressive agent. This combination is HIIHFWLYH LQ PDQ\ SDWHQWV ,Q RWKHUV LW LV LQHIIHFWLYH FDQ FDXVH VLJQLÂżFDQW VLGH HIIHFWV ZKHQ FDQ EH VHULRXV RU FDWDVWURSKLF DQG QHFHVVLWDWH GLVFRQWLQXDWLRQ ,Q IHZ SDWLHQWV WKLV FRPELQDWLRQ LV FRQWUDLQGLFDWHG ,Q WKHVH JURXS RI SDWLHQWV ELRORJLF DJHQWV DUH LQGLFDWHG 7KH ÂżUVW ELRORJLF agent to be used in treating autoimmune blistering diseases was intravenous immunoglobulin (IVIg). A panel of 38 experts from the US, Canada and Europe assembled as a Consensus Development Group and produced a Consensus Statement which included a protocol for its use. The recommended dose of IVIg is 2gm/kg/cycle. The total dose is divided into 2 or 3 equal parts given over 2 or 3 consecutive days and given as a slower infusion over 5-6 hours. It is repeated once a month until clinical recovery occurred. Thereafter the internal between the infusion cycle is increased to every 6,8,10,12,14 and last infusion at 16 weeks intervals, this is end of the therapy. It has been used in patients with pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, epidermolysis bullosa acquisita, linear IgA bullous disease and others. In addition to clinical recovery, IVIg produced long-term sustained clinical remissions and high equality of life. In patient with MMP is prevents disease progression. The second biologic agent which has become popular is RTX-it is a B cell depleting (BDT) agent that targets the CD20 molecule. It can be used by the Lymphoma protocol (375mg/m2, four weekly infusions) or Rheumatoid Arthritis protocol (1gm.15 days apart). While RA protocol is used more frequently, there is no proof it is better. Both DUH HTXDOO\ HIIHFWLYH 7KHUH ZDV QHYHU SXEOLVKHG VFLHQWLÂżF HYLGHQFH IRU WKH UDWLRQDO WR FKRRVH HLWKHU GRVH RU IUHTXHQF\ RI LQIXVLRQV 7KH striking feature is the rapid onset of action and rapid remission in 75-80 % patients. One of its main draw backs is an exceedingly high rate of relapse. These recurrences require additional RTX, corticosteroids or immunosuppressive drugs. Since peripheral blood B cells are zero, infections can occur and can sometimes be fatal. Cardiac side effects can occur. A French group of dermatologist lead by Prof. Pascal Joly, did a randomized controlled trial, showing superiority of RTX & low dose prednisone over high dose prednisone only. This trial resulted in WKH )RRG 'UXJ $GPLQLVWUDWLRQ )'$ RI WKH 86 DSSURYLQJ XVH RI 57; WR WUHDW SHPSKLJXV YXOJDULV $ FRPELQDWLRQ RI 5,; DQG ,9,J D GHÂżQHG protocol (Ahmed Protocol) has documented 15 years diseases free, drug free remissions in PV patients. Long-term remissions have been reported in Bullous Pemphigoid, MMP and EBA using this combination protocol. In the studies reported thus far, relapses are not common. This symbiotic effect of two biologic agents provides promise for the future. It is clear that in the future autoimmune blistering diseases will be treated with biologic agents, whatever they may be available, and who ever can afford them.

Alex Anstey Recent research highlights in the BJD: choices by the BJD editor-in-chief Session: BJD Editor & Genetic Forum TDA/CCD/TSID

Sunday, Nov. 18, 2018-from 10:30 to 11:00 Plenary Hall-LEVEL 3

,Q -XQH WKH %-' SXEOLVKHG D SRVLWLRQ VWDWHPHQW WR H[SODLQ ZKDW WKH %-' ZDV DOO DERXW 7KLV KLJKOLJKWHG D JUHDWHU IRFXV RQ ÂżYH PDLQ areas: 62

&OLQLFDO WULDOV (YLGHQFH EDVHG GHUPDWRORJ\ 4XDOLWDWLYH DQG RXWFRPHV UHVHDUFK (SLGHPLRORJ\ 7UDQVODWLRQDO UHVHDUFK Section editors were appointed for these five sections, with specialist teams of Associate Editors. Additionally, the BJD created a team of statistics experts with skills and interests that were matched to these five main sections. The research papers I will highlight in this talk are taken from these five main sections of the BJD. I will briefly highlight the research papers and explain why they are important. This lecture will attempt to explain how the BJDćs focus on higher quality research has been of benefit to the journal. Additionally, Alex will explain how the BJD is working hard to create additional resources that help clinicians to engage with the research content of the journal (including plain language summaries of original articles in Mandarin). After all, it is clinical dermatologists who deal with patient care. If this is to improve patient care around the globe, it is essential that clinicians can understand and share research that is published in the BJD. References: 1.What does the BJD now stand for? A position statement. DOI: 10.1111/bjd.13855 2.Commissioned scholarly reviews in dermatology. DOI: 10.1111/bjd.12453 3.Plain language summaries in the BJD: connecting with patients. DOI: 10.1111/bjd.12760 4.Getting under the skin: qualitative methods in dermatology research. DOI: 10.1111/bjd.13720

April Armstrong Innovations in Teledermatology: Direct Patient–Specialist Care Session: Teledermatology

Saturday, Nov. 17, 2018-from 13:30 to 13:50 RM 201D-LEVEL 2

Our patients are increasingly asking for communication with physicians online. Can teledermatology be used for direct patient care? In this session, we will explore the evidence for new models of healthcare delivery that use teledermatology platforms. We will discuss opportunities and challenges associated with direct-to-patient teledermatology in the new era.

April Armstrong Psoriasis pathogenesis and the development of novel targeted immune therapies Session: Psoriasis

Saturday, Nov. 17, 2018-from 15:30 to 15:55 RM 201ABC-LEVEL 2

Our understanding of pathogenesis of psoriasis is rapidly evolving, and multiple new immune therapies for psoriasis are emerging. In this session, you will learn the latest updates on psoriasis pathogenesis in the context of new and emerging immune therapies for psoriasis.

Robert L. Baran Differential diagnosis: Dystrophic nails and onychomycosis Session: Approach and Diagnosis of Nail Disease

Friday, Nov. 16, 2018-from 11:45 to 12:05 RM 201ABC-LEVEL 2

Onychomycosis is so frequently encountered in daily practice that any nail dystrophy, especially one occurring in isolation, may be wrongly diagnosed. In addition, some entirely different dermatoses may cause similar nail alterations. This is due to the fact that the nail apparatus has a limited repertoire of reaction patterns and the nail plate covers and hides the various structures involved in the pathological process.

Robert L. Baran Leukonychia Session: Miscellaneous Nail Disease

Friday, Nov. 16, 2018-from 15:50 to 16:10 RM 201ABC-LEVEL 2

The white color of the nails can be: Ŷ ,VRODWHG Ŷ 3UHVHQW DV D SDUW RI D V\QGURPH Ŷ 2U UHVXOW IURP LQWHUQDO GLVHDVH Ŷ 7KLV IDVFLQDWLQJ WRSLF PD\ EH FRQJHQLWDO RU DFTXLUHG Ŷ 7RWDO DQG VXEWRWDO OHXNRQ\FKLD FDQ UHSUHVHQW YDULDWLRQV LQ SHQHWUDQFH RI GLVHDVH Ŷ 7KLV WRSLF RI JUHDW LQWHUHVW GHSHQGV RQ WKH VNLOO RI WKH SK\VLFLDQ

Robert L. Baran Nail involvement in paraneoplastic syndromes Session: Miscellaneous Nail Disease

Friday, Nov. 16, 2018-from 16:30 to 16:50 RM 201ABC-LEVEL 2

&XWDQHRXV SDUDQHRSODVWLF V\QGURPHV ZLWK QDLO LQYROYHPHQW >&36@ GHQRWHV VNLQ GLVRUGHUV WKDW KDYH D VWDWLVWLFDOO\ VLJQLÂżFDQW DVVRFLDWLRQ ZLWK WKH presence of malignancy. The time relation between CPS and the responsible malignancy varies: the dermatosis may arise when the malignancy has already clearly developed and is evident, or it may be the revealing sign of small-sized tumor that is not manifest, or may precede its onset. CPS are intrinsically devoid of any neoplastic nature and do not originate in the skin by metastasis or as a direct consequence of compression, but are due to various mechanisms caused by the tumor. These disorders evolve in parallel to the malignancy, in that, they regress when the tumor is removed and reappear in the case of tumor recurrence. The time relation between CPS and the responsible malignancy varies: the dermatosis may arise when the malignancy has already clearly developed and is evident, or it may be the revealing sign of small-sized tumor that is not manifest, or may precede its onset.

Robert L. Baran Whatâ&#x20AC;&#x2122;s new in nail disease and treatment Session: TDA Plenary Lecture

Sunday, Nov. 18, 2018-from 09:30 to 10:00 Plenary Hall-LEVEL 3

It is impossible to summarize the multiple topics which will be the subject of this presentation.

Cun-Wei Cao 7KH ÂżJKWLQJ EHWZHHQ 7DODURP\FHV PDUQHIIHL DQG KXPDQ KRVW Session: Mycology Forum (I)

Saturday, Nov. 17, 2018-from 09:30 to 10:00 RM 103-LEVEL 1

The dimorphic fungus Talaromyces marneffei is an emerging fungal pathogen which cause a life-threatening disseminated mycosis in immunocompromise patients in Southeast Asia and southern part of China. T. marneffei, characterized by its ability to escape immune killing, VXUYLYH DQG UHSOLFDWH LQVLGH PDFURSKDJHV WKHQ VSUHDG WKH ZKROH ERG\ ,Q WKH VWXG\ ZH GHVFULEH ÂżJKWLQJ EHWZHHQ WKH IXQJDO SDWKRJHQ DQG human host. Through genes function research, we found Calcineurin pathway play a crucial role in T.marneffei immune escape and contribute WR LWV SDWKRJHQLFLW\ ,Q WKH RWKHU VLGH RXU VWXG\ SURYLGHV HYLGHQFH WKDW DQWLÂą,)1 Č&#x2013; DXWRDQWLERGLHV DFW DV QRYHO KRVW IDFWRUV DFFRXQWLQJ IRU WKH VXVFHSWLELOLW\ WR 7 PDUQHIIHLL LQ +,9 QHJDWLYH SDWLHQWV 7KH VWURQJ DVVRFLDWLRQ EHWZHHQ DQWL ,)1 Č&#x2013; DXWRDQWLERGLHV DQG +/$ '5% '4% SURYLGHV D SRVVLEOH SDWKRJHQLF UROH RI WKLV +/$ KDSORLG W\SH IRU DQWL ,)1 Č&#x2013; DXWRDQWLERG\ JHQHUDWLRQ

Mimi Chang 'LDJQRVLV DQG 0DQDJHPHQW RI ,QĂ&#x20AC;DPPDWRU\ +DLU 'LVRUGHUV Session: Immune Forum-General Dermatology

Saturday, Nov. 17, 2018-from 09:25 to 09:40 RM 101AD-LEVEL 1

Alopecia is a common complaint that not only induce cosmetic concerns, but it may also signify underlying medical conditions. The differential diagnosis includes a large number of disorders causing non-scarring and scarring alopecia. Most cases are due to disorders of hair cycling and are thus non-scarring. Inflammatory, cicatricial (scarring) alopecia, however, is a heterogeneous group of inflammatory diseases targeting primarily at the hair follicles, causing destruction of the pilosebaceous unit and irreversible hair loss. Primary cicatricial alopecia is classified histologically into lymphocytic, neutrophilic, mixed or end-stage nonspecific alopecia, based on the type of cellular infiltrates around hair follicles. Examples of the lymphocytic group include lichen planopilaris, frontal fibrosing alopecia, pseudopalade of Brocq and central centrifugal cicatricial alopecia. Chronic cutaneous lupus erythematosus is also mediated by lymphocytes with alopecia as part of its course. Examples of the neutrophilic group include folliculitis decalvans and tufted folliculitis. Dissecting cellulitis and acne keloidalis belonged to the group with mixed infiltrates. Secondary cicatricial alopecia results from non-folliculocentric inflammation which leads to destruction of hair follicles. Severe infection of the scalp, infiltrative, autoimmune and physical injury are leading causes. The management comprises of good history taking, clinical examination, dermoscopic assessment, appropriate microbiological examination and biopsy of the scalp, which should be done early in the course of disease. Delaying the diagnosis makes the condition less salvageable. Good clinicopathologic correlation is helpful. Treatment for predominantly neutrophilic group is antimicrobial agents, whereas treatment for predominantly lymphocytic group includes immunomodulating agents. Intralesional steroid injection can be considered to symptomatic sites. Early, aggressive treatment is important for disease control.

John Wen-Cheng Chang Immunotherapy in melanoma Session: Melanoma Forum (II)

Saturday, Nov. 17, 2018-from 11:30 to 12:00 North Lounge-LEVEL 3

Since anti-CTLA-4 antibody, ipilimumab demonstrated a 21% long-term survival rate for patients with metastatic melanoma in 2011, novel immune checkpoint inhibitor immunotherapy has continued to evolutionize treatment of almost very kind of cancer. These mechanisms 64

include checkpoint inhibition, antibody-drug conjugates, chimeric antigen receptor T-cell immunotherapy, and therapeutic cancer vaccine. The most notable mechanism is the checkpoint inhibitors. Several FDA-approved agents, anti-PD1 and anti-PD-L1 antibodies, are available for DQ LQFUHDVLQJ QXPEHU RI FDQFHUV &RPELQDWLRQ RI WKHVH QRYHO LPPXQRWKHUDS\ LQFUHDVHV HIÂżFDF\ EXW DOVR LQFUHDVHV WR[LFLW\ DQG FRVW 1RYHO immunotherapy has new immune-related adverse events (irAEs). The irAEs need to be carefully assessed and management. A multidisciplinary, multi-organizational panel of experts was recommended for novel immunotherapy.

Yin-Jui Chang

Saturday, Nov. 17, 2018-from 15:30 to 15:45

RM 201D-LEVEL 2 Pattern analysis and algorithms for dermoscopic diagnosis for young dermatologists Session: TDA Dermoscopy Bowl Dermoscopy has been proven to significantly enhance the accuracy of clinical diagnosis of pigmented skin lesions. Understanding the correlations of dermoscopic features and histopathologic presentations is fundamental to the most correct assessment of a pigmented lesion. The diagnostic algorithms help clinicians not to miss the diagnosis of melanoma, as well as to differentiate other pigmented and nonpigmented skin lesions. In this lecture, the dermoscopy diagnostic algorithms will be introduced to young dermatologists and beginners.

Chun-Bing Chen New Emerging Immune-elated Adverse Events: Updated Pathomechanism Session: Immune Forum-Cutaneous Adverse Drug Reactions (I)

Saturday, Nov. 17, 2018-from 13:50 to 14:05 RM 101AD-LEVEL 1

Immune checkpoint (ICP) inhibitors such as anti-CTLA-4 antibodies and anti-PD-1/PD-L1 antibodies are emerging anti-cancer agents. Although LPPXQH FKHFNSRLQW LQKLELWRUV KDYH HIÂżFDF\ LQ D SDUW RI FDQFHU SDWLHQWV WKH\ PD\ VWLOO LQGXFH â&#x20AC;&#x2DC;autoimmune-likeâ&#x20AC;&#x2122; toxicities and is called as immune checkpoint therapy adverse events (irAEs). IrAE could be classified by variable clinical features, including skin rashes, epidermal necrosis, pneumonitis, hepatitis, colitis, myocarditis or endocrinopathy. Severe irAEs have been reported in 10~20% of patients who receive ICP inhibitors, and some of them further cause life-threatening severe adverse events. Currently, several potential mechanisms were proposed, including the increasing T-cell activity against auto-antigens that are present in tumors, increasing levels of pre-existing autoantibodies, an increased production RI LQĂ&#x20AC;DPPDWRU\ F\WRNLQHV DQG HQKDQFHG FRPSOHPHQW PHGLDWHG LQĂ&#x20AC;DPPDWLRQ 7KH SUHFLVH SDWKRPHFKDQLVPV RI LU$( UHPDLQ WR EH HOXFLGDWHG

Chih-Chiang Chen Alopecia Totals: Whatâ&#x20AC;&#x2122;s New in Mechanism and Management Session: IImmune Forum- General Dermatology

Saturday, Nov. 17, 2018-from 09:40 to 09:55 RM 101AD-LEVEL 1

$ORSHFLD DUHDWD $$ LV WKH PRVW FRPPRQ RUJDQ VSHFLÂżF DXWRLPPXQH GLVRUGHU 2YDO RU URXQG ZHOO FLUFXPVFULEHG EDOG SDWFKHV ZLWK D VPRRWK surface is the typical features of AA. However, it might progress and develop as alopecia totalis (whole scalp hair loss) and alopecia universalis (whole body hair loss), which impacts patientÄ&#x2021;s emotion and quality of life profoundly. While the exact pathogenesis of AA is still elusive, current understanding of the AA suggests that Cytotoxic CD8+ T cells play major role in the pathogenesis of AA. CD8+ T cells cause up-regulation of LQWHUOHXNLQ LQ KDLU IROOLFOHV DQG VXEVHTXHQW SURGXFWLRQ RI LQWHUIHURQ Č&#x2013; ZKLFK WDUJHWV WKH KDLU IROOLFOH IRU DWWDFN -DQXV NLQDVH -$. LQKLELWRUV were shown to eliminate the interferon signature, and prevent disease development. Although promising results of JAK inhibitors in treating AA KDYH EHHQ UHSRUWHG PRUH VWXGLHV DUH QHFHVVDU\ WR GHWHUPLQH WKH XQGHUO\LQJ PHFKDQLVP DV ZHOO DV LWV ORQJ WHUP HIÂżFDF\ DQG VDIHW\

Ching-Chi Chi From Clinical Questions to Evidence-Based Research Session: Evidence Based Dermatology and Dermatoepidemiology

Saturday, Nov. 17, 2018-from 09:30 to 10:05 Joy Lounge-LEVEL 4

Evidence-based medicine (EBM) was first proposed in 1992 and defined as â&#x20AC;&#x153;the conscientious, explicit, and judicious use of current best evidence in making clinical decisions about the care of individual patients.â&#x20AC;? 7KH SUDFWLFH RI (%0 KDV EHHQ VXPPDUL]HG LQ ÂżYH EDVLF VWHSV formulating a clinical question, thoroughly searching the literature, critically appraising the validity and relevance of the retrieved articles, and integrating the results into the clinical practice. However, EBM is not â&#x20AC;&#x2DC;cookbookâ&#x20AC;&#x2122; medicine as it requires the integration of the best research evidence with our clinical expertise, patientsâ&#x20AC;&#x2122; unique values and circumstances. Research always starts with an unanswered clinical question. EBM not only provides an answer to the clinical question, but may also offer a research topic. In this speech, I will share how I developed a series of EBM research from a single clinical question.

Pin-Chi Chiu Acne treatment and Oral isotretinoin Session: Acne and Rosacea (I)

Sunday, Nov. 18, 2018-from 10:30 to 10:55 RM 201ABC-LEVEL 2

Systemic isotretinoin remains the most efficacious treatment for severe acne as well as many cases of more moderate disease that are unresponsive to other treatment modalities. Isotretinoin acts on all four major factors that cause acne: It decreases oil production, 65

reduces the presence of acne bacteria, slows cell turnover within pores thereby reducing clogging and calms inflammation. The most common adverse effects are a transient worsening of acne (lasting 1â&#x20AC;&#x201C;4 months), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Although it is very effective clinically, many people are still very afraid of its possible side effects. In today's talk, I will share my experience of how to make the best use and reduce the risk of using oral isotretinoin in acne treatment.

Cheng-Sheng Chiu

Saturday, Nov. 17, 2018-from 11:00 to 11:30

Dermoscopy of melanocytic lesions Session: Dermoscopy (I)

RM 201ABC-LEVEL 2

Dermoscope is effective to distinguish melanocytic lesions from non-melanocytic ones, and benign melanocytic nevus from malignant melanoma. Diagnostic procedures for pigmented skin lesions include the ABCD rule, Menzies method, 7-point checklist and 2-step procedure which will be dressed in the presentation. The first step is to make a decision if the lesion is melanocytic or not. If the lesion is considered as melanocytic or unknown, then one must proceed to the second step and assess one whether the lesion is malignant or benign based on pattern analysis. Palms and soles area the most prevalent site of malignant melanoma among non-white populations. Dermoscope can early detect acral melanoma since pigmentation patterns of benign and malignant melanocytic lesions are completely opposite. Nevertheless, several variants of dermoscopic patterns of volar skin must be aware to prevent from over diagnosis and unnecessary excision of benign lesions.

Steven K.W. Chow

Saturday, Nov. 17, 2018-from 10:30 to 10:45

Primary Candida onychomycosis in immune-competent patients Session: Mycology Forum (II)

RM 103-LEVEL 1

.H\ZRUGV &DQGLGD 3ULPDU\ 2Q\FKRP\FRVLV ,PPXQRGHÂżFLHQF\ &KURQLF 0XFRFXWDQHRXV FDQGLGLDVLV Introduction In todayâ&#x20AC;&#x2122;s Western literature, it is often stated that Candida spp is usually a contaminant or opportunistic agent in onychomycosis. Primary RQ\FKRP\FRVLV LV VXSSRVHG WR EH DQ H[FHSWLRQ UDWKHU WKDQ WKH UXOH H[FHSW LQ FDVHV RI LPPXQH GHÂżFLHQF\ OLNH +,9 DQG FKURQLF PXFRFXWDQHRXV candidiasis. This paper will review the data on Candida onychomycosis â&#x20AC;&#x201C; and evaluate its historical role as a primary agent in nail infections Methods Relevant data of mycological cultures of onychomycosis studies from a time-period over 40 years were reviewed and analysed for comparison of the incidence of Candida spp. Results It is clear from available data, that today, primary candida onychomycosis today is not a prevalent issue based on study data from developed countries. However, existing data do indicate that primary candida onychomycosis did exist in these developed countries as recent as 40 years ago. The question is â&#x20AC;&#x153;Why is this so? â&#x20AC;&#x153;.

Chia-Yu Chu What's New in Urticaria: Laboratory Examination and Treatment Session: Immune Forum-General Dermatology

Saturday, Nov. 17, 2018-from 09:10 to 09:25 RM 101AD-LEVEL 1

Urticaria is a condition characterized by the development of wheals (hives), angioedema or both. Urticaria is classified based on its GXUDWLRQ DV DFXWH Â&#x201D; ZHHNV RU FKURQLF ! ZHHNV DQG ERWK W\SHV FDQ EH IXUWKHU FODVVLILHG DV VSRQWDQHRXV QR VSHFLILF HOLFLWLQJ factor involved) or inducible (specific eliciting factor involved). Urticaria is a mast cell-driven disease. Histamine and other mediators, such as platelet-activating factor (PAF) and cytokines released from activated skin mast cells, result in sensory nerve activation, vasodilatation and plasma extravasation as well as cell recruitment to urticarial lesions. Acute urticaria usually does not require a diagnostic workup. The only exception is the suspicion of acute urticaria due to a type I food allergy in sensitized patients or the existence of other eliciting factors such as nonsteroidal anti-inflammatory drugs (NSAIDs). The new EAACI/GA2LEN/EDF/WAO guideline in 2017 recommended diagnostic algorithm for CU, and only limited investigations for CSU. Basic tests include differential blood count and CRP and/or ESR. In CSU, the new guideline recommended performing further diagnostic measures based on the patient history and examination, especially in patients with longstanding and/or uncontrolled disease. A basic principle of the pharmacological treatment is to aim at complete symptom relief. Another general principle in pharmacotherapy is to use as much as needed and as little as possible. Many symptoms of urticaria are mediated primarily by the actions of histamine on H1-receptors located on endothelial cells (the wheal) and on sensory nerves (neurogenic flare and pruritus). Thus, continuous treatment with H1-antihistamines is of eminent importance in the treatment of urticaria. Modern 2nd-generation antihistamines should be considered as the first-line symptomatic treatment for urticaria because of their good safety profile. There are studies showing the benefit of a higher dosage of 2nd-generation antihistamines in individual patients. This has been verified in studies using up- to fourfold higher than recommended doses of bilastine, cetirizine, desloratadine, ebastine, fexofenadine, levocetirizine and rupatadine. Therefore, modern 2nd-generation antihistamines at licensed doses are first-line treatment in urticaria and up-dosing is the second-line treatment. Omalizumab (anti-IgE) has been shown to be very effective and safe in the treatment of CSU. The guideline recommended that omalizumab is useful as an add-on treatment in patients unresponsive to high doses of H1antihistamines (third-line treatment of urticaria). In the 2017 new consensus-based treatment algorithm, it was decided that omalizumab should be tried before cyclosporin A as the 66

latter is not licensed for urticaria and has an inferior profile of adverse effects

Kee-Yang Chung

Saturday, Nov. 17, 2018-from 09:30 to 10:00

Melanoma in Koreans Session: Melanoma Forum (I)

North Lounge-LEVEL 3

Acral melanoma represents the most common form of melanoma in darker pigmented individuals. The standard of therapy for primary cutaneous melanoma is wide local excision depending on the maximum Breslow thickness of the tumor. After surgical treatment, the skin defect should be repaired using various modalities such as primary closure, secondary intention healing (SIH), local and free flaps and skin grafting, with functional and cosmetic aspects taken into consideration. A defect on the sole of the foot is very difficult to repair owing to insufficient local skin pool and lack of mobility of the skin in the area. In addition, permanent scar formation and pain when walking can be additional problems. Therefore, in this talk, I will discuss about various modalities I use to reconstruct the defect after wide excision of acral melanoma. In the second half of the talk, I will discuss about the genomic insight and its clinical significance in Korean melanoma patients. Melanoma arise through progressive accumulation of genetic and epigenetic alterations that disrupt homeostatic pathways, resulting in uncontrolled tumor cell proliferation followed by invasion and lymphatic or hematogenous dissemination of the tumor cells to distant sites. Recent efforts in genomic research have enabled characterization of molecular mechanisms underlying many types of cancers, ushering novel approaches for diagnosis and therapeutics.

Kee-Yang Chung

Saturday, Nov. 17, 2018-from 11:00 to 11:30

Comparison of slow Mohs micrographic surgery and wide local excision for melanoma treatment in Korean patients Session: Melanoma Forum (II)

North Lounge-LEVEL 3

Malignant melanoma is a neoplasm of melanocytes which emerged as a leading cause of death among skin cancers, with an increasing incidence. The primary treatment modality for cutaneous melanoma is wide local excision (WLE). The primary goal of wide excision of malignant melanoma is to achieve a histologically negative margin and prevent local recurrence. Even though WLE is considered as the standard of therapy for the removal of cutaneous melanoma, the use of Mohs micrographic surgery (MMS) appears to be increasing. MMS is a tissue-preserving surgical technique with whole-margin evaluation that is widely used for recurrent and infiltrative non-melanoma skin cancers. In recent years, MMS has been evaluated for its effectiveness as an alternative to standard wide excision for certain melanomas such as melanoma in situ (MIS) or lentigo maligna (LM), however, there is a lack of information for the use of MMS for other types of melanomas. We have applied WLE and MMS using the paraffin-embedded sections, i.e. slow MMS, for the treatment of melanoma in Korean patients. Slow MMS was used not only for melanomas with difficult anatomical locations, but for high risk melanomas such as recently excised tumours with positive margins, or locally recurred tumours. The result of this study would be helpful to surgeons in different clinical settings to establish surgical plans for melanoma.

Wen-Hung Chung Progress of SCAR in Taiwan Session: Asian SCAR Meeting-SCAR Consortium Forum

Friday, Nov. 16, 2018-from 16:40 to 16:50 North Lounge-LEVEL 3

Severe Cutaneous Adverse Drug Reactions (SCAR), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms are considered a spectrum of life-threatening adverse drug reactions. Taiwan research team has initiated genetic and immune researches of SCAR since 2002. Our previous results of genetic studies of SCAR include discoveries of several important genetic makers related to drug specific SCAR (e.g. HLA-B*1502 for carbamazepineinduced SJS/TEN, HLA-B*5801 for allopurinol-induced SCAR, HLA-B*1502 for oxcarbamazepine-induced SJS/TEN, and CYP2C9*3 and HLA-B*1502/B*1301/B*5101 for phenytoin-induced SCAR). Prospective studies of HLA-B*1502/5801screening before initiating carbamazepine or allopurinol had also been conducted in Taiwan and showed a promising decrease of SCAR risk induced by carbamazepine/allopurinol. Accordingly, genetic screening for allopurinol and carbamazepine have been advocated and implemented greatly in the past decade in most of hospitals of Taiwan. In addition to genetic studies, Taiwan research team also dedicates immune research of SCAR and show several progresses of immune researches related to SCAR, such as discovery of granulysin as a key molecule responsible for the disseminated keratinocyte death in SJS-TEN and functional studies of HLA-B molecules (B*1502/5801) in SCAR. 0RUH UHFHQWO\ RXU UHVXOW RI FOLQLFDO WULDO IRU WKH WUHDWPHQW RI 6-6 7(1 E\ XVLQJ ELRORJLF DQWL 71) ÄŽ VKRZHG WKDW ELRORJLF DQWL 71) ÄŽ could serve as an effective alternative for the treatment of SJS/TEN and we also found Treg was significantly increased after anti71) ÄŽ WUHDWPHQW ZKLFK ZDV UHODWHG WR PRUWDOLW\ LQ 6-6 7(1

Wen-Hung Chung New Era of Whole Genome Sequencing Studies in Dermatology Session: BJD Editor & Genetic Forum TDA/CCD/TSID

Sunday, Nov. 18, 2018-from 11:20 to 11:40 Plenary Hall-LEVEL 3

Patients with inherited skin diseases are often difficult diagnostic challenges in dermatology. The conventional hunt for the underlying molecular pathology may involve candidate gene screening or linkage analysis.

Recent technical advances in DNA sequencing have rapidly facilitated important progress in genomic medicine. Notably, nextgeneration sequencing (NGS) allows a more comprehensive approach to diagnosing inherited diseases, with potential savings of both time and cost. Since next-generation sequencing introduction into mainstream research in 2009, more and more reports have been published on the use of NGS in genetic disorders, including inherited skin diseases. The presentation highlights the value of wholeexome/genome sequencing, in combination with bioinformatics analysis, in determining the precise molecular pathology and clinical diagnosis in patients with genetic skin disorders. The recent development of NGS makes dermatology exciting a great possibility for discovering genes responsible for variable skin disease, better understanding complex molecular pathways, and eventually developing targeted therapy or disease prevention strategy.

Johannes F. Dayrit

Sunday, Nov. 18, 2018-from 13:45 to 14:00

Climate change and its effect on marine dermatological diseases Session: Climate Change / Tropical Dermatology

RM 103-LEVEL 1

Marine dermatological diseases are not limited to marine dermatosis-defined as dermatological entities resulting from contact with marine organisms. They also include dermatological conditions due to other elements of the marine ecosystem such as the inorganic salts. The notorious worldwide alteration of climate, known as climate change, has been occurring for several decades. In spite of the greater size of the oceans, the contributions of climate change to the marine ecosystem are less understood compared to their terrestrial counterparts. The 2014 Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC) described the climate-related alteration of the oceans’ properties, namely: warming, decreasing salinity (freshening), and acidification in the upper layer of the ocean. Reduced mixing and increased stratification between oceanic layers ensued. The hypoxic regions or oxygen minimum zones (OMZ) in the oceans increased in number and became more superficial. These changes ultimately modify the structure, biodiversity and activities of the marine ecosystem. Shifts in the abundance and locations of marine organisms, together with alteration of other ocean properties, can either increase or diminish their interaction and contact with humans-potentially changing the prevalence and pattern of marine dermatological conditions. The effects of climate change to certain marine dermatological conditions will be explained in this lecture: (1) marine bacteria; (2) algae; (3) sponges; (4) sea urchins; (5) jellyfishes; (6) vertebrates; (7) inorganic materials. Current recommended treatment of common marine dermatological diseases will also be discussed in this lecture.

Johannes F. Dayrit Updates on macular pigmentation of uncertain etiology Session: Dermatologic Surgery

Sunday, Nov. 18, 2018-from 16:10 to16:30 RM 201EF-LEVEL 2

Acquired macular pigmentation of uncertain etiology (AMPUE) has certain unique hyperpigmentation patterns. They include ashy dermatosis (AD), erythema dyschromicum perstans (EDP), lichen planus pigmentosus(LPP) and idiopathic eruptive macular pigmentation (IEMP). All other cases where the pattern of pigmentation is not characteristic like Riehl’s melanosis and IEMP with papillomatosis, are best kept under the classification of AMPUE until more disease defining features develop or the aetiology becomes clearer. Most of the available articles on these pigmentary disorders are not exactly comparable and different regions in the world describe similar conditions under different names. Previous studies also claim that histopathology is rather non-specific, with pigmentladen macrophages and sparse dermal lymphocytic infiltrate. Prototypical cases from the Philippines will be presented. And recently observed characteristic histopathological features, which may aid in differentiating these conditions from each another will also be highlighted.

Marianna Drozhdina Modern tactics of managing patients with rare and complicated forms of acne Session: Acne and Rosacea (I)

Sunday, Nov. 18, 2018-from 11:20 to 11:45 RM 201ABC-LEVEL 2

The report will present modern ideas about the methods of treatment of rare and severe forms of acne based on the principles of evidencebased medicine. The report will demonstrate the methods of treatment and the results of therapy in the photographic material of the author.

Marianna Drozhdina Features of the course of syphilitic infection at the present stage. Russian experience Session: Sexually-Transmitted Diseases

Sunday, Nov. 18, 2018-from 13:50 to 14:10 RM102-LEVEL 1

Syphilis is a socially-significant infection at the present stage. The report will present the improvement of the state system of control and prevention in a “hidden” epidemic in Russia.

Wen-Lang Fan

Sunday, Nov. 18, 2018-from 11:40 to 12:00

,GHQWLÂ¿FDWLRQ RI QRYHO GHIHFWLYH JHQHV UHODWHG WR VHYHUH HDUO\ RQVHW DWRSLF GHUPDWLWLV E\ ZKROH JHQRPH VHTXHQFLQJ Session: BJD Editor & Genetic Forum TDA/CCD/TSID

Plenary Hall-LEVEL 3

$WRSLF GHUPDWLWLV LV D FKURQLF SUXULWLF LQÃ&#x20AC;DPPDWRU\ VNLQ GLVHDVH $OWKRXJK LW PD\ EH LPSURYHG DV D FKLOG JURZV ROGHU VRPH FKLOGUHQ PD\ KDYH ORQJ ODVWLQJ VHYHUH DWRSLF GHUPDWLWLV Ã&#x20AC;DUH LQWR DGXOWKRRG 3UHYLRXV VWXGLHV KDYH VKRZQ VRPH PXWDWLRQ RI JHQHV UHODWHG WR DWRSLF GHUPDWLWLV HVSHFLDOO\ Â¿ODJJULQ D SURWHLQ PDLQWDLQ EDUULHU IXQFWLRQ RI KHDOWK\ VNLQ KRZHYHU QRW DOO SDWLHQWV ZLWK DWRSLF GHUPDWLWLV FDUULHU WKLV GHIHFWLYH JHQH Here we used whole genome sequencing to identify genetic defects in patients with severe early-onset atopic dermatitis comparing to healthy FRQWUROV IURP 7DLZDQ 7KH UHVXOW VKRZHG WKDW LQ DGGLWLRQ WR Â¿ODJJULQ VHYHUDO QRYHO GHIHFWLYH PXWDWLRQV RI JHQHV UHODWHG WR IXQFWLRQV RI VNLQ EDUULHU PDVW EDVRSKLO RU 7 FHOOV ZHUH LGHQWLÂ¿HG LQ SDWLHQWV ZLWK VHYHUH DWRSLF GHUPDWLWLV

Yun Fu

Saturday, Nov. 17, 2018-from 10:05 to 10:20 Joy Lounge-LEVEL 4

Evidence-Based Dermatology: Psoriasis as an Example Session: Evidence Based Dermatology and Dermatoepidemiology Taking psoriasis for example, herein we introduce an evidence-based medicine study.

Psoriasis has been linked with a variety of comorbidities including cardiovascular diseases, chronic kidney disease, uveitis, psychiatric disturbances, metabolic syndrome and its relevant components (obesity, hypertension, dyslipidemia, and diabetes mellitus). However, the relationship between psoriasis and inflammatory bowel disease (IBD) was unclear. Therefore, we aimed to systematically analyze the association of psoriasis with IBD by using evidence-based dermatology. We conducted a meta-analysis and searched MEDLINE, Embase, and CENTRAL on January 17, 2018. The Newcastle-Ottawa Scale was used to evaluate the risk of bias. We analyzed Crohn disease (CD) and ulcerative colitis (UC) separately and conducted random-effects model metaanalysis. We performed a subgroup analysis according to geographic regions. :H LQFOXGHG FDVH FRQWURO FURVV VHFWLRQDO VWXGLHV DQG FRKRUW VWXGLHV ZLWK VWXG\ VXEMHFWV :H IRXQG VLJQLÂ¿FDQW DVVRFLDWLRQV RI SVRULDVLV ZLWK &' 25 RGGV UDWLR FRQÂ¿GHQFH LQWHUYDO &, DQG 8& 25 &, 3VRULDWLF SDWLHQWV KDG increased risk of CD (risk ratio (RR) 2.53, 95% CI 1.65-3.89) and UC (RR 1.71, 95% CI 1.55-1.89). This evidence-base study suggests psoriasis is associated with IBD. Gastroenterology consultation is indicated when psoriatic patients present with bowel symptoms.

Lin Gao

Sunday, Nov. 18, 2018-from 15:30 to 15:50

The current progress of pulsed dye laser in combination with antiangiogenic agents for the treatment of Port-Wine Stain Session: Aesthetic Dermatology (III)

RM 201ABC-LEVEL 2

Background: Port Wine Stain (PWS)blood vessel recurrence induced by pulsed dye laser (PDL)-induced angiogenesis is a critical barrier that must be overcome to achieve a better therapeutic outcome. Objectives: To determine whether PDL-induced angiogenesis can be suppressed by topical anti-angiogenic agents, such rapamycin (RPM) or axitinib. Methods: 7KH P51$ H[SUHVVLRQ SURÂ¿OHV RI DQJLRJHQLF JHQHV DQG SKRVSKRU\ODWLRQ OHYHOV RI H[WUDFHOOXODU VLJQDO UHJXODWHG NLQDVHV (5. S$.7 DQG ribosomal protein S6 kinase (p70S6K) in rodent skin were examined with or without topical rapamycin or axitinib administration after PDL exposure. Results: The PDL-induced systematic increases in transcriptional levels of angiogenic genes showed a peak expression at days 3 to 7 post-PDL in rodent VNLQ 7RSLFDO DSSOLFDWLRQ RI WRSLFDO 530 RU D[LWLQLEVLJQLÂ¿FDQWO\ DQG V\VWHPDWLFDOO\ VXSSUHVVHG WKH 3'/ LQGXFHG LQFUHDVH LQ P51$ OHYHOV RI WKH H[DPLQHG DQJLRJHQLF JHQHV GXULQJ WKH Â¿UVW Â¿YH GD\V SRVW 3'/ 7RSLFDO DSSOLFDWLRQ RI 530 RUD[LWLQLEHIIHFWLYHO\ VXSSUHVVHG WKH 3'/ LQGXFHG increase in mRNA levels of the examined angiogenic genes and activation of AKT, P70S6K and ERKfrom days 1 to 7 post-PDL exposure. After topical administration, RPM or axitinib penetrated to an approximate depth of 768.4 or 929.5Î¼m into rodent skin, respetively. Conclusions: Topical application of RPM or axitinib can systematically suppress the PDL-induced early stages of angiogenesis via inhibition of the AKT/ mTOR/P70S6K and SHC-1/MEK/ERK pathway cascades. Key words: Pulsed dye laser; port wine stain; axitinib; RPM, angiogenesis; ERK; p70S6K

Mahmoud Afif Ghannoum Dermatophytes and their resistance Session: Mycology Forum (III)

Saturday, Nov. 17, 2018-from 14:00 to 14:30 RM 103-LEVEL 1

$]ROH DQWLIXQJDO DJHQWV H J Ã&#x20AC;XFRQD]ROH DQG LWUDFRQD]ROH KDYH EHHQ ZLGHO\ XVHG WR WUHDW VXSHUÂ¿FLDO IXQJDO LQIHFWLRQV FDXVHG E\ GHUPDWRSK\WHV DQG XQOLNH WKH DOO\ODPLQHV VXFK DV WHUELQDÂ¿QH DQG QDIWLÂ¿QH KDYH EHHQ DVVRFLDWHG ZLWK UHVLVWDQFH GHYHORSPHQW $OWKRXJK D FRQVLGHUDEOH number of published manuscripts describe resistance to azoles among yeast and moulds, reports describing resistance of dermatophytes are starting to appear. In this lecture, we discuss the mode of actions of azole antifungals and mechanisms underlying their resistance as compared with the allylamine class of compounds. We will review published and original studies will be compared, summarized, and their clinical implications discussed. Our review showed that the incidence of azole resistance in dermatophytes is reported to be as high as 19% among the 69

worldwide population. In contrast to the cidal allylamines, static drugs such as azoles inhibit the growth of the organism, permitting occurrence of mutations in enzymes involved in ergosterol biosynthesis, which serves as the drug target. Additionally, unlike allylamines, the ergosterol precursors accumulating as a consequence of azole action are not toxic.

Mahmoud Afif Ghannoum Mycobiome and skin diseases Session: Mycology Forum (IV)

Sunday Nov. 18, 2018-from 10:30 to 11:00 RM 103-LEVEL 1

Recent microbiome research is providing new insight into the interactions between the bacteriome and the mycobiome. These studies show that strong relationships between the host and the bacterial, fungal and viral inhabitants exists. We also know that the gut microbiome is a PDMRU UHJXODWRU RI WKH JXW VNLQ D[LV %DFWHULD DQG IXQJL GHYHORSHG FRRSHUDWLYH HYROXWLRQDU\ VWUDWHJLHV WKDW FXOPLQDWH LQ ELRÂżOP IRUPDWLRQ 7KHVH VWUXFWXUHV DUH EHQHÂżFLDO WR ERWK EDFWHULDO DQG IXQJDO FRPPXQLWLHV EXW GHWULPHQWDO WR WKH KRVW )XQJL EHQHÂżW E\ D VXUJH LQ YLUXOHQFH IDFWRUV while bacteria become tolerant to antibiotics. This interkingdom cooperation negatively impacts the host, as the fungi and bacteria produce H[WUDFHOOXODU HQ]\PHV WKDW LQĂ&#x20AC;LFW WLVVXH GDPDJH OHDGLQJ WR DQ LQFUHDVH LQ SURLQĂ&#x20AC;DPPDWRU\ F\WRNLQHV ZKLFK UHVXOWV LQ R[LGDWLYH GDPDJH DQG apoptotic cell death. In this lecture, we will use different disease states (Crohnâ&#x20AC;&#x2122;s, acne, atopic dermatitis) to demonstrate how the different FRPSRQHQWV RI RXU PLFURELRWD LQĂ&#x20AC;XHQFH RXU KHDOWK :H ZLOO DOVR GLVFXVV WKH SRWHQWLDO UROH RI SURELRWLFV DV D QHZ ZD\ WR PDQDJH VNLQ GLVHDVHV

Boon-Kee Goh Appraisal of Laser Therapies for Melasma Session: Vitiligo and Photodermatology (I)

Saturday, Nov. 17, 2018-from 08:30 to 08:55 RM 201D-LEVEL 1

Melasma is chronic and recurrent hyperpigmentary condition that affects a significant proportion of women in Asia. However the management of melasma remains a therapeutic challenge. In melasma refractory to medical therapy, adjunctive treatment with lasers has been tried. The early attempts to lighten melasma with Qs Ruby and Pulse Dye Lasers (PDL) were fraught with significant complications, notably post-inflammatory hyperpigmentation. The advent of fractional photothermolysis was a game-changer in cosmetic dermatology; however its ability to eliminate dermal melanin (in refractory melasma) remains controversial. Laser toning is a common intervention in Asia. In this procedure, frequent low-fluence Qs lasers (in multiple passes) are delivered to lighten melasma. The scientific basis was initially unknown, until the concept of Subcellular Selective Photothermolysis was mooted. Although significant lightening of melasma can be achieved and reproduced by this procedure, overzealous interventions can result in punctate leukoderma and rebound hyperpigmentation. Increased vascularity in melasma is an interesting discovery, and targeting this phenomenon using the copper-bromide laser as well as PDL has also been attempted with variable success. The picosecond laser has excelled over nanosecond laser in the clearance of tattoos, and its benefits over existing lasers in lightening melasma are beginning to emerge. The key mechanism of how picosecond lasers help melasma is through the process of skin rejuvenation.

Boon-Kee Goh Cellular Grafting for Vitiligo & Leukoderma: Optimising Results Session: Dermatologic Surgery

Sunday, Nov. 18, 2018-from 15:50 to 16:10 RM 201EF-LEVEL 2

&HOOXODU JUDIWLQJ LV DQ DGYDQFHG VXUJLFDO WHFKQLTXH IRU WUDQVSODQWLQJ DXWRORJRXV VNLQ FHOOV PHODQRF\WHV NHUDWLQRF\WHV DQG ÂżEUREODVWV RQWR stable vitiligo. The procedure involves harvesting an autologous ultrathin split skin graft (usually from the hip), digesting the graft with trypsin 0.25%-EDTA, extracting the epidermal cells, and transplanting them onto laser-ablated vitiliginous recipient sites. The success rates of this procedure are very high for segmental vitiligo and stable leukoderma, and satisfactory-to-good for stable non-segmental vitiligo that has failed medical treatment and phototherapy. To enhance successful results, strict patient selection criteria are paramount, including stability of lesions and managing patientâ&#x20AC;&#x2122;s expectations. 7KH ÂżUVW VWHS LQ WKH VXUJLFDO WHFKQLTXH LV DOVR LPSRUWDQW KDUYHVWLQJ DQ XOWUDWKLQ VSOLW VNLQ JUDIW LV D OHDUQLQJ FXUYH WRR WKLFN D JUDIW ZLOO UHVXOW LQ near â&#x20AC;&#x153;trypsination (digestion)â&#x20AC;? failure and leads to poor yield of the skin cells and scarring of the donor site. Laboratory extraction of the skin cells follows a standard protocol. Preparation of the wound bed of the recipient sites will determine the degree of cellular attachment and engraftment. Too shallow a laser-ablation (e.g. with CO2 laser) will result in poor take; while too deep an ablation results in unnecessary scarring. Dressing of the recipient sites after applying the skin cells usually takes the form of a collagen dressing (which reducesÄ&#x2026; run-offsâ&#x20AC;?) followed by securing it with robust dressings. Post-surgical phototherapy is usually not required, although it may hasten re-pigmentation in the early stages. This lecture will discuss the steps involves in cellular grafting, and will highlight the surgical gems in ensuring successful results.

Eckart Haneke Surgery of benign nail tumors Session: Nail Surgery

Friday, Nov. 16, 2018-from 08:40 to 08:55 RM 201ABC-LEVEL 2

Nail tumors may be specific for the nail apparatus, characteristic for the nail, occur in skin and nail or be rare in the nail unit. The tumors may be benign or malignant, but most nail tumors are diagnostically challenging. Nail specific tumors are Â&#x2021; 2Q\FKRPDWULFRPD Onychocytic matricoma 70

Onychocytic carcinoma 6XEXQJXDO ÂżODPHQWRXV WXPRU Onychopapilloma Onycholemmal horn Proliferating onycholemmal tumor Malignant onycholemmal tumour Onycholemmal carcinoma. The treatment of onychomatricoma is either a saucer-shaped excision or deep extirpation. Onychocytic matricoma is essentially a matrix acanthoma and PD\ EH UHPRYHG E\ WDQJHQWLDO H[FLVLRQ 6XEXQJXDO ÂżODPHQWRXV WXPRU LV D WKUHDG OLNH KRUQ\ OHVLRQ RULJLQDWLQJ LQ WKH GLVWDO PDWUL[ LI WUHDWPHQW LV UHTXLUHG D VPDOO VDXFHU VKDSHG H[FLVLRQ LV VXIÂżFLHQW 2Q\FKRSDSLOORPD LV D IUHTXHQW OHVLRQ DOVR GHULYLQJ IURP WKH GLVWDO PDWUL[ EXW JURZLQJ WR D ODUJHU VL]H 7DQJHQWLDO excision all along its course from the matrix to the hyponychium is necessary to avoid a recurrence. The therapy of subungual acantholytic dyskeratotic acanthoma is identical with tangential removal. Onycholemmal horn is a rare tumor originating from the nail bed. As its diagnosis requires histopathology its treatment of choice is complete surgical extirpation. Onycholemmal cysts are rarely diagnosed clinically and only diagnosed histopathologically when another lesion has been removed. Proliferating onycholemmal tumor also requires surgery for treatment. Keratoacanthoma is not exceptional in the nail XQLW ,W LV FKDUDFWHUL]HG E\ SDLQ 7UHDWPHQW LV FRPSOHWH H[WLUSDWLRQ EXW LQMHFWLRQ RI Ă&#x20AC;XRURXUDFLO PD\ DOVR EH WULHG )LEURXV WXPRXUV RI WKH QDLO DSSDUDWXV DUH YHU\ YDULHG DQG FRQVLVW RI GLIIHUHQW W\SHV RI ÂżEURPDV DFTXLUHG ÂżEURNHUDWRPD .RHQHQÄ&#x2020;s tumors, VXSHUÂżFLDO DFUDO ÂżEURP\[RPD UHFXUUHQW GLJLWDO ÂżEURXV WXPRUV RI FKLOGKRRG DQG NHORLGV 7KHLU VXUJLFDO WKHUDS\ GHSHQGV RQ VL]H GLDJQRVLV DQG VSHFLÂżF ORFDOL]DWLRQ ZLWKLQ WKH QDLO XQLW .HORLGV DUH QRW RSHUDWHG Vascular tumours of the nail apparatus are hemangioma, glomus tumor, coccal nail fold angiomatosis and pyogenic granuloma. In contrast to skin, hemangiomas are very rare in the nail unit. Glomus tumors are very characteristic painful small lesions that are mostly located in the matrix or nailbed. The transungual approach with meticulous dissection of the tumor and shelling out following by suture has a lower recurrence rate than the approach from the lateral aspect of the distal phalanx. Coccal nail fold angiomatosis is a peculiar lesion usually observed after removal of a splint that had been performed for the treatment of a wrist injury. These lesions are gently removed at their base under the proximal nail fold. True pyogenic granuloma is in fact an eruptive lobular angioma. It may be cut at the level of the surrounding skin, matrix or nail bed and the feeder artery gently cauterized, or treated conservatively with topical timolol. Osteocartilaginous tumors are osteoma, exostosis, osteochondroma, enchondroma and chondroma. Subungual exostosis may be traumatic. Its GLDJQRVLV FRQÂżUPHG E\ ; UD\ 7KH OHVLRQ LV UHPRYHG E\ FOLSSLQJ LW IURP ERQ\ SKDODQ[ SHULRSHUDWLYH DQWLELRWLF prophylaxis is considered if the lesion was erosive or secondarily infected. Myxoid pseudocysts are the most frequent pseudotumors. There are many mays to treat them but meticulous removal after intraarticular injection of sterile methylene blue has the lowest recurrence rate. Benign tumors of the nail unit should be removed with care to avoid overtreatment with consequent nail dystrophy. There are many techniques that allow to reach this aim.

Eckart Haneke

Friday, Nov. 16, 2018-from 09:15 to 09:35

Management of ingrowing nails Session: Nail Surgery

RM 201ABC-LEVEL 2

,QJURZLQJ QDLOV DUH D FRPPRQ DLOPHQW RFFXUULQJ LQ DOO DJH JURXSV $FFRUGLQJ WR WKH DJH WKH\ DUH FODVVLÂżHG DV Â&#x2021; 1HRQDWDO LQJURZLQJ QDLO Infantile ingrowing nail Adolescent type of ingrowing nail Adult type of ingrowing nail Retronychia Anterior ingrowing Pincer nail (overcurvature). In neonates, the big toenail may grow into the distolateral nail folds or into a false distal fold. Treatment is by gentle massage of the nail folds in a warm bath with plenty of a bland ointment until the nail has overgrown the tip of the toe. In babies, two types are observed: hypertrophic lateral/medial nail fold and congenital malalignment of the big toenail. The former is treated conservatively with massage; rarely is surgical removal indicated. Congenital malalignment is virtually always associated with a deviation of the distal phalanx and a hallux valgus; correction of this anomaly by consequent taping is successful in many cases. The adolescent type is the most common one seen in children from 6 years on. Usually, one or both distal corners of the ELJ WRHQDLO DUH WRR VKRUW RU EURNHQ VR WKDW WKH UHJURZLQJ QDLO SLHUFHV LQWR WKH ODWHUDO QDLO VXOFXV FDXVLQJ SDLQ LQĂ&#x20AC;DPPDWLRQ VHUR SXUXOHQW VHFUHWLRQ JUDQXODWLRQ WLVVXH DQG LQ WKH ORQJ UXQ D ÂżEURXV K\SHUWURSK\ RI WKH QDLO IROG 7UHDWPHQW VKRXOG VWDUW FRQVHUYDWLYHO\ ZLWK SDFNLQJ RI D ZLVS RI FRWWRQ XQGHU WKH RIIHQGLQJ QDLO HGJH WDSLQJ WR SXOO WKH QDLO IROG DZD\ IURP WKH QDLO PDUJLQ RU Ă&#x20AC;DWWHQLQJ WKH QDLO ZLWK DQ RUWKRQ\[ GHYLFH LQ FDVH RI DFFRPSDQ\LQJ overcurvature. Gutter treatment is a semiconservative method requiring local anesthesia. Nail avulsion should not be performed as it is virtually always IROORZHG E\ D UHFXUUHQFH ,I FRQVHUYDWLYH WKHUDS\ IDLOV VXUJHU\ LV LQGLFDWHG ZH SUHIHU WKH VHOHFWLYH ODWHUDO PDWUL[ KRUQ FDXWHUL]DWLRQ ZLWK OLTXHÂżHG SKHQRO which has a success rate of 95 â&#x20AC;&#x201C; 99% and just narrows the nail a bit, which is not cosmetically embarrassing. The generous removal of soft tissue has a high degree of morbidity with week-long healing periods, but does not narrow the nail plate. In adults, the nail is often thicker and hard and may press into the lateral nail sulcus causing discomfort and pain. Here, we also prefer selective lateral matrix horn phenolization. Retronychia is the retrograde ingrowing of the nail into the proximal nail foldâ&#x20AC;&#x2122;s ventral surface. Apart from skilled taping the application of superpotent corticosteroids appears to be successful in a certain number of cases. If these methods fail nail avulsion and postoperative taping to Âż[ WKH QDLO LV WKH WUHDWPHQW RI FKRLFH $QWHULRU LQJURZLQJ LV VHHQ LQ WKH FRQGLWLRQ FDOOHG GLVDSSHDULQJ QDLO EHG ZKLFK LQ IDFW LV â&#x20AC;&#x153;disappearedâ&#x20AC;? nail bed). If massaging the distal bulge does not help it is reduced by taking out a horizontal wedge of soft tissue from the tip of the toe. Pincer nails are very frequent in persons over the age of 30 (20-40) years. In the genetic form, there is a symmetrical involvement of both big toes associated with a lateral deviation. Uncurving the nail with nail braces requires very long treatment times and is followed by a recurrence in a short period. In mild cases, narrowing the nail is often successful. Severe pincer nails are treated by a combination of nail narrowing and a nailbed plasty including removal of the distal dorsal traction osteophyte at the dorsal aspect of the terminal phalanx. Ingrowing toenails are frequent and most cases can be treated successfully. A conservative approach is often the initial treatment and successful in skilled hands.

Eckart Haneke Histopathology of the nail: Onychopathology Session: Nail Surgery

Friday, Nov. 16, 2018-from 10:45 to 11:15 RM 201ABC-LEVEL 2

Histopathology of the nail is still a young subspecialty of dermatopathology although Unna already used the term onychopathology in 1881. However, there are still obstacles for a more common use of histopathology in onychology: most physicians are reluctant to take a biopsy, the SDWLHQWV DUH DIUDLG RI SDLQ DQG SRVW ELRSV\ GLVFRPIRUW QDLO VSHFLPHQV FDUH GLIÂżFXOW WR SURFHVV DQG FXW LQ WKH ODERUDWRU\ DQG PRVW GHUPDWR

pathologists have (therefore) very limited experience with nail sections, which in turn may result in disappointment when the dermatologist gets the report of the nail slide. There is only one remedy: take more biopsies and learn to interpret them. The easiest type of nail biopsy is a nail clipping. It should contain as much of the subungual keratosis and debris as possible. The material can be softened with 10% urea solution overnight or by placing it into cedarwood oil for approximately 3 days before further processing. Hematoxylin DQG HRVLQ VWDLQ DQG 3$6 DUH URXWLQHO\ SHUIRUPHG DQG SHUPLW WKH GLDJQRVLV RI RQ\FKRP\FRVHV WR EH FRQÂżUPHG LQ PRUH WKDQ GRXEOH WKH FDVHV compared to mycological culture. Clippings also often allow the diagnosis of nail psoriasis and to rule out a number of other ungual conditions. Biopsies including soft tissue are performed with anesthesia. Different types are possible, with and without prior nail plate avulsion: punch and fusiform biopsies of the nailbed and matrix, lateral longitudinal nail biopsy and tangential matrix and nailbed excisions. Softening of the specimen is recommended when the nail plate is included. Nail psoriasis is both similar and different from skin psoriasis. Psoriasiform acanthosis, suprapapillary epithelial thinning, leukocyte migration into the epithelium, Munroâ&#x20AC;&#x2122;s microabscesses and spongiform pustules are seen in skin and nail, but spongiosis and focal hypergranulosis are unique for nail psoriasis. Reiterâ&#x20AC;&#x2122;s disease of the nail is very similar to pustular nail psoriasis but shows more erythrocyte exocytosis. Lichen planus may show all features of cutaneous lichen planus, but in the nail, spongiosis and focal lack of hypergranulosis with parakeratosis do occur. Alopecia areata of the nail is characterized by a mild to moderate spongiotic dermatitis and cannot be reliably distinguished from mild eczema of the nail. The delineation of nail-specific tumors required histopathology and an in-depth knowledge of tumors of the hair follicle. The first of these tumors to be recognized was onycholemmal horn which got its name due to its similarity to trichilemmal horn. Onychomatricoma followed. It is D ELSKDVLF WXPRU RI WKH PDWUL[ GHUPLV DQG HSLWKHOLXP 2Q\FKRF\WLF PDWULFRPD LV D PDWUL[ DFDQWKRPD 6XEXQJXDO ÂżODPHQWRXV WXPRU LV GXH WR a tiny excrescence of the distal matrix that gives rise to a keratin thread under the nail. Onychopapilloma is another lesion of the distal matrix that runs all along the nailbed to the hyponychium. Subungual acantholytic dyskeratotic acanthoma may be an entity of its own or be a variant of onychopapilloma. Onycholemmal cysts are tiny lesions in the nail bed that may calcify, but they usually remain asymptomatic. Onychocytic carcinoma is a rare low-grade malignancy originating from the matrix. Onycholemmal carcinoma derives from the nail bed. Subungual Bowen disease and squamous cell carcinoma are probably the most common nail malignancies. Finally, ungual carcinoma is a variant of acral lentiginous melanoma with an often poor prognosis because of delay of diagnosis and treatment.

Ricky H. Hipolito HIV in the Philippines: Role of the Dermatologist in Detection and Management Session: Sexually-Transmitted Diseases

Sunday, Nov. 18, 2018-from 13:30 to 13:50 RM 102-LEVEL 1

In 2016, an average of 27 HIV cases per day is being reported in the Philippines. This epidemic has been described as a concentrated epidemic among Men Having Sex with Men (MSM) and People Who Inject Drugs (PWID). MSM having median age of 28 years have been considered as â&#x20AC;&#x153;core transmittersâ&#x20AC;? of the virus. Skin lesions can be important clinical markers that aid HIV recognition since it has been consistently shown that mucocutatneous disease is correlated with HIV clinical staging and CD4+ cell count. The close association between cutaneous disease and HIV underscores the important role of dermatologists in the detection and management of HIV/AIDS especially in high burden countries with relatively low HAART coverage such as the Philippines. .DSRVL VDUFRPD LV WKH PRVW FRPPRQ DQ $,'6 GHÂżQLQJ FDQFHU HVSHFLDOO\ DPRQJ 060 6LQFH EHLQJ UHFRJQL]HG LQ WKH â&#x20AC;&#x2122;s, considerable evidence has mounted that this neoplasm is associated with a sexually transmitted virus called Kaposi Sarcoma associated Herpesvirus (KSHV or HHV8). 7KLV LV D UHSRUW RI HOHYHQ ELRSV\ FRQÂżUPHG FDVHV RI .DSRVL 6DUFRPD IURP WR VHHQ LQ WKH 5HVHDUFK ,QVWLWXWH IRU 7URSLFDO 0HGLFLQH (RITM). RITM is a tertiary referral centre for infectious and dermatological diseases. Patients were collated from the electronic database of RITM Department of Dermatology. Biopsy slides were read by a Dermatopathologist from the same department. Mean age of the group was 36.55 yrs (SD 11.54). All patients were males belonging to the group men having sex with men (MSM). Duration of lesions ranged from 1 month to 24 months, mean was 5.1 months (SD: 6.59). Two patients were given different clinical diagnosis at presentation. Nodules were the most common lesion (8/11) followed by plaques (7/11) and papules (3/11). Combination of plaques and nodules were observed among 4 patients while all types were present in 1 patient. Four patients had oral lesions. Lesions were mostly located on the trunk (9/11), upper and lower extremities (8/11). Six patients had lesions on the face, 4 each on the head and neck, 3 on the feet and 1 patient had lesions on the hand. Among patients with facial lesions (n=6), 3 had lesions that covered at least 10% of their face. Eight patients developed AIDS-KS prior to their diagnosis of HIV. Among the patients diagnosed after HIV diagnosis, one patient each developed AIDS-KS after 4 months, 3 months and 2 months after their HIV diagnosis. AIDS related KS is a serious and debilitating neoplasm which almost exclusively occurs among HIV infected MSM. This is unique to other cutaneous diseases related to HIV since it has been known to occur even at relatively high CD 4+ cell counts. Studies have shown that AIDS related KS can be prevented by timely administration of HAART. Early recognition can be a key to diagnosing HIV and instituting interventions to contain both diseases.

Ricky H. Hipolito Dermatology in the Tropics: Interesting cases from a Tertiary Referral and Training Institution Session: Climate Change / Tropical Dermatology

Sunday, Nov. 18, 2018-from 14:15 to 14:30 RM103-LEVEL 1

Research Institute for Tropical Medicine Department of Dermatology is a Major Referral Center for Skin diseases especially tropical and LQIHFWLRXV FRQGLWLRQV ,W LV DOVR DQ ,62 FHUWLÂżHG KHDOWK VHUYLFH SURYLGHU DQG WUDLQLQJ LQVWLWXWLRQ IRU GHUPDWRORJ\ 7KUHH LQWHUHVWLQJ FDVHV seen in our department will be reported. 72

The first case is of a 37 year female who was wounded on the dorsum of the left foot due to a car accident a year prior to consult. After several unsuccessful treatments, the painless lesion progressively increased in size with development of purulent discharge draining from sinuses, prompting consultation with our department. Biopsy of the lesion showed eumycetoma. Madurella mycetomatis was isolated on fungal culture of the discharge. X ray of the affected limb showed periosteal reaction and ultrasound showed â&#x20AC;&#x153;circle in dotâ&#x20AC;? sign. The patient underwent treatment with Itraconazole 400 mg per day for 3 months then 200 mg per day for 1 year. The lesion completely resolved leaving an atrophic scar with the limb regaining functionality. The second case is of a 21 year HIV positive male. He was referred to us due to the appearance of erythematous macules and papules with collarette scales on the trunk and extremities with involvement of palms and soles. History revealed a non-painful ulcer on the shaft of his penis 2 months prior, which resolved spontaneously. Quantitative rapid plasma reagin (RPR) was positive at 1:512 dilution and Treponema pallidum particle agglutination was positive at 1:20,480 dilution. Patient was treated with 2.4 M U of Benzathine penicillin G with resolution of lesions. The patient underwent repeat RPR for surveillance with decrease in titer. After 3 months, RPR titer was positive at 1:64, 6 months at 1:28, at 9 months at 1:2 dilution and RPR reverted to negative in the 12th month. A 26 year old male is our third case. He came with nodules and plaques also with weakness and body malaise. This Patient had enlarged earlobes, widened nasal septum, loss of eyebrows and eye redness with dryness on presentation. History started 4 years prior when he noted hyperpigmented patches and plaques on the extremities. Lesions were hypoesthetic, associated with occasional myalgia and arthralgia. 4 months prior, nodules on the both extremities and earlobes developed. 1 month prior, patient was admitted for high grade fever at a local hospital. Antibiotics were given which afforded no relief. Patient was referred to our institution for specialist opinion. Biopsy done in our department showed lepromatous pole of Hansen's disease with a positive modified acid fast stain. Slit skin smear was 4 +. Multidrug treatment for multibacillary leprosy, consisting of daily clofazimine 50 mg, dapsone 100 mg and monthly Rifampin 300 mg was administered. Patient was given prednisone 60 mg per day to control the lepra reaction and oral antibiotics for urinary tract infection. There was lysis of the fever and relief of systemic symptoms. Flattening of skin nodules was also noted. The prednisone was slowly tapered every 2 weeks. After 3 months of treatment, patient was able to return to work.

Sybren de Hoog Dermatophytes-evolution and emerging resistance Session: Lu Yao Chin Lecture

Sunday, Nov. 18, 2018-from 09:00 to 09:30 Plenary Hall-LEVEL 3

The dermatophytes all belong to a single family of the fungal Kingdom, the Arthrodermataceae. Novel taxonomy, with seven genera, is based on reconstruction of main evolutionary patterns of these fungi; only three genera (Trichophyton, Epidermophyton, Microsporum) are relevant in daily routine. Recent evolution has led to the emergence of anthropophilic species which are unique in having host-to-host transmission and SUHYDOHQWO\ UHSURGXFH FORQDOO\ ,Q JHQHUDO KXPDQ LQIHFWLRQV FDXVHG E\ ]RRSKLOLF VSHFLHV DUH PRUH LQĂ&#x20AC;DPPDWRU\ WKDQ LQIHFWLRQV WUDQVPLWWHG EHWZHHQ KXPDQ KRVWV +RZHYHU VRPH VSHFLHV IURP GRPHVWLFDWHG DQLPDOV GR QRW VHHP WR IROORZ WKLV UXOH ,QĂ&#x20AC;DPPDWRU\ LQIHFWLRQV DUH FXUUHQWO\ emerging due to misuse of widely available creams that contain corticosteroids and low-doses antifungal mixtures. This has led to the recent emergence of multi-resistant dermatophytes e.g. in India. It is expected that this problem will soon acquire global dimensions.

Chien-Ching Hung Pre-Exposure Prophylaxis for HIV Infection Session: Sexually-Transmitted Diseases

Saturday, Nov. 17, 2018-from 14:10 to 14:50 RM102-LEVEL 1

Pre-exposure prophylaxis (PrEP) with coformulated tenofovir disoproxil fumarate (TDF) and emtricitabine (Truvada) is currently the alternative prevention strategy to condom use in preventing sexually transmitted HIV infection. The efficacy of PrEP using Truvada in preventing HIV infections among high-risk men who have sex with men, either used on a daily or on-demand basis, is estimated 86% in clinical trials. The effectiveness has also been demonstrated in programs implemented in several countries. With continued roll-out of PrEP programs in combination with universal testing, linkage to HIV care, and rapid initiation of combination antiretroviral therapy, achievement of control of HIV epidemic worldwide can be expedited. Barriers to successful PrEP programs may include low awareness, stigma, accessibility to PrEP, cost, adherence, concerns about adverse effects of long-term use, and commitment of the government. While Truvada is effective in preventing HIV transmission among the at-risk populations, the incidence of sexually transmitted infections are likely to increase, which require integrated DSSURDFK WR HIÂżFLHQW GLDJQRVLV DQG WUHDWPHQW

Fong Cheng Ip Wet-wrap therapy for childhood atopic dermatitis: experience from Hong Kong 6HVVLRQ ,PPXQH )RUXP ,QĂ&#x20AC;DPPDWRU\ 6NLQ 'LVRUGHUV

Saturday, Nov. 17, 2018-from 11:10 to 11:30 RM 101AD-LEVEL 1

Wet-wrap therapy has long been used in the treatment of childhood atopic dermaitits. There are variations in the topical medications used and duration of treatment applied. The main principle is the use of topical steroid under occlusive wet dressing and applied to area of skin where WKHUH LV D Ă&#x20AC;DUH XS RI GLVHDVH 7KH RXWFRPH RI WUHDWPHQW LV PRVWO\ VDWLVIDFWRU\ DQG VRPHWLPHV GUDPDWLF HVSHFLDOO\ ZKHQ XVHG WR WUHDWPHQW LQIDQWV ZLWK VHYHUH GLVHDVH Ă&#x20AC;DUH XS +RPH EDVHG WKHUDS\ LV DGYRFDWHG QRZDGD\V LQ FRQWUDVW WR LQ SDWLHQW WKHUDS\ LQ WKH SDVW DV WR DYRLG unnecessary hospital admission in which may cause stress and anxiety to the child and family members. 0DLQWHQDQFH WKHUDS\ ZLWK YDULRXV VWUDWHJ\ LV LPSRUWDQW DIWHU VHWWOLQJ WKH GLVHDVH Ă&#x20AC;DUH &RQWUDLQGLFDWLRQV DQG FRPSOLFDWLRQV WR ZHW ZUDS WKHUDS\ should be observed. Health education program including video demonstration and treatment plan provided by the nursing specialists regarding the practical issues of wet wrap therapy is highly recommended for the caretakers to improve compliance.

Mohammad Jafferany

Sunday, Nov. 18, 2018-from 13:50 to 14:10

Understanding Psychocutaneous disease: Psychosocial and psychoneuroimmunologic perspectives in Psychodermatology RM 201D-LEVEL 2 Session: Medical Dermatology Psychodermatology involves a comprehensive understanding of the complex psychoneuroimmunologic mechanisms. Patients suffering from psychocutaneous disorders are often misdiagnosed and mistreated from the lack of knowledge and awareness of the underlying disease-causing mechanisms. Individuals with psychodermatologic disease experience a lower quality of life as it has negative implications on psychosocial, emotional, and cognitive wellbeing. Factors like early-life interactions, body-image dissatisfaction, and societal stigma play a crucial role in the development of psychosocial stress experienced by individuals with visible skin conditions. This heightened level of stress serves as a trigger in the activation of the Hypothalamic-Pituitary-Axis (HPA) and mediators of inflammation. In order to improve the quality of life and treatment outcomes, it is essential to better understand the complex interplay between the various psychosocial factors and pathophysiologic pathways involved.

Sewon Kang Solar Lentigines: The Neglected Half-Sister of Photoaging Session: Vitiligo and Photodermatology (II)

Saturday, Nov. 17, 2018-from 11:45 to 12:10 RM 201D-LEVEL 2

Photoaging refers to premature skin aging from chronic exposure to ultraviolet (UV) radiation. Wrinkles and brown spots (solar lentigines) are the major clinical features. Despite being of equal cosmetic concern, solar lentigines have been studied far less than wrinkles. Nuclear factor erythroid 2-related factor 2 (NRF2) signaling, a cellular defense pathway upregulated by UV, is altered in stress-induced pigmentation disorders. Furthermore, progressive derangement of NRF2 signaling has been hypothesized to be a driver of the age-related decline in antioxidant defense of several organ systems. From skin biopsies of solar lentigines obtained from photoaged skin, we found impaired NRF2 signaling in the lesional skin, regardless of subjects’ age. Moreover, topical treatment of photoaged skin with an NRF2 inducer, sulforaphane (SF) improved hyperpigmented lesions. This human data can be replicated in a mouse model of UV-induced hyperpigmentation. Taken together, our results support a potential role for pharmacological activation of NRF2 in both the treatment and prevention of solar lentigines.

John Koo Management of psoriasis with evolving biologics Session: Psoriasis

Saturday, Nov. 17, 2018-from 15:55 to 16:20 RM 201ABC-LEVEL 2

Biologic agents represent a great progress in the treatment of psoriasis. Because biologic agents are uniquely suited for the most targeted and precise intervention on a molecular level, they were developed primarily to improve on the risk profile of older agents such as methotrexate or cyclosporine which work as a “shotgun” approach. Therefore, it is not surprising that today, many of the newer biologic agents such as guselkumab, ustekinumab, secukinumab, ixekizumab, etc. have practically no evidence-based serious side effects (“evidence-based” means there is data somewhere showing statistically significant increased risks of some serious side-effects as compared to similar patients not on the medication). Therefore, it is a delightful surprise that biologic agents also prove to be as efficacious as or more efficacious than the oral medication including cyclosporine. When biologic agents were initially developed, the first agent, Alefacept, was able to achieve PASI75 in only 15% of patients in 12 to 16 weeks. Today, several of the newer biologics such as guselkumab, brodalumab, and ixekizumab have recorded 90% or more of patients achieving PASI75 in the same time period. In the USA today, we have no less than 11 biologic agents FDA approved for use in psoriasis. However, it may be good to have many options because these biologic agents have unique merits, either medically or bureaucratically (i.e. access to the medication through insurance) and therefore they are not necessarily duplicates. For example, even the less effective biologics such as etanercept still have good use in pediatric and geriatric populations. Because of more than 20 years of good safety track record, etanercept now has pediatric indication (along with ustekinumab which also has 15+ years of good safety records) but also has one of the most favorable risk-assessment endorsements from the US FDA for geriatric populations. For patients who are only focused on best efficacy and quickest response, some of the newest agents with high PASI75 achievement rates listed above may be good options. If the patient wants the convenience of very rare need for injection, such as once every three months, ustekinumab provides that convenience. Lastly, beyond any individual, unique merits, it is always good to have more options since every psoriasis patient is unique, and one can never predict with 100% accuracy who is going to respond to which agent. Even within the same class of medication from a mechanism of action perspective, there can be a significant difference in efficacy on an individual basis. In this lecture, the entire history of biologic agents will be briefly reviewed, followed by discussion of both merits and demerits of each of the 11 biologic agents currently available for psoriasis in the USA.

Pui-Yan Kwok Emerging Landscape of Genomic Study in Taiwan: Bringing Genetics into Clinical Practice Session: BJD Editor & Genetic Forum TDA/CCD/TSID

Sunday, Nov. 18, 2018-from 12:00 to 12:20 Plenary Hall-LEVEL 3

Precision medicine takes into account individual characteristics and disease mechanism to prevent, diagnose, and treat diseases. The practice of precision medicine involves collecting large amounts of individual and disease data, and interpreting these data against population norms and other individuals with similar symptoms and genetic background. As more population data are available and our biological knowledge deepens, our ability to diagnose and treat disease based on disease mechanisms will increase. Being able to predict disease susceptibility will allow us to implement screening strategies and take active measures to prevent disease. With a national healthcare system and a relatively homogeneous population, Taiwan is well positioned to implement the practice of precision 74

medicine. The Taiwan Precision Medicine Initiative has been launched to obtain genetic profiles of 1 million patients in Taiwan over 3 years for pharmacogenetics applications and disease risk management.

William Lao 3HULRUELWDO 5HMXYHQDWLRQ ZLWK IDW JUD¿QJ Session: Dermatologic Surgery

Sunday, Nov. 18, 2018-from 15:30 to 15:50 Plenary Hall-LEVEL 3

Periorbital aging like other areas of the face is a combination of volume atrophy and tissue descend. These cases showed how the concept of tissue reduction and volume addition with fat grafting could be utilized together to achieve the best result possible.

Dong-Youn Lee The concept of onychodermis Session: Nail Surgery

Friday, Nov. 16, 2018-from 08:30 to 08:40 RM 201ABC-LEVEL 2

The nail demonstrates many features similar to hair. The nail units and hair follicles have many commonalities in relation to their origin, anatomical structures, and common involvement in many diseases. They both consist of epithelial and mesenchymal components. The hair follicles develop through epithelial–mesenchymal interactions. In the hair follicle, the follicular dermal papilla and the dermal sheath represent specialized mesenchymes which are distinguished from the dermis of the skin. Follicular dermal papilla cells and peribulbar dermal sheath cells can induce hair follicle development in vivo. Previously, we found that CD10 (neutral endopeptidase) was expressed in the perifollicular dermal sheath and in dermal sheath cells of the human hair follicles. We recently identified a well-defined mesenchymal cell population beneath the nail matrix and proximal nail bed demonstrating CD10 expression, and we proposed naming these specialized mesenchymal cells as onychofibroblasts. Furthermore, we demonstrated the presence of specialized mesenchyme containing onychofibroblasts below the nail matrix and nail bed that is histologically and immunohistochemically distinct from other parts of the nail unit, and proposed the term onychodermis for this specialized mesenchyme. Very recently, we found that CD13 were expressed in the mesenchyme below the nail matrix and nail bed. Stronger CD13 expression was observed in the mesenchyme containing onychofibroblasts below the nail matrix compared to that below the nail bed. This finding suggests that CD13 may be a marker for onychofibroblasts within nail matrix onychodermis. Because nail matrix plays a major role in nail formation, we hypothesized that the onychodermis below the nail matrix could be the nail counterpart of the follicular dermal papilla. Very recently, we sought to further characterize the histologic, histochemical and immunohistochemical features of the nail matrix onychodermis. H&E slides of 10 polydactyly nail units and 10 nail matrix biopsies from children and adults were reviewed. In polydactyly nail units, the onychodermis beneath the nail matrix was characterized by onychofibroblasts showing abundant cytoplasms. Nail matrix biopsy specimens also showed similar histology in the nail matrix onychodermis. Alcian blue stain demonstrated mucin deposition in the onychofibroblasts within the nail matrix onychodermis. Immunohistochemically, elastin was rarely expressed in the nail matrix onychodermis while it was strongly expressed in the dermis of other areas of polydactyly nail units. Elastin was not expressed in follicular dermal papilla of terminal hair follicles of the scalp. Our results demonstrate the presence and localization of nail matrix onychodermis (onychomatricodermis). Our study also demonstrates similar elastin expression patterns in the onychomatrichodermis and the follicular dermal papilla.

Dong-Youn Lee How to diagnose nail unit melanoma? Session: Approach and Diagnosis of Nail Disease

Friday, Nov. 16, 2018-from 10:30 to 10:45 RM 201ABC-LEVEL 2

Nail unit melanoma (NUM) is a rare variant of melanoma. However, in Asia, NUM accounts for about 20% of cutaneous melanoma. In its early stage NUM is often misdiagnosed and diagnostic delay results in disease progression. When NUM originates from the nail matrix, longitudinal melanonychia is the most common clinical presentation. As the melanoma spreads to other parts of the nail unit, Hutchinsonćs sign, which is a fairly diagnostic clue, occurs. Because early clinical detection improves both quality of life and survival, we sought to establish screening strategy for subungual melanoma (SUM) in situ. We retrospectively reviewed medical records of 8 patients pathologically diagnosed as SUM in situ. All patients in our study were adults and had solitary lesion. In all cases, longitudinal melanonychia as well as background pigmentation in entire nail plate was observed. Seven (87.5%) cases had periungual pigmentation. Clinical features of SUM in situ can be summarized according to new criteria categorized under initial letters of alphabet, namely nail ABCD of SUM in situ; “A” stands for adult age (age >18 years); “B” for brown bands in brown background; “C” for color in periungual skin; “D” for one digit. Our strategy was to suspect SUM in situ if solitary longitudinal melanonychia in adult was satisfying either “B” or “C” in ABCD. All cases were suspected as SUM in situ under nail ABCD rule, and histological examination confirmed diagnosis. Sensitivity and specificity of nail ABCD was 100% and 96.6%, respectively, regarding our previously published 18 SUM in situ and 28 nail matrix nevi cases as well as 8 SUM in situ presented here. In conclusion, ABCD rule is simple and sensitive clinical strategy for early detection of SUM in situ.

Joyce Siong-See Lee Interesting cases seen at the Nail clinic Session: Miscellaneous Nail Disease

Friday, Nov. 16, 2018-from 17:10 to 17:30 RM 201ABC-LEVEL 2

In this talk, a potpourri of interesting nail cases encountered in the course of running the Nail clinic or reading nail histopathology will be 75

presented. Melanonychias present to dermatologists commonly. While the main concern is excluding an acral lentiginous melanoma or melanoma in-situ, there are other conditions that may present with pigmented nails, awareness of which could help avoid unnecessary biopsies where possible. Additionally, some nail tumors as well as a few miscellaneous nail conditions and their management will be discussed.

Mario E. Lacouture

Saturday, Nov. 17, 2018-from 12:00 to 12:30 RM 201ABC-LEVEL 2

Anticancer Therapy Induced Alopecia Session: Dermoscopy (I)

Systemic anticancer therapies (cytotoxic chemotherapies, targeted therapies, immunotherapies), surgery, and radiation have resulted in remarkable improvements in patient survival. Despite this remarkable success, the majority of patients will develop dermatologic events, of which alopecia and hair disorders are amongst the most frequent and impactful. Therefore, prevention and management of alopecia and hair disorders is critical for the maintenance of quality of life and the optimization of anticancer therapies. Objectives 1 Recognize the impact on quality of life, clinical presentation, and grading of alopecia and hair disorders in cancer patients and survivors 2 Understand mechanisms and interventions to prevent and treat alopecia and hair disorders in cancer patients and survivors 3 Discuss procedures and clinical tools to assess alopecia and hair disorders in cancer patients and survivors

Mario E. Lacouture Dermatologic adverse events induced by anticancer therapies Session: Immune Forum-Cutaneous Adverse Drug Reactions (I)

Saturday, Nov. 17, 2018-from 13:30 to 13:50 RM 101AD-LEVEL 1

The activity is designed to increase the knowledge of treatment related adverse events, so they can be diagnosed at earlier grades of severity and treated accordingly. This knowledge will permit oncologists and advanced practitioners to better prevent and treat adverse events, so as to improve patients quality of life, and ensuring consistent doing of anticancer agents. All of which is likely to result in improved clinical outcomes and decreased utilization of urgent care services and dose modifications of anticancer therapies. Objectives 1 Recognize the impact on quality of life, clinical presentation, and grading of treatment-related adverse events in cancer patients 2 Understand mechanisms and interventions to prevent and treat acute and chronic adverse events in cancer patients 3 Discuss procedures and clinical tools to assess treatment-related toxicities in cancer patients

Ruoyu Li Innate immunity and cutaneous fungal infections Session: Mycology Forum (IV)

Saturday, Nov. 17, 2018-from 11:30 to 12:00 RM 103-LEVEL 1

In the past decade, an increasing number of genetic defects (including CARD9) that impair Th17 responses have been found to SUHGLVSRVH WR FKURQLF PXFRFXWDQHRXV FDQGLGLDVLV &0& DQG RWKHU VHYHUH IXQJDO LQIHFWLRQV ,Q SDUWLFXODU RXU VWXG\ ÂżUVW OLQNHG DXWRVRPDO UHFHVVLYH &$5' GHÂżFLHQF\ ZLWK GHPDWLDFHRXV IXQJDO LQIHFWLRQV &$5' PDLQO\ H[SUHVVHG LQ P\HORLG FHOOV LV D FUXFLDO DGDSWRU PROHFXOH in the downstream signaling of several C-type lectin receptors (including dectin-2, dectin-3, mincle, and intra-cellular danger sensors). CARD9 mediates anti-fungal immunity by forming a complex with BCL10 and MALT1 (CBM complex), or facilitating the interaction between Ras-GRF1 and H-Ras. It is therefore considered as a bridge that links innate and adaptive immunity in anti-fungal immunology. We summarized 10 cases with phaeohyphomycosis in China, 7 cases with Phialophora verrucosa infections, and 3 sporadic cases with other fungal infections. Autosomal recessive CARD9 mutations were identified in all the 10 patients, underscoring that CARD9 deficiencies might be an important predisposing factor underlying early-onset, recalcitrant phaeohyphomycosis in otherwise healthy individuals. Through functional studies, we showed that these mutations led to a lack of CARD9 protein expression in patients. Moreover, patient-derived CARD9-deficient cells showed a selective impairment of proinflammatory cytokine and chemokine production, NF-kB activation, and T helper type 22- and T helper type 17-associated responses upon fungus-specific stimulation, while phagocytosis and reactive oxygen species production were intact. Consistently, Card9-knockout mice were highly susceptible to dematiaceous fungal infections and exhibited immune deficiencies similar to those of patients, including diminished NF-kB and p38 MAPK activation in local and in vitro functional studies. Collectively, our data suggested that otherwise healthy patients with recurrent dematiaceous fungal infections should be examined IRU SRVVLEOH &$5' GHÂżFLHQF\ 7KLV ZRUN FODULÂżHV WKH DVVRFLDWLRQ EHWZHHQ LQKHULWHG &$5' GHÂżFLHQFLHV DQG GHPDWLDFHRXV IXQJDO LQIHFWLRQV DQG IXUWKHUV FXUUHQW NQRZOHGJH RQ WKH VSHFWUXP DQG SDWKRSK\VLRORJ\ RI GLVHDVHV UHVXOWLQJ IURP &$5' GHÂżFLHQFLHV ,W LV RXU KRSH WKDW SHUVRQDOL]HG immunotherapeutic and gene therapy strategies using bioengineered technologies might improve the clinical outcomes of these patients in the future.

Yen-Loo Lim A Practical Guide of Skin Tests in Drug Allergies: experience from Singapore Session: Immune Forum-Cutaneous Adverse Drug Reactions (II)

Saturday, Nov. 17, 2018-from 15:50 to 16:10 RM 101AD-LEVEL 1

The evaluation of drug allergies relies on clinical histories, skin tests and a few validated in-vitro tests. While some suspected drug allergies can 76

be confirmed or excluded based on clinical histories alone, skin tests remained important in scenarios where history alone is inadequate. Skin prick testing, intradermal testing and patch testing are current skin tests used in the evaluation of some drug allergies. However, the choice of these tests depends on the type of the drugs and reactions involved, as well as the understanding of the benefits/ risks and limitations of the tests. Practical tips in these aspects and requirements in the provision of such a clinical service will also be elaborated.

Yang-Chin Lin

Friday, Nov. 16, 2018-from 12:05 to 12:20 RM 201ABC-LEVEL 2

How to approach onycholysis and its treatment ? Session: Approach and Diagnosis of Nail Disease

Onycholysis is a frequently encountered medical term of nail disorder. It is defined as distal or distal lateral separation of the nail plate from the underlying structures. Clinicians need to approach onycholysis systemically to find its underlying cause and treat it accordingly. Various internal and external factors can result in onycholysis and make it difficult to handle. Diagnostic tools including detailed history taking, physical examination of the location, KOH examination, fungal culture, nail plate clipping histology, thyroid function serum test, radiological bony examination, pus culture, and patch test etc can be helpful in clarifying its etiology and lead to successful treatment.

Yi-Ting Lin

Saturday, Nov. 17, 2018-from 15:30 to 15:50

Drug-induced anaphylaxis in Taiwan Session: Immune Forum-Cutaneous Adverse Drug Reactions (II)

RM101AD-LEVEL 1

Despite the increasing incidence and awareness of drug-induced anaphylaxis, there is inadequate information on the etiology and clinical features in asian countries. Our aim is to assess the etiology and clinical findings of drug-induced anaphylaxis in Taiwan. We obtained and analyzed retrospective and prospective data of 80 patients confirmed diagnosis of drug-induced anaphylaxis, including demographic data, clinical history including the triggering agent, clinical findings, course of hospitalization, in vivo and in vitro testing results, and the management of anaphylaxis. Muscle relaxants and antibiotics are the most common causal agents. In this study, we will discuss multiple aspects of druginduced anaphylaxis, including epidemiology, mechanisms, diagnosis, and management. Gathering reliable data about these cases of anaphylaxis in the general population will decrease the related morbidity and mortality.

Chun-Wei Lu

Saturday, Nov. 18, 2018-from 14:05 to 14:20

The Role of Beta-blocker in EGFR Inhibitors Induced Paronychia with Pyogenic Granuloma Like Lesions Session: Immune Forum-Cutaneous Adverse Drug Reactions (I)

101AD-LEVEL 1

Paronychia is one of the most common adverse occurrences caused by epidermal growth factor receptor (EGFR) inhibitors, and for severe paronychia, surgical treatment of temporary discontinuation of EFGR inhibitors is sometimes necessary. However, a high percentage of post-treatment discomfort and infection, high recurrence rate, and increased time to return to work were noted after nail plate avulsion. Furthermore, poor wound healing and malnutrition were common conditions found in cancer patients. 7KLV ZDV D UHWURVSHFWLYH FDVH VHULHV DQG ZH XVHG WRSLFDO Č&#x2022; EORFNHU EHWD[RORO H\H GURSV RQFH GDLO\ RQ WKH SDURQ\FKLD ZLWK pyogenic granuloma-like lesions of fingers or toes under occlusion in 35 patients suffering from grade 2 or 3 paronychia with pyogenic granuloma-like lesions induced by EGFR inhibitors, 34 (97.1%) patients demonstrated complete resolution and only 1 (2.9%) patient with partial resolution after 12 weeks of topical betaxolol treatment.

Nai Ming Luk Progress of SCAR in Hong Kong Session: Asian SCAR Meeting - SCAR Consortium Forum

Friday, Nov. 16, 2018-from 17:10 to 17:20 North Lounge-LEVEL

It is difficult to study SCAR in Hong Kong as the public service does not have dermatology subspecialty. There is no formal reporting channel nor any registry of SCAR. Based on anecdotal reports and interpersonal communications among colleagues, SJS is the commonest SCAR with Allopurinol as the culprit drug. Other SCAR including TEN, DRESS are occasionally seen with Allopurinol, Carbamazepine and other anticonvulsants responsible. In the presentation, progress of building of the HKSCAR will be discussed.

David Hui-Kang Ma Management of cular complication f Stevens-Johnson syndrome Session: Asian SCAR Meeting - SCAR Consortium Forum

Friday, Nov. 16, 2018-from 16:10 to 16:20 North Lounge-LEVEL 3

Ocular complication of SJS is perhaps the only sequela that may deteriorate even long after the primary disease. The SJS ocular complications are mainly dry eye, lid margin keratinization, conjunctival scarring, and limbal stem cell deficiency (LSCD), which is the main cause of vision loss. 77

The severity of ocular complication in SJS is closely related to the initial damage to the eye. Recently, treatments for the eye in acute stage such as preservative-free topical steroid, debridement, and amniotic membrane dressing have been adapted, thus significantly decreases the incidence of severe corneal damage. This talk will introduce the step-by-step strategy to cope with the SJS eye diseases including: 1. Treatment of dry eye, 2. Treatment of lid abnormalities, 3. Prevention of infection, 4. Treatment of LSCD, and 5. Treatment of corneal opacity. Above all, early intervention and aggressively treatment is the key to prevent severe eye complications.

Maria Juliet E. Macarayo Year ender Thoughts on Melasma: Truth and Fallacies Session: Aesthetic Dermatology (I)

Saturday, Nov. 17, 2018-from 15:50 to 16:10 RM 103-LEVEL 1

Melasma has always been an elusive pigmentary disease. Up to this present time, pathogenesis kept on evolving and treatment modalities kept on being discovered. This talk aims to present several truths and fallacies as to how and why melasma happens, why melasma has to be treated and how it has to be managed. In a world savvy with google information, the dermatologists must be one step, if not several steps ahead than the patient. We must be the DERMAUTHORITIES on what is best for our patient.

Maria Juliet E. Macarayo Confessions from a Dermatologist-how I deal with troubled Acne Patients Session: Acne and Rosacea (I)

Sunday, Nov. 18, 2018-from 10:55 to 11:20 RM 201ABC-LEVEL 2

Being in the trade for 26 years now and dealing with all kinds of acne concerns, from all ages and genders, I came to realize that though acne may appear to be trivial compared with life-endangering skin disorders, it is one that is quite not that easy to treat. Hence, on my end, I think every dermatologist has a number of confessions that may make management of acne more worthwhile: from acne facts that one must know, quality of life a simple acne papule can change, how a dermatologist can be bothered by treating an acne patient, correct assessment to correctly treat acne and a proper preferred approach in the management of acne. This talk is a confession, mainly from my experience as a dermatologist, practicing in the Philippines, Asia.

Ramos-e-Silva Marcia Mesotherapy: adverse effect Session: Aesthetic Dermatology (II)

Sunday, Nov. 18, 2018-from 11:30 to 11:50 North Lounge-LEVEL 3

Mesotherapy is the practice of infusing small doses of medication, enzymes and/or vitamins inside the dermis with a therapeutical purpose of injecting small amounts of medication, enzymes and/or vitamins. Its use for aesthetic purpose is growing considerably. Many substances, as vitamin C, hyaluronic acid, anesthetics, and others, are used for various problems and it is not adopted in most countries. Michel Pistor, in France, introduced the technique in 1952, being formally recognized by the French Academy of Medicine in 1987. Nowadays there are more than 15 thousands physicians performing this technique in Europe and South America. Complications are frequent and a case of oleoma as adverse effect after mesotherapy for cellulitis and its evolution will be shown.

John McGrath Photogenodermatoses Session: Vitiligo and Photodermatology (II)

Saturday, Nov. 17, 2018-from 10:55 to 11:20 RM 201D-LEVEL 2

Symptoms such as photosensitivity or signs such as poikiloderma can be integral features of several diverse inherited skin disorders, a number of which have been characterized at a gene level. These data provide fascinating new insights into how sunlight impacts on skin health and add to our understanding of the pathophysiological complexity of sun-skin interactions. Providing particular insight, however, have been the genophotodermatoses caused by genetic defects in DNA repair processes. These disorders include xeroderma pigmentosum (XP), Cockayne syndrome and trichothiodystrophy (all nucleotide excision repair disorders), as well as RothmundThomson syndrome and Bloom syndrome (both DNA helicase pathologies). This presentation will review experience of these genophotodermatoses in the UK (including some international referrals), particularly relating to the UK National Service provided for XP patients. Review of the skin, ocular and neurological features of more than 100 patients with XP provides fascinating insight into variability in photosensitivity, skin and cerebral malignancy risk, neurological degeneration, and ocular surface changes. An update on the diagnosis and management of the other genophotodermatoses will also be provided. An improved understanding of the protean nature of the genophotodermatoses, allied to better genotype-phenotype correlation, is helping refine clinical management and improve the lives of affected individuals and families.

Ma. Angela Medina-Lavadia Climate Chang and the Skin Session: Climate Change / Tropical Dermatology

Sunday, Nov. 18, 2018-from 13:30 to 13:45 RM 103-LEVEL 1

Climate change is affecting the global environment on many fronts. Our skin, being our body’s primary point of contact with the environment, is particularly vulnerable. The types and variety of skin conditions we see as dermatologists are affected as well. The cutaneous physiologic and pathologic conditions brought about by environmental challenges on our skin will be discussed.

Giuseppe Micali Recent topical treatment of rosacea Session: Acne and Rosacea (II)

Sunday, Nov. 18, 2018-from 14:45 to 15:10 RM201ABC-LEVEL 2

Rosacea is a chronic, inflammatory and vascular condition of the face classically characterized with four broad clinical subtypes (erythematoteleangectatic rosacea, ETR; papulopustular rosacea, PPR, phymatous rosacea; ocular rosacea), and different cutaneous symptoms, including persistent redness (background erythema), flushing, inflammatory lesions (papules/pustules) and visible blood vessels (telangiectasias). In clinical practice a combinations of different clinical subtypes (phenotypes) may frequently be seen. Ivermectin 1% cream is a new therapeutic topical options able to control inflammatory lesions in PPR along with brimonidine tartrate 0.5% gel which is effective on background erythema of ETR. In particular, ivermectin is a macrolide agent isolated from the fermentation of Streptomyces avermitilis with DQWLLQIODPPDWRU\ DQG DQWLSDUDVLWLF HIIHFWV DQG EULPRQLGLQH WDUWUDWH LV D KLJKO\ VHOHFWLYH Į DGUHQHUJLF UHFHSWRU DJRQLVW FKDUDFWHUL]HG E\ D marked vasoconstriction effect. Discussion on the clinical use of topical ivermectin and brimonidine tartrate used singularly or in association is presented along with cases presentation.

Takashi Mochizuki Problems and prospects in training professionals to manage dermatomycoses in Japan Session: Mycology Forum (III)

Saturday, Nov. 17, 2018-from 14:30 to 15:00 RM 103-LEVEL 1

Management of dermatomycoses is an important issue for dermatologists to learn, and practical training is necessary in order to develop specialists in dermatology. During the final term of senior residents in dermatology departments, Japanese universities have a responsibility to ensure their doctors can comprehensively manage dermatomycoses. However, in recent years there has been a concern that education in this specialist field is insufficient. In 2007 and 2015, information on the current status of mycological examinations in university clinics, and the education of students, and junior and senior residents in Japanese universities was gathered using a questionnaire, which was completed by 98 of 112(87.5%) professors or directors of dermatology departments in 2007, and 98 of 117(83.8%) in 2015. The questionnaire items covered: methods and techniques used in diagnosis of cutaneous mycoses in each university clinic; need for a network and construction of a support system for medical care and education; and education of undergraduate students and residents. Regarding diagnosis of superficial mycoses, 56% of respondents in 2007 and 53% in 2015 reported that all cases were confirmed by direct KOH examination, whereas nearly half of respondents reported this process was sometimes omitted. It was found that only 3% of university clinics performed fungal culture for all or most suspect cases in 2015- a decline from 9% in 2007. By type of mycoses, fungal culture for deep mycoses was performed in 83% of facilities, but that for superficial mycoses was very low with only 39% performing cultures even for tinea capitis in 2015. It was found that 96% of respondents (up from 89% in 2007) desired help from the university network, including aid in identifying fungal isolates, diagnosing rare fungal infections, and basic training in medical mycology of young doctors (senior residents in university hospitals). Education in direct KOH preparation for senior residents was satisfactory in 80% of the facilities. However, 45% of respondents reported the majority or all senior residents in their institutes had no opportunity to perform practical fungal cultures in 2015. The results indicate that respondents desire diagnostic laboratories for medical mycology, especially for rare deep dermatomycoses, and a database for diagnosis and management of deep mycoses. It is necessary to train personnel engaged in educating doctors about dermatomycoses at each institute, and provide ‘hands-on’ practical workshops run by senior dermatologists.

Takashi Mochizuki Molecular diagnosis and molecular epidemiology of dermatophytes Session: Mycology Forum (IV)

Sunday, Nov. 18, 2018-from 11:00 to 11:30 RM 103-LEVEL 1

Dermatophytoses are the most common infectious disorders of the skin and their treatment is a very important subject among dermatologists. Recent advances in molecular techniques have markedly changed methods of identifying dermatophytes, revealing intraspecies polymorphisms in some molecular markers. Intraspecies subtyping and strain differentiation have made possible the tracking of infections, identification of common sources of infections, and observation of recurrence or reinfection after treatment. In this presentation, some examples of the molecular epidemiology of dermatophytes and dermatophytoses will be discussed along with advantages and limitations of these methods. For an analysis of the geographical distribution of Arthroderma benhamiae, i.e., Trichophyton benhamiae in the latest nomenclature, polymorphisms of non-transcribed spacer regions(NTS) of ribosomal RNA genes(rDNA) were examined. Forty-six A. benhamiae strains isolated from cases in several European and Asian countries were separated into 11 NTS subtypes. A. benhamiae had not been detected in Japan prior to 1980, yet 20 such strains were isolated in Japan in the late 1990s and early 2000s, and separated into 4 NTS subtypes. It was demonstrated that A. benhamiae had migrated to Japan on infected imported pet animals on several occasions. 79

Shifts in molecular types were found among Japanese strains of T. tonsurans isolated from an epidemic of tinea gladiatorum. Using NTS polymorphisms of rDNA, the T. tonsurans strains were separated into 8 NTS types. Among strains isolated before 2005, NTS I, in our definition, was the most predominant molecular type comprising 85.8%, followed by NTS II comprising 13.6%. A later study of strains isolated between 2010 and 2015, revealed NTS I comprised 98.1%, and NTS II comprised 1.4%. This change in prevalence rates may have been caused because wrestlers who had been infected with NTS II had retired from competitions, and wrestling communities had accepted new trainees from the judo community, where NTS I strains were exclusively prevalent. Microsporum canis infection analyzed from length polymorphisms of microsatellite repeats (MS) will be introduced. Seventy M. canis strains isolated from human lesions of tinea and samples from cats were separated into 20 genotypes by MS markers. Family onsets were monitored by the method revealing that all six outbreaks of familial incidence were caused by M. canis with the same genotypes, respectively. Thus molecular methods enable us to trace transmission routes of infections, and are useful to help us understand the spread of dermatophytoses.

Je-Ho Mun

Friday, Nov. 16, 2018-from 08:55 to 09:15

Surgical management of benign nail tumors. Tips Session: Nail Surgery

RM 201ABC-LEVEL 2

Accurate diagnosis of malignant tumors in the nail apparatus is difficult due to the unfamiliarity of nail tumors. Therefore, diagnosis is often delayed which results in a poor prognosis. Common malignant nail tumors include squamous cell carcinomas and malignant melanomas. Squamous cell carcinoma (SCC) is the most common malignant nail tumor in Caucasians. Ungual SCC in the early stages reveals a slowly growing and asymptomatic lesion with non-specific features. Consequently, misdiagnosis as paronychia, onychodystrophy, or onychomycosis is common. Treatment options included local excision, Mohs micrographic surgery, En-bloc nail excision, and amputation. Malignant melanomas of the nail apparatus are more common in Asian population. It typically presents as melanonychia striata and differentiation from benign melanonychia is often difficult. For in situ or minimally invasive subungual melanomas, conservative surgery should be the treatment of choice since amputation results in significant functional and cosmetic losses. However, for invasive melanomas, the application of digit conserving surgery may be limited. More radical surgery including amputation should be considered.

Je-Ho Mun

Saturday, Nov. 17, 2018-from 14:10 to 14:40

Dermoscopoy of the nail-- Assessment of longitudinal melanonychia using dermoscopy Session: Dermoscopy (II)

RM 201ABC-LEVEL 2

Dermoscopy is a helpful tool in making a clinical diagnosis of longitudinal melanonychia. It can be especially a useful technique in differentiating subungual melanomas from benign melanonychia. During this presentation, the key points of dermoscopic patterns in pigmented nail disorders will be discussed. In addition, the presenter's experience with cases of benign and malignant cases will be presented. Some key features of dermoscopic examination in pigmented nails are summarized below. Subungual hemorrhage can be characterized by red-purple color, homogeneous pattern, globular pattern, streaks, peripheral fading, and periungual hemorrhage. It can be found in ungual melanomas. Benign nail matrix nevi reveals symmetry or regular pattern, one or two color, Pseudo-Hutchinson’s sign, etc. However, nail matrix nevi in children are different from those in adults. Children present darker and multicolored melanonychia. In addition, irregular patterns, Hutchinson’s sign, pseudo-Hutchinson’s sign, triangular sign, and dots/globules can be found in benign melanonychia of children. Fungal melanonychia shows yellow color, multicolor, non-longitudinal homogenous pattern, reverse triangular pattern, subungual keratosis, white or yellow streaks, and scales. In our previously published cohort study, asymmetry, border fading, multicolor, a width of the pigmentation of at least 3 mm, and presence of the Hutchinson sign were statistically associated with subungual melanoma in situ. Based on the data, we proposed a predictive scoring model. We believe the scoring model has the potential to improve the prognosis of subungual melanoma by promoting informed decision making regarding the management of longitudinal melanoncyhia and by assisting patients and physicians with decisions to pursue a biopsy of the nail matrix.

Jean-Francois Nicolas

Saturday, Nov. 17, 2018-from 10:30 to 10:50

7\SH ,QÀDPPDWLRQ LV .H\ WR WKH 'HYHORSPHQW RI $WRSLF (F]HPD 6HVVLRQ ,PPXQH )RUXP ,QÀDPPDWRU\ 6NLQ 'LVRUGHUV

RM 101AD-LEVEL 1

Type 2 immunity, previously known as Th2 immunity, refers to innate and adaptive immune responses occurring in the skin and mucosal surfaces to promote barrier immunity and to prevent infections, in particular to eliminate parasitic pathogens. This inflammatory reaction could develop in response to environmental molecules leading to chronic inflammation and type 2 human diseases such as asthma, atopic dermatitis (AD), chronic sinusitis with nasal polyps (CSNP) and eosinophilic oesophagitis (EEo).

Jean-Francois Nicolas

Sunday, Nov. 18, 2018-from 13:30 to 13:50

Atopic Dermatitis What’V QHZ 0LFURLQÀDPPDWLRQ Session: Medical Dermatology All atopic dermatitis patients should receive a daily treatment with emollients to improve the barrier dysfunction 80

RM 201D-LEVEL 2

7KH LQKLELWRU\ DFWLRQ RI WKH 5KHDOED H[WUDFW RQ SUR LQÃ&#x20AC;DPPDWRU\ F\WRNLQHV KDV EHHQ LQYHVWLJDWHG E\ D QXPEHU RI LQ YLWUR VWXGLHV GHPRQVWUDWLQJ DQ DQWL LQÃ&#x20AC;DPPDWRU\ HIIHFW RI WKH FRPSRXQG 5KHDOED 2DW SODQWOHWV H[WUDFW FRQWDLQV KLJK OHYHOV RI Ã&#x20AC;DYRQRLGV ZKLFK DUH NQRZQ IRU DQWL LQÃ&#x20AC;DPPDWRU\ HIÂ¿FDF\ $ WUDQVFULSWRPLF VWXG\ ZDV SHUIRUPHG LQ DGXOW SDWLHQWV WR HOXFLGDWH WKH PROHFXODU VLJQDWXUH RI $' SDWLHQWVâ&#x20AC;&#x2122; non-lesional skin and its possible improvement after 30 days of application of Rhealba extract-based emollient with Biovect technology. The transcriptomic study revealed that after the application of the emollient with Biovect technology, the molecular signature was more similar to non-atopic skin, indicating that by reducing the skin dryness and reconstructing the skin barrier the treatment shifted the molecular signature back from chronic AD skin to non-lesional skin.

Kuniaki Ohara Nail surgery: an expert approach from the Japanese experience Session: Nail Surgery

Saturday, Nov. 17, 2018-from 09:35 to 10:00 RM 201ABC-LEVEL 2

Glomus tumor is a painful tumor affecting the nail, requiring surgical excision. Surgical approach varies according to the location of the tumor. :KHQ WKH WXPRU VLWXDWHV EHQHDWK WKH SUR[LPDO QDLO IROG QDLO IROG VNLQ LV HOHYDWHG DV D Ã&#x20AC;DS DQG LQFLVH WKH PDWUL[ WKHQ HQXFOHDWH WKH WXPRU ,Q case of under the nail plate, nail plate covering the tumor is temporally removed , and after enucleating the tumor, the removed nail plate is put back again as a biological dressing. For the larger tumor, total nail removal might be necessary to excise the tumor, which is followed by reinsertion of removed nail plate.

Amit G. Pandya New discoveries in the pathogenesis and treatment of vitiligo Session: Vitiligo and Photodermatology (I)

Saturday, Nov. 17, 2018-from 08:55 to 09:20 RM 201D-LEVEL 2

Correct management of vitiligo requires knowledge of pathogenesis, differential diagnosis and recognition of the various signs associated with active vitiligo. Evidence-based treatment strategies include topicals, systemic agents and phototherapy, all of which require a prolonged course. A combination of these therapies is most likely to be successful. Topical and oral JAK inhibitors are being investigated in multiple trials at this time and show promise in the treatment of vitiligo.

Amit G. Pandya Update on management of melasma Session: Aesthetic Dermatology (I)

Saturday, Nov. 17, 2018-from 16:10 to 16:30 RM 103-LEVEL 1

0HODVPD LV D FRPPRQ FDXVH RI K\SHUSLJPHQWDWLRQ RI WKH IDFH 0DQDJHPHQW Â¿UVW UHTXLUHV PDNLQJ WKH FRUUHFW GLDJQRVLV DV WKHUH DUH PXOWLSOH disorders in the differential diagnosis of melasma. Protection from ultraviolet and visible light are critical for success. Improvement can be DFKLHYHG E\ UHGXFLQJ PHODQLQ SURGXFWLRQ DQG LQÃ&#x20AC;DPPDWLRQ ZLWK YDULRXV WRSLFDO DJHQWV 1HZ DJHQWV VKRZ SURPLVH LQ WKH WUHDWPHQW RI PHODVPD SDUWLFXODUO\ V\VWHPLF WUDQH[DPLF DFLG &KHPLFDO SHHOV DQG ODVHUV PD\ EHQHÂ¿W VHOHFWHG SDWLHQWV ZLWK PHODVPD DV ZHOO &DXWLRQ PXVW EH H[HUFLVHG to avoid pigmentation due to treatment itself.

Kim A. Papp IL-17 and IL-23 inhibition for the treatment of psoriasis Session: Psoriasis

Saturday, Nov. 17, 2018-from 16:20 to 16:45 RM 201ABC-LEVEL 2

Bench and bedside results point to IL-17 produced by Th-17 cells as the primary mediator of plaque psoriasis. Results from clinical trials are XVHG WR FKDUDFWHUL]H ERWK VLGHV RI 7K FHOO ,/ DV DFWLYDWRU DQG ,/ DV PHGLDWRU +LJK HIÂ¿FDF\ RQVHW RI DFWLRQ DQG GLIIHUHQWLDO HIIHFWV RQ skin and joints are explored.

Eugenio Reyes Pipo III Dermatologic mimickers of Hansenâ&#x20AC;&#x2122;s Disease Session: Climate Change / Tropical dermatology

Sunday, Nov. 18, 2018-from 14:00 to 14:15 RM 103-LEVEL 1

Hansenâ&#x20AC;&#x2122;s Disease is a chronic, granulomatous mycobacterial infection with different spectrum affecting all ages, and it remains endemic in many countries worldwide. Hansenâ&#x20AC;&#x2122;s disease has a vast number of clinical presentations, and all of its spectrum can mimic a great variety of other dermatologic conditions. The diagnosis of leprosy is made from the clinical picture but in the absence of typical dermatologic features it must be FRPSOLPHQWHG E\ KLVWRSDWKRORJLF FRQÂ¿UPDWLRQ DQG RU VOLW VNLQ VPHDU H[DPLQDWLRQ (DUO\ GLDJQRVLV LV QHFHVVDU\ LQ WKH LQLWLDWLRQ RI WUHDWPHQW DQG for the prevention of disabilities due to the disease.

Daniel Popkin

Sunday, Nov. 18, 2018-from 13:30 to 13:55

Genetic vs. environmental factors associated with rosacea Session: Acne and Rosacea (II)

RM 201ABC-LEVEL 2

, ZLOO SUHVHQW WKH ÂżUVW VWXG\ RQ URVDFHD WR IRUPDOO\ GHÂżQH JHQHWLF DQG HQYLURQPHQWDO FRQWULEXWLRQV WKDW ZH SHUIRUPHG LQ WKH 86$ We studied a cohort of identical and fraternal twins to determine whether genetic factors contribute to rosacea development and, if genetic factors are present, quantitatively estimate the genetic contribution, as well as to identify environmental factors that correlate with rosacea by controlling for genetic susceptibility. DESIGN, SETTING, AND PARTICIPANTS: Identical and fraternal twins were surveyed regarding risk factors implicated in rosacea. Faculty dermatologists determined a rosacea score for each twin participant according to the National Rosacea Society (NRS) grading system. Data were collected at the annual Twins Days Festival in Twinsburg, Ohio, on August 4-5, 2012, and August 2-3, 2013. Analysis was conducted for several months after each meeting. A cohort of 550 twin individuals, with most from Ohio, Pennsylvania, and the northeastern United States, participated, with additional twins from around the world. MAIN OUTCOMES AND MEASURES: 7KH 156 VFRUH DQG URVDFHD VXEW\SH ZHUH DVVHVVHG XVLQJ WKH 156 JUDGLQJ V\VWHP DQG SK\VLFDO H[DPLQDWLRQ E\ ERDUG FHUWLÂżHG GHUPDWRORJLVWV RESULTS: Among the 275 twin pairs (550 individuals), there were 233 identical twin pairs with a mean rosacea score of 2.46 and 42 fraternal twin pairs with a mean rosacea score of 0.75. We observed a higher association of NRS scores between identical vs fraternal twins (r = 0.69 vs r = 0.46; P = .04), demonstrating a genetic contribution. Using the ACE model (proportion of variance in a trait heritable secondary to additive genetics [A] vs the proportions due to a common HQYLURQPHQW >&@ DQG XQLTXH HQYLURQPHQW >(@ ZH FDOFXODWHG WKLV JHQHWLF FRQWULEXWLRQ WR EH $ KLJKHU 156 VFRUH ZDV DOVR VLJQLÂżFDQWO\ DVVRFLDWHG ZLWK the following factors: age (r = 0.38; P < .001) and lifetime UV radiation exposure (r = 0.26; P < .001). These associations remained after use of propensity score matching to adjust for multicollinearity. Other correlated variables included body mass index (r = 0.21; P < .001), smoking (r = 0.10; P < .02), alcohol consumption (r = 0.11; P = .01), cardiovascular comorbidity (r = 0.17; P < .001), and skin cancer comorbidity (r = 0.19; P < .001). CONCLUSIONS AND RELEVANCE: 7KH VWXG\ RI WZLQV DOORZV XV WR VHSDUDWH JHQHWLF VXVFHSWLELOLW\ DQG WKH LQĂ&#x20AC;XHQFH RI HQYLURQPHQWDO IDFWRUV DIIHFWLQJ URVDFHD :H IRXQG WKDW DSSUR[LPDWHO\ KDOI RI WKH FRQWULEXWLRQ WR WKH 156 VFRUH FRXOG EH DFFRXQWHG IRU E\ JHQHWLFV DQG WKH RWKHU KDOI E\ HQYLURQPHQW :H LGHQWLÂżHG FRUUHODWLRQV EHWZHHQ URVDFHD DQG 89 UDGLDWLRQ H[SRVXUH DOFRKRO VPRNLQJ VNLQ FDQFHU KLVWRU\ FDUGLDF FRPRUELGLW\ DQG DJH 7KHVH ÂżQGLQJV may help improve current management and expectations of individuals affected by rosacea. I will discuss the Clinical Perspective and cutting edge of Rosacea Epidemiology Research here.

Daniel Popkin

Sunday, Nov. 18, 2018-from 13:55 to 14:20

The effect of the local skin microbiome on rosacea Session: Acne and Rosacea (II)

RM 201ABC-LEVEL 2

Previously, we determined and discussed in â&#x20AC;&#x153;Topic 1â&#x20AC;? that genetic and environmental factors contributed equally towards rosacea in twins. To assess an environmental factor, we characterized the malar cheek bacterial microbiome from identical (monozygotic) twins discordant for rosacea. We found no significant difference in facial microbiome alpha and beta diversity between related twins discordant for rosacea. However, the relative percentage abundance of Gordonia and Geobacillus, low-abundant genera, was positively and negatively associated with rosacea severity, respectively. Our data demonstrate a significant correlation between facial microbiome and severity of rosacea in genetically matched twins and importantly that overall microbiome composition is largely unchanged. We will discuss the Clinical Perspective and cutting edge of Rosacea Basic Research here.

Yu-Ping Ran

Saturday, Nov. 17, 2018-from 08:30 to 09:00

+DLU IXQJDO ,QIHFWLRQ SUHFLVH GLDJQRVLV DQG WKHUDSHXWLF HIIHFW HYDOXDWLRQ E\ GHUPRVFRS\ DQG Ă&#x20AC;XRUHVFHQW VWDLQLQJ Session: Mycology Forum (I)

RM 103-LEVEL 1

Objectives: Hair as appendages of the skin all over the most body surface, according the site is divided into the hair of scalp, eyelashes, eyebrows, nose hair, public hair and vellus. Hair could be singly infected, but more simultaneously or secondarily infected with the skin, and/or, hair follicles. We LQYHQWHG D PHWKRG XVH SDUDÂżOP DQG GLVSRVDEOH SRO\HWK\OHQH JORYH WR NHHS GHUPRVFRSH FOHDQ DQG WR SUHYHQW FRQWDPLQDWLRQ GXULQJ RSHUDWLRQ so dermoscopy could be routinely used for observe the details of the fungal infected hair. Methods and Results: Fungal infection with Trichophyton, Microsporum, or Yeasts could induce tinea capitis (Trichophyton violaceum, Microsporum canis), tinea in eyelashes and nose (Trichophyton mentagrophytes complexes), public (Trichosporon inkin) and vellus (Trichophyton rubrum), and Malassezia folliculitis (M. globosa). Numerous short, highly convoluted, coiled and twisted corkscrew hairs and, cigarette-ash-shaped hairs after antifungal WKHUDS\ LQ D WLQHD FDSLWLV ZHUH QRWLFHG XQGHU GHUPRVFRS\ %ULJKW JUHHQ Ă&#x20AC;XRUHVFHQFH DSSHDUV XQGHU XOWUDYLROHW 89 GHUPRVFRS\ $FFXPXODWHG scales around hair roots, black dots, and bar code-like hairs presented with horizontal white bands were observed by polarized dermoscopy. In a case of white piedra due to Trichosporon inkin mimicking trichobacteriosis, dermoscopy observed yellowish nodules distributed along the hair at LUUHJXODU LQWHUYDOV :H DOVR XVH WKH Ă&#x20AC;XRUHVFHQW VWDLQLQJ WR SUHFLVH GHWHFW WKH IXQJDO VSRUHV DQG K\SKDH YHU\ FOHDUO\ DQG TXLFNO\ Conclusion: Combination of visual observation, dermoscopy with ordinary light source, polarized light and UV-dermoscopy, microscope, transmission and scanning HOHFWURQ PLFURVFRS\ IXQJDO FXOWXUH PROHFXODU LGHQWLÂżFDWLRQ ,76 3&5 VHTXHQFLQJ FRXOG ÂżQDOO\ PDNH D ULJKW GLDJQRVH 'HUPRVFRS\ DQG Ă&#x20AC;XRUHVFHQW VWDLQLQJ ERWK DUH FRQYHQLHQW TXLFN DQG SUDFWLFDO WR ÂżQG WKH FOXHV RI IXQJDO KDLU LQIHFWLRQ DQG WR HYDOXDWH WKH WKHUDSHXWLF HIIHFW SUHFLVHO\

Francisco D. Rivera IV

Saturday, Nov. 17, 2018-from 13:50 to 14:10

Teledermatology: Service Delivery Network for Geographically Isolated and Disadvantaged Areas Session: Teledermatology

RM 201D-LEVEL 2

Teledermatology uses a variety of electronic communications media, ranging from teleconferencing to image-sharing to remote patient monitoring, to provide clinical services to a patient. We use it in dermatology as a way to provide better care to communities which are geographically isolated and disadvantaged areas (GIDA) EHFDXVH RI ODFN RI GHUPDWRORJLVWV LW LV DOVR FRQVLGHUHG D ZD\ WR VLJQLÂ¿FDQWO\ UHGXFH WKH FRVW RI WUHDWLQJ GLIIHUHQW GHUPDWRORJLFDO FRQGLWLRQV GHOD\ in consultation and thus management. Philippines being an archipelago consisting of more than 7000 islands and frequently ravaged by typhoons , benefits in this technology H[SDQGLQJ RXU VHUYLFH GHOLYHU\ QHWZRUN DQG SURYLGLQJ VLJQLÂ¿FDQW LPSDFW LQ SURYLGLQJ TXDOLW\ GHUPDWRORJLFDO KHDOWKFDUH WR RXU SHRSOH

Francisco D. Rivera IV

Sunday, Nov. 18, 2018-from 14:30 to 14:50

Different Clinical Facets of Cutaneous Tuberculosis Session: Medical Dermatology

RM 201D-LEVEL 2

Cutaneous tuberculosis is a rare manifestation of extrapulmonary tuberculosis. Diagnosis is often overlooked and difficult because of its rarity. The clinical manifestations vary depending on the immune status of the host and the mode of transmission either by exogenous and endogenous spread. The most common presentation of cutaneous tuberculosis encountered in the Department of Dermatology in Rizal Medical Center is scrofuloderma secondary to contiguous spread; two of these cases presented as lymphadenitis and one presented as tuberculosis RI WKH ULEV 2WKHU FOLQLFDO PDQLIHVWDWLRQV RI FXWDQHRXV WXEHUFXORVLV DUH WXEHUFXORVLV YHUUXFRVD FXWLV OXSXV YXOJDULV RULÂ¿FLDO WXEHUFXORVLV DFXWH military tuberculosis, tuberculous gumma, lichen scrofulosorum, papulonecrotic tuberculid and erythema induratum of Bazin. Dermatologists SOD\V D VLJQLÂ¿FDQW UROH LQ WKH GLDJQRVLV RI FXWDQHRXV WXEHUFXORVLV EHFDXVH WKHVH GLVHDVHV PLPLF FRPPRQ LQÃ&#x20AC;DPPDWRU\ FXWDQHRXV GLVHDVHV

Thomas M. Ruenger

Saturady, Nov. 17, 2018-from 10:30 to 10:55

Phototherapy in the practice of dermatology-is it obsolete? Session: Vitiligo and Photodermatology (II)

RM 201D-LEVEL 2

3KRWRWKHUDS\ ZLWK H[SRVXUH WR QDWXUDO VXQ KDV EHHQ SUDFWLFHG IRU PDQ\ FHQWXULHV 7KH PRGHUQ HUD RI SKRWRWKHUDS\ ZLWK DUWLÂ¿FLDO VRXUFHV RI ultraviolet and visible light was started in the early 20th century by Niels Nyberg Finsen and has held a prominent position in the therapeutic DUPDPHQWDULXP RI GHUPDWRORJLVWV VLQFH ,Q WKH LHV DQG LHV ZLWK WKH LQWURGXFWLRQ RI WRSLFDO DQG V\VWHPLF VWHURLGV LW EULHÃ&#x20AC;\ IHOO RXW RI fashion, but quickly regained its place when the therapeutic limitations and risks of steroids were noted. Recently, with the introduction of biologics to dermatology in the past 15 years, the use of phototherapy has again declined. Some dermatologists consider it obsolete, citing its FDUFLQRJHQLF SURSHUWLHV LWV FRQWULEXWLRQ WR SKRWRDJLQJ LQFRQYHQLHQFH IRU SDWLHQWV LQFRQVLVWHQW DFFHVVLELOLW\ DQG VXSHULRU HIÂ¿FDF\ RI DOWHUQDWLYH therapies. However, current phototherapeutic modalities are not, or hardly carcinogenic (with the exception of PUVA) and they are highly HIÂ¿FDFLRXV ZLWK UHVSRQVH UDWHV WKDW DUH RQ D SDU ZLWK ELRORJLFV DW D IUDFWLRQ RI WKHLU FRVW 3KRWRWKHUDS\ RIWHQ LQGXFHV ORQJ WHUP UHPLVVLRQV RII treatment and has no systemic toxicity. It therefore remains a viable option for the treatment of a variety of different skin conditions, in particular when only skin-directed treatment is necessary. $W LWV LQFHSWLRQ SKRWRWKHUDSHXWLF HIÂ¿FDF\ ZDV DQ HPSLULF REVHUYDWLRQ 7RGD\ ZH XQGHUVWDQG WKDW WKH PROHFXODU LQÃ&#x20AC;DPPDWRU\ SDWKZD\V DOWHUHG by phototherapy overlap with those targeted by biologics. With this new understanding of the molecular mechanisms of phototherapy on the PROHFXODU OHYHO LW DSSHDUV IHDVLEOH WR RSWLPL]H LWV WKHUDSHXWLF HIÂ¿FDF\ DQG UHGXFH LWV ULVNV 3KRWRWKHUDS\ LV QRW REVROHWH

Julio Cesar Salas-Alanis

Saturday, Nov. 17, 2018-from 12:10 to 12:35

Braf, the past, present and future Session: Vitiligo and Photodermatology (II)

RM 201D-LEVEL 2

The Braf gene is a gene that makes a protein called B-RAF, which is involved in sending signals in cellsand in cell growth. This gene may be mutated (changed) in many types of cancer, which causes a change in the B-RAF protein. The V600E mutation in the BRAF gene has also been found around 50% of noninherited (sporadic) cases of melanoma. This mutation leads only to the formation of a noncancerous mole. At least one additional mutation is necessary for the development of melanoma. There are different treatment options for metastatic melanoma skin cancer, depending on how advanced the cancer. More recently, treatment outcomes have greatly improved with the emergence of several novel agents, including targeted therapy and immunotherapy. Immunotherapy may be used to shrink the melanoma skin; ipilimumab, nivolumab, pembrolizumab, vemurafenib, cobimetinib, dabrafenib, and trametinib. BRAF and MEK inhibitors are able to block the mitogen-activated protein kinase pathway and show a rapid and strong response but are limited by a high rate of secondary resistance. Monoclonal antibodies against the immune checkpoints cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) FDQ UHVWRUH DQ HIÂ¿FLHQW DQG GXUDEOH DQWL WXPRU LPPXQLW\ HYHQ IROORZLQJ WUHDWPHQW GLVFRQWLQXDWLRQ $QWL 3' DQWLERGLHV ZHUH VKRZQ WR SURORQJ survival of metastatic melanoma patients and a real cure seems to be obtainable in some patients. Many more therapies are currently under LQYHVWLJDWLRQ JLYHQ WKDW RI SDWLHQWV VWLOO GR QRW KDYH ORQJ WHUP EHQHÂ¿WV IURP DSSURYHG WUHDWPHQW

Chew-Swee Seow 0DODVVH]LD IROOLFXOLWLV 3URÂżOH RI FDVHV VHHQ LQ 6LQJDSRUH Session: Mycology Forum (II)

Saturday, Nov. 17, 2018-from 10:45 to 11:15 RM 103-LEVEL 1

Malassezia species are lipophilic, saprophytic yeasts which can be found on the skin of 75-98% of healthy people. In the presence of predisposing factors, they result in diseases such as Tinea versicolor, Malassezia folliculitis, and many others. 7R GDWH VSHFLHV RI 0DODVVH]LD KDYH EHHQ GRFXPHQWHG &DXVDO UHODWLRQVKLS EHWZHHQ WKH YDULRXV GLVHDVHV DQG VSHFLHV RI \HDVW LVP \HW WR EH GHÂżQHG 0DODVVH]LD RU 3LW\URVSRURQ IROOLFXOLWLV RFFXUV ZKHQ WKH \HDVW LV SUHVHQW LQ WKH RVWLXP DQG GHHS VHJPHQW RI WKH KDLU IROOLFOHV OHDGLQJ WR LQĂ&#x20AC;DPPDWLRQ and presenting as folliculitis. First described in 1973, it is being seen in increasing frequency in countries with humid weather conditions. Malassezia folliculitis has not been universally accepted as a diagnostic entity, due to lack of convincing diagnostic features. Besides, Malasssezia yeast can be isolated from normal hair follicles, Acne vulgaris and folliculitis of other origin and Response to antifungal therapy is not proof of infection. Among patients presenting with folliculitis to National Skin Centre in Singapore in which Malassezia yeast detected by direct microscopic examination using GramÄ&#x2021;s and PAS stain, we were notice 3 broad groups of clinical pattern. 7KH ÂżUVW JURXS FRQVLVWV RI SDWLHQWV ZLWK VXGGHQ RQVHW DQG UDSLG SURJUHVVLRQ LQ D SUHYLRXVO\ KHDOWK SHUVRQ ,WFK LV D FRPPRQ FRPSODLQW 7KH site of predilection is upper chest, sparing the face. Lesions are densely distributed and pustule which are uniform (Monomorphic) and no comedones. The underlying skin is normal with no sebum production. The second group occurs concurrently with Acne vulgaris and Seborrhoea. Patients often note that the new lesiona different from the underling acne vulgaris. It can occur anytime in the course of Acne, following a period of antibiotic therapy for acne. The third group develops folliculitis after use of steroid. This include oral Prednisolone for Ecema or urticarial and intralesional steroid injection for Alopecia areata. The others follow long term use of topical steroid for eczema. All our patients were treated with anti-malassezia medication including oral Itraconazole , Ketoconazole , Fluconazole and topical Azoles and Selenium Sulphide. Oral medication result in rapid decrease in symptoms and signs in our experience.

Chew-Swee Seow Therapy of fungal skin and nail infection: available drugs and when treatment fails Session: Mycology Forum (III)

Saturday, Nov. 17, 2018-from 13:30 to 14:00 RM 103-LEVEL 1

Medical therapy of Onychomycosis has not been disappointing as the disease id complex as up to 100 species of fungi have been isolated IURP GLVHDVHG QDLOV DQG WKH\ FDQ EH D HLWKHU D SDWKRJHQ RU D FRPPHQVDO DQG D GHÂżQLWLYH GLDJQRVLV RI 2Q\FKRP\FRVLV LV GLIÂżFXOW &XUUHQWO\ available antifungal drugs have the shortcoming of being narrow in spectrum against the various species of fungi; and are also associated with undesirable side effects. The ideal target for Onychomycosis is cure, given that it is caused by infection of a microbial agent. 2UDO 7HUELQDÂżQH DQG ,LWUDFRQD]ROH DUH FXUUHQWO\ XVHG IRU 'HUPDWRSK\WH 2Q\FKRP\FRVLV 7KH PRVW SHVVLPLVWLF UHSRUWHG FOLQLFDO FXUH UDWH LV with high relapse rate .Their use is also limited by side effect of liver and cardiac toxicity which are over exaggerated. Immunocompromised patients, patients with widespread disease and concomitant skin involvement, patient with deformed and toes require longer treatment period and adjunct physical measures including nail avulsion. 7UXH &DQGLGD O RQ\FKRP\FRVLV LV UDUH DQG FDQGLGDO \HDVWV DUH SUHVHQW LQ PDQ\ ÂżQJHU QDLO GLVHDVHV LQFOXGLQJ 2Q\FKRO\VLV DQG &KURQLF SDURQ\FKLD secondary an underlying skin disease. Iitraconazole is highly effective in eradicating candida yeast but the underling disease need to be addressed. Recently introduced Azole antifungal, Posaconazole and Voriconazole , are effective against Dermatophyte and some moulds, especially Scytalidium and Aspergillus. Reports of their use in Dermatology have been encouraging. They are poorly absorbed when given orally and are expensive. Fusarium, a commonly fungus isolated from diseased nails in Singapore, does not respond to the antifungal drugs. We have successfully treated these patient with Thiabendazole used for parasitic infection and in post- harvest treatment of fruits in farming industries. Laser therapy of nail fungal disease created a little excitement in Dermatology. There is no convincing report of the technology and treatment outcome and is considered in its infancy to date.

Latha Selvarajah Progress of SCAR in Malaysia Session: Asian SCAR Meeting-SCAR Consortium Forum

Friday, Nov. 16, 2018-from 17:00 to 17:10 North Lounge-LEVEL 3

Severe cutaneous adverse drug reactions (SCARs) are not uncommon and potentially life-threatening. The prevalence and patterns of SCARs differ greatly between different populations and geographic distribution. In Malaysia, the rate of hospital admissions due to SCARs was 0.3/1000. SCARs contributed between 0.4-0.9% of new dermatology clinic attendance. Studies done at the various tertiary hospitals in Malaysia showed that Stevens-Johnsons Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) was the commonest SCAR encountered, followed by Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Acute Generalized Exanthematous Pustulosis (AGEP). The commonest culprit drug group implicated was antibiotics, followed by antigout, anticonvulsants and analgesia. The top five individual causative drugs were allopurinol, phenytoin, cotrimoxazole, carbamazepine and lamotrigine. DRESS was mainly caused by allopurinol, while carbamazepine and amoxicillin were the main causative drugs in SJS/TEN and AGEP respectively. HLA-B*15:02 was strongly associated with phenytoin-induced SJS/TEN, while HLA-B*15:13 was detected in all the phenytoin-induced DRESS in our Malay population. With the identification of the SCAR patterns in our local population, it is hoped that the â&#x20AC;?high riskâ&#x20AC;? drugs would be used more judiciously in our clinical practice, and genetic screening would be considered prior to starting these medications

Vinod K. Sharma Emerging therapies in Vitiligo Session: Vitiligo and Photodermatology (I)

Saturday, Nov. 17, 2018-from 09:20 to 09:45 RM 201D-LEVEL 2

Vitiligo is an acquired disease of pigmentation characterized by the selective and often progressive loss of melanocytes from the epidermis of the skin and/or mucosae and occasionally the underlying hairs. Social stigma associated with vitiligo has significant impact on social interaction, job and marriage prospects.1 Vitiligo can have a negative impact on sexual relationships as well. Various topical and systemic therapies available for vitiligo at the best achieve repigmentation in approximately 50-60% cases and extent of repigmentation is >75% , > 50% and > 25% in one third each. The response in often incomplete and patient is dissatisfied. There has been consistent attempt to improve repigmentation with help of combination therapies of narrow band and topical steroids, CO2 fractional laser and platelet rich plasma. Multivitamins, antoxidants and even homeopathy have been claimed to be effective. Vitiligo therapy is in an exciting era and there are number of new therapies including Janus kinase inhibitors , topical histamine and Yiqiqubai granules etc on the horizon and they would transform vitiligo management.

H. Peter Soyer General introduction of dermoscopic patterns and structures Session: Dermoscopy (I)

Saturday, Nov. 17, 2018-from 10:30 to 11:00 RM 201ABC-LEVEL 2

Dermoscopy is a noninvasive diagnostic technique for the in vivo observation of pigmented skin lesions, enabling better visualisation of surface and subsurface structures and improvement in diagnostic accuracy. For dermoscopic analysis, pigmented skin lesions are covered with liquid (mineral oil, alcohol, or water) and examined under magnification ranging from 6x to 100x, in some cases using a dermatoscope connected to a digital imaging system. The improved visualisation of surface and subsurface structures obtained with this technique allows the recognition of morphologic structures within the lesions that would not be detected otherwise. The basic concepts of dermoscopy, the various dermoscopic equipment and the standard criteria for diagnosing pigmented skin lesions will be discussed. In assessing dermoscopic images, both global patterns and local structures can be recognised. These features will be systematically described and illustrated. First, we will focus on morphologically rather distinctive global patterns that allow a quick, preliminary categorisation of a given pigmented skin lesion. Second, we will describe various local structures representing the letters of the dermoscopic alphabet. These structures permit a more detailed assessment of pigmented skin lesions. Classification of melanoma-specific dermoscopic criteria --- namely, atypical pigment network, irregular dots/globules, irregular streak, blue-whitish veil and regression structures, to name the most important ones --- forms the basis of diagnostic algorithms designed to aid the clinician in assessing whether or not a melanocytic lesion is a melanoma. A certain number of lesions defy both clinical and dermoscopic diagnosis, and in those cases the ultimate standard for diagnosis is dermatopathology.

H. Peter Soyer Dermoscopy of non-melanocytic lesions Session: Dermoscopy (II)

Saturday, Nov. 17, 2018-from 13:30 to 14:10 RM 201ABC-LEVEL 2

Dermoscopy is a non-invasive diagnostic technique for the in vivo observation of pigmented and non-pigmented, melanocytic and nonmelanocytic skin lesions, enabling better visualisation of surface and subsurface structures and improvement in diagnostic accuracy. For dermoscopic analysis, skin lesions are covered with liquid (mineral oil, alcohol, or water) and examined under magnification ranging from 6x to 100x, in some cases using a dermatoscope connected to a digital imaging system. The improved visualisation of surface and subsurface structures obtained with this technique allows the recognition of morphologic structures within the lesions that would not be detected otherwise. In this presentation the standard criteria for diagnosing non-melanocytic skin lesions ranging from the many faces of lentigines and seborrhoeic keratoses to dermatofibromas and vascular skin tumors will be discussed. In addition, the dermoscopic features of keratinocyte cancer, basal cell carcinoma and squamous cell carcinoma including its precursor lesions, will be addressed. In assessing dermoscopic images, both global patterns and local structures can be recognised. These features will be systematically described and illustrated.

Liang-Dan Sun Current Concepts in the Immunogenomic Mechanism of Psoriasis Session: Immune Forum-Inflammatory Skin Disorders

Saturday, Nov. 17, 2018-from 11:30 to 11:50 RM 101AD-LEVEL 1

Psoriasis is a chronic, inflammatory, immune-mediated systemic disease with a prevalence of 0.09% to 11.4%, depending on the population of origin. Both environmental and genetic factors are involved in psoriasis susceptibility. The pathogenesis of psoriasis has not yet been fully explained. Early genome-wide linkage studies of psoriasis consistently identified the major histocompatibility complex (MHC) as the major susceptibility locus. In recent years, the development of high-throughput genotyping platforms and a comprehensive map of human haplotypes have made genome-wide association study (GWAS) method feasible. Taking advantage of these developments, GWAS of psoriasis have identified more than 60 susceptibility regions. However, these susceptibility loci collectively only explained a limited proportion of the heritable component of psoriasis. In order to reveal other variants predisposed to psoriasis susceptibility. High throughput sequencing as well as HLA-imputation methods was applied, which have uncover multiple HLA-independent variants in the MHC region and coding variants in Non-MHC region. To date, most of these diseaseassociated genes are involved in skin barrier functions (LCE) and immunopathogenesis, such as antigen presentation (HLA, ERAP1, 85

ERAP2, MICA), interleukin-12/23 axis (IL-12B, IL-23A, IL-23R, Tyk2, Jak2), T-cell polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1) and negative regulators (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1). Some of these immunological pathways were conformed to be of great importance as it has been highly successful in disease treatment with biological drugs, including anti-TNF and IL-12/23 inhibitors, which have deepen our understanding of the immunogenomic mechanism of psoriasis. However, the precise interpretation of disease associations regarding to the functions of variations has been challenging. Recently, based on the crystal structure of HLA-C*06:02 and reconstruction of 7 FHOO UHFHSWRU 7&5 6WXGLHV KDYH IRXQG PHODQRF\WHV DV +/$ & ÂąUHVWULFWHG DXWRLPPXQH WDUJHW FHOOV RI WKH 9ÄŽ 6 9Č&#x2022; 6 TCR and two HLA-C*06:02â&#x20AC;&#x201C;presented autoantigens, ADAMTSL5 and LL-37 for psoriasis patients. The identification of target cells and autoantigens of the psoriatic immune responses provide direct evidence that the antigen presenting pathway plays significant roles in the pathogenesis of psoriasis. Further elucidation of molecular mechanism of psoriasis may enable the development of novel causal therapies and facilitate clinical decision.

Liang-Dan Sun

Sunday, Nov. 18, 2018-from 11:00 to 11:20

Genome-Wide Association Study in Dermatology: Experience From China Session: BJD Editor & Genetic Forum TDA/CCD/TSID

Plenary Hall-LEVEL 3

Genome-wide association studies (GWAS) have been generally applied to detect common genetic variants associated with complex disorders, which have substantially improved our understanding of the genetic basis underlying diseases/traits. The skin is the largest organ in the body, composed of different cell types expressing specific molecules and compromised in many genodermatoses that abnormalities attributed to genetic mutations. By using classical genetic techniques, the genetic basis of many monogenic skin diseases has been widely elucidated. However, it is limited to uncover the genetic complexity of non-Mendelian human skin diseases, such as psoriasis, Systemic Lupus Erythematosus, vitiligo, atopic dermatitis, systemic sclerosis, alopecia areata and androgenetic alopecia, because of their etiopathology composed of the combination of genetic and environmental factors. With the advances in high-throughput genotyping and a flood of data on human genetic variation from the Human Genome and HapMap projects have made GWAS technically feasible. It takes advantage of linkage disequilibrium structure to genotype the correlated variants in the haplotypes and offers clues about causal disease-associated variants. Over the past ten years, GWASs have significantly advanced the identification of disease-associated regions for cutaneous disorders in Chinese Han populations, including psoriasis, atopic dermatitis, acne vulgaris, vitiligo, lupus and leprosy. These discoveries from GWASs have led to the uncovering of skin disease pathways and thus have potential to facilitate novel drug development, shaping our understanding of biological effects. GWAS is an efficient way to discover disease-associated biomarkers, that it provides an initial screening for disease susceptibility loci in the common variant spectrum. They have facilitated the evaluation of new hypotheses in basic science and clinical research over the last decade. The large amount of data and information obtained from GWAS studies may inform precision/personalized medicine for individuals with skin disorders. The next wave of GWASs should aim to integrate information from clinical data by associating genetic data with health records, or drug responses. Moving forward, efforts should focus on integrating information from GWASs with a variety of other clinical biomarkers and data to produce useful tests to allow clinical decision making for individualized health care.

Yong-Hu Sun

Saturday, Nov. 17, 2018-from 14:50 to 15:05

Amino acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity in Addition to HLA-B*13:01 Session: Immune Forum-Cutaneous Adverse Drug Reactions (II)

RM 101AD-LEVEL 1

Dapsone hypersensitivity syndrome is a rare yet severe adverse drug reaction caused by dapsone, a principal drug in multidrug therapy for leprosy. HLA-B*13:01 has been identified as a strong risk factor of dapsone hypersensitivity syndrome; however, its low positive predictive value indicated that additional genetic variants may be involved in the disease development. To discover contributing genetic variants within HLA loci in addition to HLA-B*13:01, we performed a high-coverage next-generation sequencing (NGS) based HLA typing analysis in 103 dapsone-hypersensitive and 857 dapsone-tolerant HLA-B*13:01 positive leprosy patients in a Chinese population. Five amino acid variants in high linkage disequilibrium of HLA-DRB1 were significantly associated with dapsone hypersensitivity syndrome (positions 133, 142,-17, 11, and 13). This study identifies five amino acid variants within HLADRB1 that are in high linkage disequilibrium and significantly associated with dapsone hypersensitivity syndrome in a Chinese population.

Hema Sundaram Aesthetic Application of Radiofrequency and their Relevance to Asian Patients Session: Aesthetic Dermatology (III)

Sunday, Nov. 18, 2018-from 15:50 to 16:10 RM 201ABC-LEVEL 2

This lecture will provide an evidence-based and experiential overview of the applications of radiofrequency (RF)-based devices in patients of diverse skin types, with particular reference to Asian patients. Clinical indications for RF devices include fractionated resurfacing, skin tightening, and body contouring. Bipolar RF can be combined with intense pulsed light (IPL) or infrared (IR) to expand the applications and enhance treatment efficacy and specificity. Current understanding of the multifactorial etiology of the conditions to be addressed makes a combined treatment approach logical.

Hema Sundaram Pulse Dye Laser: Emerging Indications in Diverse Patient Populations Session: Aesthetic Dermatology (III)

Sunday, NOV. 18, 2018-from 16:10 to 16:30 RM 201ABC-LEVEL 2

The pulse dye laser is considered a gold standard device for treatment of vascular and pigmented lesions. This lecture will review the clinical literature, new study data and applications of the pulse dye laser for indications including lentigines and other hyperpigmentation, telangiectases, scarring and striae. Strategies for successful treatment of higher Fitzpatrick skin phototypes will be discussed, with reference to Asian patients. The potential benefits of increased pulse duration will be reviewed.

Tao-Hsin Tung Dermatoepidemiology: Psoriasis as an Example Session: Evidence Based Dermatology and Dermatoepidemiology

Saturday, Nov. 17, 2018-from 08:30 to 09:30 Joy Lounge-LEVEL 4

Epidemiology is a branch of clinical science that explores the associated risk factors responsible for the causation of diseases through perspective and retrospective obser vations, a complete disease natural histor y, and the morbidity or transmission mechanisms of disease in population and investigates preventive and treatment control measures. The application of populationbased information to medical decision making about patients is often referred to as clinical epidemiology and, more recently, evidence-based medicine. This talk introduces the physician, researcher, practitioner, or medical student to the study of epidemiology applied to psoriasis and other disciplines in the dermatologic fields. We could expect to achieve the following goals: 1. Develop sound judgment about data applicable to clinical dermatology. 2. Explain the importance of biostatistics in dermatoepidemiology. 3. Integrate the components of epidemiological studies in psoriasis

Rataporn Ungpakorn Hello, Onychomycosis Session: Miscellaneous Nail Disease

Friday, Nov. 16, 2018-from 16:50 to 17:10 RM 201ABC-LEVEL 2

Onychomycosis is a complex fungal infection to manage. Clinical presentations may resemble other skin diseases with nail dystrophy such as psoriasis and occupational paronychia. Knowing important key points in onychomycosis guide us to streamline our management. Knowledge of nail physiology helps to understand the pathogenesis of the nail disease which results in dif ferent clinical subtypes. The most impor tant clinical presentation is subungual thickening. Onycholysis and discoloration may be secondary to detached, thickened nail plate. Indirect evidence is concomitant tinea pedis on the same side. Nail dystrophies may look alike and often times misleading, therefore, mycological proof either by direct examination, cultures or nail biopsies are more important than clinical assumption. Difference in subtypes and co-existing predisposing factors play important roles in the outcome of treatment. Selection of appropriate antifungal formulation either as monotherapy or combination optimizes the success. In uncomplicated case, oral antifungal is the standard treatment of choice. Antifungal nail lacquers are available in few countries and may play roles in specific groups of patients. For dermatophytic DLSO of less than 25% involvement, topical antifungal nail lacquers may be an option especially in pregnant women, children, patients undergoing statin for hyperlipidemia, drug hypersensitivity or contraindicated for oral treatment. Newer available nail solutions include Efinaconazole, Luliconazole and Tavaborole. For difficult-to-treat onychomycosis, a combination of topical and systemic antifungal is recommended. Removal of thick, keratotic nail by partial nail extraction, avulsion or adjunctive laser reduce infected areas and dead space, thereby, enhance drug penetration to the infected nail. Non dermatophy te nail infection is not uncommon. In fact, previous studies from Asia showed a comparable incidence of Scy talidium infection to common dermatophy tes. Mycological identif ication is impor tant and requires specif ic criteria for diagnosis. There is no standard treatment regimen but combination therapy seems more promising.

Rataporn Ungpakorn Evidence-based treatment of melasma-how exciting is it? Session: Aesthetic Dermatology (I)

Saturday Nov. 17, 2018-from 16:30 to 16:50 RM 103-LEVEL 1

Melasma is a leading pigmentary disorder occurring more frequently in persons with Fitzpatrick skin type IV to VI. Although a common condition, an ideal treatment for satisfactory or permanent cure has yet to be found. Common pigmentary conditions that are misdiagnosed or may be found simultaneously with melasma are facial dermal naevi, PIH, ochronosis and pigmentary occupational dermatoses. 7R PDQDJH PHODVPD , ÂżQG LW LPSRUWDQW DW OHDVW WR NQRZ WKH SDWKRJHQHVLV WR EH DEOH WR WDLORU UHJLPHQ DQG H[SODLQ WUHDWPHQW SODQV WR SDWLHQWV The pathway is shown on the diagram. We can truly understand why even with combined treatment cannot effectively inhibit all pathways. It LV D FRQVHQVXV WKDW D FRPELQDWLRQ RI VXQ SURWHFWLRQ WRSLFDO K\SRSLJPHQWLQJ DJHQWV SK\VLFDO SHHOLQJ DQG OLJKW WKHUDS\ DUH EHQHÂżFLDO Topical depigmenting agents are all targeted at different pathways of melanogenesis but no single therapy is effective. These medications FDQ EH JURXSHG DFFRUGLQJ WR WKHLU VSHFLÂżF LQKLELWRU\ DFWLRQ RQ GLIIHUHQW VWHSV RI JO\FRV\ODWLRQ W\URVLQDVH HQ]\PH PHODQRVRPH WUDQVIHU tyrosinase gene transcription or epidermal turnover. Present available treatment involves the use of range of topical depigmenting agents, DGMXQFWLYH SK\VLFDO DQG ODVHU WKHUDSLHV 7RSLFDO K\GURTXLQRQH LV VWLOO WKH JROG VWDQGDUG (IÂżFDF\ GHSHQGV RQ WKH FRQFHQWUDWLRQ ZKLFK DOVR determines untoward side effects. A range of other natural and synthetic chemicals have also been used with various results. 87

Evidence-based data suggest that a combination of hydroquinone, topical corticosteroid and vitamin A acid is among the most effective. Other effective therapies are retinoic acid and combination with glycocolic acid or hydroquinone (level IB, IC). Further follow-up is needed to evaluate the risk-benefit in regular and long-term use. Trials with Q-switched ruby, alexandrite, erbium-YAG and IPL have been used without promising result. Different peeling agents, light and laser technology are considered as adjunctive therapy. The use in combination with standard topical medication must be individualised depending on severity and other factors which must be carefully assessed. Tranexamic acid and glutathione may improve lightening of skin pigmentation. It must be emphasized and informed that even with different treatment available, melasma is still a permanent condition

Shirley L. Van Beyond sun damaged skin Session: Vitiligo and Photodermatology (II)

Saturday, Nov. 17, 2018-from 11:20 to 11:45 RM 201D-LEVEL 2

The advancements in DNA and RNA sequencing have expanded our understanding of UV-induced melanomas. Melanomas arising in sun-exposed skin can be subtyped into High Chronic Sun Damaged (High-CSD) melanomas and Low Chronic Sun Damaged (Low-CSD) melanomas. High-CSD melanomas typically originate from the head and neck of older age individuals. They have a very high mutation burden and are associated with NF1, NRAS, non V600E BRAF or KIT mutations. In contrast, Low-CSD melanomas typically affect the intermittently sun-exposed areas, such as the trunk, of younger age individuals. They have a high mutation burden and are associated with V600E BRAF mutations. Furthermore, with increased knowledge of molecular events in the evolution of melanoma, it is now clear that UV radiation plays an important role in almost all stages of tumor progression, from the pre-malignant stage up to the invasive stage. Therefore, it is imperative to detect melanomas arising from sun damaged skin at the earliest onset. In this presentation, cases of early evolving melanomas are discussed. Important clinical clues, dermoscopy findings and immunohistochemistry stains of each case are emphasized. Evaluation of sun damaged skin in a comprehensive way is demonstrated.

Shirley L. Van Evaluation & Management of Skin Cancers Session: Dermatologic Surgery

Sunday, Nov. 18, 2018-from 16:30 to 16:50 RM 201EF-LEVEL 2

An update on the recent advancements in evaluation and treatment of skin cancers, with emphasis on evaluation and management of UVinduced melanomas. Precision Medicine-based interventions will be discussed.

Yen-Jen Wang Challenges of cinical and pathological diagnosis of melanoma Session: Melanoma Forum (II)

Saturday Nov. 17, 2018-from 10:30 to 11:00 North Lounge-LEVEL 3

The incidence of cutaneous malignant melanoma has been rising worldwide, early diagnosis and correct staging is important. Dermoscopy, optical coherence tomography and confocal microscopy can help with diagnosis but pathologic diagnosis is still the gold standard and for accurate depth measurement. Sometimes physicians may face challenges of clinical and pathological diagnosis of melanoma, especially melanoma in situ. Some subungual melanocytic lesions in children and adolescents are histologically indistinguishable from adult subungual melanoma in situ. While the biologic SRWHQWLDO UHPDLQV HOXVLYH Ă&#x20AC;XRUHVFHQFH LQ VLWX K\EULGL]DWLRQ ),6+ PLJKW DLG LQ GLDJQRVLV

Chuang-Wei Wang What is the Functional Role of HLA in Dapsone Hypersensitivity Session: Immune Forum-Cutaneous Adverse Drug Reactions (II)

Saturday, Nov. 17, 2018-from 14:35 to 14:50 RM 101AD-LEVEL 1

It has been repor ted that HL A-B*13:01 is strongly associated with dapsone-induced hypersensitivity reactions. However, the phenotype specificity and detailed immune mechanism of HLA-B*13:01 remain unclear. We enrolled patients from Taiwan and Malaysia with DRESS with chronic inflammatory dermatoses. The HLA-B*13:01 allele was present in 85.7% of patients with dapsone DRESS (odds ratio, 49.64) but in only 10.8% of general population control. The level of granulysin was increased in both the plasma of DRESS patients (36.14 ng/ml, P<0.05) and in vitro lymphocyte activation test (71.4%) compared with healthy control individuals. Furthermore, dapsone-specific cytotoxic T cells were significantly activated when co-cultured with HLA-B*13:01 expressing antigen presenting cells in the presence of dapsone (3.9-fold increase, compared with cells with no HLA-B*13:01 expression; P<0.01). This study describes a functional role for the HLA-restricted immune mechanism induced by dapsone.

Fang-Ying Wang Smartphone Wallpapers for Dermoscopy Training in Medical Students and Residents Session: Dermoscopy (II)

Saturday, Nov. 17, 2018-from 14:40 to 15:00 RM 201ABC-LEVEL 2

Dermoscopy improves the accuracy of clinical diagnosis and early malignancy detection, while decreases the necessity of skin biopsy. Both doctors and patients benefit from dermoscopy examination. However, the accuracy of dermoscopy examination depends on adequate training. Most of the current dermoscopic training courses rely on lecture series with some supervised practices or textbook learning, and they are usually time-consuming and not readily available. In the modern age, more and more medical students and residents prefer to receive news and information from electronic devices rather than traditional books. Due to the high usage of mobile phones, the idea to facilitate the learning of dermoscopic patterns through the use of smar tphone wallpapers was created. Thus, we used dermoscopic pictures as smar tphone wallpapers for dermoscopy training for medical students and residents in an academic dermatology department and evaluated the effectiveness.

Benjamin Wood Emerging concept of pathways of melanocytic neoplasia Session: Melanoma Forum (I)

Saturday, Nov. 17, 2018-from 08:30 to 09:00 North Lounge-LEVEL 3

Emerging Concepts of Pathways in Melanocytic Neoplasia Melanocytic neoplasms are driven by genetic abnormalities inducing melanocytic proliferation. These pathways are different in lesions arising in skin which is intermittently exposed to sun, in lesions with high levels of chronic sun damage and in Spitz naevi. It is becoming clear that clinical and histological differences between melanocytic neoplasms correlate with these differing molecular pathways. This lecture will explore the molecular, clinical and morphological correlates of some of the more common pathways of melanocytic neoplasia, with implications for diagnosis and management.

Jennifer Wu Cutaneous adverse reaction related to immunotherapy in melanoma Session: Melanoma Forum

Saturday, Nov. 17, 2018-from 12:00 to 12:30 RM 101AD-LEVEL 1

The emergence of immune checkpoint inhibitors targeting the cy totoxic T- lymphocy te -associated antigen- 4 (CTL A - 4) and programmed cell death protein-1 (PD-1) pathways has revolutionized cancer treatment into a new era and offers promising treatment efficacies and durability for melanoma and furthermore a broad variety of malignancies. Immune checkpoint inhibitors, by blocking the inhibitory signals of T cell regulation, restore the T cell function to attack tumor cells. However, by unbalancing the immune response, immune-related adverse events (irAEs) may occur and involve all organ systems including most commonly skin, guts, endocrine, livers or lungs, which result in treatment interruption or discontinuation, decreases in quality of life, morbidity, or even mortality. Cutaneous adverse reactions are among the most frequent irAEs and usually the first to appear within first few weeks after initiation of immunotherapy. Early diagnosis and proper management of these cutaneous irAEs are crucial for the patients to maintain their immunotherapy and quality of life. This presentation will focus on the incidence and clinical manifestations of cutaneous irAEs, the proposed pathomechanisms of irAEs, the assessment and management strategy of cutaneous irAEs.

Jashin J. Wu Psoriasis: the effect of biologics on cardiovascular disease Session: Psoriasis

Saturday, Nov. 17, 2018-from 16:45 to 17:10 RM 201ABC-LEVEL 2

Patients with psoriasis have higher risk for cardiometabolic disease. We will examine whether treatment with biologics has an effect on various markers, comorbidities, and endpoints of cardiovascular disease in psoriasis patients.

Zhi-Rong Yao The diagnosis of atypical atopic dermatitis and application of diagnostic tools Session: Immune Forum-Inflammatory Skin Disorders

Saturday, Nov. 17, 2018-from 10:50 to 11:10 RM 101AD-LEVEL 1

Various diagnostic tools for atopic dermatitis have been widely used in clinical investigations or epidermiological studies. However, the diagnosis of atopic dermatitis with atypical morphology and distribution of lesions remains to be challenging. Our data showed a respectively low sensitivity of Hanifin-Rajka diagnostic criteria or UK Working Party's criteria in diagnosis of atopic dermatitis among Chinese population. It seems to be needed to develop a diagnostic criteria for diagnosis of atopic dermatitis in Chinese population.

Roman Yaremkevych

Sunday, Nov. 18, 2018-from 11:45 to 12:10

Common acneiform eruptions- pitfalls and diagnostic tips Session: Acne and Rosacea (I)

RM 201ABC-LEVEL 2

A few acneiform eruptions exist, which may be diagnosed as acne by mistake. Eruptive vellus hair cysts (EVHC) represent a sporadic but not rare developmental abnormality of vellus hair follicles. Up till now more than 150 cases of EVHC have been published in the literature, but it may be more common than has been recognized. We present new diagnostic method of EVHC.

Roman Yaremkevych

Sunday, Nov. 18, 2018-from 14:10 to 14:30

Practical psychodermatology. Psychotherapy approaches in Atopic dermatitis and Psoriasis treatment Session: Medical Dermatology

RM 201D-LEVEL 2

Effects of family constellation seminar on itch in patients with atopic dermatitis and psoriasis: controlled study Family relationships are important source of the stress, connected with itch in patients with atopic dermatitis (AD) and psoriasis. The aim of the study was to check the influence of family constellation seminar on itch and scratch in such patients. Methods: 31 patients with itch (XX with AD and YY with psoriasis) were allocated to intervention (16 patients, XX males, average age YY years) and control group (15 patients, XX males, average age YY years). Patients from main group have participated in a series of FCS in form of 2/1/1 days during 3 months. During the study period, patients used only emollients for local skin therapy. Subjective perception of itch was measured according to 27-item inventory, objective signs of AD were measured by SCORAD, psoriasis by PASI Quality of life was measured by DLQI before, during, after the end of the intervention period, and after 12 month from the start of the intervention. Results. After series of FCS seminars participants with itch have demonstrated decrease in severity of itch and decreased excoriation score. Conclusion. FCS may be an effective additional method of psychological intervention for reduction of itch in patients with psoriasis and atopic dermatitis.

Fu-Ren Zhang Progress of SCAR in China Session: Asian SCAR Meeting - SCAR Consortium Forum

Friday, Nov. 16, 2018-from 16:20 to 16:30 North Lounge-LEVEL 3

In this topic, I will review the research progress of SCAR in China.

Fu-Ren Zhang The Sadness of Dapsone: Hypersensitivity reactions Session: Immune Forum-Cutaneous Adverse Drug Reactions (II)

Saturday, Nov. 17, 2018-from 14:20 to 14:35 RM 101AD-LEVEL 1

In this topic, I will review the dapsone hypersensitivity syndrome from research to clinical trial.

Jie Zheng Why Psoriasis Vulgaris Recur After External Application of Glucocorticoids? Session: Immune Forum-Inflammatory Skin Disorders

Saturday, Nov. 17, 2018-from 11:50 to 12:10 RM 101AD-LEVEL 1

3VRULDVLV LV DQ LPPXQH PHGLDWHG FKURQLF LQÃ&#x20AC;DPPDWRU\ VNLQ GLVHDVH UHFXUUHQFH LV LWV VSHFLÂ¿F FKDUDFWHULVWLFV $OWKRXJK D OLWWOH SVRULDVLV PD\ recur in new locations, typically it is always relapsing in primary locations1,2,3. Till now, there have been many therapies that can alleviate the severity of psoriasis, but even with the latest treatment such as brodalumab (an antibody targeted IL-17 receptor), the relapse is not able to avoid after the therapies suspended. Therefore, the recurrence of psoriasis still be a common concern. What is the major cause in relapse of psoriasis Æ¢ The key pathological cytokines like IL-17or IL-23 can be found, if the Ä&#x201E;factor of relapseÄ&#x2026; is also can be found, which is always thought by us. We proposed that long-term remission of psoriasis should be achieved by identifying the targeting factor of relapse. Study of the resolved psoriasis lesions revealed that tissue-resident memory T (TRM) cells might be the pathogenesis of psoriasis relapse, but these VWXGLHV ZHUH IRFXVHG RQ ,/ SURGXFLQJ Ä®È&#x2022; 7 FHOOV 2XU SUHYLRXV VWXG\ DSSURYHG WKDW GHUPDO È&#x2013;Ä¯ 7 FHOOV ZHUH WKH PDMRU ,/ SURGXFHUV LQ WKH VNLQ RI SVRULDVLV RU LPLTXLPRG ,04 LQGXFHG SVRULDVLV OLNH PLFH ,Q WKH PRGHO RI ,04 LQGXFHG SVRULDVLV OLNH GLVHDVH UHFXUUHQFH 9È&#x2013; 9Ä¯ VXEVHW È&#x2013;Ä¯ 7 FHOOV SURGXFLQJ ,/ DQG KDG WKH PHPRU\ OLNH IXQFWLRQ DQG WKLV VXEVHW RI È&#x2013;Ä¯ 7 FHOOV FRXOG DFFXPXODWH LQ LQÃ&#x20AC;DPHG VNLQ DV ZHOO DV WR WUDYHO WR GLVWDQW VNLQ $W KXPDQ VWXG\ LW DOVR GHÂ¿QHG 9È&#x2013; 9Ä¯ VXEVHW È&#x2013;Ä¯ 7 FHOOV KDG WKH UHGLVWULEXWLRQ IXQFWLRQ EHIRUH WUHDWPHQW 9È&#x2013; 9Ä¯ 7 FHOOV ZHUH ULFK DW SVRULDVLV OHVLRQV EXW UDUH DW FLUFXODWLQJ DIWHU VXFFHVVIXO WUHDWPHQW 9È&#x2013; 9Ä¯ 7 FHOOV ZHUH GHFUHDVHG DW SVRULDVLV OHVLRQV DUHDV EXW LQFUHDVHG DW FLUFXODWLQJ 6R ZH WKRXJKW WKDW È&#x2013;Ä¯ 7 FHOOV FRXOG ZDQGHU GLIIHUHQW WLVVXHV EDVHG RQ WKH VHYHULW\ RI SVRULDVLV 'RHV È&#x2013;Ä¯7 FHOOV KDYH PHPRU\ OLNH IXQFWLRQV" +RZ GR È&#x2013;Ä¯7 FHOOV WUDYHO EHWZHHQ GLIIHUHQW WLVVXHV" ,I WKH PLJUDWLRQ RI È&#x2013;Ä¯7 FHOO LV EORFNHG FDQ WKH UHODSVH RI WKH GLVHDVH EH UHGXFHG" In this study we topical used 0.05% Halometasone cream (one kind of potent glucocorticoid) to treat psoriasis vulgaris and imiquimod (IMQ) induced psoriasis-like mice model, then withdrawal drug to explore the mechanism of relapse of psoriasis. From these models with Tcrd90

PLFH ZH GHPRQVWUDWH WKDW GHUPDO È&#x2013;Ä¯ 7 FHOOV SOD\ NH\ UROH LQ WKH UHODSVH RI SVRULDVLV UHODSVH )URP Ã&#x20AC;RZ F\WRPHWHU DQG ,PPXQRÃ&#x20AC;XRUHVFHQFH UHVXOW ZH IRXQG WKDW KXPDQ DQG PRXVH È&#x2013;Ä¯7 FHOOV KDYH PDUNHUV RI 750 FHOOV VXFK DV &' &' &/$ $QG IURP WKH PRGHOV ZH IRXQG WKDW DIWHU JOXFRFRUWLFRLG WUHDWPHQW VNLQ FKHPRNLQHV ZHUH VLJQLÂ¿FDQW GHFUHDVHG DW SVRULDVLV VNLQ EXW WKH PDMRU ,/ SURGXFLQJ FHOOV GHUPDO È&#x2013;Ä¯ 7 WUDQVIHU WR SHULSKHUDO EORRG 30 LQ KXPDQ RU O\PSK QRGH LQ PLFH $IWHU SVRULDVLV UHODSVH WKH FKHPRNLQHV DQG VNLQ GHUPDO È&#x2013;Ä¯ 7 ZHUH LQFUHDVHG at psoriasis skin again. In chemokine ko mice or inhibit T cells transfer from lymph node, psoriasis relapse was relief. These observations VXSSRUW WKH LGHD WKDW FKHPRNLQHV DQG GHUPDO È&#x2013;Ä¯ 7 FHOOV DUH WKH NH\ FRPSRQHQWV LQ WKH SDWKRJHQHVLV RI SVRULDVLV UHODSVH

Depali Rathod

Friday, Nov. 16, 2018-from 08:30 to 08:40

Utility of dermoscope in diagnosing various facial melanoses: A cross-sectional descriptive study Session: Young Dermatologist Awards

RM 201D-LEVEL 2

Background and objective: )DFLDO PHODQRVHV DUH FRPPRQO\ HQFRXQWHUHG LQ WKH GXVN\ SRSXODWLRQ :H DLPHG WR VWXG\ WKH GHUPRVFRSLF Â¿QGLQJV LQ IDFLDO PHODQRVHV SDWLHQWV as information on this topic is limited. Materials and methods: Total 50 patients were enrolled after written informed consent. Each patient was examined with Heineâ&#x20AC;&#x2122;s delta dermoscope and images were captured with Canon 1200 D DSLR camera after a detailed history of demographic data and underlying systemic disease. Results: Fifty patients(42 females,8 males) were enrolled. Male to female ratio-1:5.25. Mean age-45.98 years. Majority belonged to 4th decade. Total 8 GLIIHUHQW W\SHV RI IDFLDO PHODQRVHV ZHUH VWXGLHG ZLWK WKHLU FKDUDFWHULVWLF GHUPRVFRSLF Â¿QGLQJV 7DEOH Conclusion: 7KLV VWXG\ WKHUHIRUH SURYLGHV QHZ LQVLJKWV LQWR WKH GHUPRVFRSLF Â¿QGLQJV RI YDULRXV IDFLDO PHODQRVHV LQ )LW]SDWULFN VNLQ W\SH ,9 9,

Le Huyen My

Friday, Nov. 16, 2018-from 08:40 to 08:50

Correlation between autoantibodies and skin manifestation in SLE patients Session: Young Dermatologist Awards

RM 201D-LEVEL 2

Background: Skin lesions in SLE may be lupus-specific or lupus non-specific. Autoantibodies is important for diagnosis, follow up and prognosis. Aims: To evaluate the prevalence and relationship between some antibodies and skin manifestations in SLE patients. Methodes: This cross sectional descriptive survey assessed 80 SLE patients. The prevalence of some antibodies and their correlation with skin manifestations was examined. Results: We found the prevalence of antibodies to be as follows: 65% (anti-SSA), 27,5% (anti-SSB), 32,5% (anti- Smith), 18,8% (anti U1-RNP). Anti- U1-RNP was associated with Raynaud's phenomenon, periungual hemorrhage; anti-Smith with oral ulcer; anti-SSA with subacute cutaneous lupus erythematosus, photosensitivity, malar rash, oral ulcer, RCLASI activity scores; anti-SSB with subacute cutaneous lupus erythematosus, oral ulcer. Conclusions: There is a significant association between some antibodies and various cutaneous manifestations of SLE patients.

Chu-Sung Hu

Friday, Nov. 16, 2018-from 08:50 to 09:00

Changes in skin physiological parameters in breast cancer patients undergoing radiotherapy Session: Young Dermatologist Awards

RM 201D-LEVEL 2

Background: Acute radiation dermatitis is a common and serious side effect in breast cancer patients receiving radiotherapy. Objective: We evaluated the effects of radiotherapy for breast cancer on skin physiological parameters. Methods: We measured various skin physiological parameters in 144 breast cancer patients by non-invasive methods before and after radiotherapy. Results: )ROORZLQJ UDGLDWLRQ WKHUDS\ WKH LUUDGLDWHG EUHDVW VKRZHG D VLJQLÂ¿FDQW GHFUHDVH LQ VNLQ K\GUDWLRQ LQFUHDVH LQ VNLQ S+ LQFUHDVH LQ SLJPHQWDWLRQ LQFUHDVH LQ WHPSHUDWXUH DQG LQFUHDVH LQ FXWDQHRXV EORRG Ã&#x20AC;RZ 7KH FRQWUDODWHUDO XQ LUUDGLDWHG EUHDVW VKRZHG D VOLJKW LQFUHDVH LQ SLJPHQWDWLRQ EXW QR VLJQLÂ¿FDQW DOWHUDWLRQV LQ DQ\ RI WKH RWKHU SK\VLRORJLFDO SDUDPHWHUV DIWHU UDGLRWKHUDS\ Conclusions: 7KHVH ILQGLQJV JLYH XV D JUHDWHU XQGHUVWDQGLQJ RI WKH HIIHFWV RI UDGLRWKHUDS\ RQ VNLQ SK\VLRORJ\ DQG SURYLGH QRQ LQYDVLYH DQG REMHFWLYH techniques to evaluate radiation dermatitis.

Zih-Chan Lin

Friday, Nov. 16, 2018-from 09:00 to 09:10

&XWDQHRXV DSSOLFDWLRQ RI DQWKUDQLODWH GHULYDWLYHV IRU LQKLELWLQJ QHXWURSKLOLF LQÃ&#x20AC;DPPDWLRQ LQ SVRULDVLV OLNH PRXVH PRGHO Session: Young Dermatologist Awards

RM 201D-LEVEL 2

Background: The psoriasis pathogenesis involves the significance of neutrophil-keratinocyte interaction in the early pathogenesis of psoriasis, showing the importance of neutrophils in psoriasis. Objectives: We aimed to examine the anti-psoriatic activity of 2 anthranilate derivatives. The possible mechanisms of the anti-psoriatic potency of both compounds were also explored. Materials & Methods: We used the IMQ-induced mouse, as well as human keratinocytes and neutrophils, as the models. All results will show by the methods of western blot, Real-time qRT-PCR and ELISA. Results: The results showed that topical treatment with both compounds could attenuate epidermal thickness and scaling in a psoriasis mouse model via decreased expression of cytokines and chemokines. Conclusions: 7KH ILQGLQJV RI WKLV VWXG\ LQGLFDWHG WKDW WRSLFDO WUHDWPHQW ZLWK DQWKUDQLODWH GHULYDWLYHV H[HUW SRWHQWLDO DQWL SVRULDWLF HIIHFWV RQ VNLQ keratinocytes exposed to IMQ by prohibiting neutrophil recruitment.

Vaishnavi Gowda

Friday, Nov. 16, 2018-from 09:20 to 09:35

Atypical mycobacterial cutaneous infections: A 5 years retrospective study Session: Maria Duran Awards

RM 201D-LEVEL 2

Background: Atypical mycobacteria are non-tuberculous acid-fast bacteria . Objectives : Clinical, pathological and species profile of atypical mycobacteria with treatment response. Materials and Methods: Clinical features, histology, investigations and treatment response. Results: A retrospective study of patients attending our hospital in the past 5-years was carried . 30 cases of atypical mycobacterial cutaneous infections were diagnosed. Cases with a clinical suspicion and histology of suppurative granulomatous inflammation were included. 'LDJQRVLV ZDV SURYHG E\ WLVVXH FXOWXUH 3RO\PHUDVH FKDLQ UHDFWLRQ SURYLGHG VSHFLHV GLDJQRVLV 7KH RUJDQLVPV LVRODWHG ZHUH0 fortuitum(36.36%) ,M.fortuitum and chelonae complex(27.27%), M.chelonae(18.18%),M.marinum (9.09%)and abscesses(9.09%). Patients were treated with tetracyclines for 8 to 54 weeks. Conclusions: &XWDQHRXV DW\SLFDO P\FREDFWHULDO LQIHFWLRQV DUH VKRZLQJ D ULVLQJ WUHQG 7HWUDF\FOLQH JURXS RI DQWLELRWLFV DUH IRXQG WR EH HIIHFWLYH

Grace Monica Ibaviosa

Friday, Nov. 16, 2018-from 09:35 to 09:50

$ UDQGRPL]HG GRXEOH EOLQG FRQWUROOHG VWXG\ RQ WKH VDIHW\ DQG HIÂ¿FDF\ RI 7LQRVSRUDUXPSKLL 0DNDEXKD\ FUHDP YHUVXV PXSLURFLQ FUHDP RQ VXSHUÂ¿FLDO S\RGHUPDV FDXVHG E\ 6WDSK\ORFRFFXV DXUHXV Session: Maria Duran Awards

RM 201D-LEVEL 2

Background: Superficial pyoderma is commonly caused by S aureus. Drug of choice is 2% mupirocin cream. T rumphii had antibacterial activity in vivo making it a cost-effective alternative. Objectives: To determine safety & efficacy of 25% T rumphii cream vs 2% mupirocin cream in treating superficial pyodermas by S aureus. Methodes: A randomized, double-blind, controlled study of 60 patients with superficial pyodermas by S aureus, ages 18-60, given 25% T.rumphii or 2% mupirocin cream for 2 weeks. Bactericidal activity, erythema, edema, induration & lesion size were evaluated. Participants Global Assessment score & adverse events were noted. Statistical analysis done using Mann-Whitney & Pearson Chi square test. Results: 51 subjects (85%) completed the trial with no statistically significant differences between the two treatment groups. No adverse events noted. Conclusions: 25% T rumphii cream is safe and effective as 2% mupirocin cream in treating superficial pyodermas by S aureus.

Veronica Uy

Friday, Nov. 16, 2018- from 10:30 to 10:38

$ UDQGRPL]HG GRXEOH EOLQG FRPSDUDWLYH VWXG\ RQ WKH VDIHW\ DQG HIÂ¿FDF\ RI 9LUJLQ FRFRQXW RLO DJDLQVW +\GURFRUWLVRQH DV DQ DQWL LQÃ&#x20AC;DPPDWRU\ DQG DQWL SUXULWLF SUHSDUDWLRQ IRU PRVTXLWR ELWHV UHDFWLRQV Session: ISD Global Education Awards

RM 201D-LEVEL 2

INTRODUCTION 9&2 KDV EHHQ UHSRUWHG WR KDYH DQWL LQÃ&#x20AC;DPPDWRU\ DQG DQWL SUXULWLF SURSHUWLHV DQG FDQ EH DQ DOWHUQDWLYH WR FRUWLFRVWHURLGV IRU PRVTXLWR ELWHV 1R studies on VCO for mosquito bites have been done. OBJECTIVES 7R FRPSDUH WKH VDIHW\ DQG HIÂ¿FDF\ RI 9&2 DJDLQVW +\GURFRUWLVRQH DV DQ DQWL LQÃ&#x20AC;DPPDWRU\ DQG DQWL SUXULWLF SUHSDUDWLRQ IRU PRVTXLWR ELWHV METHODS $ UDQGRPL]HG GRXEOH EOLQG VWXG\ FRPSDULQJ WKH DQWL LQÃ&#x20AC;DPPDWRU\ DQG DQWL SUXULWLF HIIHFW RI 9&2 YHUVXV +\GURFRUWLVRQH E\ PHDVXULQJ the mean lesion size, subjective assessment of lesions, pruritus intensity through the visual analog and verbal rating scale among subjects at baseline, 1 hour, days 1, 3 and 7. RESULTS During the first hour and throughout the seven day period, there was a decrease in the mean lesion size, visual, and verbal scale score for both groups. The mean lesion size for both groups were not statistically significant after one hour and one day. On day 3, the mean lesion size for the VCO group was 0.02 and 0.71 for the Hydrocortisone group and this was statistically significant in favor of VCO. The mean visual and verbal scale scores for pruritus for both treatment groups were not statistically significant. As early as first hour, proportion of patients who reported total clearance of lesions in the VCO group was 34.09% compared to 6.38% in the Hydrocortisone group. On day 7, both treatment groups had resolution of lesions. No adverse reactions were noted. CONCLUSION 9LUJLQ FRFRQXW RLO LV VDIH FRVW HIIHFWLYH DQG FRPSDUDEOH WR +\GURFRUWLVRQH DV DQ DQWL LQÃ&#x20AC;DPPDWRU\ DQG DQWL SUXULWLF DJHQW Commercial Funding: N/A &RQÃ&#x20AC;LFW RI ,QWHUHVW 1 $ Keywords: Virgin coconut oil, Hydrocortisone, mosquito bite reaction

AsmaToumi

Friday, Nov. 16, 2018- from 10:38 to 10:46

&OLQLFDO GHUPRVFRSLF DQG WUHDWPHQW SURÂ¿OH RI RQ\FKRP\FRVLV LQ 7XQLVLD Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background Onychomycosis is the most prevalent nail disease, amounting to 50% of onychopathies Objectives 'HVFULEH WKH FOLQLFDO GHUPRVFRSLF DQG WUHDWPHQW SURÂ¿OH RI RQ\FKRP\FRVLV Materials & methods We conducted a prospective study enrolling 184 patients with mycologically proven onychomycosis. Results 3DWLHQWV RYHU WKH DJH RI ZHUH WKH PRVW DIIHFWHG 7KH PRVW IUHTXHQW IXQJDO VSHFLHV ZHUH 7 5XEUXP RQ WRHQDLOV DQG & $OELFDQV RQ Â¿QJHUQDLOV 'LVWDO DQG ODWHUDO VXEXQJXDO RQ\FKRP\FRVLV ZDV WKH PRVW IUHTXHQW VXEW\SH 'HUPDWRVFRSLF Â¿QGLQJV ZHUH VXEXQJXDO NHUDWRVLV GLVWDO VXEXQJXDO ORQJLWXGLQDO VWULDH 6SLNHV RI WKH SUR[LPDO PDUJLQ RI DQ RQ\FKRO\WLF DUHD 7UHDWPHQW GXUDWLRQ ZDV KLJKHU ZLWK Ã&#x20AC;XFRQD]ROH WKDQ ZLWK WHUELQDÂ¿QH OHDGLQJ WR KLJKHU FOLQLFDO FXUH UDWHV Conclusions 'HWHFWLRQ RI VSHFLÂ¿F GHUPRVFRSLF VLJQV RI RQ\FKRP\FRVLV FDQ KHOS WR DYRLG P\FRORJ\ ,Q ORZ LQFRPH FRXQWULHV OLNH 7XQLVLD Ã&#x20AC;XFRQD]ROH FRXOG EH D PRUH DSSURSULDWH WUHDWPHQW RSWLRQ WKDQ WHUELQDÂ¿QH

Bryan Guevara

Friday, Nov. 16, 2018- from 10:46 to 10:54

$ UDQGRPL]HG GRXEOH EOLQG FOLQLFDO WULDO RQ WKH HIÂ¿FDF\ DQG VDIHW\ RI WXUPHULF FUHDP LQ WKH WUHDWPHQW of plaque-type psoriasis in adults Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background Turmeric demonstrated anti-inflammatory properties in laboratory and clinical studies that suggest its usefulness in psoriasis. Objectives To determine the efficacy and safety of turmeric 1% cream. Materials and Methods This was a randomized, double-blind clinical trial. Outcome measures were the proportion of patients with clinical remission, mean PASI and pruritus scores per visit, time to remission and incidence of adverse effects. Results Fifty-nine patients were randomized into two groups: a turmeric (n=30) and a clobetasol (n=29) group. After four weeks of treatment, there was no significant difference (p=0.36) in the proportions of patients with clinical remission in the turmeric group (5/20, 25%) and the clobetasol group (8/23, 35%). There was no significant difference in post-treament mean PASI scores in turmeric and clobetasol groups (p=0.40). Conclusion Turmeric cream was comparable to clobetasol cream based on efficacy and safety outcome measures 93

Ana Maria Draganita

Friday, Nov. 16, 2018-from 10:54 to 11:02

Digital analyses of patients with rosacea-implications for treatment Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background: 5RVDFHD LV D FKURQLF LQÀDPPDWRU\ VNLQ GLVHDVH DVVRFLDWHG ZLWK D KLJK LPSDFW RQ SDWLHQWVć quality of life and one of the most important things LV WR LQGLYLGXDOL]H WKH WUHDWPHQW DFFRUGLQJ WR WKH VSHFL¿F QHHGV RI WKH SDWLHQWV Objectives: Initial evaluation and follow-up of patients with rosacea using a digital technology for assesment of spots, UV spots, red areas and porphyrins. Materials & Methods: 60 women with rosacea with a mean age 35,2 years (minimum=26 years, maximum=43 years). We performed for each patient digital photography from frontal view, right view and left view using standard light, UV light and polarized light. Results: We found high values of porphyrins and a high scores of UV spot. A positive correlation UV spot/red areas, and an inverse correlation spot/Porphyrins and red areas/Porphyrins. Conclusions: The digital evaluation is an important noninvasive tool for first evaluation of patients with rosacea and follow-up.

Shashank Bhargava

Friday, Nov. 16, 2018-from 11:02 to 11:10

DOES PLATELET RICH PLASMA REALLY WORK SYNERGISTICALLY WITH MICRONEEDLING AND SUBCISION FOR GRADE 4 ATROPHIC ACNE SCARS? Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background Scarring affects up to 95% of patients of acne vulgaris. Atrophic scarring is the most common type and can represent a therapeutic challenge. Objective To evaluate the role of platelet rich plasma (PRP) as adjunctive therapy to a combined subcision and needling treatment in severe (Grade 4) atrophic acne scarring. Materials and Methods 30 patients with Grade 4 acne scars were recruited. They were randomly divided into 2 groups, 15 patients each: Group A underwent 3 sessions of subcision and needling while group B 3 sessions of subcision, needling and topical application of PRP 3 weeks apart. All patients were DVVHVVHG IRU VFDU JUDGLQJ PRQWKV IROORZLQJ WKH ¿QDO VHVVLRQ 3DWLHQW UHVSRQVH ZDV JUDGHG DV ‘poor’, ‘good’, ‘very good’ or ‘excellent’ with 0-24%, 25-49%, 50-74% and 75-100% improvement, respectively, in acne scars. Results 14 out of 15 patients in group A improved by at least 1 grade while all patients in group B improved. Two (13.3%) and 5 (33.3%) patients improved to Grade 2 in Group A and B, respectively. The improvement correlated with the patient's assessment of scar improvement: 60% of Group A and 66.6 % of Group B patients assessed an improvement of 25-49% and 50-74%, respectively. Overall, substantial improvement was noticed in rolling and boxcar scars with a minimal change in ice-pick scars. Conclusion PRP adds to the improvement of Grade 4 atrophic acne scars when combined with needling and subcision.

Mehak Singh

Friday, Nov. 16, 2018-from 11:10 to 11:18

A Randomised control comparison of treatment of Acne vulgaris using carbon augmented Q switched Nd:YAG versus salicylic acid chemical peeling. Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background and objective Acne vulgaris is a common inflammatory disorder but its treatment is a vexing problem due to its recurrent nature. The treatment modalities comprise mostly of agents that cause antimicrobial resistance or are teratogenic. Thus, the effectiveness of two Acne vulgaris treatments was compared: peeling with salicylic acid (SA) and carbon Q switched Nd:Yag laser(CQSL). Methodology 31 consecutive patients with moderate to severe facial acne attending the skin department were randomized in to 2 groups after matching: group I, treatment with SA peels (20%) and group II, treated with carbon Q switched laser. Baseline grading of acne was done with Michelsons Acne severity index(MASI).Right and left sides of the face were scored separately and total score was taken. Photographs were taken before and after six sessions of each treatment, carried out twice weekly. To compare the differences between the treatments, the Student t-test was used. Results 23 enrolled patients completed the study (M:F=2.29); both the groups revealed a reduction in the number of lesions but topical carbon solution with Q switched laser showed a significant difference in reducing thenumber of lesions(1st group reduction of approximately 56.23% of MASI and 2nd group showed areduction of 89.3 % at the end of 16 weeks,p=0.0026) and achieving a long term sustained remission atthe end of 6 months.(53.2% relapse rate in SA group vs 19.7% in CQSL). Conclusion Topical Carbonassisted Q-switched Nd:YAG laser showed significantly better clearance of acne than SA peel.

Anil Kumar Bhatta

Friday, Nov. 16, 2018-from 11:18 to 11:26

(IÂżFDF\ DQG VDIHW\ RI IUDFWLRQDO FDUERQ GLR[LGH &2 ODVHU FRPELQHG WRSLFDO WKHUDS\ IRU WKH WUHDWPHQW RI RQ\FKRP\FRVLV Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background: Inability of topical medications to penetrate via nail plate brings a great challenge toclinicians in treating onychomycosis. Objectives: We sought to evaluate the clinical efficacy of fractional carbon-dioxide laser-assisted topical therapy for onychomycosis. Materials & Methods: In total, 75 patients with 356 onychomycotic nails confirmed by mycologic examination wereincluded in this study. All the affected nails received 3 sessions of laser therapy at 4-week intervals andonce-daily application of terbinafine cream for 3 months. Results: In all, 94.66% and 92% of the treated patients were potassium hydroxide and culture negative,respectively, after 3 months of treatment. However, only 84% and 80% were potassium hydroxide andculture negative, respectively, at 6 months of follow-up. Conclusions: Fractional carbon-dioxide laser therapy combined with topical antifungal was found to beeffective in the treatment of onychomycosis.

Ayush Jha

Friday, Nov. 16, 2018-from 11:26 to 11:34

Muco-cutaneous manifestations of hiv infected patients in anti-retroviral era: a cross-sectional study from central nepal. Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background: Muco-cutaneous dermatoses (MCD) are commonly associated with Human Immunodeficiency Virus (HIV) infection. However, introduction of combined antiretroviral therapy (cART) is bound to alter the prevalence and pattern of these dermatoses. Objective: To compare MCD observed in HIV infected patients on cART with treatment naĂŻve seropositive patients. Methods: A total of 300 HIV seropositive cases (cART=200, Treatment naive=100) were screened. Diagnosis was made clinically with relevant laboratory investigations when necessary. Results: Overall, 66% of our patients had MCD and they were more prevalent in treatment naĂŻve group (p value=.002). Infectious and noninfectious dermatoses were more prevalent in treatment naĂŻve group (p value<.001) and cART group (p value=.007), respectively.(Table 1,2) The observed CD4 count was higher in the cART group (p value<.001). Conclusion: Prevalence and pattern of MCD in HIV has significantly altered with introduction of cART.

Fatma Jendoubi

Friday, Nov. 16, 2018-from 11:34 to 11:42

Gingival enlargement revealing a laryngeal and pulmonary tuberculosis Session: ISD Global Education Awards

RM 201D-LEVEL 2

Tuberculosis is a chronic granulomatous infectious disease and is a major health problem in most developing countries. Oral tuberculosis lesions are extremely rare. We report a case of a 27- years-old female who presented with a gingival enlargement associated with regional lymphadenopathies and dysphonia. Intraoral examination showed diffuse enlargement of palatal mucosa and labial maxillary gingiva. Gingival mucosa was red and had tendency for bleeding. Diagnosis of oral tuberculosis was based on histopathologic examination. Endoscopy of the nasal cavities revealed exophytic nasopharyngeal mucosa. The cervico- thoracic-CT scan showed an enlargement of the laryngeal mucosa associated with multiple laryngeal cyst associated with multiple pulmonary nodules. Features were consistent with laryngeal and pulmonary tuberculosis. Tuberculin skin test was also performed and was positive. The patient was given an anti-tuberculosis treatment for 6 months with a great clinical improvement.

Mihoub Bourakba

Friday, Nov. 16, 2018-from 11:42 to 11:50

Unusual presentations of Kaposi Sarcoma :Series of clinical cases Session: ISD Global Education Awards

RM 201D-LEVEL 2

NTRODUCTION Kaposi sarcoma (KS) is a multifocal angioproliferative disorder of vascular endothelium. Four clinical variants of classic, endemic, iatrogenic, and epidemic KS are described for the disease. Kaposi sarcoma lesions evolve from patch macules into plaques that grow into larger nodules. The aim of this paper is to report 6 particular clinical presentations of this disease MATERIAL-METHODS We selected six patients that were followed in our clinic of dermatology. Diagnosis was based on clinical manifestations, systemic examinations and treatment of biopsy-proved. All patients presented vascular proliferation and human herpesvirus 8 infection RESULTS 'LIIHUHQW FOLQLFDO YDULDQWV RI WKH FXWDQHRXV OHVLRQV RI .6 KDYH EHHQ LGHQWLÂżHG &DVH RQH 3\RJHQLF JUDQXORPDÂąOLNH D UHG ÂżUP QRGXOH DERXW FP GLDPHWHU JURZLQJ IURP WKH ODWHUDO DVSHFW RI WKH QHFN 95

Case two: lupus pernio-like; purple indurated plaques and nodules affecting the nose and cheeks Case three: Nodules with sporotrichoid spread, located on the left extensor forearm &DVH IRXU ODUJH YLROHW SODTXH ZLWK LQGXUDWLRQ DQG LQÂ¿OWUDWLRQ RI WKH VNLQ ORFDWHG RQ WKH OHIW OHJ &DVH Â¿YH $QJLRNHUDWRPD OLNH EOXH SDSXOHV RQ VFURWXP VNLQ &DVH VL[ O\PSKDQJLRPD OLNH OHVLRQV GHYHORS RQ WKH ORZHU H[WUHPLWLHV WKDW FRQVLVW RI FRPSUHVVLEOH QRGXOHV WKDW DSSHDU WR EH Ã&#x20AC;XLG Â¿OOHG F\VWV CONCLUSION The clinical spectrum of KS has been expanded to include other forms. This rare neoplasm can mimic other disease processes, the correct diagnosis relies heavily on the recognition of salient clinical and histological features of conventional KS, including a strong immunohistochemical expression of HHV-8 Keywords: kaposi sarcoma,unusual presentations,Imitator

Awatef Kelati

Friday, Nov. 16, 2018-from 11:50 to 11:58

3DWWHUQV RI YLWDPLQ ' GHÂ¿FLHQF\ LQ GHUPDWRORJLFDO GLVHDVHV $ FURVV VHFWLRQDO VWXG\ Session: ISD Global Education Awards

RM 201D-LEVEL 2

Introduction: Vitamin D is recognizable today as a vitamin with multiple potentialities, involved in many physiological processes and in different tissues including the skin. The aim of the study was to describe the profile of Vitamin D in different dermatoses and to detect the factors significantly related to vitamin D deficiency in these dermatoses. Material/Methods: A Cross-sectional study over a period of one year (2015-2016). Results: The number of patients in whom Vitamin D was measured was 194 patients, which represents 7.5% (194/2570) of the total dosages of Vitamin D at the hospital Hassan II of Fez. The average age of patients was 47.4 (+/- 18.8). There was a female predominance (65% of cases). Inflammatory diseases represented 67% of the dermatoses included in our study as: psoriasis (45.4%), pemphigus (12.2%) and lupus (8.3%). Tumoral diseases (17% of cases ) were mainly represented by squamous cell carcinoma (29.4%), melanoma (26.4%) and Mycosis fungoides (17.6%). Vitamin D was normal or sufficient in 7.8% of cases (19), insufficient in 59.3% (115) and deficient in 36.6% (71). Vitamin D was insufficient in inflammatory, tumoral and infectious diseases, while it was deficient in toxidermia and eschar. 3VRULDVLV KDG WKH KLJKHVW PHDQ RI YLWDPLQ ' LQ WKH LQÃ&#x20AC;DPPDWRU\ SDWKRORJ\ FRPSDUHG WR EXOORXV GHUPDWRVHV OXSXV YLWLOLJR DQG RWKHUV The means of the tumoral diseases and genodermatoses were almost the same, while leishmaniasis had the lowest average of Vitamin D in the infectious pathologies. 9LWDPLQ ' ZDV VLJQLÂ¿FDQWO\ GHÂ¿FLHQW DQG LQVXIÂ¿FLHQW LQ LQÃ&#x20AC;DPPDWRU\ GLVHDVHVâ&#x20AC;&#x2122; Ã&#x20AC;DUH XSV DQG DGYDQFHG VWDJH RI PDOLJQDQW WXPRUDO GLVHDVHV Conclusions: Our results proved that there is a deficiency of vitamin D in patients having dermatoses, which was also confirmed in recent data of the OLWWHUDWXUH 9LWDPLQH ' OHYHOV ZHUH VWXGLHG LQ VHYHUDO GHUPDWRVHV ZKLFK DOORZHG XV WR PDNH D FRPSDULVRQ $OWKRXJK 9LWDPLQH ' ZDV LQVXIÂ¿FLHQW in psoriasis, this frequent inflammatory disease had the highest mean of vitamin D level compared to other dermatoses, which could be explained by sun exposure usually advised to these patients. 7KH YLWDPLQ ' GHÂ¿FLHQF\ LQ GHUPDWRVHV VKRXOG OHDG WR WKH HVWDEOLVKPHQW RI JXLGHOLQHV IRU WKH V\VWHPDWLF GRVLQJ RI WKLV YLWDPLQ LQ SDWLHQWV ZLWK dermatological diseases in addition to the supplementation of vitamine D alongside the medical treatment

Shivani Reddy

Friday, Nov. 16, 2018-from 11:58 to 12:06

$QWL LQÃ&#x20AC;DPPDWRU\ WKHUDS\ ZLWK WXPRU QHFURVLV IDFWRU LQKLELWRUV LV DVVRFLDWHG ZLWK UHGXFHG ULVN RI PDMR adverse cardiovascular events in psoriasis Session: ISD Global Education Awards

RM 201D-LEVEL 2

Background 3VRULDVLV LV D V\VWHPLF FKURQLF LQÃ&#x20AC;DPPDWRU\ FRQGLWLRQ DVVRFLDWHG ZLWK LQFUHDVHG ULVN RI FDUGLRYDVFXODU &9 GLVHDVH Objective To determine whether tumor necrosis factor inhibitor (TNFi) therapy is associated with decreased major adverse CV events (MACE) in psoriasis patients. Methods Retrospective cohort study in which patients had at least 3 ICD-9 codes for psoriasis and no antecedent MACE codes. Propensity scoreadjusted multivariable cox regression assessed hazard ratios (HR) of MACE associated with TNFi use. Results 7KH 71)L FRKRUW KDG VLJQLÂ¿FDQWO\ ORZHU 0$&( +5 FRPSDUHG ZLWK WKH WRSLFDO FRKRUW +5 &, 7KH RUDO SKRWRWKHUDS\ FRKRUW had similar MACE HR compared with the topical cohort (HR, 1.19 (95% CI, 0.99-1.42). Conclusions :H REVHUYHG VLJQLÂ¿FDQWO\ ORZHU 0$&( ULVN LQ SVRULDVLV SDWLHQWV UHFHLYLQJ 71)L FRPSDUHG WR WRSLFDO RU RUDO SKRWRWKHUDS\ DJHQWV

Frank Po-Chao Chiu The utility of Tele-Derm in the diagnosis and management of two rare dermatological presentations Session: ISD Global Education Awards

Friday, Nov. 16, 2018-from 12:06 to 12:14 RM 201D-LEVEL 2

We present two cases with extremely rare presentations that used an Australian teledermatology service called Tele-Derm National (TDN) to assist in their diagnosis and management. Firstly, a 20-year-old male presented with a 1-month history of centrally-umbilicated, papular lesions and associated pale exudate, localised to both ears. TDN correctly diagnosed his condition as perforating granuloma annulare (PGA), which was supported on biopsy. There is one case report of PGA at this site to date. Secondly, a 90-year-old male presented with an 8-month history of an eruptive papular rash to his upper arms, trunk and face that did not respond to topical steroids or anti-histamines. Biopsies revealed Indeterminate Cell Histiocytosis-roughly 80 cases have been reported to date. TDN recommended patient admission for topical therapy, from which the patient improved. In conclusion, teledermatology can be effective in diagnosing and managing even rare dermatological presentations.

Nathalia H. Malvehy Frontal Fibrosing Alopecia in a Latinamerican man Session: ISD Global Education Awards

Friday, Nov. 16, 2018-from 12:14 to 12:22 RM 201D-LEVEL 2

A 38-year-old man consulted for longstanding history of hair loss. Clinical examination showed diminished hair density and recession of frontotemporal hairline involving sideburns, eyebrows, beard and armpitsÄ&#x2021; hair. He had flesh color papules in the face giving a cobbled appearance. Biopsies were consistent with frontal fibrosing alopecia (FFA), but increased variability in hair shaft diameter suggested coexistence of androgenetic alopecia. Patient was started on intralesional triamcinolone, hydroxychloroquine, and topical dutasteride, minoxidil, mometasone. :H SUHVHQW WKH ÂżUVW FDVH RI ))$ LQ D \RXQJ ODWLQDPHULFDQ PDQ FDVHV LQ PHQ KDYH EHHQ UHSRUWHG FRH[LVWHQFH ZLWK DQGURJHQHWLF DORSHFLD its common. In men, presentation before 40 years-old is exceptional. FFA is characterized by recession of hairline in frontal region. It is not clear why alopecia occurs in this pattern; the distribution of androgen-sensitive follicles could be a link between hormones and autoimmunity.

Welcome Message Dear Friends and Colleagues, We are delighted to invite you to the biannual Regional Medical Mycology Training Network (MMTN) Conference 2018, which will be held in conjunction with the 44th Annual General Meeting of the Taiwan Dermatological Association and the 6th Continental Congress of Dermatology on 17â&#x20AC;&#x201C;18 November 2018 in Taipei International Convention Center, Taipei, Taiwan.

The meeting is the 6th in the series of regional MMTN conferences organized by the Asia Fungal Working Group (AFWG), an International Society for Human and Animal Mycology (ISHAM) working group. The program will keep you up to date with contemporary perspectives and hot topics in the diagnosis and management of invasive fungal infections, including culture-based and nonâ&#x20AC;&#x201C; culture-based diagnostic techniques, clinical management of fungal diseases in Asian hospitals, and collaborative diagnostic-therapeutic approach to improve outcomes. There will be a strong focus on Asian perspectives and practical application through workshops, interactive cases and discussions led by an esteemed faculty from Asia and beyond. The Regional MMTN Conference is not to be missed for infectious disease physicians, intensivists, transplant physicians, hemato-oncologists, microbiologists, laboratory personnel and all those with interests in medical mycology in the region. We are grateful for the collaboration with Taiwan Dermatological Association and International Society of Dermatology to make this a truly collaborative and comprehensive fungal conference. We look forward to seeing you and to insightful scientific exchange in the beautiful city of Taipei !

Co-chairs Professor Arunaloke Chakrabarti and Professor Ruoyu Li Asia Fungal Working Group, an ISHAM working group

Arunaloke Chakrabarti, MD, Dip NB, FAMS, FNASc, FIDSA

Ruoyu Li, MD

About the Asia Fungal Working Group

The Asia Fungal Working Group (AFWG) , an International Society for Human and Animal Mycology (ISHAM) working group, is dedicated to advancing the standards of diagnosis and management of invasive fungal infections in the $VLD 3DFL¿F UHJLRQ The AFWG was founded in 2009 by a group of infectious disease and mycology experts from various Asian countries. The AFWG became a working group under ISHAM in 2010. AFWG’s core commitments and activities include education and training to disseminate updated knowledge and share experience, research and collaborative studies, and surveillance of fungal infections in the AsiaPacific region. 7KH RI¿FLDO $):* ZHEVLWH ZZZ DIZJRQOLQH FRP VHUYHV DV D FRPSUHKHQVLYH portal for the delivery of mycology information tailored to researchers and healthcare professionals in the region.

About the Medical Mycology Training Network

The Medical Mycology Training Network (MMTN) is a series of regional and local conferences specially designed and organized by the AFWG to provide essential knowledge and practical experience in the diagnosis and management of invasive fungal infections, ultimately helping to improve patient outcomes across the Asia-Pacific region. Each MMTN Conference features a variety of learning activities, including clinical lectures, laboratory practice and workshops, demonstrations, case challenges and interactive discussions. The programs are led by highly esteemed experts in the field. Since its inception, the AFWG has held biannual Regional MMTN Conferences and numerous country-based MMTN conferences per year, training and benefiting many clinicians, microbiologists and other mycology professionals across the region

Saturday, 17 NOV. RM 102 Level 1 08:30-10:00

MMTN (I) Moderator: Ruoyu Li (China) 澽 08:30-08:40 Welcome and opening remarks 澽 08:40-09:20 The bad news: Emerging resistant fungi 澽 09:20-10:00 The good news? Making best use of current and new antifungal therapy

Li-Fang Wang ( 䉉則共 , Taiwan) Yee-Chun Chen ( 攱⩚⋙ , Taiwan) Yee-Chun Chen ( 攱⩚⋙ , Taiwan) Tan Ban Hock (Singapore)

10:30-12:00

MMTN (II) Moderator: Low Lee Lee (Malaysia) 澽 10:30-11:00 (QGHPLF P\FRVHV LQ WKH $VLD 3DFL¿F UHJLRQ 澽 11:00-11:30 Advances in fungal diagnostics and application in Asian laboratories 澽 11:30-12:00 New susceptible group of patients for invasive fungal infections

Methee Chayakulkeeree (Thailand) Ariya Chindamporn (Thailand) Tan Ban Hock (Singapore)

13:30-15:00

MMTN (III) Moderator: Tan Ban Hock (Singapore) 澽 13:30-14:00 Fungal infections in solid organ transplant patients 澽 14:00-14:30 How to use antifungal PK/PD in clinical practice 澽 14:30-15:00 Is prophylaxis for PJP infection necessary during the use of biologic agents?

Hsin-Yun Sun ( ⨩ⴶ䨞 , Taiwan) Atul Patel (India) Kai-Che Wei ( 樍㠵⎰ , Taiwan)

15:30-17:15

MMTN (IV) Moderators: Retno Wahyuningsih (Indonesia), Ming-Long Hsu ( 壯㓌敄 , Taiwan)

澽 15:30-16:00 澽 16:00-16:30 澽 16:30-17:00 澽 17:00-17:15

Burden of invasive cutaneous fungal infections in Asia Secondary cutaneous mycosis-indicator of lethal disease 'LI¿FXOW WR WUHDW LQYDVLYH FXWDQHRXV IXQJDO LQIHFWLRQV Closing remarks of Day 1

Ruoyu Li (China) Sybren de Hoog (Nederland) Pei-Lun Sun ( ⨩⚷ứ , Taiwan) Ruoyu Li (China)

Sunday, 18 NOV. RM 102 Level 1 08:30-10:05

MMTN (V) Moderator: Mitzi Chua (Philippine) 澽 08:30-08:35 澽 08:35-09:05 澽 09:05-09:35 澽 09:35-10:05

Welcome and opening remarks What’s new in Malassezia infections? Sporothricosis in Asia Chronic pulmonary aspergillosis

Tan Ban Hock (Singapore) Ariya Chindamporn (Thailand) Fairuz Amran (Malaysia) Retno Wahyuningsih (Indonesia)

10:30-12:00

MMTN (VI) Moderator: Methee Chayakulkeeree (Thailand), Atul Patel (India) 澽 10:30-10:50 澽 10:50-11:10 澽 11:10-11:30 澽 11:30-11:50 澽 11:50-12:00 100

Case challenge 1 Case challenge 2 Case challenge 3 Case challenge 4 Closing remarks

Atul Patel (India) Zhengyin Liu (China) Methee Chayakulkeeree (Thailand) Low Lee Lee (Malaysia) Tan Ban Hock (Singapore)

Speakers MMTN

101

Fairuz Amran, Fairuz Amran is a Clinical Microbiologist in the Institute for Medical Research (IMR) since 1997 with diagnostic laboratory responsibilities and research interest in human leptospirosis, mycology and infections in the immunocompromised. She acquired both her professional degrees [MD and MPath (Clinical Microbiology) ) from Universiti Kebangsaan Malaysia and trained in leptospirosis work in Amsterdam and the Veterinary Faculty of Universiti Putra Malaysia. In mycology, she established the first anti-fungal susceptibility testing services in the Ministry of Health and subsequently the applications of antigen and molecular detection and characterisation of invasive fungal infection. The mycology laboratory in IMR now has the breadth and depth of expertise befitting a national reference mycology laboratory. It also served as the research laboratory for industry-sponsored phase II antifungal clinical trial conducted in Ministry of Health hospitals. Several innovative fungal diagnostic kits have also been developed with commercialisation potential. Besides diagnostic and research, she is also involved in the training and dissemination of laboratory practices and establishment of laboratory standards in leptospirosis and mycology. The emphasis is on the development of a national center of excellence in IMR and the setting up of basic fungal and leptospirosis laboratory services in the regional centres. Dr Fairuz Amran is also an active member of numerous professional societies, both locally and abroad. Methee Chayakulkeeree, Methee Chayakulkeeree is associate professor at the Division of Infectious Diseases and Tropical Medicine of the Department of Medicine of the Faculty of Medicine Siriraj Hospital, Mahidol University in Bangkok, Thailand. Dr. Chayakulkeeree is a diplomate of the Thai Board of Internal Medicine and the Subspecialty Board of Infectious Diseases, and a fellow of The Royal College of Physicians of Thailand. He received further training in the USA for infectious Diseases and molecular Mycology, and received his PhD in Infectious Diseases and Microbiology from the University of Sydney, Australia. Dr. Chayakulkeeree is affiliated with various local and international medical societies, including the International Society for Infectious Diseases, American Society for Microbiology, and the Infectious Diseases Society of America. He has published more than 30 papers in peer-reviewed scientific journals, and has written several book chapters on infectious disease.

Yee-Chun Chen, Yee-Chun Chen is a professor of medicine at the National Taiwan University Hospital and College of

Medicine in Taipei, Taiwan. She is also an investigator of the National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes of Taiwan. Professor Chen also serves as vice president of the International Society for Human and Animal Mycology (ISHAM). One of Taiwanâ&#x20AC;&#x2122;s leaders in medical mycology and infection control, Professor Chenâ&#x20AC;&#x2122;s research focus includes clinical and molecular epidemiology of invasive fungal diseases, surveillance of healthcare-associated infection and informatics, the development of new diagnostic and therapeutic strategies for invasive fungal infections, and pathogenesis of Candida infections. Professor Chen has received several achievement awards (including the Asia Pacific Hand Hygiene Excellence Award in 2011), and has authored and co-authored more than 200 peer-reviewed journal articles published in prestigious journals, including the Clinical Infectious Diseases, Emerging Infectious Diseases, the Journal of Antimicrobial Chemotherapy, Clinical Microbiology and Infection, the Journal of Clinical Microbiology, Medical Mycology, and many others.

Ariya Chindamporn, Ariya Chindamporn is associate professor at the Department of Microbiology of the Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand. She is also head of the Mycology Unit at King Chulalongkorn Memorial Hospital in Bangkok. Dr. Chindamporn received her doctoral degree in basic sciences from Nagoya University, Japan, in 1995. Her research interests are in the molecular diagnosis, molecular identification, epidemiology and pathogenesis of medically emerging fungi and parafungi in Thailand, including AIDS-related mycoses and pythiosis, which are becoming endemic in Thailand.

Mitzi Chua, Mitzi Chua is associate professor and current chair of the Department of Microbiology and Parasitology

of the Cebu Institute of Medicine, and is affiliated as infectious disease specialist in the major hospitals of Cebu City, Philippines. She obtained her medical degree from the Cebu Institute of Medicine and trained at the Cebu (Velez) General Hospital and the University of the Philippines-Philippine General Hospital in Manila, Philippines. Dr. Chua is a past president of the local/regional chapters of the Philippine Society for Microbiology and Infectious Diseases and the Philippine College of Physicians. She is also a fellow of the Infectious Diseases Society of America.

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Ruoyu Li, Ruoyu Li serves as director of the Department of Dermatology at Peking University First Hospital, director of the Beijing Skin Disease Molecular Diagnostic Laboratory, director of the Skin Disease Prevention and Control Center at Peking University, and associate director of the Mycology and Mycological Diseases Research Institute at Peking University in Beijing, China. Dr. Li is involved in numerous professional organizations: she is currently the president of the China Dermatologist Association; standing committee member of the Chinese Society of Dermatology of the Chinese Medical Association; and past chair of the Dermatology Committee of the Beijing Medical Association, among others. Dr. Li has tremendously advanced Chinaâ&#x20AC;&#x2122;s progress in the field of mycology and has received recognitions from Chinaâ&#x20AC;&#x2122;s Ministry of Health and Ministry of Education for her contributions in medical research and education. Her research on non-culture diagnosis has improved diagnostic practices and standardized diagnosis of mycological infections in China. She has also helped to establish an in-vitro monitoring system for antifungal therapy. Some resistance strains were isolated through the monitoring, and the mechanisms were further investigated.

Zhengyin Liu, Zhengyin Liu is the professor at the Infectious Disease Section of the Department of Internal Medicine, Peking Union Medical College Hospital in Beijing, China. Professor Liu completed his postgraduate studies (masterâ&#x20AC;&#x2122;s degree) at the Peking Union Medical College and Chinese Academy of Medical Sciences. He received certification of GCP in clinical pharmacological training in August 2000. Professor Liu also received HIV/AIDS training from the Regional Physicians Training Course in HIV medicine in association with the John E Fogarty International AIDS International Training and Research Program and from the AIDS Healthcare Foundation in the USA. Professor Liu is on the editorial board of the Chinese Journal of Internal Medicine, the Chinese Journal of Fungus, the Chinese Journal of Practical Internal Medicine and the Journal of Internal Intensive Medicine. He is also a clinical expert of the AIDS Group and the Rational Use of Antibiotics Group of the Ministry of Health, China, and is a board member of the Infectious Disease Society of China.

Low Lee Lee, Low Lee Lee is Infectious Disease Physician in the Department of Medicine, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia. Dr. Low graduated from the National University of Malaysia and obtained her MRCP (UK) in 2006. She has trained as an infectious disease fellow in Hospital Pulau Pinang and Hospital Sungai Buloh in Malaysia, as well as in St Vincentâ&#x20AC;&#x2122;s Hospital in Sydney Australia. At the Hospital Sultanah Bahiyah, Dr. Low is also Head of the Infection Control Unit and a committee member of the Antibiotic Stewardship Program. She has been co-investigator of several major studies in the field of infectious diseases.

Atul Patel, Atul Patel is the chief consultant and director of the Infectious Diseases Clinic of the Vedanta Institute of Medical Sciences and at the Department of Infectious Diseases of Sterling Hospital in Ahmedabad, India. He is also visiting assistant professor at the Division of Infectious Diseases at the University of South Florida in Tampa, Florida, USA. Dr Patel was conferred with fellowship of the Infectious Diseases Society of America (FIDSA) in 2014. Dr. Patelâ&#x20AC;&#x2122;s major interest and expertise is in the management of HIV-positive patients, particularly the use of antiretroviral therapy and treatment of opportunistic infections apart from invasive fungal infections. He has been presenting his work at Indian and international meetings since 1996, and has published extensively in peer-reviewed journals, including the Journal of Acquired Immune Deficiency Syndromes, Intensive Care Medicine, Mycoses, Muscle & Nerve, Medical Mycology, the Journal of Postgraduate Medicine, the Journal of the Association of Physicians of India, the Journal of Global infectious Diseases and the Journal of the International Association of Physicians in AIDS Care.

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Pei-Lun Sun, Pei-Lun Sun is an attending physician and assistant professor in the Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. Dr Sun completed his medical degree at Kaohsiung Medical College, a master’s degree in clinical medicine at National Taiwan University and a PhD degree in ecology and evolutionary biology at the National Taiwan University. Dr Sun completed his residency in the Department of Dermatology at Mackay Memorial Hospital in Taiwan. He has a broad interest in medical mycology, from diagnosis and treatment of mycoses, to isolation of pathogenic fungi from the environment. His long-term interest is in the study of dermatophyte infections, especially tinea capitis, zoonotic dermatophytosis and onychomycosis. He also constantly cooperates with veterinary physicians in the diagnosis of animal mycoses. He is now the head of Research Laboratory of Medical Mycology at Chang Gung Memorial Hospital. Dr Sun is a member of a number of scientific organizations, including the Taiwanese Dermatological Association, the Taiwanese Society for Investigative Dermatology, the American Academy of Dermatology, the International Society for Human and Animal Mycology and the Mycological Society of Taiwan.

Hsin-Yun Sun, Hsin-Yun Sun is Attending Physician at the Division of Infectious Diseases, Department of Internal

Medicine, National Taiwan University Hospital, Taipei, Taiwan. She is also Clinical Associate Professor of Internal Medicine at the National Taiwan University College of Medicine, Taipei, Taiwan. Dr Sun graduated with a MD from the National Yang-Ming University and completed her residency training in internal medicine and her fellowship in infectious diseases at the National Taiwan University Hospital in Taiwan. She was a visiting scholar at the University of Pittsburgh Medical Center and a researcher at the VA Medical Center, Pittsburgh, USA, from 2007–2009. Dr Sun specializes in infectious diseases in solid organ transplant recipients and in patients with HIV/AIDS. She has authored or co-authored 8 book chapters, published more than 90 papers in peer-reviewed journals and presented more than 30 abstracts at international congresses.

Tan Ban Hock, Tan Ban Hock is a senior consultant in the Department of Infectious Diseases at the Singapore

General Hospital, where he was head of the department until April 2014. He was instrumental in setting up the department, and has since established programs where the department works closely with the transplant, hematology and oncology units. Dr. Tan is also adjunct associate professor at the Duke-NUS Graduate Medical School, Singapore. Dr. Tan graduated from the National University of Singapore and obtained his MRCP (Edinburgh) in 1995. He went on to train in infectious diseases in Singapore and at the Massachusetts General Hospital in Boston, Massachusetts, USA. He was conferred the title of FRCP in 2009. He is past president of the Society of Infectious Diseases (Singapore) , and was a member of Singapore’s Ministry of Health SARS Taskforce in 2003. He is currently a council member of the Transplant Infections Disease Section of The Transplantation Society, and sits on the editorial board of Transplant Infectious Disease. Dr. Tan has a keen interest in the study of infections in immunocompromised hosts, and is particularly interested in infections in transplant recipients and febrile neutropenic patients.

Retno Wahyuningsih, Retno Wahyuningsih is a professor of medical mycology at the Division of Mycology, Department of Parasitology, Faculty of Medicine of the University of Indonesia in Jakarta, Indonesia. She is also affiliated with the Department of Parasitology, Faculty of Medicine of the Christian University of Indonesia in Jakarta.

Kai-Che Wei, E-mail: kaijhe@gmail.com

Current position: Dermatology, Kaohsiung Veterans General Hospita, Taiwan Education: Medical School of National Cheng-Kung University, Tainan, Taiwan (MD. & M.S.) Occupation History: Visiting Staff of Dermatology, Medical Center of National Cheng Kung University, Tainan, Taiwan Research fields: 1. Radiation skin damage, percutaneous cardiac intervention-induced 2. Dengue virus induced skin disorder 3. Pathophysiology of pemphigus

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Abstract MMTN

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Fairuz Amran Sporotrichosis in Asia Session: MMTN (V)

Sunday, Nov. 18, 2018-from 09:05 to 09:35 RM102-LEVEL 1

Sporotrichosis is caused by the dimorphic fungus Sporothrix schenckii. It has a worldwide distribution, occurring in countries with tropical, subtropical and temperate climates. The global incidence of sporotrichosis is unknown but is estimated to range between 1 in 1,000 population to 1 in 1 million population from reports obtained all over the world. Hyperendemic countries for the infections include China, Peru, India and Brazil. The disease is grossly under reported in many countries especially in Asia due to the limited availability of diagnostic facilities. Most reports of sporotrichosis in Asia were from China, India and Japan, although there were scattered publications from countries like Malaysia, Thailand, Indonesia, Vietnam and Cambodia. The gold standard for sporotrichosis diagnosis is culture. However, serological, histopathological, and molecular approaches are important additional tools for diagnosis of the infections. Sporothrix schenckii is found ubiquitously in soil, plants and organic matter. The most common form of infections are cutaneous and subcutaneous sporotrichosis which may extend to adjacent lymphatics, characterized by nodular and sometimes suppurative and ulcerative lesions. Other rare infections include osteoarticular, pulmonary, central nervous system and genitourinary infections. Infections were traditionally caused by traumatic inoculation of the skin with fungal spores from plants or decaying matter, such as rose thorns (â&#x20AC;&#x153;rose gardenerâ&#x20AC;&#x2122;s diseaseâ&#x20AC;?), decaying corn stalks and wood. Zoonotic sporotrichosis which were commonly related to cat scratches and bites have been described in isolated cases and in small epidemics. The mortality due to this disease in human is very XQFRPPRQ +RZHYHU LW LV D VLJQLÂżFDQW FDXVH RI PRUELGLW\ DPRQJVW WKRVH DW ULVN DQG FDQ EH D VLJQLÂżFDQW WKUHDW WR LPPXQRVXSSUHVVHG SDWLHQWV Therefore, there is a need to explore ways of prevention and control of the disease especially in the hyperendemic regions.

Methee Chayakulkeeree (QGHPLF P\FRVHV LQ WKH $VLD 3DFLÂżF UHJLRQ Session: MMTN (II)

Saturday, Nov. 17, 2018-from 10:30 to 11:00 RM102-LEVEL 1

(QGHPLF P\FRVHV DUH V\VWHPLF IXQJDO LQIHFWLRQV FDXVHG E\ VSHFLÂżF WKHUPDOO\ GLPRUSKLF IXQJL FRPPRQO\ IRXQG LQ SDUWLFXODU DUHDV 7KHVH IXQJDO pathogens include Histoplasma capsulatum, Talaromyces marneffei, Sporothrix schenckii, Coccidioides immitis, Paracoccidioides brasiliensis and Blastomyces dermatitidis. Histoplasmosis, talaromycosis and sporothricosis are considered endemic mycoses, at least in some parts, in WKH $VLD 3DFLÂżF UHJLRQ $OWKRXJK WKH WUXH EXUGHQ RI WKHVH HQGHPLF IXQJDO GLVHDVHV LQ WKH $VLD 3DFLÂżF DUH XQFOHDU GXH WR IHZ HSLGHPLRORJLFDO surveys performed, these infections cause a significant public health and economic impacts. Talaromycosis is prevalent in Southeast and East Asia such as northern Thailand, northern Vietnam and southern China. However, there is no certain ecological niche for histoplasmosis and sporothricosis. In a country, histoplasmosis may be more prevalent in some areas than the others, such as southern Thailand. During the pandemic of HIV/AIDS, the incidence of these endemic mycoses rose dramatically. Histoplasmosis is one of the common systemic mycoses that can be found in apparently immunocompetent individuals. Nowadays, the number of cases with endemic mycoses is still substantial in those with immunocompromised condition such as transplant recipients or patients with corticosteroid use. Furthermore, recent evidence also shows that there is a link between talaromycosis and anti-interferon-gamma autoantibody syndrome. Exploring new risk factors and extensive epidemiological study are therefore warranted to improve the diagnosis and treatment outcome of patients in the endemic areas of systemic mycoses.

Ariya Chindamporn Advances in fungal diagnostics and application in Asian laboratories Session: MMTN (I)

Saturday, Nov. 17, 2018-from 11:00 to 11:30 RM102-LEVEL 1

The frequency of fungal infections, especially of invasive fungal infections, has risen dramatically. The mortality rate is high as 50% of patients HYHQ ZLWK SURSHU WUHDWPHQW 1RQVSHFLÂżF FOLQLFDO VLJQV DQG V\PSWRPV DUH RQH RI WKH FKDOOHQJHV OHDGLQJ WR WKH DEVHQFH RI GLDJQRVLV ,QDFFXUDWHO\ diagnosed fungal sepsis and failure to diagnose chronic pulmonary aspergillosis in smear-negative pulmonary tuberculosis are attributed to the usage of broad-spectrum antibacterial drugs. Thus, poor clinical outcomes owing to these situations warrant greater access to advanced fungal diagnostics to improve clinical outcomes, control antimicrobial resistance and decrease the unnecessary use of antifungal agents. Currently, conventional microbiological, histological and radiological techniques remain the cornerstone of diagnosis. Additionally, several novel tests have been established to overcome the limited impact of conventional methods on clinical decision-making. Molecular-based techniques, including T2 magnetic resonance for candidemia diagnosis, immunohistochemistry-molecular identification of the fungus in the tissue, fluorescence in situ hybridization (FISH) and proteomic-based techniques such as matrix-assisted laser desorption ionization (MALDI) for fungal identification, have become common tests. One limitation with these tests is that they are only able to detect pathogens upon clinical infection. To overcome this defective point, novel prospective diagnostic tests have been developed in recent years. These include the combination of polymerase chain reaction (PCR) and galactomannan tests, proximity ligation assay, detection of siderophore production and electronic nose technology for Aspergillus detection, and cryptococcal antigen lateral flow assay. These methods have various rates of success and need further validation. Based on the recent survey of 241 laboratory practices for fungal diagnosis in 7 Asian countries by an Asia Fungal Working Group (AFWG) LQLWLDWLYH SRRU DVVHVVPHQW RI ELRPDUNHU WHVWV VXFK DV JDODFWRPDQQDQ Č&#x2022; ' JOXFDQ DQG 3&5 ZDV UHYHDOHG LQ ,QGRQHVLD WKH 3KLOLSSLQHV DQG Thailand. This information indicates that training on advanced nonâ&#x20AC;&#x201C;culture-based diagnostic tests is needed for Asian laboratories to improve the process of fungal diagnostics and promote better quality of. in Asian populations.

Ariya Chindamporn Whatâ&#x20AC;&#x2122;s new in Malassezia infections? Session: MMTN (V)

Sunday, Nov. 18, 2018-from 08:35 to 09:05 RM102-LEVEL 1

Malassezia spp. are commensal fungi found on healthy skin and are also associated with skin-related diseases, seborrheic dermatitis, atopic dermatitis, and psoriasis in human. In the last two decades, the research on Malassezia has been increasing. 106

Variation of the Malassezia species is shown on the skin regardless of host conditions and their distribution is influence by age and geographic factors. The question of the association between these basidiomycetous yeasts and the skin is still ambiguous; whether the yeasts stimulate the skin disorders or the immune response from the skin disorders affect the yeasts is still largely unknown. Among 17 species of Malassezia, the recently identified species was Malassezia arunalokei (in 2016), which was found in patients with seborrheic dermatitis and in healthy individuals in India. Two main clinical spectrums are illustrated: pityriasis versicolor and Malassezia folliculitis. Identification of the organism to a species level is not necessary for diagnosis. However, it should be performed when the focus is on skin disease or epidemiological studies. It is also indispensable to identify up to the species level if appropriate antifungal agent is required.

Sybren de Hoog Secondary cutaneous mycosis-indicator of lethal disease Session: MMTN (IV)

Saturday, Nov. 17, 2018-from 16:00 to 16:30 RM 102-LEVEL 1

Most systemic infections caused by fungi such as Aspergillus or mucoralean members are of opportunistic nature. The course of disease is then largely dependent on the infection site and underlying conditions of the host, and hence quite variable. True systemic pathogens; however follow a pre-determined infection route. The majority of these, e.g. Histoplasma and Blastomyces, are members of the family Ajellomycetaceae. The number of recognized species is currently increasing dramatically, which can only partly be explained by the higher degree of diagnostic precision using molecular tools. The fungi are environmental pathogens with a double life cycle; several are mammal-associated, but some as yet are known from humans only. Pulmonary dissemination is followed by formation of cutaneous pustules and crusts. Underlying diseases generally involve impairment of acquired cellular immunity, and without therapy the infection is fatal. An overview is provided of the current taxonomic status of these fungi and the diseases they cause.

Ruoyu Li Burden of invasive cutaneous fungal infections in Asia Session: MMTN (IV)

Saturday, Nov. 17, 2018-from 15:30 to 16:00 RM 102-LEVEL 1

Invasive cutaneous fungal infections are relatively rare and usually occurs in immunosuppressed individuals. This talk will summarize the burden of mycoses in Asia that invade deep into the dermis and subcutaneous tissue, such as the neglected tropical disease: chromoblastomycosis, sporotrichosis and eumycotic mycetoma. In addition, deep dermatophytosis, cutaneous phaeo/hyalohyphomycosis as well as cutaneous mucormycosis, etc, will be discussed.

Atul Patel How to use antifungal PK/PD in clinical practice Session: MMTN (I)

Saturday, Nov. 17, 2018-from 14:00 to 14:30 RM 102-LEVEL 1

Invasive fungal infections (IFI) are associated with high mortality despite their diagnosis. The high mortality with IFI is likely associated with multiple factors like underlying immune dysfunction, organ dysfunctions, co-infections, fungal virulence and growing antifungal drug resistance (Candida glabrata, C. auris, and Aspergillus fumigatus). Antifungal drug resistance can emerge in a patient who has prior antifungal therapy, and suboptimal drug exposure. Agricultural use of antifungals is also an important concern for the emergence of voriconazole resistance to Aspergillus. Successful treatment outcome with antifungal drugs depends upon potency of drug (minimum inhibitory concentration [MIC]) and in vivo exposure of drug (pharmacokinetic [PK]). Understanding PK and pharmacodynamics (PD) of antifungal agents will help clinicians determine optimal dosage and duration of administration of antifungals to keep levels above MIC to eradicate fungal infections. PK describes how human body handles antifungal drug, ie, absorption (bioavailability), distribution (protein bound, penetrations to various body compartments), metabolism (cytochrome enzymes, drug-drug interactions) and elimination. PD is a link between PK, in vitro susceptibility and treatment efficacy. Apart from determining dosage and frequency of administration, PK/PD will also help in developing in vitro drug susceptibility break points. PK of antifungal is assessed by estimation of drug levels, while PD is examined by peak concentration in relation to MIC, AUC in relation to MIC, time above MIC, expressed as percentage of the dosing interval (%T>MIC). Broadly antimicrobials have concentration-dependent killing (Cmax/MIC) or time-dependent killing property (AUC/MIC). Drugs with concentration-dependent activity requires a single dose or infrequent dosage, while drugs with time-dependent activity requires frequent administration to keep drug level above MIC for longer duration of time (%T/MIC). Many drugs also induce a prolonged period of fungal growth inhibition after discontinuation/decreased drug level, this period of growth suppression is termed post-antifungal effect (PAFE). Triazole and flucytosine antifungal agents are examples of drugs with time-dependent killing and they also induce prolonged PAFE. Polyene and echinocandins demonstrate marked concentration-dependent killing activity and in vitro study also suggests PAFE. Table 1 summarizes the important PK/PD parameters of antifungal classes. Application of PK/PD principles to antifungal drug therapy has provided an understanding of the relationship between drug exposure and outcome. Optimal dosage selection based on PK/PD is associated with improved clinical outcomes and reduced drug toxicity; voriconazole and flucytosine are classic examples.

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Pei-Lun Sun 'LIÂżFXOW WR WUHDW LQYDVLYH FXWDQHRXV IXQJDO LQIHFWLRQV Session: MMTN (IV)

Saturday, Nov. 17, 2018-from 16:30 to 17:00 RM102-LEVEL 1

Fungal infections of the skin can be primary cutaneous or secondarily from a remote infection focus. Deep dermatophytosis, chromoblastomycosis, eumycotic mycetoma, sporotrichosis are diseases with skin as their primary organ of involvement. Occasionally, fungi can be incidentally introduced into the skin through traumatic implantation and result in cutaneous phaeohyphomycosis, cutaneous hyalohyphomycosis, cutaneous candidiasis, and cutaneous cryptococcosis. Small and localized lesion of these infections can be successfully treated with simple surgical excision. However, long-term systemic antifungals are usually necessary for patients having extensive and deep involvement of skin tissue. Currently, there is no guideline for the treatment of invasive cutaneous fungal infections. The treatment outcome depends on the host immunity, comorbidity of the patient, type of clinical disease, and susceptibility of the pathogen to antifungals.

Hsin-Yun Sun Fungal infections in solid organ transplant patients Session: MMTN (III)

Saturday, Nov. 17, 2018-from 13:30 to 14:00 RM102-LEVEL 1

Attending Physician, Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital; and Clinical Associate Professor, National Taiwan University College of Medicine, Taipei, Taiwan Despite the enlarging anti-fungal armamentarium, challenges in taking care of transplant recipients with invasive fungal infections remain. Candidiasis, aspergillosis, cryptococcosis, and mucormycosis are the common invasive fungal infections in solid organ transplant recipients. With the widespread use of anti-fungal agents, drug-resistant non-albican Candida, C. auris, and Aspergillus further complicate the situation. For solid organ transplant recipients, pre-transplant cryptococcosis, donor-derived cryptococcosis, cryptococcosis-related immune reconstitution inflammatory syndrome, and C. gattii are the issues to be discussed. Newly approved anti-fungal agents, such as isavuconazole, might mitigate the emerging resistance.antibiotics and the response observed. This presentation will discuss how to diagnose CPA, especially in resource-limited setting, and the options available to treat it in view of the emergence of drug-resistant strains.

Tan Ban Hock The good news? Making best use of current and new antifungal therapy Session: MMTN (I)

Saturday, Nov. 17, 2018-from 09:20 to 10:00 RM 102-LEVEL 1

The anti-fungal arsenal has never been better stocked. The past 20 years have seen a variety of new, friendlier anti-fungals enter the market. This development has been coupled with the introduction of new diagnostic techniques. Together the approach to fungal infections has been streamlined. In the setting of persistent fever in neutropenia, for example, empirical anti-fungals are challenged by the "diagnosis-driven" approach. New anti-fungals have enabled this refined approach, without compromising outcomes. In the ICU, the attempt to manage candidemia pre-emptively has spawned several interesting studies employing the new agents. Though the results have not been sterling, much insight has been gained into the problem of candidemia in the ICU. Perhaps what has been most satisfying to clinicians is the fact that many life-threatening fungal infections are now potentially treatable. The new azoles, in particular, have brought about remarkable improvements in survival.

Tan Ban Hock New susceptible group of patients for invasive fungal infections Session: MMTN (II)

Saturday, Nov. 17, 2018-from 11:30 to 12:00 RM 102-LEVEL 1

Traditional risk factors for invasive aspergillosis (IA) are neutropenia and steroid use. While these remain important, invasive aspergillosis is being seen in many different hosts. We can continue to improve survival in many patients by recognizing new risk factors for invasive aspergillosis. The proliferation of new drugs in haematology has meant new host categories for invasive aspergillosis. A few will be highlighted in the talk. Invasive aspergillosis, however, is also being recognized in more standard categories of patients. The main categories of patients increasingly recognized as being at risk for invasive aspergillosis include those in an intensive care unit, those with chronic obstructive pulmonary disease, those with liver failure, and those with severe influenza. The audience will be brought up to date on the latest literature on invasive aspergillosis and these "new" hosts.

Retno Wahyuningsih Chronic pulmonary aspergillosis Session: MMTN (V)

Sunday, Nov. 18, 2018-from 09:35 to 10:05 RM102-LEVEL 1

Chronic pulmonary aspergillosis (CPA) is a long-term lung infection that is progressive and incurable. It is caused by the same pathogens of the acute form of the disease, mainly Aspergillus fumigatus and, less frequently, A. niger and A. flavus; however, the 2 108

forms of the disease have different pathologic pathways. Untreated CPA may result in fibrosis and death. CPA affects more than 3 million individuals worldwide. Of these patients, approximately 1.2 million have a history of tuberculosis (TB) infection. This is of particular importance in Asia, as the majority of patients with active or residual TB are in India, China and Indonesia. CPA arises from underlying conditions that accommodate cavity formation or cause tissue damage. These prove to be fertile sites for the growth of Aspergillus. Aspergillus destroys lung tissue, which is further worsened by the production of proteolytic enzymes, toxins and other metabolites. Underlying conditions that are risk factors of CPA include: Deterioration in local and systemic defenses against infection due to alcohol/tobacco abuse and diabetes, presence of cavity due to bronchopulmonary disease such as active/ residual TB, sarcoidosis or chronic obstructive pulmonary disease, and prolonged use of low-dose oral or inhaled corticosteroids. Symptoms of CPA are often similar to that of other chronic infections, therefore, imaging and mycology investigations are important in supplementing clinical presentation when making a diagnosis. It is crucial to obtain an accurate history of underlying conditions to determine the likelihood of CPA. Conventional mycology tests can also be used to aid diagnosis; however, sensitivity and specificity, contamination and colonization issues should be considered when interpreting test results. Treatment can be initiated with antibiotics and the response observed. This presentation will discuss how to diagnose CPA, especially in resource-limited setting, and the options available to treat it in view of the emergence of drug-resistant strains.

Kai-Che Wei Is Prophylaxis for Pneumocystis jirovecii pneumonia infection Necessary during Use of Biologic Agents in Dermatologic Diseases? Session: MMTN (III)

Saturday, Nov. 17, 2018-from 14:30 to 15:00 RM 102-LEVEL 1

Rituximab is associated with higher incidence of Pneumocystis jirovecii pneumonia (PJP) infection. The mortality rate could be as high as 30%. Delay in PJP diagnosis is common because its initial manifestations are nonspecific. Although life threatening, PJP infection is preventable by administration of oral trimethoprim/sulfamethoxazole (TMP/SMX). Thus, regular PJP prophylaxis is recommended by treatment guidelines for WegenerÄ&#x2021;s granulomatosis and organ or hematopoietic transplant; however, the necessity of PJP prophylaxis for use of rituximab in dermatologic patients remains controversial. Our experience in one fatal PJP case prompted us to conduct a nationwide epidemiologic study in Taiwan. Our study reveals that rituximab have significantly higher PJP infection rate in pemphigus, but not in rheumatoid disease. Considering the high mortality rate of PJP and availability of easy and effective prophylaxis measure, PJP prophylaxis should be considered in rituximab treated pemphigus.

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About the Taiwan Dermatopathology Conference (TDPC) The Taiwan Dermatopathology Conference is an annual dermatopathology meeting organized by the dermatopathology group of both Taiwanese Dermatological Association and Taiwan Society of Pathology since 2013. Itâ&#x20AC;&#x2122;s an English-speaking meeting since the first one-and-half day meeting and then developed into two-day meeting in 2017. International speakers from Japan, Thailand, India, Philippines, Korea, Singapore, Malaysia, China, United States, have been invited to share their knowledge with dermatologists, pathologists, and students here. There are various activities, including lectures, microscope or digital self-assessment, videomicroscope session, and dermatopathology competition, to promote and enhance the learning of dermatopathology.

About the Asian Society of Dermatopathology (ASD)

In recent years, there has been growing international exchange of dermatopathology between Asian countries. Beginning in early 2016, there was a move to select representatives from each country to form a founding committee. After multiple meetings and discussions, the framework for the Asian Society of Dermatopathology (ASD) was drafted, and the decision was made to register the society in Taipei. On January 30th, 2018 the society was officially registered with the Ministry of the Interior of Taiwan and was approved on April 23rd, 2018. The aims and objectives of ASD are to enhance education of dermatopathology in Asia, reduce learning barriers, and promote the exchange of expertise and research among Asian member countries. By combining the expertise of each country, ASD endeavors to contribute to the improved care of patients with skin diseases. Through the joint meeting of the 44th Annual Meeting of the Taiwanese Dermatological Association, 6th Continental Congress of Dermatology, and 6th Taiwan Dermatopathology Conference in Taipei, ASD members can have the opportunity to gather together. In addition to giving lectures and exchanging scientific knowledge, the first Executive Committee business meeting will be held on November 17th, 2018. This will mark the official start of ASD.

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Welcome Message Dear distinguished guests and colleagues, On behalf of the Taiwanese Dermatological Association, I would like to welcome you to join the 2018 Taiwan Dermatopathology Conference. This year, we are happy to have joint meeting with 6th Continental Congress of Dermatology and the 44th annual meeting of Taiwanese Dermatological Association in the Taipei International Convention Center from Nov 16th to 18th in 2108. We are also glad to know that the Asian Society of Dermatopathology will be launched in the same time, which will work on the promotion and development of dermatopathology in Asia. In the 2018 program, we are honorable to invite many international experts from the United States, Australia, and Asian countries who will join this event and share their knowledge. I personally highly appreciate the members in organizing committee that dedicates themselves in preparing all the program. We welcome and look forward to your participating. LI-FANG, WANG MD PhD President Taiwanese Dermatological Association

YU-HUNG WU MD Chair, Educational Committee Taiwanese Dermatological Association

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Friday, 16 NOV. RM 201EF Level 2 08:30-10:00

Dermatopathology (I) Moderator: Chung-Hong Hu ( 侟Ẉⷖ , Taiwan)

澽 08:30-09:00 ,QÀDPPDWRU\ JHQRGHUPDWRVHV 澽 09:00-09:30 Approach papulosquamous disorder 澽 09:30-10:00 Blistering Disorders

Darius R. Mehregan (USA) Yu-Hung Wu ( ⋱佰ⷖ , Taiwan) Tan Suat Hoon (Singapore)

10:30-12:00

Dermatopathology (II) Moderator: Han-Nan Liu ( ⅇ㷠∕ , Taiwan)

澽 10:30-11:00 Drug reaction 澽 11:00-11:30 6RPH QRYHO ¿QGLQJV DQG FOXHV 澽 11:30-12:00 Self-assessment Case 1-5

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Cher-Wei Liang ( 㜿⎰䱫 , Taiwan)

13:30-15:00

Dermatopathology (III) Moderator: Greg Kuo-Hsien Wang ( 䉉◉ば , Taiwan)

澽 13:30-14:00 Clinico-histopathological pearls 澽 14:00-14:30 Clinicopathological correlations in alopecia 澽 14:30-15:00 Self-assessment Case 6-10

Sujay Khandpur (India) Joyce Siong-See Lee (Singapore) Bai-Yao Wu ( ⋱䔼⛭ , Taiwan)

15:30-17:30

Dermatopathology (IV) Moderators: Yu-Hung Wu ( ⋱佰ⷖ , Taiwan)

澽 15:30-16:00 Challenging cases in infectious diseases from histopathological point of view 澽 16:00-17:30 Dermatopathology Contest

114

Sondang Aemilia Pandjaitan Sirait (Indonesia) Yu-Hung Wu ( ⋱佰ⷖ , Taiwan)

Saturday, 17 NOV. RM 201EF Level 2 08:30-10:00

Dermatopathology (V) Moderator: Tseng-tong Kuo ( 徫ㄽ䰯 , Taiwan)

澽 08:30-09:15 Keynote Speech: Emergencies in dermatopathology 澽 09:15-10:00 .H\QRWH 6SHHFK 'H¿FLHQF\ GHUPSDWK

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10:30-12:00

Dermatopathology (VI) Moderator: Cheng-Hsiang Hsiao ( 含㨡䠣 , Taiwan)

澽 10:30-11:00 Tubulopapillary cystic adenoma with apocrine differentiation 澽 11:00-11:30 Pediatric dermatopathology 澽 11:30-12:00 Self assseement Case 11-15

Shinichi Ansai (Japan) Thuy L. Phung (USA) Chi-Shun Yang ( 㠈␝曄 , Taiwan)

13:30-15:00

Dermatopathology (VII) Moderator: Jie-Yang Jhuang ( 剈὏ᶮ , Taiwan) 澽 13:30-14:10 Free Paper 澽 14:10-15:00 Case Report

15:30-17:00

Dermatopathology(VIII) Moderator: Julia Yu-Yun Lee ( 㘌䉇新 , Taiwan)

澽 15:30-16:00 Melanoma arising within the dermis 澽 16:00-16:30 Acral nevus vs acral melanoma 澽 16:30-17:00 Self-assessment Case 16-20

Benjamin Wood (Australia) Dong-Youn Lee (Korea) Jau-Yu Liau ( ⶔ佅垓 , Taiwan)

17:00-17:20

TDPC closing ceremony

115

Speakers TDPC

116

Shin-ichi Ansai 1990 1992 1994 2001

PhD, Yamagata University School of Medicine, Yamagata, Japan Lecturer, Department of Dermatology, Yamagata University Hospital Chief of Division of Dermatology, Yamagata Prefectural Nihonkai Hospital, Yamagata, Japan Associate Professor, Department of Dermatology and Plastic surgery, Akita University School of Medicine2004 Vice-president Sapporo Institute for Dermatopathology, Sapporo, Japan 2007 Associate Professor, Department of Dermatology, Tokushima University School of Medicine, Tokushima, Japan 2009 Associate Professor, Department of Dermatology, Nippon Medical School, Tokyo. Japan 2011 Chief of Division of Dermatology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Japan 2015 Professor, Department of Dermatology, Nippon Medical School 2016 Chief of Division of Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Japan Scientific activities President of the Japan Dermatohistopathology Society Board member of the Society for Skin Structure Research

Maxwell A. Fung, Maxwell A. Fung, MD is Professor of Clinical Dermatology & Pathology and Executive Vice Chair

for Academic Affairs, Department of Dermatology, University of California Davis in Sacramento, California, USA. Since 2003, Dr. Fung is the founding and current Director of the UC Davis Dermatopathology Service, where he enjoys the daily practice and teaching of dermatopathology and values the many opportunities to learn, teach, and network at regional, national and international meetings. In the words of his Program Director, Dr. Fung became â&#x20AC;&#x153;enamored of dermatopathologyâ&#x20AC;? as a dermatology resident in San Francisco, California, being inspired by his attendings, Philip LeBoit and Timothy McCalmont, to pursue a career in academic dermatopathology. Dr. Fung serves on two Editorial Boards (Journal of Cutaneous Pathology, Dermatology Online Journal), the Test Development & Advisory Committee, American Board of Pathology & American Board of Dermatology (Dermatopathology) and is incoming Vice Chair, Appropriate Use Task Force, American Society of Dermatopathology. He is a former member of the Executive Committee of the International Society of Dermatopathology and Board of Directors of the American Society of Dermatopathology.

Sujay Khandpur, After completing MD with a Gold Medal, I joined the faculty in 2001. My fields of interest include dermatopathology, photodermatology, vesicobullous diseases, psoriasis, atopic dermatitis, leprosy, lasers. I have published over 120 scientific articles in indexed journals and 37 chapters in various books besides editing 3 books and 2 CDs. I have also delivered over 90 lectures in various international and national conferences. I am founding Editor-inChief of Indian Journal of Dermatopathology and Diagnostic Dermatology and was Associate Editor of Indian Journal of Dermatology, Venereology and Leprology and am reviewer for journals like Dermatology, BJD, Clinical & Experimental Dermatology and Indian Pediatrics. I am currently Secretary of Dermatopathology Society of India. I am recipient of DR LN Sinha Award and Dr. Ganapati Panja award for overall contribution to Dermatology and Dermatopathology respectively, have undertaken 2 international fellowship trainings (USA- dermatopathology and Commonwealth, UKphotodermatology) and won travel fellowships to international conferences

Joyce Siong-See Lee, Dr. Joyce Lee is a Senior Consultant Dermatologist at the National Skin Centre (NSC), Singapore. She completed her Dermatopathology Fellowship at the Skin and Cancer Foundation, Australia, and obtained the ICDP-UEMS International Board Certification in Dermatopathology in 2006. Dr. Lee currently heads the Dermatopathology and Laboratories Division at NSC, and is also the Consultant-in-charge of the Hair and Nail clinic. Her subspecialty interests lie in hair disorders and hair pathology. She is actively involved in research at NSC, with most of her research interests in the areas of hair disorders and dermatopathology, and is a recipient of various national research grants. As an active member of the academia, Dr. Lee is Clinical Tutor to medical students from both Yong Loo Lin School of Medicine, and Lee Kong Chian School of Medicine, Singapore. She is the course organizer for the Dermatopathology National Training Program, and serves as core clinical faculty member for the Dermatology Senior Residency Program at NSC. Dr. Lee also oversees the Dermatopathology Fellowship program at NSC since it became an ICDP-UEMS accredited specialty training centre in 2015. Dr. Lee had served in the executive committee of the International Society of Dermatopathology, and in the International Committee for Dermatopathology. Dong-Youn Lee, Dong-Youn Lee is a professor and chair of the Department of Dermatology at Samsung Medical

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Jau-Yu Liau, 2017-Now Assistant professor, National Taiwan University College of Medicine, National Taiwan

University, Taipei, Taiwan 2015-2016, Visiting scholar, Dermatopathology and Oral Pathology Service, The University of California, San Francisco 2010-Now, Faculty, Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan

Darius R. Mehregan

University of Michigan, Ann Arbor, Michigan Bachelor of Science, Biology, Graduated with High Honors University of Michigan, Medical School Professor-Wayne State University; Detroit, MI Hermann Pinkus Chairman of Dermatology, Wayne State University; Detroit, MI Clinical Assistant Professor, Pathology, University of Toledo; Toledo, OH Clinical Associate Professor, Michigan State University, Department of OMS Editorial Board of Cutis Assistant Editor-International Journal of Dermatology Reviewer-Journal of Cutaneous Pathology Reviewer-American Journal of Dermatopathology Reviewer-Journal of Dermatologic Surgery

1980-1984 1984-1988 2006-Present 2006-Present 2004-Present 2012-Present 1998-Present 2001-Present 2001-Present 2008-Present 2012-Present

Thuy L. Phung, Thuy Phung, MD, PhD is an associate professor and associate director of Global Pathology in the

Department of Pathology at Texas Childrenćs Hospital and Baylor College of Medicine, Houston, Texas, USA. Dr. Phung specializes in skin pathology and is a staff dermatopathologist at Texas Childrenćs Hospital. She directs a cancer research laboratory that studies molecular causes driving cancer growth and metastasis, and the biology of vascular anomalies. Her publications include topics in skin pathology and molecular pathogenesis of vascular tumors and tumor angiogenesis. She is the lead author of a comprehensive textbook Pediatric Dermatopathology. In addition to her scientific and clinical work, Dr. Phung is passionate about global health. She is a co-founder of the award-winning Vietnam Vascular Anomalies Center in Ho Chi Minh City. She and other US physicians return to Vietnam each year to participate in physician education and treatment of children with vascular and pigmented birthmarks. Dr. Phung has been spearheading a program in global pathology to enhance the standard of practice of pathology in Vietnam and Southeast Asia.

M Ramam, Dr M Ramam is Professor of Dermatology & Venereology at the All India Institute of Medical Sciences,

New Delhi. He was editor-in-chief of the Indian Journal of Dermatology, Venereology and Leprology till January 2017 and is currently editor emeritus of the journal. He is President of the Dermatopathology Society of India. His areas of clinical and research interest include granulomatous diseases, pigmentary disorders, dermatopathology and drug reactions. He enjoys teaching.

Omar P. Sangueza, Omar P. Sangüeza, MD was born in La Paz, Bolivia. He began his medical studies at the Universidad Mayor de San Andres and later he transfer to the Universidad Literaria in Valencia, Spain, where he received his M.D. and studied dermatology. He returned to Bolivia and began and working with his father the renowned pathologist and dermatopathologist, Pastor Sangüeza. Dr. Sangüeza is Professor and director of Dermatopathology at Wake Forest University Medical Center where he remains today. He has instituted an international fellowship training both dermatologists and pathologists from all over Latin America, Spain and the Middle East in the field of dermatopathology. In 2014 he was awarded the Walter R. Nickel Award for Excellence in Teaching of Dermatopathology. He served for 6 years as the Secretary/ Treasurer and President of the International Society of Dermatopathology. He was also elected President of International Committee for Dermatopathology from 2014-16. He is the current Editor-in-Chief of the American Journal of Dermatopathology. He has been an invited lecturer throughout the world and authored more than 200 publications.

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Sondang MH Aemilia Pandjaitan Sirait

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Sharmaine Ivy Sun, Dr. Sharmaine Ivy Sun received her medical degree from the University of Santo Tomas in Manila, Philippines. She finished her dermatology residency training at the University of Santo Tomas Hospital. Dr. Sun then pursued her fellowship training in dermatopathology at the University of California, San Francisco. She was also a visiting fellow in the scar and laser clinic of Yonsei Severance Hospital and Yonsei Star Skin Clinic in Seoul, South Korea. Dr. Sun is a fellow of the Philippine Dermatological Society, international fellow of the American Academy of Dermatology, and an International Associate of the American Society of Dermatopathology. She is board certified by the International Committee for Dermatopathology/ European Union of Medical Specialists and is a member of the dermatopathology core group of the Philippine Dermatological Society.

Tan Suat Hoon, Dr. Tan Suat Hoon is Director of the National Skin Centre, Singapore and is a Senior Consultant Dermatologist and Dermatopathologist. She holds a Clinical Associate Professor appointment with the Yong Loo Lin School of Medicine, National University of Singapore (NUS) and holds dual adjunct positions with the Duke-NUS Graduate Medical School Singapore and with the Lee Kong Chian School of Medicine, Nanyang Technological University/Imperial College London. She is Chairman of the national Residency Advisory Committee for Dermatology. She has authored more than 130 indexed publications and 6 book chapters in clinical dermatology and dermatopathology.

Benjamin Wood, A graduate of the University of Newcastle and trained in Anatomical Pathology with the Hunter Area

Pathology Service, Dr. Wood joined PathWest as a consultant pathologist in 2006. In 2010 he established the PathWest Dermatopathology Group, which now provides a State-Wide public Dermatopathology service in Western Australia, serving all three major teaching hospitals in Western Australia, as well as numerous smaller hospitals and community practitioners. As a Clinical Associate Professor at the University of Western Australia, Dr Wood has research interests in melanocytic pathology, cutaneous adnexal tumours and other areas of Dermatopathology. Dr Wood has authored over 100 publications and multiple text book chapters, including in the upcoming WHO classification of Tumours of the Skin. He is a member of the executive committee of the Australian Dermatopathology Society, convenor of the RCPA QAP Dermatopathology Module and a member of the Western Australian Kirkbride Melanoma Advisory Service panel.

Yu-Hung Wu, Dr. Yu-Hung Wu is currently the Associate Professor and director of international dermatopathology fellowship program in Mackay Memorial Hospital. The program was the first dermpath training program accredited by International Committee for Dermatopathology in Asia. He had served the chair of department of dermatology in Mackay Memorial Hospital, Chief-in-Editor of Dermatological Sinica (the official journal of Taiwanese Dermatological Association, indexed in SCI), and the executive committee member of International Society of Dermatopathology. He is also the current board of directors and chair of continuing education committee of Taiwanese Dermatological Association, and leader of dermatopathology group of Taiwan Society of Pathology. He had published more than 120 peer-reviewed articles.

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Bai-Yao Wu, Adjunct Assistant Professor of Dermatology Department, National Defense Medical Center and attending physician of Yang Guang Dermatology clinic

Chi-Shu Yang, Dr. Chi-Shun Yang graduated from Kaohsiung Medical University, College of Medicine in 2001. He

performed residency training and served as chief resident in Department of Pathology and Laboratory Medicine at Taichung Veterans General Hospital from 2003 to 2008. He also served as a visiting scholar at the pathology laboratory of Indiana University Health in the United States from 2015 to 2016. He is now an attending pathologist in Department of Pathology and Laboratory Medicine at Taichung Veterans General Hospital and practicing diagnostic histopathology with a special interest in dermatopathology and cytopathology

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Abstract TDPC

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Shinichi Ansai Tubulopapillary cystic adenoma with apocrine differentiation Session: Dermatopathology (VI)

Saturday, Nov. 17, 2018-from 10:30 to 11:00 RM 201EF-LEVEL 2

Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillar y adenoma (TPA) with apocrine dif ferentiation are defined as proliferations of apocrine epithelium with myoepithelial cells. At Sapporo Dermatopathology Institute, we retrieved 308 benign neoplastic lesions diagnosed as SCAP, AGC, or TPA and combinations of these entities. Among the 308 lesions, 202 (66%) exhibited features of only one type, of which 144 (47%) were AGC, 39 (13%) were TPA, and 19 (6%) were SCAP. The other 106 lesions (34%) had features of two or more types, including 56 lesions that were AGC+TPA (18%), 2 that were AGC+SCAP (1%), 34 that were TPA+SCAP (11%), and 14 that were AGC+TPA+SCAP (5%).The most frequent site of these lesions was the face (56%), followed by the scalp (13%). Lesions with the features of AGC were more frequently found on the face, especially the periocular region, than at other sites. TPA lesions were more frequent on the face and scalp than at other sites, while SCAP lesions were preferentially found on the face, scalp, and trunk. We also retrieved clinicopathological data and other information. We propose a unifying concept for AGC, TPA, and SCAP. Approximately one third of these lesions are composite entities with the features of two or three different tumors, and we propose calling such tumors tubulopapillary cystic adenoma with apocrine differentiation.

Maxwell A. Fung 'HÂżFLHQF\ 'HUPSDWK Session: Dermatopathology (V)

Saturday, Nov. 17, 2018-from 09:15 to 10:00 RM 201EF-LEVEL 2

Amidst ongoing and revolutionary advances in medicine, the daily practice of dermatopathology continues for the foreseeable future to rely primarily, and usually exclusively, upon traditional techniques of H&E histomorphology and clinical pathologic correlation (CPC). 'HÂżFLHQFLHV â&#x20AC;&#x153;knowledge gapsâ&#x20AC;? â&#x20AC;&#x153;practice gapsâ&#x20AC;? â&#x20AC;&#x153;learning opportunitiesâ&#x20AC;?) in dermatopathology within the realms of H&E and CPC persist aplenty, sometimes at the most basic level of terminology or diagnostic criteria. This presentation will include a targeted selection of perspectives and evidence-based practical diagnostic tips for selected neoplastic DQG LQĂ&#x20AC;DPPDWRU\ GLVRUGHUV RI WKH VNLQ 3URSRVHG WRSLFV LQFOXGH G\VSODVWLF QHYXV DFDQWKRO\WLF VTXDPRXV FHOO FDUFLQRPD SVRULDVLV interface dermatitis, scarring alopecia, and dermal hypersensitivity reactions that the Presenter hopes will be appropriate and of practical value to trainees and practitioners of dermatology, pathology, and dermatopathology.

Sujay Khandpur Clinico-histopathological pearls Session: Dermatopathology (III)

Friday, Nov. 16, 2018-from 13:30 to 14:00 RM 201EF-LEVEL 2

The presentation is on a series of varios dermatoses which posed considerable diagnostic challenge based on clinical morphology. They mimicked other skin diseases. Histopathology helped in resolving the dilemma in these conditions. There are also few cases ZKHUH WKHUH LV VLJQLÂżFDQW KLVWRSDWKRORJLFDO RYHUODS DZDUHQHVV RI ZKLFK ZRXOG KHOS LQ EHWWHU XQGHUVWDQGLQJ DQG GLDJQRVLQJ WKH GLVHDVH

Joyce Siong-See Lee Clinicopathological correlations in alopecia Session: Dermatopathology (III)

Friday, Nov. 16, 2018-from 14:00 to 14:30 RM 201EF-LEVEL 2

Alopecia can be challenging to diagnose, in part because of overlapping clinical and histopathological manifestations of various forms of alopecia. To complicate matters, different causes of alopecia may co-exist in the same patient at the same time. Interpretation of biopsy specimens of alopecias is best done in the context of a proper clinical history and preferably with photography of clinical lesions. Clinicopathological correlation is thus integral to arriving at an accurate diagnosis, which is a crucial step in the proper treatment and management of the patient. In this talk, some interesting cases of alopecia will be discussed and the importance of clinicopathological correlation highlighted.

Dong-Youn Lee Acral nevus vs acral melanoma Session: Dermatopathology (VIII)

Saturday, Nov. 17, 2018-from 16:00 to 16:30 RM 201EF-LEVEL 2

Acral lentiginous melanoma develops on palmar, plantar, and nail unit areas. It is the most common type of melanoma in Asians. In its early stage (in situ lesion) only histopathologic findings seen in small biopsies may be subtle, consisting of irregular epidermal hyperplasia and scattered, basally located, atypical melanocytes. Clinical and dermatoscopic findings are often necessary for the diagnosis. As the lesion progresses the number of atypical melanocytes increases and they are characterized by nuclear pleomorphism DQG K\SHUFKURPDWLVP DQG VKRZLQJ D F\WRSODVPLF Âż[DWLRQ UHWUDFWLRQ DUWLIDFW 3LJPHQWHG GHQGULWHV PD\ EH YLVLEOH DVFHQGLQJ LQWR KLJK OHYHOV RI WKH HSLGHUPLV 1HVW IRUPDWLRQ DSSHDUV LQ WKH ODWH VWDJH $ KHDY\ EDQG OLNH LQĂ&#x20AC;DPPDWRU\ FHOO LQÂżOWUDWH LV IUHTXHQWO\ SUHVHQW Acral nevus is characterized by a circumscribed and usually symmetrical, lentiginous and nested melanocytic proliferation along the 122

dermo-epidermal junction. The nests are commonly variable in size and often vertically orientated. A retraction artifact separating the nests from the adjacent keratinocytes is a characteristic finding. The nevus cells have conspicuous pale cytoplasm and hyperchromatic to vesicular nuclei, sometimes showing mild cytological atypia. Mild to moderate pagetoid spread may be present, particularly in the center of the lesion. Sometimes it can be very marked and involve almost the entire lesion, which is called melanocytic acral nevus with intraepidermal ascent of cells (MANIAC). Subungual melanoma originates from the nail matrix and spread to nail bed, hyponychium and proximal nail fold. We analyzed clinical and histopathological findings of 18 cases of SUM in situ. Increase in the number of scattered atypical melanocytes with large hyperchromatic nuclei in a partial nail matrix may provide a diagnostic clue in concert with its clinical suspicion. As little is known about the progression pattern of subungual melanoma (SUM), further advances on the subject may provide better guidance on the optimal surgical approach. We reviewed histopathology slides of 23 cases of SUM, in which each area of the nail unit in longitudinal sections was available. Dermal invasion of SUM in the nail matrix area tends to occur later than other areas of the nail unit. This finding suggests that conservative surgical treatment for early SUM may be justified as the nail matrix area, an area of thin dermis and close proximity to the underlying bone, appears to be more resistant to invasion. Very recently, we analyzed clinical, dermoscopic and histopathological findings of 28 nail matrix nevi (NMN). Compared with NMNs in adults, pediatric NMNs are wider and nail dystrophy and Hutchinsonćs sign are more common. Histologically, although enlarged and hyperchromatic melanocytes were found, their presence was focal. In pediatric cases of even-width, sharply demarcated longitudinal melanonychia, the presence of Hutchinsonćs sign with longitudinal brushy pigmentation may favor a diagnosis of nevus.

Darius R. Mehregan ,QÀDPPDWRU\ JHQRGHUPDWRVHV Session: Dermatopathology (I)

Friday, Nov. 16, 2018-from 08:30 to 09:00 RM 201EF-LEVEL 2

Diagnosis of genetic skin diseases can be challenging. In particular, histopathologic findings in many of the inflammatory genodermatoses can be quite subtle. In this talk, we will review the histologic findings in inflammatory genedermatoses. These will be correlated with clinical findings and pathogenesis.

Thuy L. Phung Pediatric dermatopathology Session: Dermatopathology (VI)

Saturday, Nov. 17, 2018-from 11:00 to 11:30 RM 201EF-LEVEL 2

Skin diseases in children present a range of unique presentations that are not commonly encountered in adults. As is the case with many cutaneous disorders, the histologic changes are subtle and raise a broad differential diagnosis that requires careful clinicopathologic correlation in order to arrive at the correct diagnosis. Clinical treatment and disease outcome are markedly affected by the ultimate diagnosis. The presentation is designed to address the fact that other than dedicated specialists, most dermatologists, pathologists and even dermatopathologists have limited exposure to these diagnostic entities in children. The presentation will highlight unique inflammatory dermatoses present in children.

M. Ramam 6RPH QRYHO ¿QGLQJV DQG FOXHV Session: Dermatopathology (II)

Friday, Nov. 16, 2018-from 11:00 to 11:30 RM 201EF-LEVEL 2

The histopathological findings in mosaic variants of genodermatoses are believed to be the same as in non-mosaic variants of the same disorder and clinical information is required to tell the two apart. We found an alternating pattern of disease and normal findings in biopsies from some mosaic disorders providing a histopathological clue to this genetic variant. Polymorphous light eruption in dark skin presents with tiny, skin coloured, grouped papules on sun-exposed skin that clinically and histopathologically resemble lichen nitidus. This has led to the condition being called actinic lichen nitidus, summertime lichenoid eruption or lichenoid polymorphous light eruption. In a series of patients, we found a lichenoid reaction pattern in only a quarter of biopsies while a spongiotic dermatitis was noted in about 40%. These findings suggest that it is incorrect to label this condition a lichenoid eruption. Patients presenting with tiny, grouped papules on the nose may represent the facial variant of this disease. Hypopigmented macules with hair loss are often clinically diagnosed as leprosy or hypopigmented mycosis fungoides. We found that follicular spongiosis was a consistent finding in some of these patients suggesting that these cases may represent a manifestation of pityriasis alba on the trunk. Recognition of this entity will prevent mis-diagnosis and inappropriate treatment.

Sondang MH Aemilia Pandjaitan Sirait Challenging cases in infectious diseases from histopathological point of view Session: Dermatopathology (IV)

Friday, Nov. 16, 2018-from 15:30 to 16:00 RM 201EF-LEVEL 2

Infectious diseases are becoming more frequent due to at risk populations expansion such as those using immunosuppressive and chemotherapy medications and increasing elderly population. Diagnosing certain infectious diseases of the skin can be difficult 123

especially when cultures and direct examinations give negative results. Histopathology can give a presumptive and definitive diagnosis on those difficult cases. Direct microscopic visualization of infectious agent is useful when cultures cannot be made or infectious agent is slow growing or fastidious. Tissue reaction to the pathologic agent can also give clue to the correct diagnosis. Communication with the clinician is also important in giving patients history and a clinical picture of the patient, also to follow up the patients final diagnosis after successful treatment, sometimes diagnosis is confirmed when patient give a good response to a specific therapy. Several challenging cases of diagnostic difficulty in infectious skin diseases by bacteria, fungal and viral will be discussed.

Sharmaine Ivy Sun Drug reaction Session: Dermatopathology (II)

Friday, Nov. 16, 2018-from 10:30 to 11:00 RM 201EF-LEVEL 2

Drugs are substances administered to the body, in order to elicit a positive effect in correlation to a disease entity. However, adverse effects are likewise possible. Drug eruptions can present with various clinical and histopathologic changes. This talk aims to review clues that would point to a drug eruption.

Tan Suat Hoon Blistering Disorders Session: Dermatopathology (I)

Friday, Nov. 16, 2018-from 09:30 to 10:00 RM 201EF-LEVEL 2

To understand blistering diseases in the skin, it is necessary to understand something about the structure of normal skin. Desmosomal proteins confer structural continuity and tensile strength on entire epidermis while the basement membrane allows the epidermis to adhere to dermis, and confers structural stability. Blistering can occur through the epidermis resulting in intraepidermal blistering, which may be subcorneal, through stratum spinosum or suprabasal; and at the basement membrane zone, resulting in subepidermal blistering. From the pathomechanistic point of view, blistering occurs because of genetic mutations involving keratins, cell adhesion proteins or basement membrane zone proteins (eg hereditary epidermolysis bullosa, Hailey Hailey disease), autoimmunity targeting cell antigens (immunobullous diseases including pemphigus, pemphigoid, linear IgA disease, dermatitis herpetiformis, bullous SLE), intercellular oedema (eczema/ dermatitis), ballooning degeneration (viral infections). $ KLVWRSDWKRORJLFDO DSSURDFK LV E\ GHOLQHDWLRQ RI WKH SODQH RI FOHDYDJH DQG ZKHWKHU WKH EOLVWHULQJ LV DFFRPSDQLHG E\ DQ LQĂ&#x20AC;DPPDWRU\ LQÂżOWUDWH FHOO SRRU RU FHOO ULFK DQG WKH SUHGRPLQDQW W\SH RI LQĂ&#x20AC;DPPDWRU\ LQÂżOWUDWH QHXWURSKLOV HRVLQRSKLOV RU O\PSKRF\WHV Direct immunofluorescence (DIF) studies are needed to confirm the different immunobullous diseases. Dermatitis-herpetiformis like histopathology will be discussed and new variant: anti-laminin-gamma 1 pemphigoid will be highlighted.

Benjamin Wood Melanoma arising within the dermis Session: Dermatopathology (VIII)

Saturday, Nov. 17, 2018-from 15:30 to 16:00 RM 201EF-LEVEL 2

The large majority of melanomas arise from melanocytes within the epidermis, manifesting as a component of melanoma in situ. A small number of melanomas and melanocytomas arise without a component of melanoma in situ, including in the setting of congenital naevi in children, primary dermal melanoma in adults and a range of proliferations resembling blue naevus and Spitzoid lesions. This lecture will explore some of the patterns of melanoma and atypical melanocytic proliferation without a component of melanoma in situ, and examine the pathological differential diagnosis of such proliferations.

Yu-Hung Wu Approach papulosquamous disorder Session: Dermatopathology (I)

Friday, Nov. 16, 2018-from 09:00 to 09:30 RM 201EF-LEVEL 2

Papulosquamous disorders are common and may represent different diseases. Most of them can be diagnosed easily, such as psoriasis. However, there are several entities, such as lichen planus, pityriasis rubra pilaris, lupus erythematosus, pityriasis lichenoides, and pityriasis rosea, that may show similar clinical presentation. In cases that cannot be diagnosed clinically, they are also challengeable for pathologists. The papule means inflammatory cell infiltration in the skin. The desquamation indicate the presence of parakeratosis. We will discuss the morphological change of parakeratosis (mounds of parakeratosis with or without trapped neutrophils, parakeratosis with serum exudate, DOWHUQDWLQJ SDUDNHUDWRVLV DQG RUWKRNHUDWRVLV LQÂżOWUDWHG SDWWHUQ RI LQĂ&#x20AC;DPPDWLRQ VSRQJLRWLF LQWHUIDFH OLFKHQRLG RU SVRULDVLIRUP SDWWHUQ DQG WKH FHOOV LQYROYHG LQ WKH LQĂ&#x20AC;DPPDWLRQ O\PSKRF\WHV QHXWURSKLOV RU HRVLQRSKLOV WR KHOS SDWKRORJLVWV PDNLQJ WKH FRUUHFW GLDJQRVLV

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Free Papers

125

SCAR consortium forum Date: November 16th, 2018

Location: North Lounge

Moderators: Wen-Hung Chung ( 拖㑅⩍ , Taiwan), Fu-Ren Zhang ( ⷳ䡍ᵿ , China) SF01 15:30-15:40

Human leukocyte antigen typing in Mefenamic acid related Fixed drug eruption Fang-Ying Wang, MD1,2 ; Ya-Hui Chuang, MD1,2 ; Wen-Hung Chung, MD, PhD1,2,3 1 Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan 2 College of medicine, Chang Gung University, Taoyuan, Taiwan 3 Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan SF02 15:40-15:50

Carbamazepine-induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and HLA-B*1502 Screening Among First-Degree Relatives of Index Patients Siqing Ee, MBBS1 ; Yong Kwang Tay, MBBS1 Department of Dermatology, Changi General Hospital, Singapore

SF03 15:50-16:00

Severe cutaneous adverse reactions induced by sulfa drugs: A clinical and in vitro T-cell reactivity study Wei-Ti Chen, MD, MMS1,2 ; Hsin-Chun Ho, MD1,2,3 ; Chuang-Wei Wang, PhD1,2 ; Chun-Bing Chen, MD1,2,3 ; Chun-Wei Lu, MD1,2,3 ; Chung-yee Rosaline Hui, MD, PhD1,2,3 ; Wen-Hung Chung, MD, PhD1,2,3 1 Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taiwan 2 Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan 3 College of Medicine, Chang Gung University, Taoyuan, Taiwan SF04 16:00-16:10

Toxic epidermal necrolysis treated with etanercept, a case report Yuan-Hsin Lo, MD1,2 ; Yi-Chien Lee, MD2,3 1 Department of Dermatology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan. 2 School of medicine, Fu Jen Catholic University, New Taipei City, Taiwan. 3 Department of Infection, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.

TDPC Pathology Date: November 17th, 2018

Location: RM 201EF

Moderator: Jie-Yang Jhuang ( 剈὏ᶮ , Taiwan) TF01 13:30-13:40

Chronic Macrocheilia: A Clinico-pathological Study of 50 Patients Asma Toumi, MD.1 ; Noureddine Litaiem, MD.1 ; Meriem Jones, MD.1 ; Faten Zeglaoui, MD.1 1 Department Of Dermatology, Charles Nicolle Hospital of Tunis, Tunisa 2 Depatment of Pathology, Charles Nicolle Hospital of Tunis, Tunisia TF02 13:40-13:50

Computer-aided diagnosis using deep learning method for mycobacteria bacilli detection in digital whole slid images for cutaneous mycobacterial infection Lee, Chieh-Chi, MD.1 ; Lo, Chung-Ming, PhD1 ; Wu, Yu-Hung, MD.2 ; Li, Yu-Chuan (Jack), MD., PhD1,3 1 Graduate Institute of Biomedical Informatics 2 Department of Dermatology, Mackay Memorial Hospital 3 Department of Dermatology, Taipei Medical University-Wan Fang HospitalTaipei, Taiwan TF03 13:50-14:00

Clinical, Dermoscopic and Histopathological Features of Pigmented Basal Cell Carcinoma in Filipinos: A Series of 20 Cases Elisabeth Ryan, MD.1 ; Marie Claudine Francesca B. Perlas, MD.1 ; Johannes F Dayrit, MD.1 1 Research Institute for Tropical Medicine

TF04 14:00-14:10

Melanotic macules among Asians: A clinicopathologic study of 41 Taiwanese patients Bryan Edgar K. Guevara, MD.1,2 ; Chao-Kai Hsu, MD., PhD2 ; Julia Yu-Yun Lee, MD.2 Department of Dermatology, Southern Philippines Medical Center, Davao, Philippines 2 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

126

Free Paper (I) Dermoscopy Date: November 17th, 2018

Location: RM 202A

Moderators: Chao-Chun Yang ( 㠈㗛惜 , Taiwan), Yau-Li Huang ( 涁亾䦉 , Taiwan) F01

08:30-08:40 Dermoscopic Patterns of 26 melanocytic nevi in Filipinos and correlation with clinical diagnosis and histopathology: A preliminary study Julius Garcia Gatmaitan, MD.1 ; Johannes Flores Dayrit, MD.1 Research Institute for Tropical Medicine

F02

08:40-08:50 Dermoscopy for pigmented basal cell carcinoma in Asian patients Tay Shi Huan, MD.1 ; Michelle Chan Mei Fung, MBBS2 ; Oh Choon Chiat, MBBS3 Duke-NUS Medical School, Singapore 2 Department of Pathology, Singapore General Hospital, Singapore 3 Department of Dermatology, Singapore General Hospital, Singapore

F03

08:50-09:00 Dermoscopy for post-treatment follow-up of Bowen’s disease Chi-Ling Lin, MD.1 ; Stephen Chu-Sung Hu, MBBS, M.Phil1 ; Cheng-Che Lan, MD., PhD1 ; Shih-Tsung Cheng, MD.1 Department of Dermatology, Kaohsiung Medical University Hospital

Free Paper (I) Benign and Malignant Neoplasms Date: November 17th, 2018 F04

Location: RM 202A

09:00-09:10 Glomus Tumors of The Hand: Report of 12 cases. Asma Toumi, MD.1 ; Nidhal Mahdhi, MD.1 ; Mariem Chaieb, MD.1 ; Khayri Saibi, MD.1 ; Amal Abid, MD.1 1 Plastic, Reconstructive and Aesthetic Surgery Department, Sahloul Hospital of Sousse, Tunisia.

F05

09:10-09:20 ZnPc-loaded chitosan/mPEG-PLA nanoparticle enhanced the effectiveness of photodynamic therapy in the treatment of cutaneous squamous cell carcinoma Uma Keyal1 Shanghai Skin Disease Hospital, Tongji University

F06

09:20-09:30 Clinical features of Kaposi’s sarcoma: Experience from a Taiwanese medical center Ya-Yun Huang1 ; Stephen Chu-Sung Hu, MD.1 1 Kaohsiung Medical University

F07

09:30-09:40 Nipple eczema revisited: always bilateral? Divya Sachdev, MBBS, MD.1 ; Satyaki Ganguly, MBBS, MD.2 Senior Resident, Department of Dermatology, All India Institute of Medical Sciences, Raipur 2 Associate Professor, Department of Dermatology, All India Institute of Medical Sciences, Raipur

F08

09:40-09:50 Leukemia cutis in a medical center in southern Taiwan: a retrospective study of 42 patients Yung-Wei Chang, MD.1 ; Yu-Wen Cheng, MD.1; Chih-Hung Lee, MD., PhD1 ; Han-Chi Tseng, MD.1,2 ; 1 Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan 2 Department of Cosmetic Applications and Management, Lecturer, Yuh Ying Junior College of Healthcare and Management, Kaohsiung, Taiwan

Free Paper (II) Acne and Rosacea Date: November 17th, 2018

Location: RM 202A

Moderators: Yu-Ping Hsiao ( 含䉇⬍ , Taiwan), Heng Gu ( 朥⼐ , China) F09

10:30-10:40 A Randomized, Comparative Study on the Efficacy and Safety of Mangosteen 1% Extract Gel versus Benzoyl Peroxide 5% Gel in the Treatment of Mild to Moderate Acne Vulgaris Janice Natasha C. Ng, MD.1 ; Maria Vinna N. Crisostomo, MD.1 ; Margaret Stephanie L. Jimenez, MD.1 Mary Jo Kristine S. Bunagan, MD.1 ; 1 Department of Dermatology- Southern Philippines Medical Center, Davao City, Philippines 127

F10

10:40-10:50 The Relationship between Acne Vulgaris and Diet: A Systematic Review Shi Yu Derek Lim, MBBS1 ; Hazel H Oon, MD.2 1 National Healthcare Group, Singapore 2 National Skin Centre, Singapore

Free Paper (II) Basic Research Date: November 17th, 2018 F11

Location: RM 202A

10:50-11:00 Using Baff in Monitoring Treatment Response in Early Systemic Sclerosis Vu Nguyet Minh1,2 ; Tran Hau Khang1,2 ; Matsushita Takashi3 ; Nguyen Ha Vinh1,2,3 ; Hoang Bao Long4, Le Huyen My1 ; Le Huu Doanh1,2 National Hospital of Dermatology and Venereology, Vietnam 2 Hanoi Medical University, Vietnam 3 DIÂżOLDWLRQ WR EH XSGDWHG

4 Oxford University Clinical Research Unit-Vietnam

F12

11:00-11:10 Expression and Cellular Localization of Matriptase, Prostasin, HAI-1, and HAI-2 in Human Skin Chien-Ping Chiang, MD., PhD1,2 ; Jehng-Kang Wang, PhD2 ; Hong-Wei Gao, MD.3 1 Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center 2 Department and Graduate Institute of Biochemistry, National Defense Medical Center 3 Department of Pathology, Tri-Service General Hospital, Medical Defense Medical Center

F13

11:10-11:20 Microphthalmia-Associated Transcription Factor Reprograms Proton Transport in Human Melanoma Cells Oscar C. Y. Yang, MBBS1,2 ; Chien-Ping Chiang, MD., PhD3 ; Hong-Wei Gao, MD.4 ; Shih-Hurng Loh, PhD2 1 Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. 2 Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan 3 Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China. 4 Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan.

F14

11:20-11:30 Oleic acid-containing nanoparticles encapsulating cilomilast for inhibition against activated neutrophil in of psoriasis-like lesion Cheng-Yu Lin, 1,2 ; Tsong-Long Hwang, PhD2,3 ; Jia-You Fang, PhD2,3 1 Graduate Institute of Biomedical Sciences, Chang Gung University 2 Healthy Aging Research Center, Chang Gung University 3 Graduate Institute of Natural Products, Chang Gung University

Free Paper (II) Infectious Diseases Date: November 17th, 2018 F15

Location: RM 202A

11:30-11:40 A Study to Evaluate The Role of Intradermal and Intralesional Measles, Mumps, Rubella (MMR) Vaccine in Treatment of Common Warts PRAGYA GUPTA, MD. 1 IGMC SHIMLA

F16

11:40-11:50 A Study on awareness, perceived stigma and quality of life among patients with Leprosy attending a Tertiary Care Hospital in Sri Lanka Dr.(Mrs) C R Maddumarachchi, MD. ; Dr. Janaka Akarawita, MD. ; Dr. (Mrs) C Gunasekara, MD. ; Dr. (Mrs) C Wickramarathne, MD.

F17

11:50-12:00 Optical coherence tomography imaging of varicella-zoster viral infection blisters-a pilot study Wei-Yu Chen, MD.1 ; Chung-Hsing Chang, MD., PhD1 1 Department of dermatology, Hualien Tzu-Chi hospital

128

Free Paper (III) Clinical Studies and Public Health Date: November 17th, 2018

Location: RM 202A

Moderators: Ya-Ching Chang ( ⷳ斃剿 , Taiwan), Tong Lin ( 㙕⸢ , China) F18

13:30-13:40 The Effect of High SPF Sunscreen on Vitamin D Production Dr Kim Ansley, MBBS, MHS1 ; Dr Mahlatse Kgokolo, MBBS, MHS2 University of Pretoria, Pretoria, Gauteng, South Africa 2 University of Pretoria, Pretoria, Gauteng, South Africa

F19

13:40-13:50 Genotrichosis, a Classification´s Proposal Julio Cesar Salas-Alanis, MD., PhD 1 School of Medicine and Health Sciences TecSalud ITESM

F20

13:50-14:00 A Split-Face Study: Comparison of Picosecond Alexandrite Laser and Q-Switched Nd:YAG Laser in the Treatment of Melasma in Asians Mei-Chin Lee, MD.1 ; Ying-Fang Lin, MD.1 ; Sindy Hu, MD.1 ; Yau-Li Huang, MD.1 ; Shyue-Luen Chang, MD.1 ; Chun-Yu Cheng, MD.1 ; Chun-Shin Chan, MD.2 1 Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan 2 Craniofacial Research Center, Department of Medical Research, Department of Plastic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

F21

14:00-14:10 Ectodermal dysplasia-A case series in a medical center in southern Taiwan Sheau-Chiou Chao, MD.1 ; Ching-Yuang Huang, MD.2 ; Yi-Cehn Liao, MD.1 1 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Department of Dermatology, Sinlau Christian Hospital, Tainan, Taiwan

F22

14:10-14:20 Correlation of cardiovascular autonomic function, peripheral vascular endothelial function and quality of life with disease severity in primary hyperhidrosis Saurabh Singh, MD.1 ; Omlata Bhagat, MD.2 ; Purvi Purohit, MD.3 ; Abhishek Bhardwaj, MD.1 Department of Dermatology, AIIMS Jodhpur, Rajasthan (India)-342005 2 Department of Physiology, AIIMS Jodhpur, Rajasthan (India)-342005 3 Department of Biochemistry, AIIMS Jodhpur, Rajasthan (India)-342005

F23

14:20-14:30 A comparison of efficacy and complications between three minimal invasive treatments to axillary osmidrosis : a retrospective cohort study Yu-Tsung Chen, MD.1 ; Donald Liu, MD.1 ; Wei-His Lin, MD.1 ; Woan-Rouh Lee, MD., PhD1 ; Hung-Hsu Yang, MD., PhD1 Department of Dermatology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

F24

14:30-14:40 Dermatology Conditions in the Emergency Department: characteristics of presentations and admissions Emily Shao, MBBS, MPH1 ; Tina Bazianas, MBBS2 ; Robert Eley, PhD1,2 University of Queensland, Faculty of Medicine, Herston QLD 4006, Australia 2 Princess Alexandra Hospital, Emergency Department, Woolloongabba QLD 4102, Australia

F25

14:40-14:50 Team-Based Care in Dermatology Hazel Oon1 National Skin Centre, Singapore

Free Paper (IV) Psoriasis Date: November 17th, 2018

Location: RM 202A

Moderators: Chun-Hua Wang ( 䉉㲱㣸 , Taiwan), Po-Yuan Wu ( ⋱ᷭ , Taiwan) F26

15:30-15:40 Anti-inflammatory therapy with tumor necrosis factor inhibitors is associated with reduced risk of major adverse cardiovascular events in psoriasis Jashin Wu, MD.1 ; Aditya Joshi, MD.2 ; Shivani Reddy, MD.1 ; Michael Batech, 3 ; Alexander Egeberg, MD., PhD4 ; Ole Ahlehoff, MD., PhD ; Nehal Mehta, MD.2 1 Kaiser Permanente Los Angeles Medical Center, Department of Dermatology, Los Angeles, California, United States 2 National Institutes of Health, National Heart, Lung, and Blood Institute 3 Kaiser Permanente Southern California, Department of Research and Evaluation, Pasadena, California, United States 4 Copenhagen University Hospital Rigshospitalet, The Heart Centre, Department of Cardiology, Copenhagen, Denmark 5 Herlev and Gentofte Hospital, Department of Dermatology and Allergy, Hellerup, Denmark 6 Department of Cardiology, Odense University Hospital, Odense, Denmark 129

F27

15:40-15:50 The relationship between BMI and psoriasis severity Narges Alizadeh, MD.1 ; Somayeh Hoseinzadeh, MD.2 ; Ehsan Kazemnejad, MD.3 ; Seyyede Zeinab Azimi, MD.4 1 Associated professor, Department of Dermatology, Guilan University of Medical sciences, Rasht, Iran 2 Dermatologist, Department of Dermatology, Guilan University of Medical sciences, Rasht, Iran 3 Associated professor, Department of Biostatistic, Guilan University of Medical sciences, Rasht, Iran 4 Dermatology Resident, Department of Dermatology, Guilan University of Medical sciences, Rasht, Iran

F28

15:50-16:00 Association between psoriasis and vitiligo: a meta-analysis of observational studies Hsi Yen, MD., MPH1 ; Ching-Chi Chi, MD., MMS, PhD1,2 1 Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan 2 College of Medicine, Chang Gung University, Taoyuan, Taiwan

F29

16:00-16:10 Serum homocysteine, folate, and vitamin B12 levels in patients with psoriasis: A systematic review and meta-analysis Tsung-Yu Tsai, MD.1 ; Hsuan Yen, MD., MPH1 ; Yu-Chen Huang, MD.1,2 Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 2 Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

F30

16:10-16:20 Change in body weight and body mass index in psoriasis patients receiving biologics Ming-Ying, Wu, MD.1 ; Shih-Jyun Yang, MD.1 ; Chi, Ching-chi, MD., MMS, PhD1,2 Department of dermatology, Chang Gung Memorial Hospital, Linkou branch 2 College of Medicine, Chang Gung University, Taoyuan, Taiwan

F31

16:20-16:30 Efficacy of Subcutaneous Secukinumab in Patients with Psoriasis Stratified by Prior Biologics Use or Reimbursement in Real-World Practice: A Multicentric Observational Study Tzong-Yun Ger, MD. ; Chien-Hsun Chen, MD. ; Yu-Huei Huang, MD. ; Rosaline Chung-yee Hui, PhD ; Tsen-Fang Tsai, MD. ; Hsien-Yi Chiu, PhD ; 1 Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan 2 Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan 3 Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan

F32

16:30-16:40 Effects of fish oil supplement on psoriasis: a meta-analysis of randomized controlled trials Shih-Jyun Yang, MD.1 ; Ching-Chi Chi, MD., MMS, PhD1,2 Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan 2 College of Medicine, Chang Gung University, Taoyuan, Taiwan

F33

16:40-16:50 Juvenile Generalized Pustular Psoriasis: Case Series and Literature Review Chun-Yi Li, MD.1 ; Tsen-Fang Tsai, MD.1 Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan

Free Paper (V) Drug Reactions Date: November 18th, 2018

Location: Presentation Stage

Moderators: Tsu-Man Chiu ( 彯山㶽 , Taiwan), Ya-Ju Hsieh ( 姛斃⡀ , Taiwan) F34

10:30-10:40 Topical betaxolol improved paronychia with pyogenic granuloma-like lesions induced by epidermal growth factor receptor inhibitors Chi-Feng Yen, MD.1 ; Sindy Hu, MD.1 ; Ching-Chi Chi, PhD1 ; Wen-Hung Chung, PhD1 ; Chun-Wei Lu, MD.1 Department of Dermatology, Chang Gung Memorial Hospital, Linkuo, Taiwan

F35

10:40-10:50 Immune Checkpoint Inhibitors Related Urticaria Shih-Wen Hsu, MD.1,2 ; Chin-Yi Yang, MD.1,2 ; Rosaline Chung-Yee Hui, MD., PhD1,2 ; Pei-han Kao, MD.1,2 ; Chun-Wei Lu, MD.1,2 ; Wen-Hung Chung, MD., PhD2,3 ; Chuang-Wei Wang, PhD4 ; Chun-Bing Chen, MD.2,3 1 Department of Dermatology, Chang Gung Memorial Hospitals, Taipei, Linkou, Taiwan 2 College of Medicine, Chang Gung University, Taoyuan, Taiwan 3 Department of Dermatology, Chang Gung Memorial Hospitals, Keelung, Taipei, Linkou, Taiwan 4 Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan

130

)UHH 3DSHU 9 ,QÀDPPDWRU\ 'HUPDWRVHV Date: November 18th, 2018

Location: Presentation Stage

Moderators: Tsu-Man Chiu ( 彯山㶽 , Taiwan), Ya-Ju Hsieh ( 姛斃⡀ , Taiwan) F36

10:50-11:00 Peri-orbital lichen planus pigmentosus: a distinctive clinical entity in young adults-observational case-control study of 177 patients Vinay Keshavamurthy, MD.1 ; Muhammad Razmi, MD.1 ; Uma N Saikia, MD.1 ; Sendhil Kumaran, MD.1 ; Davinder Parsad, MD.1 1 Postgraduate Institute of Medical Education and Research

F37

11:00-11:10 Is Acanthosis Nigricans in Children a marker of Impending Metabolic Syndrome? Ranthilaka R. Ranawaka, MBBS, MD.1 ; Sivadarshiya Pathmanadan, MBBS, MD.1 General Hospital Kalutara, Sri Lanka

F38

11:10-11:20 Tofacitinib with and without Adjuvant Fractional CO2 Laser Therapy for the Treatment of Severe Alopecia Areata Ying-Xiu Dai, MD.1,2 ; Chen-Pu Yeh, MD.1,2 ; Han-Nan Liu, MD.1,2,3 ; Chih-Chiang Chen, MD., PhD1,2,4 1 Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan 2 Department of Dermatology, National Yang-Ming University, Taipei, Taiwan 3 Department of Dermatology, National Defense Medical Center, Taipei, Taiwan 4 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

F39

11:20-11:30 Increased keloid risk in patients with atopic dermatitis Ying-Yi Lu, MD.1,2 ; Chun-Ching Lu, MD.3 ; Chieh-Hsin Wu, MD., PhD4 Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 2 Cosmetic Applications and Management Department, Yuh-Ing Junior College of Health Care & Management, Kaohsiung, Taiwan 3 Department of Orthopedics, Taipei Veterans General Hospital, Taipei, Taiwan 4 Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

F40

11:30-11:40 Periorbital Erythema and Swelling as a Presenting Sign of Lupus Erythematosus in Tertiary Referral Centers and Literature Review Chi-Hui Wang, MD.1 ; Yue-Zon Kuan, MD.1 ; Ming-Ying Wu, MD.1,4 ; Tseng-Tong Kuo, MD., PhD2 ; Chun-Bing Chen, 1,3,4 Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Linkou, and Keelung, Taiwan 2 Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan 3 College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan 4 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan

F41

11:40-11:50 Scleromyxedema and lichen myxedematosus: Is it associated with hepatitis? Kuan-Yu Chen, MD.1 ; Hong-Shang Hung, MD., PhD1 ; Chau-Yee Ng, MD.1 Chang Gung Memorial Hospital, Linko, Department of Dermatology

F42

11:50-12:00 Antiviral Therapy of Six Patients with Erythema Multiforme Diagnosed by the Quick Tzanck Test Lily Hsiao, PhD1 1 Shibuya International Skin Clinic; Moriya Eye and Skin Clinic

F43

12:00:12:10 A 5-year Experience at a Tertiary Hospital on Anti-MDA5 Antibody and Palmar Papules in Clinically Amyopathic Dermatomyositis Wei-Che Chang, MD.1 ; Chia-Tse Weng, MD.2 ; Tzu-Chien Hsu, MD.1 ; J. Yu-Yun Lee, MD.1 ; Chao-Chun Yang, MD., PhD1 ; Sheau-chiou Chao, MD.1 ; Chaw-Ning Lee, MD.1 1 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Department of Rheumatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

F44

12:10-12:20 Patch Testing in Patients with Suspected Shoe Contact Dermatitis: A retrospective study from a regional hospital in northern Taiwan Connie Liu, MD.1 ; Meng-Sui Lee, PhD1 ; Ruey-Yi Lin, MD.1 1 Taipei City Hospital

131

Case Reports

132

TDPC pathology Date: November 17th, 2018

Location: RM 201EF

Moderator: Jie-Yang Jhuang ( 剈὏ᶮ , Taiwan) TC01 14:10-14:18

A Rare Case-Variegate Porphyria in Taiwan Meng-Han Shen, MD.1 ; Min-Hui Chi, MD.2 ; Tseng-Tong Kuo, MD., PhD2 1 Department of dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan 2 Department of dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan TC02 14:18-14:26

A case of non-Langerhans cell histiocytosis with joints and lymph nodes involvement Yi-Hsiang Yu, MD.1 ; Shang-Hung Lin, MD.1 ; Chih-Hung Lee, PhD1 Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital

TC03 14:26-14:34

Superficial CD34-positive fibroblastic tumor: A case report and review of the literature. Teng-Li Lin, MD.1 ; Chi-Shun Yang, MD.2 ; Chao-Kuei Juan, MD.1,3 ; Yi-Ju Chen, MD., PhD1,3 1 Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan 2 Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan 3 Department of Dermatology, National Yang-Ming University, Taipei, Taiwan TC04 14:34-14:42

Erythrodermic cutaneous lymphoma mimicking atopic dermatitis in a young adult Chia-Hsien Yen, MD.1 ;Chih-Hung Lee, MD., PhD1 Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital

TC05 14:42-14:50

Xanthogranulomatous reaction to a ruptured galactocele: a case report Paul-Chen Hsieh, MD.1 ; Chun-Jen Yu, MD.1 ; Wei-Hsin Wu, MD.1 Department of Dermatology, National Taiwan University Hospital, Taiwan

133

LEVEL 2

οᓞൢ֙ ńŢŴŦġųŦűŰųŵ ŇųŦŦġőŢűŦųġĩŗĪġ űųŦŴŦůŵŢŵŪŰů ŴŵŢŨŦġġ

Case Report (I): Infection Date: November 17th, 2018

Location: Presentation stage

C01 13:30-13:36

Various faces of leprosy: A great imitator revisited ManojPawar, MD.1 1 MVP's Dr.VasantraoPawar Medical College & Hospital & Research Center, Nashik, Maharashtra, India C02 13:36-13:42

A rare case of cutaneous cytomegalovirus infection in an immunocompromised renal transplant patient Dr Priyanka Karagaiah, MBBS, MD.1 ; Dr Shilpa K, MBBS, MD.2 Dept of dermatology , Bangalore medical college and research institute, Bangalore 2 Dept of dermatology , Bangalore medical college and research institute, Bangalore

C03 13:42-13:48

Utility and Pitfalls of molecular diagnostics in cutaneous tuberculosis: two case reports Lim Ziying Vanessa, MBBS1 ; Yeo Koon Wee Benson, MBBS1 1 National Skin Centre, Singapore C04 13:48-13:54

It Takes More Than a Kiss to Spread Syphilis: A 32-Year Old Male with Rare Presentation of Secondary Syphilis Ruby Ann B. Imson, MD.1 ; Elizabeth P. Prieto, MD1 East Avenue Medical Center Department of Dermatology, Quezon City, Metro Manila, Philippines

134

Case Report (II): Genodermatosis Date: November 17th, 2018

Location: Presentation stage

C05 13:54-14:00

Epidermolysisbullosa (EB)-a case of a patient followed for 19 years. HanaZelenkova C06 14:00-14:06

A case of late-onset localized epidermolysis bullosa simplex associated with a missense mutation of p.Asp158Ala in the head domain of keratin 5 Makoto Nagai, MD.1 ; Yoshihiro Wada, MD.1 ; MinoriKusakabe, MD.1 ; Yasutomo Imai, MD., PhD1 ; KiyofumiYamanishi, MD., PhD1 Department of Dermatology, Hyogo College of Medicine

C07 14:06-14:12

A case report: a male infant presented with collodion membrane at birth.

Min-Hsin Lin, MD.1,2 ; Jen-Jung Cheng, MD.1 ; Ting-Shun Wang, MD.1 ; Xiu-Juan Wei, MD.1 ; Ben-Hua Su, MD., PhD3 ; Yu-Ping Hsiao, MD., PhD1,2 1 Department of dermatology, Chung-Shan Medical University Hospital, Taiwan. 2 Institute of medicine, Chung-Shan Medical University, Taiwan. 3 Department of pediatrics, Chung-Shan Medical University Hospital, Taiwan. C08 14:12-14:18

Mal de Meleda or psoriasis: A case report in Taiwan Hsuan Ning Wang, MD.1 ; Chung-yee Rosaline Hu, MD.1 ; ShyueLuen Chang, MD.1 Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

&DVH 5HSRUW ,,, ,QÀDPPDWRU\ 'HUPDWRVLV Date: November 17th, 2018

Location: Presentation stage

C09 14:18-14:24

The experience of methotrexate treatment in epidermolysis bullosa acquisita Tzu-Yu, Weng, MD.1 ; Szu-Ying, Chin, MD.1 ; Donald Liu, MD., PhD1 1 Department of Dermatology, Taipei Medical University Shuang Ho Hospital C10 14:24-14:30

Cutaneous sarcoidosis in an HIV-infected patient : a case report Yu-Ting Hung, MD.1 ; Meng-Sui Lee, PhD1 ; Ruey-Yi Li, MD.1 C11

14:30-14:36 Behcet’s disease in 2 Filipinos Carminda P. Rogacion, MD.1 ; Emmanuel C. Perez,, MD., MPH2 ; Johannes F. Dayrit, MD.1 Department of Dermatology, Research Institute for Tropical Medicine, Muntinlupa City, Philippines 2 De La Salle Medical Center, Dasmarinas, Cavite, Philippines

C12 14:36-14:42

“Small but Terrible”: A Case of Lupus Vulgaris in a 54-year old Filipino female Monique Lianne C. Lim, MD.1 ; Elizabeth P. Prieto, MD1 East Avenue Medical Center Department of Dermatology, Quezon City, Metro Manila, Philippines

C13 14:42-14:48

A successful combination therapy of tacrolimus, hydroxychloroquine, and picosecond laser for lichen planus pigmentosus Chen-Yu Wu, MD.1 ; Feng-Ling Lin, MD.1 ; Shiou-Hwa Jee, MD., PhD1 Department of Dermatology, Cathay General Hospital

C14 14:48-14:54

Facial discoid dermatosis: a case series Tai-Siang Chiu, MD.1 ; Tsen-Fang Tsai, MD.1 Department of Dermatology, National Taiwan University Hospital

C15 14:54-15:00

Fingertip infarcts-a rare presentation of carpal tunnel syndrome D.P Liyanagama, MD.1 ; J.Akarawita, MD.1 Dermatology unit,NationalHospital,Sri Lanka

135

&DVH 5HSRUW ,9 ,QĂ&#x20AC;DPPDWRU\ 'HUPDWRVLV Date: November 17th, 2018

Location: Presentation stage

C16 15:30-15:36

Clinical, Dermoscopy and Histopathological findings of four cases of Exogenous Ochronosis at the Research Institute for Tropical Medicine Maria Isabel M. Belizario, MD.1 ; Julius G. Gatmaitan, MD.1 ; ohannes F. Dayrit, MD.1 Research Institute for Tropical Medicine

C17 15:36-15:42

Anti-PD-1-induced bullous lichen planus-like reactions in a patient with renal cancer: a case report and literature review Hua-Ching Chang, MD., MMS1 ; Ming-Hsiu Lin, MD.1 1 Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan C18 15:42-15:48

Vitiligo universalis: Long term sequelae of drug reaction with eosinophilia and systemic symptoms Pin-Hsuan Chiang, MD.1 ; Yau-Li Huang, MD.2 ; Chau-Yee Ng, MD.1 ; Wen-Hung Chung, MD., PhD1 ; Tseng-Tong Kuo, MD., PhD1 Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan City, Taiwan 2 Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan , Taoyuan City, Taiwan

C19 15:48-15:54

Erythema nodosum in a patient with psoriasis treated with adalimumab Po-Wei Huang, MD.1 ; Tai-Siang Chiu, MD.1 ; Tsen-Fang Tsai, MD.1 1 National Taiwan University Hospital C20 15:54-16:00

Radiation-induced localized bullous pemphigoid in a patient with Kaposi's scarcoma Jia-Di Lin, MD.1 ; Sung-Jen Hung, MD.1,2 ; Jen-Hung Yang, MD., PhD1,2 ; Chung-Hsing Chang, MD., PhD1,2,3 ; Kan-Tang Fang, MD., PhD1,2 ; Yung-Hsiang Hsu, MD., MHS4 1 Skin Institute, Department of Dermatology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan. 2 Department of Dermatology, Tzu-Chi University, Hualien, Taiwan. 3 Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. 4 Departments of Pathology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan C21 16:00-16:06

Chessboard surgical excision of hidradenitis suppurativa-A novel method Donald Liu, MD., PhD1 ; Che-Yuan Hsu, MD.1 ; Yu-Tsung Chen, MD.1 ; Wei-Hsi Lin, MD.1 ; Woan-Ruoh Lee, MD., PhD1 ; Shih-Wei Yeh, MD., PhD1 1 Department of Dermatology, Taipei Medical University Shuang-Ho Hospital C22 16:06-16:12

Use of biologics in patients with psoriasisduring pregnancy: A case series Yun-Ju Tsai, MD.1 ; Tsen-Fang Tsai, MD.1 1Department of Dermatology, National Taiwan University Hospital

Case Report (V): Benign neoplasm Date: November 17th, 2018

Location: Presentation stage

C23 16:12-16:18

Cutaneous Rosai-Dorfman Disease of Face: A case report and the Treatment Outcome Yung-Yueh, Su, MD.1 ; Yi-Chen Juan, MD.1 ; Hui-Ju Yang, MD.1 ; Hsiu-Cheng Hsu, MD.1 ; Kuo-Chia Yang, MD.1 Changhua Christian Hospital

C24 16:18-16:24

Tubular apocrine adenoma clinically mimicking keloid on the forearm : a case report Shiow-Jen Juang, MD.1 ; Shu-Hui Wang, MD.1 ; Cheng-Hsiang Hsiao, MD.3 ; Ying-Jui Chang, MD., PhD1,2 Department of Dermatology, Far Eastern Memorial Hospital, New Taipei city, Taiwan 2 New Taipei Institute of Dermatology, New Taipei city, Taiwan 3 Department of Pathology, ChengHsin General Hospital, Taipei, Taiwan

C25 16:24-16:30

Osteoma multiplex cutis: a new clinical entity with rare presentation Yang, Lo, MD.1 ; Shiou-Hwa, Jee, MD., PhD1 ; Yi-An, Chen, MD.1,2 Department of Dermatology, Cathay General Hospital, Taipei 2 Department of Dermatology, Cathay General Hospital, Hsinchu

136

Case Report (VI): Malignancy Date: November 17th, 2018

Location: Presentation stage

C26 16:30-16:36

Cutaneous involvement as the initial presentation of follicle centre lymphoma of the spleen Magdalena ĩychowska, MD.1 ; MaágorzataTupikowska-Marzec, PhD1 ; ZdzisáawWoĨniak, PhD2 ;Joanna Maj, PhD1 1 Department of Dermatology, Venereology and Allergology, Wrocáaw Medical University 2 Department of Pathomorphology, Wrocáaw Medical University C27 16:36-16:42

Successful treatment of recalcitrant actinic keratoses with daylight photodynamic therapy Hsuan Chen, MD.1 ; Chaw-Ning Lee, MD.1 ; Julia Yu-Yun Lee, MD., PhD1 ; Tak-Wah Wong, MD., PhD1,2,3 Department of dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 3 Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan

C28 16:42-16:48

Metastatic Extramammary Paget’s Diease: a multidisciplinary approach incorporating targeted therapy Chih-Yu Chen, MD.1 ; Hung-Wei Gao, MD.2 ; Ping-Ying Chang, MD., PhD3 ; Shyi-Gen Chen, MD.4 ; Wen-Yen Huang, MD.4 ; Chien-Ping Chiang, MD., PhD1 1 Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center 2 Department of Pathology, Tri-Service General Hospital, National Defense Medical Center 3 Division of Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center 4 Division of Plastic surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center C29 16:48-16:54

Folliculotropic mycosis fungoides with good response to narrowband UVB and oral retinoid: A case report Lin, Wei-hsi, MD.1 ; Chiu, Yun-wen, MD.1 ; Shih, Yi-Hsien, MD.1 Taipei Medical University-Shuang Ho Hospital

C30 16:54-17:00

Successful treatment of hypopigmentedextramammary Paget’s disease with carbon dioxide laser ablation Wei-Ting, Liu, MD.1 ; Tak-Wah Wong, MD., PhD1,2,3 1 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Department of Molecular Biology & Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan 3 3Center of Applied Nanomedicine, National Cheng Kung University

137

E-posters

138

LEVEL 2

P01

Malignant melanoma in Eastern Taiwan: clinicopathologic analysis of 60 cases Kai-Chi Tsai, MD.1 ; Sung-Jen Hung, MD.1,2 ; Jen-Hung Yang, MD., PhD1,2 ; Kan-Tang Fang, MD., PhD1,2 ; Yung-Hsiang Hsu, MD.3 ; Chung-Hsing Chang, MD., PhD1,2,4 1 Skin Institute, Department of Dermatology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan. 2 Department of Dermatology, Tzu-Chi University, Hualien, Taiwan. 3 Departments of Pathology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan. 4 Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.

P02

Anti-inflammatory effect of T-cell specific Wwox on TPA induced skin inflammation Feng-Jie Lai, MD., PhD1 ; Li-Jin Hsu, PhD2 ; Ching-Hao Teng, PhD3 ; Nan-Shan Chang, PhD3 1 Department of Dermatology, Chi-Mei Medical Center, Tainan, Taiwan 2 Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University Medical College, Tainan, Taiwan 3 Institute of Molecular Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan,

P03

Treatment with propanolol for infantile hemangioma : one single-center experience Chin-Yi Yang, , MD.1 ; I-Hsin Shih, , MD.1 Departments of Pediatric Dermatology, Chang Gung Memorial Hospital, Linkou, Taiwan

P04

A case report of linear lupus panniculitis of the scalp presenting as alopecia along Blaschkoâ&#x20AC;&#x2122;s lines Wang, Yu-An, MD.1 ; Liu, Cheng Han , MD.1 1 National Cheng Kung University Hospital

P05

A recalcitrant case of chromoblastomycosis and review of literature Ting-Jung, Hsu, MD.1 ; Han-Chi Tseng, MD.1,2 Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital 2 Department of cosmetic applications and management, Lecturer, Yuh Ying Junior College of Health Care and Management

P06

A case series report of lymphocytic thrombophilic arteritis Hsiao-Yu Li, MD.1 ; Yu-Hung Wu, MD.1 1 Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan

P07

Dermoscopy of accidental AgNO3 Staining: The phenomenon and mechanism appraisal Ching-Ying Wu, MD.1,2 ; Gon-Yau Chu, MD.3 Department of Dermatology, Kaohsiung Municipal Ta-Tong Hospital 2 Department of Dermatology, Kaohsiung Medical University Hospital 3 Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital

139

P08

A case of mixed connective tissue disease with secondary Raynauld’s phenomenon effectively treated with intravenous prostaglandin E1 (Alprostadil) and oral phosphodieastase 5 inhibitor (Sildenafil) Huang, Yu-Jen, MD.1 ; Cheng-Che Eric Lan, MD., PhD1 Department of Dermatology, Kaohsiung Medical University Chung-Ho Memorial Hospital

P09

Extensive silicone granuloma of the face successfully treated with corticosteroid and doxycycline Yu-Chen Chen, MD. ; Julia Yu-Yun Lee, MD. 1 National Cheng Kung University Hospital

P10

Kikuchi-Fujimoto disease in a patient with primary Sjögren's syndrome: a case report and review of the literature Tsai-Hsien Lee, MD.1 ; Hsiou-Hsin Tsai, MD.1 1 Department of Dermatology, Taipei Medical university Hospital

P11

Primary Cutaneous Anaplastic Large Cell Lymphoma in a 73-year-old Filipino Male: A Diagnostic Conundrum Juan Antonio D. Cervantes, MD.1 ; Eunice Kaye M. Rayos-Lopez, MD.1 ; Ma. Teresita G. Gabriel, MD.1 ; Reynaldo L. Ugalde, MD.1 ; Johannes F. Dayrit, MD.1 ; Eduardo Calonje, MD.2 1 Department of Dermatology, Research Institute for Tropical Medicine, Muntinlupa City, Philippines 2 Department of Dermatopathology, St. John’s Institute of Dermatology, St. Thomas Hospital, London, UK

P12

Novel compound heterozygous deletion and insertion ZMPSTE24 mutations in a Taiwanese patient with restrictive dermopathy Tzu-Chien Hsu, MD.1 ; Chao-Kai Hsu, MD., PhD1,3 ; Bryan Edgar K. Guevara, MD.2 ; Mei-Hiu Yang, MD.1 ; Chen-Han Wu, MD.3 ; Julia Yu-Yun Lee, MD.1 ; John McGrath, MD., PhD4 ; Sheau-Chiou Chao, MD.1 1 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Department of Dermatology, Southern Philippines Medical Center, Davao, Philippines 3 International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan 4 St. John's Institute of Dermatology, King's College London (Guy's Campus), London, UK

P13

Modified suction-assisted cartilage shaver for axillary osmidrosis Yu-Ju Tseng, MD.1 ; Shang-Hong Lin, MD.1 ; Chih-Hung Lee, MD., PhD1 Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital

P14

Porokeratosis ptychotropica: the clinicopathological features in a case series of 5 patients Yen-Kai Huang, MD.1 ; Bryan Edgar K. Guevara, MD.2 ; Yu-Hung Wu, MD.1 1 Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan 2 Department of Dermatology, Southern Philippines Medical Center Davao City, Philippines

P15

Pseudomonas aeruginosa and Serratia marcescens infection-a rare cause of multiple facial erythematous papulonodules Charlene Wee Li Ping, MBBS1 ; Brian Chia Keng Yong, MBBS1 ; Yong Anning Angeline, MBBS1 1 National Skin Centre Singapore

P16

Successful treatment of invasive squamous cell carcinoma in a dystrophic epidermolysis bullosa patient with combination of CO2 laser, cyroimmunotherapy, in situ photoimmunotherapy and acitretin Ting-Yu Yeh, 1 ; Tzu-Kun Lo, MD.1 ; Chaw-Ning Lee, MD.1 ; Julia Yu-Yun Lee, MD.1 ; Tak-Wah Wong, 1,2,3 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Department of Molecular Biology & Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan 3 Center of Applied Nanomedicine, National Cheng Kung University 1

P17

The value of dermoscopy in generalized granuloma annulare: from time of diagnosis to successful treatment with acitretin and narrowband UV-B phototherapy Marie Claudine Francesca Perlas, , MD.1 ; Elisabeth Ryan, , MD.1 ; Johannes Dayrit, , MD.1 1 Research Institute for Tropical Medicine, Muntinlupa City, Philippines

P18

Lupus erythematosus/lichen planus overlap syndrome in a breast cancer patient receiving letrozole Hsing-San Yang, MD.1 ; Bryan Edgar K. Guevara, MD.1,2 ; Julia Yu-Yun Lee, MD.1 ; Chao-Kai Hsu, MD., PhD1,3 1 Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2 Southern Philippines Medical Center, Davao, Philippines 3 International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan

P19

A Rare Case Report of Lichen Myxedematosus Yi-Chen Juan, MD.1 ; Chih-Jung Chen, MD., PhD2,3 ; Yu-Hung Wu, MD.4 ; Yen-Shuo Tseng, MD.1 ; Tsu-Man Chiu, MD.1 1 Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan 2 Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan 3 School of Medicine, Chung Shan Medical University, Taichuang, Taiwan 4 Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan

P20

Two morphologic forms of porokeratosis within a family and the treatment with the carbon dioxide laser Yi-Chien Yang, MD., PhD1 1 Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

140

P21

Primary Cutaneous Follicular Center Lymphoma with Spindle Cell Morphology and Aberrant Expression of p63 and PAX8-a Case Report Chung-Hao Hsu, MD.1 ; Chih-Jung Chen, MD., PhD2,3 ; Kung-Chao Chang, MD., PhD4 ; Hsiu-Cheng Hsu, MD.1 1 Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan 2 Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan 3 School of Medicine, Chung Shan Medical University, Taichung, Taiwan 4 Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan.

P22

Expression of Melanin Correlates with Progression and Metastasis of Malignant Melanoma Yuying Yang, MD.1 ; Hong Zhe, MD.1 ; Hengning Ke, PhD1,2 General Hospital of NingXia Medical University. 2 Zhongnan Hospital of Wuhan University, Training Center of AIDS prevention and Cure of Hubei Province

P23

Terlipressin-induced skin necrosis: Two cases report with unusual Hailey-Hailey disease-like histopathological features. Jeng Yuan, MD.1 ; Julia Yu-Yun Lee, MD.1 ; Yi-chen,Liao, MD.1 1 Department of Dermatology, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan

P24

Granular C3 Dermatosis- a Case report and review of article Po-Huan Ko, MD.1 ; Hsiou-Hsin Tsai, PhD1 ; Min-Hsiu Lin, MD.1 Taipei Medical University Hospital

P25

CD68-negative nonlipidized juvenile xanthogranuloma, a case series Tzu-Kun Lo, MD.1 ; Julia Yu-Yun Lee, MD.1 1 Dermatology Department of National Cheng Kung University Hospital, Tainan, Taiwan

P26

A report of three Pleosporales cutaneous infection, an exceptional and novel fungus Han Chi Tseng, MD.1,2 1 Department of Dermatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan 2 Department of cosmetic applications and management, Lecturer, Yuh Ying junior college of healthcare and management, Kaohsiung, Taiwan

P27

Cutaneous chromoblastomycosis effectively treated by local heat monotherapy Tzu-Hung Huang, MD.1 ; Cheng-Che E. Lan, MD., PhD1,2 1 Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 2 Department of Dermatology, College of Medicine, Kaohsiung Medical University

P28

Congenital ichthyosis with neurosensory hearing impairment: report of a case and review of the literature Yang-Yi Chen, MD.1,2; Pei-Ling Chi, MD. 1; Chu-Sung Hu, MBBS, M.Phil 1,3; Hamm-Ming Shen, MD.; Cheng-Che Lan, MD., PhD1,3 Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 2 Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 3 Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

P29

Effect of size and location of nevi on the postoperative pain and emergence agitation in children undergoing nevi excision: observational study Ji Eun Kim, MD.1 1 Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Republic of Korea

P30

The enlarging black nodule on left flank mimics melanoma Chia-Hui, Chu, MD.1 ; Chia-Wen, Shih, MD.2 1 Department of Dermatology, Lo-Hsu Medical Foundation , Lotung Poh-Ai Hospital 2 Department of Pathology, Lo-Hsu Medical Foundation , Lotung Poh-Ai Hospital

P31

Pemphigus vulgaris complicated with atypical Kaposi varicelliform eruption Szu Hao Chiu, MD.1 ; Cheng-Che E. Lan, MD., PhD1,2 1 Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 2 Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

P32

Etoricoxib induced Steven-Johnson syndrome: a case report Chung Yi Cheng, MD.1 ; Tyng-Shiuan Hsieh, 1,2 1 Taipei Municipal Wanfang Hospital 2 School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

P33

Using the Least absolute shrinkage and selection operator (LASSO) in risk factors selection of postinflammatory hyperpigmentation after Nd-Yag laser toning treatment Wei-Han Lu, 1 ; Chao-Hong Liu, MD., MMS1,2 ; Ming-Xiang Liu, PhD1,3 ; Tsair-Fwu Lee, PhD1,3,4 1 Medical Physics and Informatics Laboratory, Department of Electronics Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan 2 Cosmetic Dermatology, Yuan's General Hospital, Kaohsiung, Taiwan 3 Department of Radiation Oncology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan 4 Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan 141

P34

Tattoo-Induced Pseudolymphoma: A Case Report Beatrice Maxine Chan, , MD. 1 Jose R. Reyes Memorial Medical Center

P35

A Case of A 1-Month Old Female with Incontinentia Pigmenti Maria Rosa Noliza Encarnacion, MD.1 East Avenue Medical Center

P36

A case report: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder Chiang Yan-Cheng, MD.1,2 ; Lin Min-Hsin, MD.1,2 ; Hung Chu-Ju, MD.1,2 ; Liu Chin-Yin, MD.1 ; Lai Po-Ju, MD., PhD1,2 ; Lin Zi-Jun, MD.1 ; Hsu Jeng-Dong, MD.1 ; Hsiao Yu-Ping, MD., PhD1,2 1 Department of dermatology, Chung-Shan Medical University Hospital, Taiwan. 2 Institute of medicine, Chung-Shan Medical University, Taiwan. 3 Department of pathology, Chung-Shan Medical University Hospital, Taiwan.

P37

Diffuse cutaneous leishmaniasis mimicing tuberous xanthoma Messay Tesfaye, MD.1 1 Addis Ababa University Colledge of health sience

P38

Beau's lines following influenza Hsiu-Hui Chiu, MD.1 1 Department of Dermatology, Pingtung Christian Hospital, Pingtung County, Taiwan

P39

Cutaneous Spindle Squamous cell carcinoma of scalp in an 88-year-old man: a case report Tyng-Shiuan Hsieh, 1,2 ; Hsian-Jenn Wang, MD.1 1 Taipei Municipal Wanfang Hospital 2 School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

P40

Scalp Angiosarcoma Hugo Gamez-Torres, MD.1 ; Luis Lavin-Fuentes, MD.1 ; Rodrigo Cepeda-Valdes, MD.2 ; Julio Cesar Salas-Alanis, MD.2 1 Universidad de Monterrey 2 DeBRA- Mexico

P41

Penile Calciphylaxis in an end-stage-renal disease patient under conservative management: a case report Corazon Almira Mella, MD.1 ; Ma. Lourdes Aragon De Veyra, , MD.1 1 Makati Medical Center, Department of Dermatology

P42

Cutaneous lesions in Neurofibromatosis type 2 Khriz Anne G. Angbengco, MD. ; Krisinda Dim-Jamora, MD. 1 Makati Medical Center

P43

A Pregnant Woman with Cobb Syndrome Yi-Hsien Chen, MD.1 ; Zhi-Wei Wang, MD.2 ; Wei-Ming Wang, MD., PhD1 ; Chih-Tsung Hung, MD.1 ; Chien-Ping Chiang, MD., PhD1 1 Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center 2 Department of Radiology, Tri-Service General Hospital, National Defense Medical Center

P44

Contact dermatitis with rosin shaped like a human Hiroyuki Miura, MD., PhD1 ; Syoko Suzuki, MD.1 ; Sakuhei Fujiwara, MD., PhD1 1 Department of Dermatology, Osaka Minato Central Hospital, Osaka, Japan

P45

A Case of A 30 year old Female with Systemic Lupus Erythematosus Initially Manifesting as Lupus Panniculitis Ma. Corazon A. Iniego, MD.1 ; Elizabeth P. Prieto, MD.1 1 East Avenue Medical Center Department of Dermatology

P46

Dermoscopy of tinea nigra- A useful tool Ching-Hao Chang, MD.1 ; Chia-Wen Shih, MD., PhD2 1 Department of Dermatology, Lotung Poh-Ai Hospital, Yilan, Taiwan 2 Department of Pathology, Lotung Poh-Ai Hospital, Yilan, Taiwan

P47

Impact of allergen avoidance on the quality of life among patch test positive patients with allergic contact dermatitis in a tertiary hospital in the Philippines Mark Gerald R. Serrano, , MD.1 ; Lillian Lopez-Villafuerte, , MD.1,2 ; Melanie Joy Doria-Ruiz, , MD.1,2 1 Jose R. Reyes Memorial Medical Center 2 Philippine Dermatological Society

P48

RENAL INVOLVEMENT IN GENERALISED PUSTULAR PSORIASIS (GPP) Dr Stephanie Sutjipto, MBBS2 ; Dr Lim Hua Liang, Joel, MBBS1 ; Prof Chong Wei Sheng, MBBS1 1 National Skin Center, Singapore 2 Tan Tock Seng Hospital, Singapore

142

P49

Darier disease-our clinical experience in an Asian centre Adeline Yong Mei Yen, MBBS1 ; Tan Chee Hian, MBBS1 ; Madeline Ho Sheun Ling, MBBS1 ; Lucinda Tan Siyun, MBBS1 1 National Skin Centre, Singapore. 1 Mandalay Rd, Singapore 308205

P50

Effect of intralesional vitamin D3 on molluscum contagiosum Daniel Henry, MBBS, MD.1 ; AL SINGH, MD., PhD1 ; BHUSHAN MADKE, MD.1 ; Sandeep kulkarni, MD.1

P51

Pseudoxanthoma elasticum: dermoscopy and mutation analysis. Rodrigo Cepeda-Valdes, MD.1 ; Julio Cesar Salas-Alanis, PhD1 ; Giulio Fortuna, PhD2 ; Regina Isabella-Matus, MD.1 ; Qiaoli Li, MD., PhD3 Jouni Uitto, MD., PhD3 ; 1 Dystrophic Epidermolysis Bullosa Research Association Mexico Foundation, Nuevo Leon, Mexico 2 Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, via Pansini 5, 80131, Naples, Italy. 3 Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, Pen

P52

Churg–Strauss syndrome with multi-organ involvement: Report of a case and review of Taiwanese patients Hsin-Wei Huang, MD.1 ; Yi-Chien Yang, MD., PhD1,2 1 Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan 2 Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, Kaohsiung, Taiwan

P53

The application of 595-nm pulsed dye laser for vascular anomalies in a Chinese population: a 10-year experience LIN MAO-YING, MD.1 1 Xiamen Chang Gung Hospital

P54

Dermoscopy of Basal Cell Carcinoma on Vulvar Region Diego de los Cobos-Davalos, MD.1,3 ; Rodrigo Cepeda-Valdes, MD.3 ; Luis Faevla-Fernandez, MD.1,3 ; Claudia Villarreal-Carrillo, MD.2,3 ; Julio Salas-Alanis, MD.3 1 Departamento de Ciencias Básicas, Escuela de Medicina, Universidad de Monterrey.San Pedro Garza 2 Facultad de Medicina, Universidad Autonoma de Nuevo Leon 3 DEBRA México, Monterrey Nuevo León, México.

P55

Chemical Nail Avulsion: An alternative treatment for nail dystrophy Pan Jiun Yit, MD.1 1 NATIONAL SKIN CENTRE, SINGAPORE

P56

Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi-ethnic Asian cohort: A 12-year review Lim Hua Liang Joel, MD.1 ; Tan Sern Ting Eugene, MD.1 ; Tee Shang Ian, MD.1 ; Tan Suat Hoon, MD.1 1 National Skin Centre, Singapore

P57

Adult T-cell lymphoma/leukemia presenting as granulomatous mycosis fungoides Ching-Ting Huang, MD.1 ; Pa-Fan Hsiao, MD.1 ; Yu-Hung Wu, MD.1,2 ; Jie-Yang Jhuang, , MD.3 1 Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan 2 Department of Medicine, Mackay Memorial College, New Taipei City, Taiwan 3 Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan

P58

Neonatal acne in a three-week old infant treated with zinc coceth sulfate foaming wash Mabelle F. Colayco, MD.1 1 Philippine Dermatological Society

P59

Dermatosis on the soles and seeing grey patches Shiu Ming Pang, , MD.2 1 Department of Dermatology, Singapore General Hosptial 2 Duke-National University of Singapore Medical School

P60

The rope sign: Interstitial granulomatous dermatitis associated with systemic lupus erythematosus Yuki Iwai, MD.1 ; Natsumi Hama, MD.1 ; Riichiro Abe, MD., PhD1 1 Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences

P61

Concomitant occurrence of multiple myeloma and diffuse large B-cell lymphoma, leg type Chih-Ting Chen, MD.1 ; Chih-Chiang Chen, MD., PhD1 1 Taipei Veterans General Hospital

P62

Association between psoriasis and non-alcoholic fatty liver disease: a meta-analysis of observational studies Shu-Hui Wang, MD., MHS1 ; Ching-Chi Chi, MD., MMS, PhD2 ; Chin-Yu Lee, 3 ; Chia-Yu Liu, 3 ; Tao-Hsin Tung, PhD4 1 Department of Dermatology, Far Eastern Memorial Hospital 2 Department of Dermatology, Chang Gung Memorial Hospital, Linkou and College of Medicine, Chang Gung University 3 School of Medicine, College of Medicine, Fu Jen Catholic University 4 Department of Medical Research and Education, Cheng Hsin General Hospital 143

P63

Acute Localized Exanthematous Pustulosis of the Lower Limb-An Unusual Adverse Drug Reaction to BetaLactam Antibiotics WEI SHENG CHONG, MBBS1 ; SEAN LEONG, MBBS1 ; 1 NATIONAL SKIN CENTRE, SINGAPORE

P64

Fusarium Pneumonia in a Immunocompromised Pemphigus Vulgaris Patient Ranthilaka R. Ranawaka, MBBS, MD.1 ; Ravini de S. Karunatillake, MD.1 ; Janaki Dissanayake, MBBS, MD.1 1 General Hospital Kalutara, Sri Lanka

P65

Multiple Warty Dyskeratoma on forehead: a case report and review of the literature PRARTHANA ADHIKARI, MBBS, MD. ; HUANG CHANGZHENG, MD., PhD 1 TONGJI MEDICAL COLLEGE, HUAZHONG UNIVERITY OF SCIENCE AND TECHNOLOGY

P66

The utility of Tele-Derm in the diagnosis and management of two rare dermatological presentations Frank Po-Chao Chiu, MBBS1 ; Jesse Johnston, MBBS2 ; James Correy, MBBS3 ; Sumi Ranjit, MBBS4 ; Jim Muir, 1,2 1 Australian College of Rural and Remote Medicine 2 Australian College of Dermatology 3 Royal Australian College of General Practitioners 4 Capital Pathology

P67

Cutaneous leishmaniasis in an overseas Filipino worker who responded favorably to oral itraconazole Audi, MD.1 ; Aliza Bellamy R. Limcangco, MD.1 ; Johannes F. Dayrit, MD.1 1 Research Institute for Tropical Medicine

P68

A case of ichthyosiform lichen planus pigmentosus in a Filipino male Audi, MD.1 ; Johannes F. Dayrit, MD.2 1 Research Institute for Tropical Medicine

P69

Common Dermatoses and Predisposing Factors in Food Handlers in a University Campus: a cross-sectional study Patricia Anne Nicole O. Ramirez, MD.1 ; Alexis Paula D. Ibanez, MD.1 ; Ma. Angela M. Lavadia, MD.1 1 East Avenue Medical Center Department of Dermatology

P70

Efficacy, safety and tolerability of single versus multiple intralesional immunotherapy injection with purified protein derivative in the treatment of multiple verruca vulgaris: a non-inferiority trial Riza R. Milante, MD.1 ; Daisy King-Ismael, MD. ; Abelaine Venida-Tablizo, MD. 1 Jose R. Reyes Memorial Medical Center 2 Philippine Dermatological Society

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Mistaken identity: Eumycetoma masquerading as squamous cell carcinoma Riza I. Sarne, MD.1 ; Ira Theresia, MD.1 ; Johannes F. Dayrit, MD.1 ; Reynaldo L. Ugalde, MD.1 ; Catherina Jessica Sutantoyo, MD.1 ; Glen Purnomo, MD.2 1 Research Institute for Tropical Medicine 2 Philippine Orthopedic Center

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A rare case of D-penicillamine-induced elastosis perforans serpiginosa Balaban Mihaela, MD.1 ; Popescu Catalin Mihai, MD., PhD2,3 ; Popescu Raluca, MD., PhD2,3 Derma360 Clinic, Bucharest, Romania 2 "Carol Davila" University of Medicine and Pharmacy, Dermatology Department, Bucharest, Romania 3 Colentina Clinical Hospital, Dermatology Department, Bucharest, Romania

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Erythrokeratodermia variabilis et progressiva in a Filipino girl Franchesca Marie D. Ilagan, MD.1 ; Maria Lourdes H. Palmero, MD.1 1 University of Santo Tomas Hospital

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Therapeutic response in patients with vitiligo ten years after the initiation of unconventional therapies in Madagascar. Sendrasoa Fandresena Arilala, MD.1 ; Ranaivo Irina Mamisoa, MD. ; Rakotoarisaona Mendrika Fifaliana, MD. Raharolahy Onivola, MD. ; Andrianarison Malalaniaina, MD. ; Razanakoto Naina Harinjara, MD. ; Ramarozatovo Lala Soavina, MD. ; Rapelanoro Rabenja Fahafahantsoa, PhD ; 1 Department of Dermatology, Joseph Raseta Hospital Antananarivo Madagascar

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Erythromelalgia as a first symptom of polycythemia vera Shiang-Yu Yang, MD.1,2 ; Gow-Shing Chen, MD., PhD2,3 1 Departments of Dermatology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan 2 Departments of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 3 Departments of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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A case of leukocytoclastic vasculitis following administration of rivaroxaban Maria Vinna N. Crisostomo, , MD.1 ; Maricarr Pamela Lacuesta-Gutierrez, , MD.1 ; Karla Phoebe Castanos, , MD.1 1 Department of Dermatology, Southern Philippines Medical Center, Davao City, Philippines

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Efficacy and safety of fractional carbon-dioxide (CO2) laser-combined topical therapy for the treatment of onychomycosis Anil Kumar Bhatta, MD.1 ; Xin Huang, PhD2 ; Uma Keyal, MD.1 1 Department of Dermatology, Shanghai Skin DIsease Hospital Tongji University school of Medicine 2 Department of Dermatology, Shanghai Tongji Hospital Tongji University school of Medicine

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Impact of urticaria on the risk of anaphylaxis: A nationwide population-based retrospective cohort study in Taiwan Su-Boon YONG 1,2,3 ; Huang-Hsi CHEN1 ; Jing-Yang HUANG4 ; James Cheng-Chung WEI 1,5,6 1 Institute of Medicine, Chung Shan Medical University, Taichung 2 Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Show Chwan Memorial Hospital, Changhua 3 Department of Nursing, Meiho University, Neipu 4 Department of Medical Research, Chung Shan Medical University Hospital 5 Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital 6 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan

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Dermoscopy as a Diagnostic and Monitoring Tool for Recurrent Extramammary Pagetâ&#x20AC;&#x2122;s Disease (EMPD) Chou, Pei-Chien1,2; Cheng, Shih-Tsung1,3 Kaohsiung Medical University, Department of Medicine 2 Chang Gung Memorial Hospital Kaohsiung Branch 3 Kaohsiung Medical University, Department of Dermatology

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Atypical mycobacterial cutaneous infections: A 5 years retrospective study Dr Vaishnavi Gowda, MBBS, MD. ;

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Lichen Planus-like Secondary Syphilis Wong Yisheng, MBBS ; Pan Jiun Yit, MBBS ; 1 National Skin Centre

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Pyoderma Vegetans: A diagnostic dilemma in an Immuno-competent Individual. Dr. Shashank Bhargava, , MBBS, MD.1,2 ; Dr. Krishnendra Varma, , MD.2 1 Jawaharlal Nehru Medical College, Belgaum, India 2 R. D. Gardi Medical College, Ujjain, India

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Baicalein protects human epidermal keratinocyte against bullous pemphigoid Xia Da1, Duerna Tie1 ; Eishin Morita1 Department of Dermatology, Shimane University Faculty of Medicine

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Clinical outcome of high-dose-rate (HDR) electronic brachytherapy (EBT) for nonmelanoma skin cancer in Taiwan Tang, Tsz-Yi 1, Cheng ; Shih-Tsung 2 School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 3 Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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Rare Malignant Melanomas with Neural Differentiation â&#x20AC;&#x201C; p53 Positive Anna-Marie Hosking BS1 ; Franchesca Choi BS, RPh1,2 ; Jessica Shiu MD, PhD1 ; Terese Bergheim MD1 ; Sebastian de Feraudy MD, PhD1 ; Ronald Barr MD3 ; Ashley Elsensohn MD, MPH1 1 Department of Dermatology, University of California Irvine, Irvine, CA, USA 2 School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 3 Laguna Pathology Medical Group, Laguna Hills, CA, USA

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A case of hyperpigmented macules in the flexures Chee Hian Tan, MBBS ; Hua-Liang Joel Lim, MBBS ;

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Primary Cutaneous CD 30-Positive Anaplastic Large Cell Lymphoma presenting as ulcerated nodules in a 50-year old woman Elisabeth Ryan, MD.1 ; Yoga Waskito, , MD.1 ; Johannes F Dayrit, , MD.1 Research Institute for Tropical Medicine, Muntinlupa city, Philippines

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A bone marrow transplant recipient with rapidly progressing skin detachment Tay Wan Jiun, MBBS ; Yeo Yi Wei, MBBS ; Busmanis Inny, MBBS ; Tang Po Yin, MBBS ; Oh Choon Chiat, MBBS

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Dilemma in Eczema: A Case of Extramammary Pagetâ&#x20AC;&#x2122;s disease Catherine T. Go-Teodosio, MD.1 ; Ma. Teresita G. Gabriel, MD.1 ; Roy Lawrence S. Paredes, MD.1 ; 1 Research Institute for Tropical Medicine

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Cutaneous epidermotropic metastasis of an esophageal squamous cell carcinoma: wound healing and transepidermal elimination as possible mechanisms for epidermotropism Franchesca Choi1 ; Wan-Tzu Chen2 ; Stephen Chu-Sung Hu, MBBS, M.Phil3,4 School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 3 Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 4 Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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Non-Cultured Cellular grafting in Vitiligo patients Yin Hlaing Win, MBBS1 1 Yin Hlaing Win

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Picosecond Laser Treatment for Longitudinal Melanonychia with Benign Clinical Features - A Case Report. Kwei-Lan Liu, MD1 ; Wen-Chien Tsai, MD2 Department of Dermatology, Chang Gung Memorial Hospital - Kaohsiung Medical Center 2 Huang PH Dermatology and Aesthetics

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